Dr. Maria Elena Sales

Dr. Maria Elena Sales

Principal Investigator
University of Buenos Aires, Argentina


Highest Degree
Ph.D. in Pharmacology from University of Buenos Aires, Argentina

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Biography

Dr. Maria Elena Sales obtained her Ph.D. in Pharmacology from University of Buenos Aires, Argentina. Her area of interest focused on Biomedical Sciences. She has published 35 articles in peer-reviewed journals.

Area of Interest:

Biomedical Sciences
100%
Anti-Cancer Agents
62%
Clinical Immunology
90%
Pharmacology
75%
Neuroimmunology
55%

Selected Publications

  1. Sordelli, M.S., J.S. Beltrame, E. Zotta, N. Gomez and G. Dmytrenko et al., 2017. Endogenous lysophosphatidic acid participates in vascularisation and decidualisation at the maternal-fetal interface in the rat. Reprod. Fertility Dev. 10.1071/RD16235.
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  2. Dmytrenko, G., M.E. Castro and M.E. Sales, 2017. Denatonium and naringenin promote SCA-9 tumor growth and angiogenesis: Participation of arginase. Nutr. Cancer, 69: 780-790.
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  3. Michelini, F.M., M.G. Lombardi, C.A. Bueno, A. Berra, M.E. Sales and L.E. Alche, 2016. Synthetic stigmasterol derivatives inhibit capillary tube formation, herpetic corneal neovascularization and tumor induced angiogenesis: Antiangiogenic stigmasterol derivatives. Steroids, 115: 160-168.
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  4. Elena Sales, M., 2016. Muscarinic receptors as targets for metronomic therapy in breast cancer. Curr. Pharm. Design, 22: 2170-2177.
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  5. Pontillo, C., A. Espanol, F. Chiappini, N. Miret and C. Cocca et al., 2015. Hexachlorobenzene promotes angiogenesis in vivo, in a breast cancer model and neovasculogenesis in vitro, in the human microvascular endothelial cell line HMEC-1. Toxicol. Lett., 239: 53-64.
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  6. Espanol, A.J., A. Salem, D. Rojo and M.E. Sales, 2015. Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase. Int. Immunopharmacol., 29: 87-92.
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  7. Penas, F., G.A. Mirkin, M. Vera, A. Cevey and C.D. Gonzalez et al., 2014. Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice. Biochimica et Biophysica Acta (BBA)-Mol. Basis Dis., 1852: 893-904.
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  8. Orqueda, A.J., M.V. Dansey, A. Espanol, A.S. Veleiro and E.B.K. Joffe et al., 2014. The rigid steroid 21-hydroxy-6, 19-epoxyprogesterone (21OH-6, 19OP) is a dissociated glucocorticoid receptor modulator potentially useful as a novel coadjuvant in breast cancer chemotherapy. Biochem. Pharmacol., 89: 526-535.
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  9. Espanol, A.J., M.O. Maddaleno, M.G. Lombardi, M. Cella, P.M. Pulido and M.E. Sales, 2014. Treatment with LPS plus INF-γ induces the expression and function of muscarinic acetylcholine receptors, modulating NIH3T3 cell proliferation: Participation of NOS and COX. Br. J. Pharmacol., 171: 5154-5167.
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  10. Vulcano, M., M.G. Lombardi and M.E. Sales, 2013. Nonneuronal cholinergic system in breast tumors and dendritic cells: Does it improve or worsen the response to tumor? Int. Scholarly Res. Notices, Vol. 2013. 10.1155/2013/486545.
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  11. Sales, M.E., 2013. Cholinergic drugs as therapeutic tools in inflammatory diseases: Participation of neuronal and non-neuronal cholinergic systems. Anti-inflamm. Anti-allergy Agents Med. Chem., 12: 109-116.
    CrossRef  |  PubMed  |  

  12. Penas, F., G.A. Mirkin, E. Hovsepian, A. Cevey, R. Caccuri, M.E. Sales and N.B. Goren, 2013. PPARγ ligand treatment inhibits cardiac inflammatory mediators induced by infection with different lethality strains of Trypanosoma cruzi. Biochim. Biophys. Acta Mol. Basis Dis., 1832: 239-248.
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  13. Pelegrina, L.T., M.G. Lombardi, G.L. Fiszman, M.E. Azar, C.C. Morgado and M.E. Sales, 2013. Immunoglobulin G from breast cancer patients regulates MCF-7 cells migration and MMP-9 activity by stimulating muscarinic acetylcholine receptors. J. Clin. Immunol., 33: 427-435.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Lombardi, M.G., M.P. Negroni, L.T. Pelegrina, M.E. Castro and G.L. Fiszman et al., 2013. Autoantibodies against muscarinic receptors in breast cancer: Their role in tumor angiogenesis. PLoS One, Vol. 8. 10.1371/journal.pone.0057572.
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  15. Espanol, A.J., G. Jacob, G. Dmytrenko and M.E. Sales, 2013. Muscarinic activation enhances the anti-proliferative effect of paclitaxel in murine breast tumor cells. Anti-cancer Agents Med. Chem., 13: 1273-1279.
    CrossRef  |  PubMed  |  

  16. De la Torre, E., E. Hovsepian, F.N. Penas, G. Dmytrenko, M.E. Castro, N.B. Goren and M.E. Sales, 2013. Macrophages derived from septic mice modulate nitric oxide synthase and angiogenic mediators in the heart. J. Cell. Physiol., 228: 1584-1593.
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  17. Sales, M.E., 2012. Tumor growth is stimulated by muscarinic receptor agonism: Role of autoantibodies in breast cancer patients. Immunol. Endocrine Metab. Agents Med. Chem., 12: 208-215.
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  18. Espanol, A., M. Dasso, M. Cella, N. Goren and M.E. Sales, 2012. Muscarinic regulation of SCA-9 cell proliferation via nitric oxide synthases, arginases and cyclooxygenases. Role of the nuclear translocation factor-κB. Eur. J. Pharmacol., 683: 43-53.
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  19. Bueno, C.A., M.G. Lombardi, M.E. Sales and L.E. Alche, 2012. A natural antiviral and immunomodulatory compound with antiangiogenic properties. Microvascular Res., 84: 235-241.
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  20. Salamone, G., G. Lombardi, S. Gori, K. Nahmod and C. Jancic et al., 2011. Cholinergic modulation of dendritic cell function. J. Neuroimmunol., 236: 47-56.
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  21. Dasso, M., R. Pagotto, O.P. Pignataro, R.A. Diez and M.E. Sales, 2011. Effect of bitter compounds on amylase secretion in murine submandibular glands: Signaling pathway mechanisms. Biochim. Biophys. Acta General Subjects, 1810: 1212-1219.
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  22. Sales, M.E., 2010. Muscarinic receptors as targets for anti-inflammatory therapy. Curr. Opin. Invest. Drugs, 11: 1239-1245.
    PubMed  |  

  23. Negroni, M.P., G.L. Fiszman, M.E. Azar, C.C. Morgado and A.J. Espanol et al., 2010. Immunoglobulin G from breast cancer patients in stage I stimulates muscarinic acetylcholine receptors in MCF7 cells and induces proliferation. Participation of nitric oxide synthase-derived nitric oxide. J. Clin. Immunol., 30: 474-484.
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  24. Espanol, A., N. Goren, M.L. Ribeiro and M.E. Sales, 2009. Nitric oxide synthase 1 and cyclooxygenase-2 enzymes are targets of muscarinic activation in normal and inflamed NIH3T3 cells. Inflamm. Res., 59: 227-238.
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  25. Fiszman, G.L. and M.E. Sales, 2008. Antibodies against muscarinic receptors in breast cancer: Agonizing tumor growth. Curr. Immunol. Rev., 4: 176-182.
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  26. De la Torre, E., A.M. Genaro, M.L. Ribeiro, R. Pagotto, O.P. Pignataro and M.E. Sales, 2008. Proliferative actions of muscarinic receptors expressed in macrophages derived from normal and tumor bearing mice. Biochim. Biophys. Acta Mol. Basis Dis., 1782: 82-89.
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  27. Fiszman, G.L., M.C. Middonno, E. de la Torre, M. Farina, A.J. Espanol and M.E. Sales, 2007. Activation of muscarinic cholinergic receptors induces MCF-7 cells proliferation and angiogenesis by stimulating nitric oxide synthase activity. Cancer Biol. Ther., 6: 1106-1113.
    CrossRef  |  PubMed  |  Direct Link  |  

  28. Espanol, A.J., E. de la Torre, G.L. Fiszman and M.E. Sales, 2007. Role of non-neuronal cholinergic system in breast cancer progression. Life Sci., 80: 2281-2285.
    CrossRef  |  PubMed  |  Direct Link  |  

  29. Fiszman, G., V. Cattaneo, E. de la Torre, A. Espanol, L. Colombo, E.S. de Lustig and M.E. Sales, 2006. Muscarinic receptors autoantibodies purified from mammary adenocarcinoma-bearing mice sera stimulate tumor progression. Int. Immunopharmacol., 6: 1323-1330.
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  30. Rimmaudo, L., E. de la Torre and M.E. Sales, 2005. mAchR are involved in murine mammary adenocarcinoma cells LMM3 proliferation and angiogenesis. Biochem. Biophys. Res. Commun., 334: 1360-1365.

  31. De la Torre, E., L. Davel, M.A. Jasnis, T. Gotoh, E.S. de Lustig and M.E. Sales, 2005. Muscarinic receptors participation in angiogenic response induced by macrophages from mammary adenocarcinoma-bearing mice. Breast Cancer Res., 7: R345-R352.
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  32. Espanol, A.J. and M.E. Sales, 2004. Different muscarinc receptors are involved in the proliferation of murine mammary adenocarcinoma cell lines. Int. J. Mol. Med., 13: 311-317.
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  33. Davel, L.E., L. Rimmaudo, A. Espanol, E. de la Torre and M.A. Jasnis et al., 2004. Different mechanisms lead to the angiogenic process induced by three adenocarcinoma cell lines. Angiogenesis, 7: 45-51.
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  34. Espanol, A.J., E. de la Torre and M.E. Sales, 2003. Parasympathetic modulation of local acute inflammation in murine submandibular glands. Inflammation, 27: 97-105.
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  35. Espanol, A., A.M. Eijan, E. Mazzoni, L. Davel, M.A. Jasnis, E.S. de Lustig and M.E. Sales, 2002. Nitric oxide synthase, arginase and cyclooxygenase are involved in muscarinic receptor activation in different murine mammary adenocarcinoma cell lines. Int. J. Mol. Med., 9: 651-657.
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  36. Davel, L.E., M.A. Jasnis, E. de la Torre, T. Gotoh and M. Diament et al., 2002. Arginine metabolic pathways involved in the modulation of tumor-induced angiogenesis by macrophages. FEBS Lett., 532: 216-220.
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  37. Davel, L., A.M. Eijan, M.E. Sales, A. Espanol and A. D'Agostino et al., 2002. Reactivity of tumor-draining lymph nodes and the nitric oxide pathway. Int. J. Oncol., 20: 59-67.
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  38. Espanol, A.J. and M.E. Sales, 2001. Parasympathetic modulation of amylase secretion by IFNγ in murine submandibular glands. Int. Immunopharmacol., 1: 903-910.
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  39. Davel, L., A. D'Agostino, A. Espanol, M.A. Jasnis, D.C.L. Lauria, E.S. de Lustig and M.E. Sales, 2001. Nitric oxide synthase-cyclooxygenase interactions are involved in tumor cell angiogenesis and migration. J. Biol. Regul. Homeostatic Agents, 16: 181-189.
    PubMed  |  

  40. Leiros, C.P., F. Rosignoli, A.M. Genaro and M.E. Sales, 2000. Differential activation of nitric oxide synthase through muscarinic acetylcholine receptors in rat salivary glands. J. Autonomic Nervous Syst., 79: 99-107.
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  41. Espanol, A.J. and M.E. Sales, 2000. Participation of nitric oxide synthase and cyclo-oxygenase in the signal transduction pathway of ileal muscarinic acetylcholine receptors. Pharmacol. Res., 42: 489-493.
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