Dr. Nilberto Robson Falcao do Nascimento
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Dr. Nilberto Robson Falcao do Nascimento

Professor
Universidade Estadual do Ceara, Brazil

Highest Degree
Ph.D. in Pharmacology from Federal University of Ceara, Brazil

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Area of Interest:

Pharmacology and Toxicology
100%
Pharmacology
62%
Applied Toxicology
90%
Physiology
75%
Urology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
89
Abstracts
2

Selected Publications

  1. da Silva Filho, P.M., I.A. Paz, N.R.F. do Nascimento, D.S. Abreu, L.G. de França Lopes, E.H.S. Sousa and E. Longhinotti, 2022. Nitroprusside-expanding the potential use of an old drug using nanoparticles. Mol. Pharm., 20: 6-22.
    CrossRef  |  Direct Link  |  
  2. Mesquita, L.S.F., T.S. Matos, F. do Nascimento Ávila, A. da Silva Batista and A.F. Moura et al., 2021. Diterpenoids from leaves of cultivated Plectranthus ornatus. Planta Med., 87: 124-135.
    CrossRef  |  Direct Link  |  
  3. Sousa, L.G.F., L.U.A. de Souza Cortez, J.S.A.M. Evangelista, F.A.F. Xavier-Jr. and D.B. Heimark, 2020. Renal protective effect of pinitol in experimental diabetes. Eur. J. Pharmacol., Vol. 880. 10.1016/j.ejphar.2020.173130.
    CrossRef  |  Direct Link  |  
  4. Magalhães, H.S., A.B. da Silva, N.R.F. Nascimento, L.G.F. de Sousa and M.J.S. da Fonseca et al., 2020. Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission. Fitoterapia, Vol. 143. 10.1016/j.fitote.2020.104545.
    CrossRef  |  Direct Link  |  
  5. Costa, P.P.C., R. Campos, P.H.B. Cabral, V.M. Gomes and C.F. Santos et al., 2020. Antihypertensive potential of cis-[Ru(bpy)2(ImN)(NO)]3+, a ruthenium-based nitric oxide donor. Res. Vet. Sci., 130: 153-160.
    CrossRef  |  Direct Link  |  
  6. Carvalho, E.M., T. de Freitas Paulo, A.S. Saquet, B.L. Abbadi and F.S. Macchi et al., 2020. Pentacyanoferrate(II) complex of pyridine-4-and pyrazine-2-hydroxamic acid as source of HNO: Investigation of anti-tubercular and vasodilation activities. J. Biol. Inorg. Chem., 25: 887-901.
    CrossRef  |  Direct Link  |  
  7. do Nascimento, N.R.F., F.L.N. de Aguiar, C.F. Santos, A.M.L. Costa and D. de Jesus Hardoim et al., 2019. In vitro and in vivo leishmanicidal activity of a ruthenium nitrosyl complex against Leishmania (Viannia) braziliensis. Acta Trop., 192: 61-65.
    CrossRef  |  Direct Link  |  
  8. Peruchetti, D.B., A.C. Freitas, V.C. Pereira, J.V. Lopes and C.M. Takiya et al., 2019. PKB is a central molecule in the modulation of Na+-ATPase activity by albumin in renal proximal tubule cells. Arch. Biochem. Biophys., Vol. 674. 10.1016/j.abb.2019.108115.
    CrossRef  |  Direct Link  |  
  9. Muller, C.R., A.P.O. Leite, R. Yokota, R.O. Pereira and A.L.V. Americo et al., 2019. Post-weaning exposure to high-fat diet induces kidney lipid accumulation and function impairment in adult rats. Front. Nutr., Vol. 6. 10.3389/fnut.2019.00060.
    CrossRef  |  Direct Link  |  
  10. Filho, P.M.S., I.A. Paz, N.R.F. Nascimento, C.F. Santos and V.R. Araújo et al., 2019. Incorporation of nitroprusside on silica nanoparticles-a strategy for safer use of this NO donor in therapy. Mol. Pharm., 16: 2912-2921.
    CrossRef  |  Direct Link  |  
  11. Farias, V.X., P.N. Uchoa, C.P. Aquino, L.R.G. Britto and M.C. Fonteles et al., 2019. Expression of myo-inositol cotransporters in the sciatic nerve and dorsal root ganglia in experimental diabetes. Braz. J. Med. Biol. Res., Vol. 52. 10.1590/1414-431X20198589.
    CrossRef  |  Direct Link  |  
  12. Yokota, R., F.A. Ronchi, F.B. Fernandes, Z.P. Jara and R.M. Rosa et al., 2018. Intra-renal angiotensin levels are increased in high-fructose fed rats in the extracorporeal renal perfusion model. Front. Physiol., Vol. 9. 10.3389/fphys.2018.01433.
    CrossRef  |  Direct Link  |  
  13. Linhares, B.L., N.R.F. Nascimento, L.F. Gonzaga-Silva, C.F. Santos and M.O. Moraes et al., 2018. Effect of co-administration of two different phosphodiesterase inhibitors and a β3-adrenoceptor agonist in an experimental model of detrusor overactivity. Eur. J. Pharmacol., 833: 425-431.
    CrossRef  |  Direct Link  |  
  14. Matos, T.S., A.K.O. Silva, A.L. Quintela, L.F. das Chagas Pinto and K.M. Canuto et al., 2017. Neuroinhibitory meroterpenoid compounds from Cordia oncocalyx. Fitoterapia, 123: 65-72.
    CrossRef  |  Direct Link  |  
  15. Sá, D.S., A.F. Fernandes, C.D.S. Silva, P.P.C. Costa and M.C. Fonteles et al., 2015. Non-nitric oxide based metallovasodilators: Synthesis, reactivity and biological studies. Dalton Trans., 44: 13633-13640.
    CrossRef  |  Direct Link  |  
  16. Lopes, D.M., N.E.G. Junior, P.P.C. Costa, P.L. Martins and C.F. Santos et al., 2014. A new structurally atypical bradykinin-potentiating peptide isolated from Crotalus durissus cascavella venom (South American rattlesnake). Toxicon, 90: 36-44.
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  17. Cabral, P.H.B., R. de Morais Campos, M.C. Fonteles, C.F. Santos, J.H.L. Cardoso and N.R.F. do Nascimento, 2014. Effects of the essential oil of Croton zehntneri and its major components, anethole and estragole, on the rat corpora cavernosa. Life Sci., 112: 74-81.
    CrossRef  |  Direct Link  |  
  18. Teixeira, M., N. Nascimento, M. Fonteles and O. Vale, 2013. Uroguanylin induces electroencephalographic spikes in rats. Braz. J. Biol., 73: 623-627.
    PubMed  |  Direct Link  |  
  19. Alves, R.S., R.M. Ximenes, A.R.C. Jorge, N.R.F. Nascimento and R.D. Martins et al., 2013. Isolation, homology modeling and renal effects of a C-type natriuretic peptide from the venom of the Brazilian yellow scorpion (Tityus serrulatus). Toxicon, 74: 19-26.
    CrossRef  |  PubMed  |  Direct Link  |  
  20. Cerqueira, J.B.G., L.F.G. Silva, F.O.N. Silva, J.V.M. Cerqueira, R.R. Maia, M.E.A. de Moraes and N.R.F. Nascimento, 2012. Identification of mechanisms involved in the relaxation of rabbit cavernous smooth muscle by a new nitric oxide donor ruthenium compound. Braz. J. Urol., 38: 687-694.
    PubMed  |  Direct Link  |  
  21. Arnaud-Batista, F.J., G.T. Costa, I.M. Oliveira, P.P. Costa and C.F. Santos et al., 2012. Natriuretic effect of bufalin in isolated rat kidneys involves activation of the Na+-K+-ATPase-Src kinase pathway. Am. J. Physiol. Renal Physiol., 302: F959-F966.
    CrossRef  |  PubMed  |  Direct Link  |  
  22. Salles, H.O., I.M. Vasconcelos, L.F.L. Santos, H.D. Oliveira and P.P.C. Costa et al., 2011. Towards a better understanding of Ipomoea asarifolia toxicity: Evidence of the involvement of a leaf lectin. Toxicon, 58: 502-508.
    CrossRef  |  PubMed  |  Direct Link  |  
  23. Nascimento, N.R.F., B.A. Kemp, N.L. Howell, J.J. Gildea, C.F. Santos, T.E. Harris and R.M. Carey, 2011. Role of SRC family kinase in extracellular renal cyclic guanosine 3',5'-monophosphate- and pressure-induced natriuresis. Hypertension, 58: 107-113.
    CrossRef  |  PubMed  |  Direct Link  |  
  24. Fonteles, M.C. and N.R.F. do Nascimento, 2011. Guanylin peptide family: History, interactions with Anp and new pharmacological perspectives. Canad. J. Physiol. Pharmacol., 89: 575-585.
    CrossRef  |  PubMed  |  Direct Link  |  
  25. Farias, V.X., Macedo, F.H.P., M.B. Oquendo, A.R. Tome and S.N. Bao, 2011. Chronic treatment with D-chiro-inositol prevents autonomic and somatic neuropathy in STZ-induced diabetic mice. Diabetes, Obesity Metabol., 13: 243-250.
    CrossRef  |  PubMed  |  Direct Link  |  
  26. Evangelista, J.S., J.J. Evangelista, I.L. Evangelista, D.M. Nojosa and N.R. Nascimento, 2011. Hypotensive effects of the crotalus durissus cascavella venom: Involvement of NO. Nat. Product Commun., 6: 871-874.
    PubMed  |  Direct Link  |  
  27. Costa, C.T.C., C.M.L. Bevilaqua, N.R.F. Nascimento, D.C.S. Nunes-Pinheiro, A.R. Tome, A.L.F. Camurca-Vasconcelos and L.M.B. de Oliveira, 2011. Toxicological activity evaluation of Cocos nucifera L. in experimental models. Ciencia Anim., 21: 35-44.
    Direct Link  |  
  28. Carneiro, R.F.V., N.R.F. Nascimento, P.P.C. Costa, V.M. Gomes and A.J.F. de Souza et al., 2011. The extract of the jellyfish Phyllorhiza punctata promotes neurotoxic effects. J. Applied Toxicol., 31: 720-729.
    CrossRef  |  PubMed  |  
  29. Benvindo, O.D., N.R.F. Nascimento, C.F. Santos, M.C. Fonteles and E.R. Silveira et al., 2011. Relaxant effect and possible mechanism of 17-nor-subincanadine E in rabbit corpora cavernosa. Asian J. Androl., 13: 747-753.
    CrossRef  |  PubMed  |  
  30. Sousa, C.M., A. Havt, C.F. Santos, F.J. Arnaud-Batista and K.M.A. Cunha et al., 2010. The relaxation induced by uroguanylin and the expression of natriuretic peptide receptors in human corpora cavernosa. J. Sexual Med., 7: 3610-3619.
    CrossRef  |  PubMed  |  Direct Link  |  
  31. Macedo, I.T.F., C.M.L. Bevilaqua, L.M.B. de Oliveira, A.L.F. Camurca-Vasconcelos and L.S. Vieira et al., 2010. Anthelmintic effect of eucalyptus staigeriana essential oil against goat gastrointestinal nematodes. Vet. Parasitol., 173: 93-98.
    CrossRef  |  PubMed  |  Direct Link  |  
  32. Evangelista, J.S.A.M., A.M.C. Martins, A.M.C. Martins, N.R.F. Nascimento and J.J.F. Evangelista et al., 2010. Efeitos do veneno da serpente Crotalus durissus cascavella na pressao arterial em ratos. Ciencia Anim., 20: 111-114.
    Direct Link  |  
  33. Evangelista, I.L., A.M.C. Martins, N.R.F. Nascimento, A. Havt and J.S.A.M. Evangelista et al., 2010. Renal and cardiovascular effects of Bothrops marajoensis venom and phospholipase A2. Toxicon, 55: 1061-1070.
    CrossRef  |  
  34. Nascimento, N.R.F., R.M.C. Refosco, E.C.F. Vasconcelos, M.R. Kerntopf and C.M. Sousa et al., 2009. 1,8-cineole induces relaxation in rat and guinea-pig airway smooth muscle. J. Pharm. Pharmacol., 61: 361-366.
    CrossRef  |  PubMed  |  Direct Link  |  
  35. Limaverde, P.T., N.R.F. Nascimento, J.S.A.M. Evangelista, A.R. Tome and M.C. Fonteles et al., 2009. Isolation and pharmacological effects of leptoxin, a novel proteic toxin from Leptodactylus pentadactylus skin secretion. Toxicon, 54: 531-538.
    CrossRef  |  PubMed  |  Direct Link  |  
  36. Freitas, F.C., N.R.F. Nascimento, J.B.G. Cerqueira, M.E.A. Morais, R.P. Regadas and L.F. Gonzaga-Silva, 2009. Yohimbine relaxes the human corpus cavernosum through a non-adrenergic mechanism involving the activation of K+ATP-dependent channels. Int. J. Impot. Res., 21: 356-361.
    CrossRef  |  PubMed  |  Direct Link  |  
  37. Fonteles, M.C., A. Havt, R.B. Prata, P.H.B. Prata and H.S.A. Monteiro et al., 2009. High-salt intake primes the rat kidney to respond to a subthreshold uroguanylin dose during ex vivo renal perfusion. Regul. Peptides, 158: 6-13.
    CrossRef  |  PubMed  |  Direct Link  |  
  38. Lima, A.A.M., Nascimento, N.R.F., G.D. Fang, P. Yotseff, M.H. Toyama, R.L. Guerrant and M.C. Fonteles, 2008. Role of phospholipase A2 and tyrosine kinase in Clostridium difficile toxin A-induced disruption of epithelial integrity, histologic inflammatory damage and intestinal secretion. J. Applied Toxicol., 28: 849-857.
    CrossRef  |  PubMed  |  Direct Link  |  
  39. Fontenelle, R.O.S., S.M. Morais, E.H.S. Brito, R.S.N. Brilhante and R.A. Cordeiro et al., 2008. Antifungal activity of essential oils of Croton species from the Brazilian Caatinga biome. J. Applied Microbiol., 104: 1383-1390.
    CrossRef  |  PubMed  |  Direct Link  |  
  40. Ferreira, M.A.D., N.R.F. do Nascimento, C.M. Sousa, O.D.L. Pessoa and T.L.G. de Lemos et al., 2008. Oncocalyxone A inhibits human platelet aggregation by increasing cGMP and by binding to GP Ibα glycoprotein. Br. J. Pharmacol., 154: 1216-1224.
    CrossRef  |  PubMed  |  Direct Link  |  
  41. Evangelista, J.S.A.M., A.M.C. Martins, N.R.F. Nascimento, C.M. de Sousa and R.S. Alves et al., 2008. Renal and vascular effects of the natriuretic peptide isolated from Crotalus durissus cascavella venom. Toxicon, 52: 737-744.
    CrossRef  |  PubMed  |  Direct Link  |  
  42. Cerqueira, J.B.G., L.F.G. Silva, L.G.F. Lopes, M.E.A. de Moraes and N.R.F. Nascimento, 2008. Relaxation of rabbit corpus cavernosum smooth muscle and aortic vascular endothelium induced by new nitric oxide donor substances of the nitrosyl-ruthenium complex. Int. Braz. J. Urol., 34: 638-645.
    PubMed  |  Direct Link  |  
  43. Carvalho, A.F., M.S. Santos-Neto, H.S.A. Monteiro, S.M. Freitas, L. Morhy, N.R.F. Nascimento and M.C. Fonteles, 2008. BTCI enhances guanylin-induced natriuresis and promotes renal glomerular and tubular effects. Braz. J. Biol., 68: 149-154.
    Direct Link  |  
  44. Campos, A.R., K.M.A. Cunha, F.A. dos Santos, E.R. Silveira, D.E.A. Uchoa, N.R.F. Nascimento and V.S. Rao et al., 2008. Relaxant effects of an alkaloid rich fraction from Aspidosperma ulei root bark on isolated rabbit corpus cavernosum. Int. J. Impotence Res., 20: 255-263.
  45. Fontenelle, R.O.S., S.M. Morais, E.H.S. Brito, M.R. Kerntopf and R.S.N. Brilhante et al., 2007. Chemical composition, toxicological aspects and antifungal activity of essential oil from Lippia sidoides Cham. J. Antimicrobial Chemother., 59: 934-940.
    PubMed  |  Direct Link  |  
  46. Nascimento, N.R.F. L.M. Lessa, M.R. Kerntopf, C.M. Sousa and R.S. Alves et al., 2006. Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide. Proc. Nat. Acad. Sci. USA., 103: 218-223.
    CrossRef  |  PubMed  |  Direct Link  |  
  47. Barbosa, P.S.F., A.M.C. Martins, R.S. Alves, D.N. Amora and R.D. Martins et al., 2006. The role of indomethacin and tezosentan on renal effects induced by Bothrops moojeni Lys49 myotoxin I. Toxicon, 47: 831-837.
    CrossRef  |  PubMed  |  Direct Link  |  
  48. Silva, R.M., F.A. Oliveira, K.M.A. Cunha, J.L. Maia and M.A.M. Maciel et al, 2005. Cardiovascular effects of Trans-dehydrocrotonin, a diterpene from Croton cajucara in rats. Vascul. Pharmacol., 43: 11-18.
    CrossRef  |  Direct Link  |  
  49. Silva, L.F.G., N.R.F. Nascimento, M.C. Fonteles, G. de Nucci, M.E. Moraes, P.R.L. Vasconcelos and M.O. Moraes, 2005. Phentolamine relaxes human corpus cavernosum by a nonadrenergic mechanism activating ATP-sensitive K+ channel. Int. J. Impot. Res., 17: 27-32.
    CrossRef  |  Direct Link  |  
  50. Nascimento, N.R.F., J.H.L. Cardoso, L.M.A. Lessa, J.S. Roriz-Filho, K.M.A. Cunha and M.C. Fonteles, 2005. Terpinen-4-ol: Mechanisms of relaxation on rabbit duodenum. J. Pharm. Pharmacol., 57: 467-474.
    CrossRef  |  PubMed  |  Direct Link  |  
  51. Havt, A., M.H. Toyama, N.R.F. do Nascimento, D.O. Toyama and A.C.L. Nobre et al., 2005. A new C-type animal lectin isolated from Bothrops pirajai is responsible for the snake venom major effects in the isolated kidney. Int. J. Biochem. Cell Biol., 37: 130-141.
    CrossRef  |  PubMed  |  Direct Link  |  
  52. Alves, R.S., N.R.F. do Nascimento, P.S.F. Barbosa, M.R. Kerntopf and L.M.A. Lessa et al., 2005. Renal Effects and vascular reactivity induced by Tityus serrulatus venom. Toxicon, 46: 271-276.
    CrossRef  |  PubMed  |  Direct Link  |  
  53. Camurca-Vasconcelos, A.L.F., N.R.F. Nascimento, C.M. Sousa, L.M. Melo, S.M. Morais, C.M.L. Bevilaqua and M.F.G. Rocha, 2004. Neuromuscular effects and acute toxicity of an ethyl acetate extract of Spigelia anthelmia Linn. J. Ethnopharmacol., 92: 257-261.
    CrossRef  |  PubMed  |  Direct Link  |  
  54. Nascimento, N.R.F., A. Costa-e-Forti, A.A. Peter and M.C. Fonteles, 2003. Free radical scavengers improve the impaired endothelium-dependent responses in aorta and kidneys of diabetic rabbits. Diabetes Res. Clin. Pract., 61: 145-153.
    CrossRef  |  PubMed  |  Direct Link  |  
  55. Camara, C.C., N.R.F. Nascimento, C.L.M. Filho, F.B.S. de Almeida and M.C. Fonteles, 2003. Antispasmodic effect of the essential oil of plecthranthus barbatus and some major constituents on the guinea-pig ileum. Planta Medica, 69: 1080-1085.