Prof. Amir Feisal Merican

Prof. Amir Feisal Merican

Professor
University of Malaya, Malaysia


Highest Degree
Ph.D. in Biochemistry from University of Oxford, United Kingdom

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Biography

Prof Amir Merican was the founder and current Head of CRYSTAL (Centre of Research in Computational Sciences and Informatics for Biology, Bioindustry, Environment, Agriculture and Healthcare), a University of Malaya research centre. He obtained a First Class Honours degree in Microbiology from the University of Malaya in 1992. He was appointed as a lecturer in University of Malaya in 1995 after successfully completing his DPhil in Biochemistry and Molecular Microbiology at the University of Oxford, England. He had also being awarded a MPhil degree in Computational Biology from the University of Cambridge, England in 2006. He has spearheaded the development of the curriculum for both the Bachelor of Science (Bioinformatics) and Master in Bioinformatics (by coursework) degree programmes, both are the first in Malaysia. He also contributed his expertise at the national level, among the significant contributions include: Director of the Centre for Computational and Systems Biology at the Malaysia Genome Institute of the Ministry of Science, Technology and Innovation (MOSTI) (from Nov 2009 to Nov 2011) and panel evaluator appointed by the Malaysian Qualifications Agency for Bioinformatics and Biotechnology programmes in Private Higher Learning Institutions (present). He was one of the co-founders and the current President of the Malaysian Society of Bioinformatics and Computational Biology (MaSBiC). He has received several distinguished awards: Japanese Bioindustry Association for research in Molecular Systematics with Professor Takayuki Ezaki at Gifu University School of Medicine, Japan (1998), Fulbright Fellowship for research in Bioinformatics with Nobel Laureate Professor Walter Gilbert at Harvard University (2000), Commonwealth Fellowship for research in Molecular Microbial Ecology with Professor Jon Saunders at Liverpool University (2001) and Excellent Service Award, University of Malaya (2003). His expertise is in the area of Bioinformatics, Computational Biology and Microbial Environmental Biotechnology. Prof Amir Merican is an alumni of Sekolah Rendah Kebangsaan Iskandar, Alor Setar, Kedah (primary school) and Sekolah Menengah Sultan Abdul Halim, Jitra, Kedah (boarding secondary school).

Area of Interest:

Biomedical Sciences
100%
Computational Biology
62%
Bioinformatics
90%
Environmental Biotechnology
75%
Protein Biochemistry
55%

Selected Publications

  1. Abu Bakar, A.R., T. Manaharan, A.F. Merican and S.B. Mohamad, 2017. Experimental and computational approaches to reveal the potential of Ficus deltoidea leaves extract as α-amylase inhibitor. Nat. Prod. Res. 10.1080/14786419.2017.1312393.
    CrossRef  |  

  2. Abdelhafiz, Y.A., T. Manaharan, S.B. Mohamad and A.F. Merican, 2017. Whole genome sequencing and functional features of UMX-103: A new Bacillus strain with biosurfactant producing capability. Genes Genomics. 10.1007/s13258-017-0550-7.
    CrossRef  |  

  3. Abdelhafiz, Y.A., T. Manaharan, S. BinMohamad and A.F. Merican, 2017. Draft genome sequence of a biosurfactant-producing Bacillus subtilis UMX-103 isolated from hydrocarbon-contaminated soil in Terengganu, Malaysia. Curr. Microbiol. 10.1007/s00284-017-1249-3.
    CrossRef  |  

  4. Mirsafian, H., S.M. Srinivas, J.M. Christopher, S. Sreelakshmi and F.M. Amir et al., 2016. Long non-coding RNA expression in primary human monocytes. Genomics, 108: 37-45.
    CrossRef  |  Direct Link  |  

  5. Mirsafian, H., M.R. Adiratna, M. Thamilvaani, B.M. Saharuddin and F.M. Amir, 2016. Towards a reference gene catalogue of human primary monocytes. OMICS: A J. Integr. Biol., 20: 627-634.
    CrossRef  |  Direct Link  |  

  6. Japar, S., M. Thamilvaani, A.S. Asma, M.M. Abdul and F.M.A.M. Amir, 2016. Assessment of abdominal obesity using 3D body scanning technology. Sains Malaysiana, .

  7. Hassan, N.N.N., J.P. Plazzer, T.D. Smith, H. Halim-Fikri, F. Macrae, A.Z. Al and B.A. Zilfalil, 2016. Harmonizing the interpretation of genetic variants across the world: The Malaysian experience. BMC Res. Notes, Vol. 9. 10.1186/s13104-015-1798-0.
    CrossRef  |  

  8. Halim-Fikri, A.H., E. Ali, Z.A.L. Ahmad, F.M. Amir and A.B. Atif et al., 2015. The first malay database toward the ethnic-specific target molecular variation. BMC Res. Notes, 10.1186/s13104-015-1123-y.
    CrossRef  |  Direct Link  |  

  9. Bong, Y.B., A.S. Asma, M. Abdul Majid and F.M. Amir, 2015. Malaysian growth centiles for children under six years old. Ann. Hum. Biol., 42: 109-116.
    CrossRef  |  Direct Link  |  

  10. Bong, Y.B., A.A. Shariff, A.M. Majid and A.F. Merican, 2015. Growth curves for school children from kuching, Sarawak: A methodological development. Asia Pac. J. Public Health, 27: 1217-1227.
    CrossRef  |  Direct Link  |  

  11. Siow-Wee, C., S. Abdul-Kareem, A.F. Merican and R.B. Zain, 2014. A hybrid prognostic model for oral cancer based on clinicopathologic and genomic markers. Sains Malaysiana, 43: 567-573.

  12. Mohamoud, H.S.A., R.M.H. Muhammad, A.A. El-Harouni, A.S. Noor and F.M. Amir et al., 2014. First comprehensive in silico analysis of the functional and structural consequences of SNPs in Human GalNAc-T1 Gene. Comput. Math. Meth. Med., 10.1155/2014/904052.
    CrossRef  |  Direct Link  |  

  13. Mohamed, A.M., A.S. Asma, F.M. Amir and Y.B. Bong, 2014. Fitting multiphasic logistic functions to the lactation curves of Girlando (Gir x Friesian) crossbred dairy cattle in Malaysia. Sains Malaysiana, 43: 987-993.
    Direct Link  |  

  14. Mirsafian, H., M.R. Adiratna, S. Aarti, H.T. Phaik, F.M. Amir and B.M. Saharuddin, 2014. A comparative analysis of synonymous codon usage bias pattern in human albumin superfamily. Sci. World J., 10.1155/2014/639682.
    CrossRef  |  Direct Link  |  

  15. Mirsafian, H., M.R. Adiratna, F.M. Amir and B.M. Saharuddin, 2014. Amino acid sequence and structural comparison of BACE1 and BACE2 using evolutionary trace method. Sci. World J., 10.1155/2014/482463.
    CrossRef  |  Direct Link  |  

  16. Juhari, W.W.K., N.A. Tamrin, M.H.R.M. Daud, H.W. Isa and.AF. Merican et al., 2014. A whole genome analyses of genetic variants in two Kelantan Malay individuals. HUGO J., 10.1186/s11568-014-0004-0.
    CrossRef  |  Direct Link  |  

  17. Haq, I., A.B.M.S. Hossain, M.M. Khandaker, A.F. Merican, G. Faruq, A.N. Boyce and M.S. Azirun, 2014. Antioxidant and antibacterial activities of different extracts and fractions of a mangrove plant Sonneratia alba. Int. J. Agric. Biol., 16: 707-714.
    Direct Link  |  

  18. Siow-Wee, C., S. Abdul-Kareem, F.M. Amir and B.Z. Rosnah, 2013. Oral cancer prognosis based on clinicopathologic and genomic markers using a hybrid of feature selection and machine learning methods. BMC Bioinf., 10.1186/1471-2105-14-170.
    CrossRef  |  Direct Link  |  

  19. Salleh, M.N., M.L. Halim, N.O. Siti and F.M. Amir, 2013. Development of a flexible customised compression garment pattern design system. Int. J. Adv. Mechatron. Syst., 5: 202-208.
    CrossRef  |  Direct Link  |  

  20. Othman, S.A., A. Roshahida, F.M. Amir and J. Marhazlinda, 2013. Reproducibility of facial soft tissue landmarks on facial images captured on a 3D camera. Aust. Orthodontic J., 29: 58-65.
    Direct Link  |  

  21. Bong, Y.B., A.A. Shariff, A.M. Majid and A.F. Merican, 2012. Reference charts for height and weight of school children from West Malaysia in comparison with the united states centers for disease control and prevention. Iran. J. Public Health, 41: 27-38.
    Direct Link  |  

  22. Zulkifly, S., S.K. Young, A.M. Mohamed and F.M. Amir, 2011. Distribution of lichen flora at different altitudes of gunung machinchang, langkawi island, Malaysia. Sains Malaysiana, 40: 1201-1208.
    Direct Link  |  

  23. Siow-Wee, C., A.K. Sameem, G.K. Thomas, F.M.A.M. Amir, T.A. Mannil and B.Z. Rosnah, 2011. Feature selection methods for optimizing clinicopathologic input variables in oral cancer prognosis. Asian Pac. J. Cancer Prev., 12: 2659-2664.
    Direct Link  |  

  24. Hoque, M.A., K. Attia, O. Alattas and A.F. Merican, 2011. Metabolic flux distribution and mathematical models for dynamic simulation of carbon metabolism in Escherichia coli. Afr. J. Biotechnol., 10: 2340-2352.
    CrossRef  |  Direct Link  |  

  25. Hoque, A., A.T. Fard, M. Rahman, O. Alattas, K. Akazawa and A.F. Merican, 2011. Comparison of dynamic responses of cellular metabolites in Escherichia coli to pulse addition of substrates. Biologia (Sec. Cell. Mol. Biol.), 66: 954-966.
    CrossRef  |  Direct Link  |  

  26. Sarinder, K.K.S., L.H.S. Lim, A.F. Merican and K. Dimyati, 2010. Biodiversity information retrieval across networked data sets. Aslib Proc. New Inf. Perspect., 62: 514-522.
    CrossRef  |  Direct Link  |  

  27. Zeti, A.M.H., M.S. Shamsir, K. Tajul-Arifin, A.F. Merican and R. Mohamed et al., 2009. Bioinformatics in Malaysia: Hope, initiative, effort, reality, and challenges. Plos Comput. Biol., 10.1371/journal.pcbi.1000457.
    CrossRef  |  Direct Link  |  

  28. Sarinder, K.K.S., L.H.S. Lim, K. Dimyati and A.F. Merican, 2009. Communication architecture for biodiversity information retrieval (CABIR). Malaysian J. Sci., 28: 113-125.
    Direct Link  |  

  29. Kueh, R., N. Abd Rahman and A.F. Merican, 2009. Electrostatic properties of Escherichia coli wild-type and mutant arginine repressor C- terminal domain (ArgRc) protein-ligand complexes: Insights into molecular interaction and function. Asia Pac. J. Mol. Biol. Biotechnol., 17: 11-18.

  30. Sarinder, K.K.S., L.H.S. Lim, K. Dimyati and A.F. Merican, 2007. An indigenous integration system for biodiversity databases. Online J. Bioinf., 8: 56-60.
    Direct Link  |  

  31. Zulkifly, S and F.M. Amir, 2005. Some lichens of north eastern langkawi and gunung machincang, langkawi islands. Malaysian J. Sci., 24: 103-110.
    Direct Link  |  

  32. Asi, A.M., N.A. Rahman and A.F. Merican, 2004. Application of the linear interaction energy method (LIE) to estimate the binding free energy values of Escherichia coli wild-type and mutant arginine repressor C-terminal domain (ArgRc)-l-arginine and ArgRc-l-citrulline protein-ligand complexes. J. Mol. Graph Model, 22: 249-262.
    PubMed  |  

  33. Kueh, R., S.A.R. Noor and F.M. Amir, 2003. Generating isopotential contours of L-arginine binding to the C-terminal domain of Escherichia coli arginine repressor protein (ArgRc). KUTPM J. Technol. Manag., 1: 39-42.

  34. Kueh, R., N.A. Rahman and A.F. Merican, 2003. Computational docking of L-arginine and its structural analogues to C-terminal domain of Escherichia coli arginine repressor protein (ArgRc). J. Mol. Model., 9: 88-98.
    CrossRef  |  Direct Link  |  

  35. Merican, A.F., Y.O. Rofina, I. Norzamzurina, P.C. Khoo, M. Louisa, K.C.Y. Yong and K. Sarinder, 2002. Development of malaysian indigenous microorganisms online database system. Asia Pac. J. Mol. Biol. Biotechnol., 10: 69-72.
    Direct Link  |  

  36. Merican, A.F., R.K. Mohamad, H. Huszalina, A. Rosnizah, D. Arul and E. Takayuki, 2002. Molecular and microbiological characterization of an Acinetobacter sp., isolated from petroleum-contaminated soil in Sentul, Kuala Lumpur, Malaysia. Asia Pac. J. Mol. Biol. Biotechnol., 10: 21-29.

  37. Fedorov, A., F.M. Amir and G. Walter, 2002. Large-scale comparison of intron positions among animal, plant, and fungal genes. Proceed. National Acad. Sci., 99: 16128-16133.
    CrossRef  |  Direct Link  |  

  38. Tawfiq, M.F., A.R. Abdullah and A.F. Merican, 2001. Biodegradation of naphthalene, a low molecular weight polycyclic aromatic hydrocarbon, by bacteria isolated from petroleum contaminated soil. Malaysian J. Sci., 20: 41-49.

  39. Nordin, N.F.H and F.M. Amir, 2001. Identification of bacterial diversity from oil spill contaminated marine environment in tanjung karang, selangor, Malaysia. Malaysian J. Sci., 20: 9-14.
    Direct Link  |  

  40. Kamarudin, M.R., M. Shafiza, M.A. Nuraizah and F.M. Amir, 2001. Isolation and characterization of hydrocarbon-utilizing bacteria from soils contaminated with used engine oil and diesel oil. Malaysian J. Sci., 20: 35-39.
    Direct Link  |  

  41. Merican, A.F., M.A. Azizah and A.R. Noorsaadah, 2000. Molecular modeling studies of C- terminal arginine repressor protein (ArgRc) interaction with its co-repressor L-arginine. Asia Pac. J. Mol. Biol. Biotechnol., 8: 13-26.
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