Dr. Chin Kok Yong
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Dr. Chin Kok Yong

Lecturer
Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia

Highest Degree
Ph.D. in Pharmacology from Universiti Kebangsaan Malaysia, Malaysia

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Area of Interest:

Pharmacology and Toxicology
100%
Drug Target
62%
Pharmacodynamics Clinical Trials
90%
Immune-Pharmacology
75%
Osteoporosis
55%

Research Publications in Numbers

Books
1
Chapters
1
Articles
186
Abstracts
1

Selected Publications

  1. Mahdy, Z.A., K.Y. Chin, N.L. Nik-Ahmad-Zuky, A. Kalok and R.A. Rahman, 2022. Tocotrienol in pre-eclampsia prevention: A mechanistic analysis in relation to the pathophysiological framework. Cells, Vol. 11. 10.3390/cells11040614.
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  2. Ekeuku, S.O., E.S.M. Ramli, N.A. Sani, N.A. Ghafar, I.N. Soelaiman and K.Y. Chin, 2022. Tocotrienol as a protecting agent against glucocorticoid-induced osteoporosis: A mini review of potential mechanisms. Molecules, Vol. 27. 10.3390/molecules27185862.
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  3. Chin, K.Y., S.O. Ekeuku and M.R. Hamzah, 2022. The role of healthcare providers in promoting human papillomavirus vaccines among men who have sex with men: A scoping review. Vaccines, Vol. 10. 10.3390/vaccines10060930.
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  4. Chin, K.Y., K.L. Pang, S.K. Wong, D.C.H. Chew and H.M.S. Qodriyah, 2022. Relationship amongst vitamin K Status, vitamin K antagonist use and osteoarthritis: A review. Drugs Aging, 39: 487-504.
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  5. Chan, C.Y., S. Subramaniam, K.Y. Chin, S. Ima-Nirwana and N. Muhammad et al., 2022. Effect of a screening and education programme on knowledge, beliefs, and practices regarding osteoporosis among Malaysians. Int. J. Environ. Res. Public Health, Vol. 19. 10.3390/ijerph19106072.
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  6. Yee, M.M.F., K.Y. Chin, S. Ima-Nirwana and S.K. Wong, 2021. Vitamin A and bone health: A review on current evidence. Molecules, Vol. 26. 10.3390/molecules26061757.
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  7. Wong, S.K., Y.H. Wong, K.Y. Chin and S. Ima-Nirwana, 2021. A review on the enhancement of calcium phosphate cement with biological materials in bone defect healing. Polymers, Vol. 13. 10.3390/polym13183075.
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  8. Wong, S.K., K.Y. Chin and S. Ima-Nirwana, 2021. A review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury. Drug Des. Dev. Ther., 15: 4615-4632.
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  9. Shadisvaaran, S., K.Y. Chin, M.S. Shahida, S.I. Nirwana and X.F. Leong, 2021. Effect of vitamin E on periodontitis: Evidence and proposed mechanisms of action. J. Oral Biosci., 63: 97-103.
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  10. Sapian, S., I.S. Taib, J. Latip, H. Katas and K.Y. Chin et al., 2021. Therapeutic approach of flavonoid in ameliorating diabetic cardiomyopathy by targeting mitochondrial-induced oxidative stress. Int. J. Mol. Sci., Vol. 22. 10.3390/ijms222111616.
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  11. Pang, K.L., Y.Y. Chow, L.M. Leong, J.X. Law, N.A. Ghafar, I.N. Soelaiman and K.Y. Chin, 2021. Establishing SW1353 chondrocytes as a cellular model of chondrolysis. Life, Vol. 11. 10.3390/life11040272.
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  12. Pang, K.L., S.O. Ekeuku and K.Y. Chin, 2021. Particulate air pollution and osteoporosis: A systematic review. Risk Manage. Healthcare Policy, 14: 2715-2732.
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  13. Pang, K.L., N.A. Ghafar, I.N. Soelaiman and K.Y. Chin, 2021. Protective effects of annatto tocotrienol and palm tocotrienol-rich fraction on chondrocytes exposed to monosodium iodoacetate. Appl. Sci., Vol. 11. 10.3390/app11209643.
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  14. Pang, K.L., J.N. Lumintang and K.Y. Chin, 2021. Thyroid-modulating activities of olive and its polyphenols: A systematic review. Nutrients, Vol. 13. 10.3390/nu13020529.
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  15. Ng, J.S. and K.Y. Chin, 2021. Potential mechanisms linking psychological stress to bone health. Int. J. Med. Sci., 18: 604-614.
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  16. Mohamad, N.V., S. Ima-Nirwana and K.Y. Chin, 2021. Therapeutic potential of annatto tocotrienol with self-emulsifying drug delivery system in a rat model of postmenopausal bone loss. Biomed. Pharmacother., Vol. 137. 10.1016/j.biopha.2021.111368.
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  17. Mohamad, N.V., S. Ima-Nirwana and K.Y. Chin, 2021. The skeletal effects of gonadotropin-releasing hormone antagonists: A concise review. Endocr. Metabol. Imm. Disord. Drug Targets, 21: 1713-1720.
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  18. Low, T.Y., K.Y. Chin and S.C. Tan, 2021. On the critical importance of meticulous data extraction for meta-analysis of genetic association study. Arch. Physiol. Biochem., 10.1080/13813455.2021.1890132.
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  19. Khor, B.H., H.C. Tiong, S.C. Tan, S.K. Wong and K.Y. Chin et al., 2021. Effects of tocotrienols supplementation on markers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE, Vol. 16. 10.1371/journal.pone.0255205.
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  20. Jolly, J., N.F.M. Fozi, K.Y. Chin, S. Wong and K. Chua et al., 2021. Skeletal microenvironment system utilising bovine bone scaffold co‑cultured with human osteoblasts and osteoclast‑like cells. Exp. Ther. Med., Vol. 22. 10.3892/etm.2021.10112.
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  21. Ismail, N.H., S.F. Ibrahim, F.H.F. Jaffar, M.H. Mokhtar, K.Y. Chin and K. Osman, 2021. Augmentation of the female reproductive system using honey: A mini systematic review. Molecules, Vol. 26. 10.3390/molecules26030649.
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  22. Hashim, K.N., K.Y. Chin and F. Ahmad, 2021. The mechanism of honey in reversing metabolic syndrome. Molecules, Vol. 26. 10.3390/molecules26040808.
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  23. Ekeuku, S.O., M.F.N. Azlina and K.Y. Chin, 2021. Effects of Piper sarmentosum on metabolic syndrome and its related complications: A review of preclinical evidence. Appl. Sci., Vol. 11. 10.3390/app11219860.
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  24. Ekeuku, S.O., K.Y. Chin, N.Z. Ramli, K.A. Zarkasi and F. Ahmad, 2021. Effect of Kelulut honey supplementation on bone health in male rats on high-carbohydrate high-fat diet. Trop. J. Pharm. Res., 20: 1185-1192.
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  25. Ekeuku, S.O., K.L. Pang and K.Y. Chin, 2021. The skeletal effects of tanshinones: A review. Molecules, Vol. 26. 10.3390/molecules26082319.
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  26. Ekeuku, S.O., K.L. Pang and K.Y. Chin, 2021. Effects of caffeic acid and its derivatives on bone: A systematic review. Drug Des. Dev. Ther., 15: 259-275.
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  27. Ekeuku, S.O., I.N. Soelaiman and K.Y. Chin, 2021. Health beneficial properties of spirulina in preventing non-communicable diseases - the green metabolic regulator from the sea. Sains Malaysiana, 50: 803-819.
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  28. Ekeuku, S.O. and K.Y. Chin, 2021. Application of propolis in protecting skeletal and periodontal health-A systematic review. Molecules, Vol. 26. 10.3390/molecules26113156.
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  29. Chan, A.M.L., A.M.H. Ng, M.H.M. Yunus, R.B.H. Idrus and J.X. Law et al., 2021. Recent developments in rodent models of high-fructose diet-induced metabolic syndrome: A systematic review. Nutrients, Vol. 13. 10.3390/nu13082497.
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  30. Ali, S.H., N.H.A. Rahman, N.M. Shariff, J. Karim and K.Y. Chin, 2021. Protocol for a mixed‐method systematic review on challenges perceived by final‐year undergraduate nursing students in a clinical learning environment. J. Adv. Nurs., 77: 3933-3939.
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  31. Al-Saadi, H.M., K.Y. Chin, F. Ahmad, E.S.M. Ramli and A.M. Arlamsyah et al., 2021. Effects of palm tocotrienol-rich fraction alone or in combination with glucosamine sulphate on grip strength, cartilage structure and joint remodelling markers in a rat model of osteoarthritis. Appl. Sci., Vol. 11. 10.3390/app11188577.
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  32. Aizuddin, A.N., C.M. Chan, A.R. Anwar, Y.X. Ong and K.Y. Chin, 2021. Performance of body mass index in identifying obesity defined by body fat percentage and hypertension among Malaysian population: A retrospective study. Int. J. General Med., 14: 3251-3257.
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  33. Wong, S.K., Y. Kamisah, N. Mohamed, N. Muhammad and N. Masbah et al., 2020. Potential role of tocotrienols on non-communicable diseases: A review of current evidence. Nutrients, Vol. 12. 10.3390/nu12010259.
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  34. Wong, S.K., S. Ima‑Nirwana and K.Y. Chin, 2020. Effects of astaxanthin on the protection of muscle health (Review). Exp. Ther. Med., 20: 2941-2952.
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  35. Wong, S.K., S. Ima-Nirwana and K.Y. Chin, 2020. Can telomere length predict bone health? A review of current evidence. Biomol. Biomed., 20: 423-429.
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  36. Wong, S.K., K.Y. Chin, F. Ahmad and S. Ima‐Nirwana, 2020. Biochemical and histopathological assessment of liver in a rat model of metabolic syndrome induced by high‐carbohydrate high‐fat diet. J. Food Biochem., Vol. 44. 10.1111/jfbc.13371.
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  37. Wong, S.K., K.Y. Chin, F. Ahmad and S. Ima-Nirwana, 2020. Regulation of inflammatory response and oxidative stress by tocotrienol in a rat model of non-alcoholic fatty liver disease. J. Funct. Foods, Vol. 74. 10.1016/j.jff.2020.104209.
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  38. Wong, S.K., K.Y. Chin and S. Ima-Nirwana, 2020. Vitamin C: A review on its role in the management of metabolic syndrome. Int. J. Med. Sci., 17: 1625-1638.
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  39. Wong, S.K., K.Y. Chin and S. Ima-Nirwana, 2020. The skeletal-protecting action and mechanisms of action for mood-stabilizing drug lithium chloride: Current evidence and future potential research areas. Front. Pharmacol., Vol. 11. 10.3389/fphar.2020.00430.
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  40. Wong, S.K., K.Y. Chin and S. Ima-Nirwana, 2020. Quercetin as an agent for protecting the bone: A review of the current evidence. Int. J. Mol. Sci., Vol. 21. 10.3390/ijms21176448.
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  41. Subramaniam, S., C.Y. Chan, I.N. Soelaiman, N. Mohamed and N. Muhammad et al., 2020. The performance of a calcaneal quantitative ultrasound device, CM-200, in stratifying osteoporosis risk among Malaysian population aged 40 years and above. Diagnostics, Vol. 10. 10.3390/diagnostics10040178.
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  42. Subramaniam, S., C.Y. Chan, I.N. Soelaiman, N. Mohamed and N. Muhammad et al., 2020. Development of osteoporosis screening algorithm for population aged 50 years and above in Klang Valley, Malaysia. Int. J. Environ. Res. Public Health, Vol. 17. 10.3390/ijerph17072526.
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  43. Smandri, A., A. Nordin, N.M. Hwei, K.Y. Chin, I.A. Aziz and M.B. Fauzi, 2020. Natural 3D-printed bioinks for skin regeneration and wound healing: A systematic review. Polymers, Vol. 12. 10.3390/polym12081782.
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  44. Shahudin, N.N., M.J. Sameeha, A.F.M. Ludin, Z.A. Manaf, K.Y. Chin and N.A. Jamil, 2020. Barriers towards sun exposure and strategies to overcome these barriers in female indoor workers with insufficient Vitamin D: A qualitative approach. Nutrients, Vol. 12. 10.3390/nu12102994.
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  45. Ramli, F.F. and K.Y. Chin, 2020. A review of the potential application of osteocyte-related biomarkers, fibroblast growth factor-23, sclerostin, and dickkopf-1 in predicting osteoporosis and fractures. Diagnostics, Vol. 10. 10.3390/diagnostics10030145.
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  46. Ramli, E.S.M., K. Sukalingam, M.A. Kamaruzzaman, I.N. Soelaiman and K.L. Pang and K.Y. Chin, 2020. Direct and indirect effect of honey as a functional food against metabolic syndrome and its skeletal complications. Diabetes Metab. Syndr. Obes., 14: 241-256.
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  47. Pang, K.L., N.Y. Low and K.Y. Chin, 2020. A review on the role of denosumab in fracture prevention. Drug Des. Dev. Ther., 14: 4029-4051.
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  48. Pang, K.L. and K.Y. Chin, 2020. Comment on: Food for Bone: Evidence for a role for delta-tocotrienol in the physiological control of osteoblast migration. Int. J. Mol. Sci., Vol. 21. 10.3390/ijms21186674.
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  49. Mohamad, N.V., S. Ima-Nirwana and K.Y. Chin, 2020. The effects of gonadotropin-releasing hormone agonist (buserelin) and orchidectomy on bone turnover markers and histomorphometry in rats. Aging Male, 23: 327-334.
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  50. Mohamad, N.V., S. Ima-Nirwana and K.Y. Chin, 2020. Are oxidative stress and inflammation mediators of bone loss due to estrogen deficiency? A review of current evidence. Endocr. Metab. Immune Disord. Drug Targets, 20: 1478-1487.
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  51. Hasan, W.N.W., K.Y. Chin, N.A. Ghafar and I.N. Soelaimanm, 2020. Annatto-derived tocotrienol promotes mineralization of MC3T3-E1 cells by enhancing BMP-2 protein expression via inhibiting RhoA activation and HMG-CoA reductase gene expression. Drug Des. Dev. Ther., 14: 969-976.
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  52. Ekeuku, S.O., K.L. Pang and K.Y. Chin, 2020. Palmatine as an agent against metabolic syndrome and its related complications: A review. Drug Des. Dev. Ther., 14: 4963-4974.
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  53. Ekeuku, S.O., B.K.S. Thong, A. Quraisiah, F. Annuar, A. Hanafiah, M.F.N. Azlina and K.Y. Chin, 2020. The skeletal effects of short-term triple therapy in a rat model of gastric ulcer induced by Helicobacter pylori infection. Drug Des. Dev. Ther., 14: 5359-5366.
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  54. Chin, K.Y., C.Y. Chan, S. Subramaniam, N. Muhammad and A. Fairus et al., 2020. Positive association between metabolic syndrome and bone mineral density among Malaysians. Int. J. Med. Sci., 17: 2585-2593.
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  55. Chin, K.Y., B.K.S. Thong, R.F. Kamalulloh, N.V. Mohamad and S.K. Wong et al., 2020. Effects of calcium and annatto tocotrienol supplementation on bone loss induced by pantoprazole in male rats. Drug Des. Dev. Ther., 14: 2561-2572.
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  56. Chin, K.Y., 2020. The relationship between vitamin K and osteoarthritis: A review of current evidence. Nutrients, Vol. 12. 10.3390/nu12051208.
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  57. Chin, K.Y., 2020. Recreational inhaled nitrite use among Asian men who have sex with men. J. Mens. Health, 16: 109-127.
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  58. Chin, K.Y. and K.L. Pang, 2020. Skeletal effects of early-life exposure to soy isoflavones-A review of evidence from rodent models. Front. Pediatr., Vol. 8. 10.3389/fped.2020.00563.
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  59. Chan, C.Y., S. Subramaniam, N. Mohamed, S. Ima-Nirwana and N. Muhammad et al., 2020. Prevalence and factors of T-score discordance between hip and spine among middle-aged and elderly Malaysians. Arch. Osteoporos., Vol. 15. 10.1007/s11657-020-00821-5.
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  60. Chan, C.Y., S. Subramaniam, N. Mohamed, S. Ima-Nirwana and N. Muhammad et al., 2020. Determinants of bone health status in a multi-ethnic population in Klang Valley, Malaysia. Int. J. Environ. Res. Public Health, Vol. 17. 10.3390/ijerph17020384.
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  61. Aziz, N.H.A., N.A. Yazid, R.A. Rahman, N.A. Rashid and S.K. Wong et al., 2020. Is first trimester maternal 25-hydroxyvitamin D level related to adverse maternal and neonatal pregnancy outcomes? A prospective cohort study among Malaysian women. Int. J. Environ. Res. Public Health, Vol. 17. 10.3390/ijerph17093291.
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  62. Wong, S.K., N.V. Mohamad, T.R. Giaze, K.Y. Chin, N. Mohamed and S. Ima-Nirwana, 2019. Prostate cancer and bone metastases: The underlying mechanisms. Int. J. Mol. Sci., Vol. 20. 10.3390/ijms20102587.
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  63. Wong, S.K., N.V. Mohamad, P.A. Jayusman, A.N. Shuid, S. Ima-Nirwana and K.Y. Chin, 2019. The use of selective estrogen receptor modulators on bone health in men. Aging Male, 22: 89-101.
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  64. Wong, S.K., N.V. Mohamad, N.I. Ibrahim, K.Y. Chin, A.N. Shuid and S. Ima-Nirwana, 2019. The molecular mechanism of vitamin E as a bone-protecting agent: A review on current evidence. Int. J. Mol. Sci., Vol. 20. 10.3390/ijms20061453.
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  65. Wong, S.K., K.Y. Chin and S. Ima-Nirwana, 2019. Toll-like receptor as a molecular link between metabolic syndrome and inflammation: A review. Curr. Drug Targets, 20: 1264-1280.
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  66. Wong, S.K., K.Y. Chin and S. Ima-Nirwana, 2019. The osteoprotective effects of kaempferol: The evidence from in vivo and in vitro studies. Drug Des. Dev. Ther., Vol. 13. 10.2147/DDDT.S227738.
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  67. Wong, S.K., K.Y. Chin and S. Ima-Nirwana, 2019. The effects of tocotrienol on bone peptides in a rat model of osteoporosis induced by metabolic syndrome: the possible communication between bone cells. Int. J. Environ. Res. Public Health, Vol. 16. 10.3390/ijerph16183313.
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  68. Thong, B.K.S., S. Ima-Nirwana and K.Y. Chin, 2019. Proton pump inhibitors and fracture risk: A review of current evidence and mechanisms involved. Int. J. Environ. Res. Public Health, Vol. 16. 10.3390/ijerph16091571.
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  69. Subramaniam, S., C.Y. Chan, I.N. Soelaiman, N. Mohamed and N. Muhammad et al., 2019. The performance of osteoporosis self-assessment tool for Asians (OSTA) in identifying the risk of osteoporosis among Malaysian population aged 40 years and above. Arch. Osteopor., Vol. 14. .
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  70. Subramaniam, S., C.Y. Chan, I.N. Soelaiman, N. Mohamed and N. Muhammad et al., 2019. Prevalence and predictors of osteoporosis among the chinese population in klang valley. Malaysia. Applied Sci., Vol. 9. 10.3390/app9091820.
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  71. Ramli, N.Z., K.Y. Chin, K.A. Zarkasi and F. Ahmad, 2019. The beneficial effects of stingless bee honey from heterotrigona itama against metabolic changes in rats fed with high-carbohydrate and high-fat diet. Int. J. Environ. Res. Public Health, Vol. 16. 10.3390/ijerph16244987.
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  72. Pang, K.L. and K.Y. Chin, 2019. The role of tocotrienol in protecting against metabolic diseases. Molecules, Vol. 24. 10.3390/molecules24050923.
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  73. Pang, K.L. and K.Y. Chin, 2019. Emerging anticancer potentials of selenium on osteosarcoma. Int. J. Mol. Sci., Vol. 20. 10.3390/ijms20215318.
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  74. Mohamad, N.V., S.K. Wong, W.N.W. Hasan, J.J. Jolly, M.F. Nur-Farhana, S. Ima-Nirwana, and K.Y. Chin, 2019. The relationship between circulating testosterone and inflammatory cytokines in men. Aging. Male., 22: 129-140.
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  75. Mohamad, N.V., S. Ima-Nirwana and K.Y. Chin, 2019. The effects of annatto tocotrienol on body composition and serum adiponectin, leptin and glucose level in a rat model of androgen deficiency induced by buserelin. Med. Health, 14: 168-179.
  76. Kamaruzzaman, M.A., K.Y. Chin, M. Ramli and E. Suhana, 2019. A Review of potential beneficial effects of honey on bone health. Evid. Based Complem. Altern. Med., 10.1155/2019/8543618.
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  77. Jamil, N.A., N.N. Shahudin, A. Aziz, N. Surfina and C.J. Qi et al., 2019. 2019 Knowledge, attitude and practice related to vitamin d and its relationship with vitamin d status among malay female office workers. Int. J. Environ. Res. Public Health, Vol. 16. 10.3390/ijerph16234735.
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  78. Jaffar, F.H.F., K. Osman, N.H. Ismail, K.Y. Chin and S.F. Ibrahim, 2019. Adverse effects of wi-fi radiation on male reproductive system: A systematic review. Tohoku J. Exp. Med., 248: 169-179.
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  79. Fahami, N.A.M., A.N. Shuid, A. Abdullah, I. Naina-Mohamed and K.Y. Chin et al., 2019. A systematic review of methadone maintenance therapy studies in preventing relapses in addiction: Evidence from asean countries. Heroin Addicti. Related Clin. Problems, 21: 15-32.
  80. Chin, K.Y., S.K. Wong, J. Sidik, F. Zuhair and J.A. Hamid et al., 2019. The effects of annatto tocotrienol supplementation on cartilage and subchondral bone in an animal model of osteoarthritis induced by monosodium iodoacetate. Int. j. Environ. Res. Public Health, Vol. 16. 10.3390/ijerph16162897.
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  81. Chin, K.Y. and S. Ima-Nirwana, 2019. The role of tocotrienol in preventing male osteoporosis-A review of current evidence. Int. J. Mol. Sci., Vol. 20. 10.3390/ijms20061355.
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  82. Chan, C.Y., S. Subramaniam, K.Y. Chin, S. Ima-Nirwana and N. Muhammad, 2019. Levels of knowledge, beliefs, and practices regarding osteoporosis and the associations with bone mineral density among populations more than 40 years old in malaysia. Int. J. Environ. Res. Public Health, Vol. 16. 10.3390/ijerph16214115.
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  83. Chan, C.Y., S. Subramaniam, K.Y. Chin, S. Ima-Nirwana and N. Muhammad et al., 2019. Knowledge, beliefs, dietary, and lifestyle practices related to bone health among middle-aged and elderly chinese in klang valley, Malaysia. Int. J. Environ. Res. Public Health, Vol. 16. 10.3390/ijerph16101787.
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  84. Aminuddin, A., N. Salamt, A. Fuad, A. Faiz and K.Y. Chin et al., 2019. Vascular dysfunction among malaysian men with increased BMI: An indication of synergistic effect of free testosterone and inflammation. Medicina, Vol. 55. 10.3390/medicina55090575.
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  85. Al-Saadi, H.M., K.L. Pang, S. Ima-Nirwana and K.Y. Chin, 2019. Multifaceted protective role of glucosamine against osteoarthritis: Review of its molecular mechanisms. Sci. Pharm., Vol. 87. 10.3390/scipharm87040034.
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  86. Wong, S.K., K.Y. Chin, F.H. Suhaimi, F. Ahmad, N.A. Jamil and S. Ima-Nirwana, 2018. Osteoporosis is associated with metabolic syndrome induced by high-carbohydrate high-fat diet in a rat model. Biomed. Pharmacother., 98: 191-200.
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  87. Wong, S.K., K.Y. Chin, F.H. Suhaimi, F. Ahmad, N.A. Jamil and S. Ima-Nirwana, 2018. Osteoporosis is associated with metabolic syndrome induced by high-carbohydrate high-fat diet in a rat model. Biomed. Pharmacother., 98: 191-200.
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  88. Wong, S.K., K.Y. Chin, F.H. Suhaimi, F. Ahmad and S. Ima-Nirwana, 2018. The effects of vitamin e from Elaeis guineensis (Oil palm) in a rat model of bone loss due to metabolic syndrome. Int. J. Environ. Res. Public Health, Vol. 15. 10.3390/ijerph15091828.
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  89. Wong, S.K., K.Y. Chin, F.H. Suhaimi, F. Ahmad and S. Ima-Nirwana, 2018. The effects of palm tocotrienol on metabolic syndrome and bone loss in male rats induced by high-carbohydrate high-fat diet. J. Funct. Foods, 44: 246-254.
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  90. Wong, S.K., K.Y. Chin, F.H. Suhaimi, F. Ahmad and S. Ima-Nirwana, 2018. The effects of a modified high-carbohydrate high-fat diet on metabolic syndrome parameters in male rats. Exp. Clin. Endocrinol. Diabetes, 126: 205-212.
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  91. Wong, S.K., K.Y. Chin, F.H. Suhaimi, F. Ahmad and S. Ima-Nirwana, 2018. Exploring the potential of tocotrienol from Bixa orellana as a single agent targeting metabolic syndrome and bone loss. Bone, 116: 8-21.
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  92. Wong, S.K., K.Y. Chin, F.H. Suhaimi, F. Ahmad and S. Ima-Nirwana, 2018. Effects of metabolic syndrome on bone mineral density, histomorphometry and remodelling markers in male rats. PLoS ONE, Vol. 13. 10.1371/journal.pone.0192416.
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  93. Wong, S.K., K.Y. Chin and S. Ima-Nirwana, 2018. Vitamin D and depression: The evidence from an indirect clue to treatment strategy. Curr. Drug Targets, 19: 888-897.
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  94. Subramaniam, S., S. Ima-Nirwana and K.Y. Chin, 2018. Performance of osteoporosis self-assessment tool (OST) in predicting osteoporosis-a review. Int. J. Environ. Res. Public Health, Vol. 15. 10.3390/ijerph15071445.
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  95. Ramli, N.Z., K.Y. Chin, K.A. Zarkasi and F. Ahmad, 2018. A review on the protective effects of honey against metabolic syndrome. Nutrients, Vol. 10. 10.3390/nu10081009.
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  96. Pang, K.L. and K.Y. Chin, 2018. The biological activities of oleocanthal from a molecular perspective. Nutrients, Vol. 10. 10.3390/nu10050570.
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  97. Natasha, A.A., A.A. Syukri, M.K.S.N. Diana, S. Ima-Nirwana and K.Y. Chin, 2018. The association between backpack use and low back pain among pre-university students: A pilot study. J. Taibah Univ. Med. Sci., 13: 205-209.
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  98. Mohamad, N.V., S. Ima-Nirwana and K.Y. Chin, 2018. Effect of tocotrienol from Bixa orellana (Annatto) on bone microstructure, calcium content, and biomechanical strength in a model of male osteoporosis induced by buserelin. Drug Des. Dev. Ther., 12: 555-564.
    CrossRef  |  Direct Link  |  
  99. Mohamad, N.V., S. Ima-Nirwana and K.Y. Chin, 2018. A review on the effects of testosterone supplementation in hypogonadal men with cognitive impairment. Curr. Drug Targets, 19: 898-906.
    CrossRef  |  Direct Link  |  
  100. Mohamad, N.V., M.A.A.C. Zulkepli, K.M. Theseira, N. Zulkifli and N.Q. Shahrom et al., 2018. Establishing an animal model of secondary osteoporosis by using a gonadotropin-releasing hormone agonist. Int. J. Med. Sci., 15: 300-308.
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  101. Mohamad, N.V., I.N. Soelaiman and K.Y. Chin, 2018. Effects of tocotrienol from bixa orellana (Annatto) on bone histomorphometry in a male osteoporosis model induced by buserelin. Biomed. Pharmacother., 103: 453-462.
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  102. Jolly, J.J., K.Y. Chin, M.F.N. Farhana, E. Alias, K.H. Chua, W.N.W. Hasan and S. Ima-Nirwana, 2018. Optimization of the static human osteoblast/osteoclast co-culture system. Iran. J. Med. Sci., 43: 208-213.
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  103. Jolly, J., K.Y. Chin, E. Alias, K.H. Chua, I.N. Soelaiman, 2018. Protective effects of selected botanical agents on bone. Int. J. Environ. Res. Public Health, Vol. 15. 10.3390/ijerph15050963.
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  104. Ibrahim, N.I., S.K. Wong, I.N. Mohamed, N. Mohamed, K.Y. Chin, S. Ima-Nirwana and A.N. Shuid, 2018. Wound healing properties of selected natural products. Int. J. Environ. Res. Public Health, Vol. 15. 10.3390/ijerph15112360.
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  105. Hasan, W.N.W., N.A. Ghafar, K.Y. Chin and S. Ima-Nirwana, 2018. Annatto-derived tocotrienol stimulates osteogenic activity in preosteoblastic mc3t3-e1 cells: A temporal sequential study. Drug Des. Dev. Ther., 12: 1715-1726.
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  106. Hasan, W.N., K.Y. Chin, J.J. Jolly, N.A. Ghafar and I.N. Soelaiman, 2018. Identifying potential therapeutics for osteoporosis by exploiting the relationship between mevalonate pathway and bone metabolism. Endocrine, Metab. Immune Dis. Drug Targets, 18: 450-457.
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  107. Chin, K.Y., K.L. Pang and W.F. Mark-Lee, 2018. A review on the effects of bisphenol a and its derivatives on skeletal health. Int. J. Med. Sci., 15: 1043-1050.
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  108. Chin, K.Y., 2018. The relationship between follicle-stimulating hormone and bone health: Alternative explanation for bone loss beyond oestrogen. Int. J. Med. Sci., 15: 1373-1383.
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  109. Chin, K.Y. and W.F. Mark-Lee, 2018. A review on the Antinociceptive effects of Mitragyna speciosa and its derivatives on animal model. Curr. Drug Targets, 19: 1359-1365.
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  110. Chin, K.Y. and S.S. Tay, 2018. A review on the relationship between tocotrienol and Alzheimer Disease. Nutrients, Vol. 10. 10.3390/nu10070881.
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  111. Chin, K.Y. and S. Ima-Nirwana, 2018. Vitamin C and bone health: Evidence from cell, animal and human studies. Curr. Drug Targets, 19: 439-450.
    CrossRef  |  PubMed  |  Direct Link  |  
  112. Chin, K.Y. and S. Ima-Nirwana, 2018. The role of vitamin e in preventing and treating osteoarthritis–a review of the current evidence. Front. Pharmacol., Vol. 9. 10.3389/fphar.2018.00946.
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  113. Chan, C.Y., N. Mohamed, S. Ima-Nirwana and K.Y. Chin, 2018. Attitude of Asians to calcium and vitamin D rich foods and supplements: A systematic review. Sains Malaysiana, 47: 1801-1810.
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  114. Chan, C.Y., N. Mohamed, S. Ima-Nirwana and K.Y. Chin, 2018. A review of knowledge, belief and practice regarding osteoporosis among adolescents and young adults. Int. J. Environ. Res. Public Health, Vol. 15. 10.3390/ijerph15081727.
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  115. Ariffin, M., M.A. Shairazi, F.N. Fazil, N.M. Yassin and N.S. Junaida et al., 2018. Prevalence of vitamin d deficiency and its associated risk factors during early pregnancy in a tropical country: A pilot study. J. Clin. Diagnostic Res., 12: 18-22.
  116. Wong, S.K., K.Y. Chin, F.H. Suhaimi, F. Ahmad and S. Ima-Nirwana, 2017. Vitamin E as a potential interventional treatment for metabolic syndrome: Evidence from animal and human studies. Front. Pharmacol., Vol. 8. 10.3389/fphar.2017.00444.
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  117. Wong, S.K., K.Y. Chin and S. Ima-Nirwana, 2017. Vitamin D and depression: The evidence from an indirect clue to treatment strategy. Curr. Drug Targets, Vol. 18. 10.2174/1389450118666170913161030.
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  118. Shen, C.L., A. Klein, K.Y. Chin, H. Mo and P. Tsai et al., 2017. Tocotrienols for bone health: A translational approach. Ann. N. Y. Acad. Sci., 1401: 150-165.
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  119. Mohamad, N.V., S. Ima-Nirwana and K.Y. Chin, 2017. A review on the effects of testosterone supplementation in hypogonadal men with cognitive impairment. Curr. Drug Targets, Vol. 18. 10.2174/1389450118666170913162739.
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  120. Mohamad, N.V., I.N. Soelaiman and K.Y. Chin, 2017. A review on the effects of Androgen Deprivation Therapy (ADT) on bone health status in men with prostate cancer. Endocr. Metab. Immune Disord.-Drug Targets, 17: 276-284.
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  121. Chua, S.K., D.K.A. Singh, B.S. Rajaratnam, S.A. Mokhtar and R. Sridharan et al., 2017. A study protocol: Spinal morphology, physical performance, quality of life and biochemical markers in adults at risk of osteoporotic fractures. Pertanika J. Sci. Technol., 25: 1123-1134.
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  122. Chin, K.Y., S. Abdul-Majeed, N. Mohamed and S. Ima-Nirwana, 2017. The effects of tocotrienol and lovastatin co-supplementation on bone dynamic histomorphometry and bone morphogenetic protein-2 expression in rats with estrogen deficiency. Nutrients, Vol. 9, No. 2. 10.3390/nu9020143.
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  123. Chin, K.Y., N.Y. Low, W.I. Dewiputri and S. Ima-Nirwanaa, 2017. Factors associated with bone health in Malaysian middle-aged and elderly women assessed via quantitative ultrasound. Int. J. Environ. Res. Public Health, Vol. 14, No. 7. 10.3390/ijerph14070736.
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  124. Chin, K.Y., N.Y. Low, A.A.A. Kamaruddin, W.I. Dewiputri and I.N. Soelaiman, 2017. Agreement between calcaneal quantitative ultrasound and osteoporosis self-assessment tool for asians in identifying individuals at risk of osteoporosis. Therapeut. Clin. Risk Manage., 13: 1333-1341.
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  125. Chin, K.Y., 2017. A review on the relationship between aspirin and bone health. J. Osteoporosis, Vol. 2017. 10.1155/2017/3710959.
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  126. Chin, K.Y., 2017. A review on the performance of osteoporosis self-assessment tool for Asians in determining osteoporosis and fracture risk. Postgrad. Med., 129: 734-746.
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  127. Chin, K.Y. and W.F. Mark-Lee, 2017. A review on the antinociceptive effects of mitragyna speciosa and its derivatives in animal model. Curr. Drug Targets, Vol. 18. 10.2174/1389450118666170925154025.
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  128. Chin, K.Y. and S. Ima-Nirwana, 2017. The effects of testosterone deficiency and its replacement on inflammatory markers in rats: A pilot study. Int. J. Endocrinol. Metab., Vol. 15, No. 1. 10.5812/ijem.43053.
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  129. Chin, K.Y. and K.L. Pang, 2017. Therapeutic effects of olive and its derivatives on osteoarthritis: From bench to bedside. Nutrients, Vol. 9, No. 10. 10.3390/nu9101060.
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  130. Wong, S.K., K.Y. Chin, F.H. Suhaimi, F. Ahmad and S. Ima-Nirwana, 2016. The relationship between metabolic syndrome and osteoporosis: A review. Nutrients, Vol. 8, No. 6. 10.3390/nu8060347.
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  131. Wong, S.K., K.Y. Chin, F.H. Suhaimi, A. Fairus and S. Ima-Nirwana, 2016. Animal models of metabolic syndrome: A review. Nutr. Metab., Vol. 13, No. 1. 10.1186/s12986-016-0123-9.
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  132. Mohamad, N.V., I.N. Soelaiman and K.Y. Chin, 2016. A concise review of testosterone and bone health. Clin. Interventions Aging, 11: 1317-1324.
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  133. Chin, K.Y., W.Z.W. Ngah and S. Ima-Nirwana, 2016. Lessons from the bone chapter of the malaysian aging men study. Int. J. Environ. Res. Public Health, Vol. 13, No. 6. 10.3390/ijerph13060531.
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  134. Chin, K.Y., D. Gengatharan, F.S.M. Nasru, R.A. Khairussam, S.L.H. Ern, S.A.W. Aminuddin and S. Ima-Nirwana, 2016. The effects of annatto tocotrienol on bone biomechanical strength and bone calcium content in an animal model of osteoporosis due to testosterone deficiency. Nutrients, Vol. 8, No. 12. 10.3390/nu8120808.
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  135. Chin, K.Y., A.A.A. Kamaruddin, N.Y. Low and S. Ima-Nirwana, 2016. Effects of age, sex, and ethnicity on bone health status of the elderly in Kuala Lumpur, Malaysia. Clin. Interventions Aging, 11: 767-773.
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  136. Chin, K.Y., 2016. The spice for joint inflammation: Anti-inflammatory role of curcumin in treating osteoarthritis. Drug Des. Dev. Ther., 10: 3029-3042.
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  137. Chin, K.Y. and S. Ima-Nirwana, 2016. Olives and bone: A green osteoporosis prevention option. Int. J. Environ. Res. Public Health, Vol. 13, No. 8. 10.3390/ijerph13080755.
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  138. Chakraborty, C., K.Y. Chin and S. Das, 2016. miRNA-regulated cancer stem cells: Understanding the property and the role of miRNA in carcinogenesis. Tumor Biol., 37: 13039-13048.
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  139. Chin, K.Y., S.I. Nirwana and W.Z.W. Ngah, 2015. Significant association between parathyroid hormone and uric acid level in men. Clin. Interventions Aging, 10: 1377-1380.
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  140. Chin, K.Y., S. Ima-Nirwana, I.N. Mohamed, F. Ahmad, E.S.M. Ramli, A. Aminuddin and W.Z.W. Ngah, 2015. The association between bone health indicated by calcaneal quantitative ultrasound and metabolic syndrome in Malaysian men. J. Diabetes Metab. Disord., Vol. 14. 10.1186/s40200-015-0136-3.
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  141. Chin, K.Y., S. Ima-Nirwana and W.Z.W. Ngah, 2015. Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men. Aging Male, 18: 175-179.
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  142. Chin, K.Y. and S. Ima-Nirwana, 2015. The effects of orchidectomy and supraphysiological testosterone administration on trabecular bone structure and gene expression in rats. Aging Male, 18: 60-66.
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  143. Chin, K.Y. and S. Ima-Nirwana, 2015. The biological effects of tocotrienol on bone: A review on evidence from rodent models. Drug Des. Dev. Ther., 9: 2049-2061.
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  144. Chin, K.Y., S. Ima-Nirwana, S. Ibrahim, I.N. Mohamed and W.Z.W. Ngah, 2014. Vitamin D status in Malaysian men and its associated factors. Nutrients, 6: 5419-5433.
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  145. Chin, K.Y., S. Ima-Nirwana, I.N. Mohamed, M.H. Johari, F. Ahmad, E.S.M. Ramli and W.Z.W. Ngah, 2014. Insulin-like growth factor-1 is a mediator of age-related decline of bone health status in men. Aging Male, 17: 102-106.
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  146. Chin, K.Y., S. Ima-Nirwana, I.N. Mohamed, F. Ahmad, E.S.M. Ramli, A. Aminuddin and W.Z.W. Ngah, 2014. Serum osteocalcin is significantly related to indices of obesity and lipid profile in Malaysian men. Int. J. Med. Sci., 11: 151-157.
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  147. Chin, K.Y., S. Ima-Nirwana, I.N. Mohamed, A. Aminuddin, M.H. Johari and W.Z.W. Ngah, 2014. The relationships between thyroid hormones and thyroid-stimulating hormone with lipid profile in euthyroid men. Int. J. Med. Sci., 11: 349-355.
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  148. Chin, K.Y., S. Abdul-Majeed, N.F.M. Fozi and S. Ima-Nirwana, 2014. Annatto tocotrienol improves indices of bone static histomorphometry in osteoporosis due to testosterone deficiency in rats. Nutrients, 6: 4974-4983.
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  149. Chin, K.Y., I.N. Soelaiman, I.N. Mohamed and W.Z.W. Ngah, 2014. The influence of age, ethnicity and body anthropometry on the level of serum osteocalcin and terminal-C telopeptides of type I collagen in men. Malays. J. Health Sci., 12: 7-13.
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  150. Chin, K.Y. and S. Ima-Nirwana, 2014. The effects of α-tocopherol on bone: A double-edged sword? Nutrients, 6: 1424-1441.
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  151. Chin, K.Y. and S. Ima-Nirwana, 2014. Effects of annatto-derived tocotrienol supplementation on osteoporosis induced by testosterone deficiency in rats. Clin. Interventions Aging, 9: 1247-1259.
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  152. Chin, K.Y., S. Ima-Nirwana, I.N. Mohamed, A. Aminuddin, M.H. Johari and W.Z.W. Ngah, 2013. Thyroid-stimulating hormone is significantly associated with bone health status in men. Int. J. Med. Sci., 10: 857-863.
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  153. Chin, K.Y., S. Ima-Nirwana, I.N. Mohamed, A. Aminuddin and W.Z.W. Ngah, 2013. Total testosterone and sex hormone-binding globulin are significantly associated with metabolic syndrome in middle-aged and elderly men. Exp. Clin. Endocrinol. Diabetes, 121: 407-412.
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  154. Chin, K.Y., I.N. Soelaiman, I.N. Mohamed, N. Mohamed, A.N. Shuid, N. Muhammad and W.Z.W. Ngah, 2013. Discrepancy between the quantitative ultrasound value of Malaysian men and the manufacturer's reference and the impact on classification of bone health status. J. Clin. Densitometry, 16: 189-195.
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  155. Chin, K.Y., I.N. Soelaiman, I.N. Mohamed, F. Ahmad, E.S.M. Ramli, A. Aminuddin and W.Z.W. Ngah, 2013. Sex hormones in Malay and Chinese men in Malaysia: Are there age and race differences? Clinics, 68: 159-166.
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  156. Chin, K.Y., H. Mo and I.N. Soelaiman, 2013. A review of the possible mechanisms of action of tocotrienol-a potential antiosteoporotic agent. Curr. Drug Targets, 14: 1533-1541.
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  157. Chin, K.Y. and S. Ima-Nirwana, 2013. Can soy prevent male osteoporosis? A review of the current evidence. Curr. Drug Targets, 14: 1632-1641.
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  158. Chin, K.Y. and S. Ima-Nirwana, 2013. Calcaneal quantitative ultrasound as a determinant of bone health status: What properties of bone does it reflect? Int. J. Med. Sci., 10: 1778-1783.
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  159. Chin, K.Y., S. Ima-Nirwana, M.I. Naina, M. Norazlina and S.A. Nazrun et al., 2012. Calcaneal quantitative ultrasound value for middle-aged and elderly Malaysian Chinese men and its association with age and body anthropometry. J. Clin. Densitometry, 15: 86-91.
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  160. Chin, K.Y., I.N. Soelaiman, I.N. Mohamed, S. Shahar and N.I.M.F. Teng et al., 2012. Testosterone is associated with age-related changes in bone health status, muscle strength and body composition in men. Aging Male, 15: 240-245.
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  161. Chin, K.Y., I.N. Soelaiman, I.N. Mohamed, S. Ibrahim and W.Z.W. Ngah, 2012. The effects of age, physical activity level and body anthropometry on calcaneal speed of sound value in men. Arch. Osteoporosis, 7: 135-145.
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  162. Chin, K.Y., I.N. Soelaiman, I.N. Mohamed, H. Johari and W.Z.W. Ngah, 2012. Ethnicity, smoking and body composition influence testosterone and estradiol levels in healthy young adult men in Malaysia: A pilot study. Int. J. Endocrinol. Metab., 10:: 404-410.
  163. Chin, K.Y., I.N. Soelaiman, I.N. Mohamed and W.Z.W. Ngah, 2012. Serum testosterone, sex hormone-binding globulin and total calcium levels predict the calcaneal speed of sound in men. Clinics, 67: 911-916.
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  164. Chin, K.Y. and S. Ima-Nirwana, 2012. Vitamin E as an antiosteoporotic agent via receptor activator of nuclear factor kappa-b ligand signaling disruption: Current evidence and other potential research areas. Evidence-Based Complement. Altern. Med. 10.1155/2012/747020.
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  165. Chin, K.Y. and S. Ima-Nirwana, 2012. Sex steroids and bone health status in men. Int. J. Endocrinol. 10.1155/2012/208719.
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