Dr. Ziganshin   Ayrat

Dr. Ziganshin Ayrat

Head of Academic Department/Faculty
Kazan State Medical University, Russia


Highest Degree
Ph.D. in Pharmacology from Kazan State Medical University, Russia

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Biography

Dr. Ziganshin Ayrat is currently working as Head of Department of Pharmacology at Kazan State Medical University, Russia, He has completed his Ph.D. in Pharmacology from same University. His main area of interest focuses on Pharmacology, Neurophysiology. His area of expertise includes ATP, Adenosine, Purinoceptors, Synapse, Smooth muscles, Vas Deferens, Autonomic Nervous System, Urinary Bladder, and New drugs. He has published 2 books, more than 92 research articles in journals contributed as author/co-author.

Area of Interest:

Pharmacology and Toxicology
100%
Neurophysiology
62%
Pharmacology
90%
Drug Delivery
75%
Medical Chemistry
55%

Selected Publications

  1. Grishin, S.N., A.Y. Teplov, A.M. Farhutdinov, B.A. Ziganshin and A.U. Ziganshin, 2013. Different effects of ATP on the contractility and nonquantal acetylcholine release of rat tonic and phasic muscles. Pharmacologia, 4: 519-524.
    CrossRef  |  Direct Link  |  

  2. Ziganshina, A.P., B.A. Ziganshin and A.U. Ziganshin, 2012. Dual effects of ATP on isolated arteries of the bovine eye. Pharmacol. Res., 66: 170-176.
    CrossRef  |  PubMed  |  Direct Link  |  

  3. Kazakova, R.R., I.G. Mustafin, T.I. Mavludov, A.P. Kiyasov and A.U. Ziganshin, 2011. Expression of P2X receptor subtypes on CD34+ Cells and c-kit+ cells of human umbilical blood. Bull. Exp. Biol. Med., 151: 33-37.
    CrossRef  |  PubMed  |  Direct Link  |  

  4. Grishin, S.N., R.R. Kamaliev, A.Y. Teplov and A.U. Ziganshin, 2011. Opposite effect of ATP on contraction force of tonic and phasic skeletal muscles in frogs. Bull. Exp. Biol. Med., 151: 280-283.
    CrossRef  |  Direct Link  |  

  5. Filimonova, A.A., L.E. Ziganshina, A.U. Ziganshin and A.A. Chichirov, 2011. New specific marker of cytochrome P450 1A2 activity. Bull. Exp. Biol. Med., 150: 762-764.
    CrossRef  |  PubMed  |  Direct Link  |  

  6. Ziganshina, L.E., R.R. Nyazov and A.U. Ziganshin, 2009. Biopharmaceuticals in the Russian Federation: A snapshot of policies for registration, reimbursement and use. Int. J. Risk Safety Med., 21: 75-88.
    CrossRef  |  Direct Link  |  

  7. Ziganshin, A.U., R.R. Kamaliev, S.N. Grishin, B.A. Ziganshin and G. Burnstock, 2009. Interaction of hydrocortisone with ATP and adenosine on nerve-mediated contractions of frog skeletal muscle. Eur. J. Pharmacol., 607: 54-59.
    CrossRef  |  Direct Link  |  

  8. Teplov, A.Y., S.N. Grishin, M.A. Mukhamedyarov, A.U. Ziganshin, A.L. Zefirov and A. Palotas, 2009. Ovalbumin-induced sensitization affects non-quantal acetylcholine release from motor nerve terminals and alters contractility of skeletal muscles in mice. Exp. Physiol., 94: 264-268.
    CrossRef  |  Direct Link  |  

  9. Ziganshin, A.U., Z.R. Vafina and I.F. Fatkullin, 2008. Contrasting effects of P2 receptor agonists on spontaneous contractility of human fallopian tubes with and without acute inflammation. Pharmacol. Res., 57: 56-59.
    CrossRef  |  PubMed  |  Direct Link  |  

  10. Markovskaya, A., A. Crooke, A.I. Guzman-Aranguez, A. Peral and A.U. Ziganshin et al., 2008. Hypotensive effect of UDP on intraocular pressure in rabbits. Eur. J. Pharmacol., 579: 93-97.
    CrossRef  |  PubMed  |  Direct Link  |  

  11. Burashnikova, I.S., A.U. Ziganshin and L.E. Ziganshina, 2008. Attitudes to pharmaceutical promotion techniques among healthcare professionals in the Republic of Tatarstan, Russia. Int. J. Risk Safety Med., 20: 57-71.
    CrossRef  |  Direct Link  |  

  12. Ziganshin, A.U., A.P. Zaitcev, A.A. Khasanov, A.F. Shamsutdinov and G. Burnstock et al., 2006. Term-dependency of P2 receptor-mediated contractile responses of isolated human pregnant uterus. Eur. J. Obstet.Gynecol. Reprod. Biol., 129: 128-134.
    CrossRef  |  PubMed  |  Direct Link  |  

  13. Grishin, S.N., A.Y. Teplov, A.V. Galkin, A.M. Devyataev and A.L. Zefirov et al., 2006. Different effects of ATP on the contractile activity of mice diaphragmatic and skeletal muscles. Neurochem. Int., 49: 756-763.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Ziganshin, A.U., R.R. Kamaliev, S.N. Grishin, L.E. Ziganshina, A.L. Zefirov and G. Burnstock, 2005. The influence of hypothermia on P2 receptor-mediated responses of frog skeletal muscle. Eur. J. Pharmacol., 509: 187-193.
    CrossRef  |  Direct Link  |  

  15. Ziganshin, A.U., J.T. Zefirova, T.P. Zefirova, L.E. Ziganshina and C.H. Hoyle et al., 2005. Potentiation of uterine effects of prostaglandin F2alpha by adenosine 5'-triphosphate. Obstet. Gynecol., 105: 1429-1436.
    PubMed  |  

  16. Ziganshin, A.U., D.F. Khaziakhmetov, L.E. Ziganshina, V.N. Khaziakhmetova and R.K. Jourjikiya et al., 2004. Varicose disease affects the P2 receptor-mediated responses of human greater saphenous vein. Vasc. Pharmacol., 42: 17-21.
    CrossRef  |  PubMed  |  Direct Link  |  

  17. Burger, E.J., L. Ziganshina and A.U. Ziganshin, 2004. Academic medicine in Russia. Croat. Med. J., 45: 674-676.
    PubMed  |  

  18. Ziganshin, A.U., A.V. Rychkov, L.E. Ziganshina and G. Burnstock, 2002. Temperature dependency of P2 receptor-mediated responses. Eur. J. Pharmacol., 456: 107-114.
    CrossRef  |  PubMed  |  Direct Link  |  

  19. Zefirova, J.T., T.P. Zefirova, L.E. Ziganshina and A.U. Ziganshin, 2002. Effects of chronic specific urogenital infections on contractility of the human isolated pregnant myometrium. Autonomic Neurosci. Basic Clin., 99: 58-61.
    CrossRef  |  PubMed  |  Direct Link  |  

  20. Korthuis, P.T., L. Nekhlyudov, A.U. Ziganshin, M. Sadigh, and M.L. Green, 2002. Implementation of a cross-cultural evidence-based medicine curriculum. Med. Teacher, 24: 444-446.
    CrossRef  |  PubMed  |  Direct Link  |  

  21. Jacobson, K.A., C. Hoffmann, Y.C. Kim, E. Camaioni and E. Nandanan et al., 1999. Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis. Prog. Brain Res., 120: 119-132.
    PubMed  |  

  22. Kim, Y.C., E. Camaioni, A.U. Ziganshin, X. Ji and B.F. King et al., 1998. Synthesis and structure-activity relationships of pyridoxal-6-arylazo-5'-phosphate and phosphonate derivatives as P2 receptor antagonists. Drug Dev. Res., 45: 52-66.
    CrossRef  |  PubMed  |  Direct Link  |  

  23. Ziyal, R., A.U. Ziganshin, P. Nickel, U. Ardanuy and E. Mutschler et al., 1997. Vasoconstrictor responses via P2X-receptors are selectively antagonized by NF023 in rabbit isolated aorta and saphenous artery. Br. J. Pharmacol., 120: 954-960.
    CrossRef  |  PubMed  |  Direct Link  |  

  24. Ziganshin, A.U., L.E. Ziganshina and D.Z. Burnstok, 1997. Ecto-ATPases and receptors for ATP. Eksp Klin Farmakol., 60: 78-82.
    PubMed  |  

  25. Ziganshina, L.E., A.U. Ziganshin, C.H.V. Hoyle and G. Burnstock, 1996. Acute paw oedema formation induced by ATP: Re-evaluation of the mechanisms involved. Inflammation Res., 45: 96-102.
    CrossRef  |  PubMed  |  Direct Link  |  

  26. Ziganshin, A.U., L.E. Ziganshina, B.F. King, J. Pintor and G. Burnstock, 1996. Effects of P2-purinoceptor antagonists on degradation of adenine nucleotides by ecto-nucleotidases in folliculated oocytes of Xenopus laevis. Biochem. Pharmacol., 51: 897-901.
    CrossRef  |  PubMed  |  Direct Link  |  

  27. Ziganshin, A.U., L.E. Ziganshina, B.F. King and G. Burnstock, 1996. Differential degradation of extracellular adenine nucleotides by folliculated oocytes of Xenopus laevis. Comp. Biochem. Physiol. A: Physiol., 114: 335-340.
    CrossRef  |  PubMed  |  Direct Link  |  

  28. King, B.F., J. Pintor, S. Wang, A.U. Ziganshin and L.E. Ziganshina et al., 1996. A novel P1 purinoceptor activates an outward K+ current in follicular oocytes of Xenopus laevis. J. Pharmacol. Exp. Ther., 276: 93-100.
    PubMed  |  Direct Link  |  

  29. King, B.F., C. Dacquet, A.U. Ziganshin, D.F. Weetman and G. Bumstock et al., 1996. Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor. Br. J. Pharmacol., 117: 1111-1118.
    2Y1 purinoceptor.' target='_blank'>CrossRef  |  2Y1 purinoceptor.' target='_blank'>PubMed  |  2Y1 purinoceptor.' target='_blank'>Direct Link  |  

  30. Jarlebark, L., M. Erlandsson, A. Uri, B.F. King and A.U. Ziganshin et al., 1996. Peptidyl conjugates of adenosine 5'-carboxylic acid synthesized and evaluated as ligands for P2 purinoceptors. Biochem. Biophys. Res. Commun., 229: 363-369.
    CrossRef  |  PubMed  |  Direct Link  |  

  31. Hoyle, C.H.V., A.U. Ziganshin, J. Pintor and G. Burnstock, 1996. The activation of P1- and P2-purinoceptors in the guinea-pig left atrium by diadenosine polyphosphates. Br. J. Pharmacol., 118: 1294-1300.
    CrossRef  |  PubMed  |  Direct Link  |  

  32. Ziganshin, A.U., V. Ralevic and G. Burnstock, 1995. Contractility of urinary bladder and vas deferens after sensory denervation by capsaicin treatment of newborn rats. Br. J. Pharmacol., 114: 166-170.
    CrossRef  |  PubMed  |  Direct Link  |  

  33. Ziganshin, A.U., L.E. Ziganshina, C.H.V. Hoyle and G. Burnstock, 1995. Effects of divalent cations and La3+ on contractility and ecto-ATPase activity in the guinea-pig urinary bladder. Br. J. Pharmacol., 114: 632-639.
    CrossRef  |  PubMed  |  Direct Link  |  

  34. Ziganshin, A.U., L.E. Ziganshina, B.F. King and G. Burnstock, 1995. Characteristics of ecto-ATPase of Xenopus oocytes and the inhibitory actions of suramin on ATP breakdown. Pflugers Archiv, 429: 412-418.
    CrossRef  |  PubMed  |  Direct Link  |  

  35. Ziganshin, A.U., E.A. Berdnikov, L.E. Ziganshina, F.R. Tantasheva and C.H.V. Hoyle et al., 1995. Effects of α,β-unsaturated sulphones and phosphonium salts on ecto-ATPase activity and contractile responses mediated via P-purinoceptors. Gen. Pharmacol. Vasc. Syst., 26: 527-532.
    CrossRef  |  PubMed  |  Direct Link  |  

  36. Windscheif, U., O. Pfaff, A.U. Ziganshin, C.H.V. Hoyle and H.G. Baumert et al., 1995. Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical field stimulation in guinea-pig taenia coli and rat duodenum. Br. J. Pharmacol., 115: 1509-1517.
    CrossRef  |  PubMed  |  Direct Link  |  

  37. Ziganshin, A.U., C.H.V. Hoyle, L.E. Ziganshina and G. Burnstock, 1994. Effects of cyclopiazonic acid on contractility and ecto-ATPase activity in guinea-pig urinary bladder and vas deferens. Br. J. Pharmacol., 113: 669-674.
    CrossRef  |  PubMed  |  Direct Link  |  

  38. Ziganshin, A.U., C.H.V. Hoyle, G. Lambrecht, E. Mutschler and H.G. Baumert et al., 1994. Selective antagonism by PPADS at P2X-purinoceptors in rabbit isolated blood vessels. Br. J. Pharmacol., 111: 923-929.
    CrossRef  |  PubMed  |  Direct Link  |  

  39. Ziganshin, A.U., C.H.V. Hoyle and G. Burnstock, 1994. Ecto-enzymes and metabolism of extracellular ATP. Drug Dev. Res., 32: 134-146.
    CrossRef  |  Direct Link  |  

  40. Burnstock, G., B. Fischer, C.H.V. Hoyle, M. Maillard and A.U. Ziganshin et al., 1994. Structure activity relationships for derivatives of adenosine-5'-triphosphate as agonists at P2 purinoceptors: Heterogeneity within P2x and P2y subtypes. Drug Dev. Res., 31: 206-219.
    2 purinoceptors: Heterogeneity within P2x and P2y subtypes.' target='_blank'>CrossRef  |  2 purinoceptors: Heterogeneity within P2x and P2y subtypes.' target='_blank'>Direct Link  |  

  41. Ziganshin, A.U., C.H.V. Hoyle, X. Bo, G. Lambrecht, E. Mutschler, H.G. Baumert and G. Burnstock, 1993. PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder. Br. J. Pharmacol., 110: 1491-1495.
    CrossRef  |  PubMed  |  Direct Link  |  

  42. Fischer, B., J.L. Boyer , C.H.V. Hoyle , A.U. Ziganshin and A.L. Brizzolara et al., 1993. Identification of potent, selective P2γ-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate. J. Med. Chem., 36: 3937-3946.
    CrossRef  |  PubMed  |  Direct Link  |  

  43. Ziganshin, A.U., I.A. Studentsova and I.V. Zaikonnikova, 1988. Effect of dimephosphon on the adenine nucleotide system. Farmakol Toksikol., 51: 80-82.
    PubMed  |