Dr. Xiukun  Lin

Dr. Xiukun Lin

Professor
Capital Medical University, China


Highest Degree
Ph.D. in Pharmacology from Peking Union Medical College, China

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Area of Interest:

Pharmacology and Toxicology
100%
Bioactive Compounds
62%
Alternative Medicine
90%
Natural Products
75%
Cancer Biology
55%

Selected Publications

  1. Yuan, R., H. Xu, X. Liu, Y. Tian and C. Li et al., 2016. Zinc-doped copper oxide nanocomposites inhibit the growth of human cancer cells through reactive oxygen species-mediated NF-κB activations. ACS Applied Mater. Interfaces, 8: 31806-31812.
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  2. Xu, H., T. Yang, X. Liu, Y. Tian and X. Chen et al., 2016. Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism. Life Sci., 144: 138-147.
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  3. Wang, X., H. Xu, X. Chen, Y. Tian, F. Wang and X. Lin, 2016. Cloning, expression and cytotoxicity of granulin A, a novel polypeptide contained in human progranulin. Biosci. Trends, 10: 181-187.
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  4. Rytblat, I., N. Wu, H. Xu, A. Gedanken and X. Lin, 2016. In vitro studies of polyethyleneimine coated miRNA microspheres as anticancer agents. Nano Res., 9: 1609-1617.
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  5. Lin, X., A.A. Farooqi, M.Z. Qureshi, M.A. Romero, S. Tabassum and M. Ismail, 2016. Prostate cancer stem cells: Viewing signaling cascades at a finer resolution. Arch. Immunol. Ther. Exp., 64: 217-223.
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  6. Chen, X., H. Xu, B. Li, F. Wang, X. Chen, D. Kong and X. Lin, 2016. Preparation and antitumor activity of CS5931, a novel polypeptide from sea squirt Ciona savignyi. Mar. Drugs, Vol. 14. 10.3390/md14030047.
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  7. Zhu, S., J. Wang, B. Xie, Z. Luo, X. Lin and D.J. Liao, 2015. Culture at a higher temperature mildly inhibits cancer cell growth but enhances chemotherapeutic effects by inhibiting cell-cell collaboration. PLoS ONE, Vol. 10. 10.1371/journal.pone.0137042.
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  8. Xu, H., X. Zhao, X. Liu, P. Xu, K. Zhang and X. Lin, 2015. Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway. Drug Des. Dev. Ther., 9: 2735-2744.
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  9. Wu, N., J. Liu, X. Zhao, Z. Yan and B. Jiang et al., 2015. Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells. Tumor Biol., 36: 9667-9676.
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  10. Qi, X., G. Liu, L. Qiu, X. Lin and M. Liu, 2015. Marine bromophenol bis (2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems. Biomed. Pharmacother., 75: 58-66.
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  11. Liu, M., X. Zhao, L. Xiao, G. Liu and H. Liu et al., 2015. Cytotoxicity of the compounds isolated from Pulsatilla chinensis saponins and apoptosis induced by 23-hydroxybetulinic acid. Pharm. Biol., 53: 1-9.
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  12. Lin, X., A.A. Farooqi and M. Ismail, 2015. Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells. Drug Des. Dev. Ther., 9: 1797-1804.
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  13. Zheng, L., Y. Yi, J. Liu, X. Lin and K. Yang et al., 2014. Isolation and characterization of marine Brevibacillus sp.S-1 collected from South China sea and a novel antitumor peptide produced by the strain. PLoS ONE, Vol. 9. 10.1371/journal.pone.0111270.
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  14. Liu, M., G. Wang, L. Xiao, X. Xu, X. Liu, P. Xu and X. Lin, 2014. Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, a marine algae derived bromophenol, inhibits the growth of Botrytis cinerea and interacts with DNA molecules. Mar. Drugs, 12: 3838-3851.
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  15. Liu, J., N. Wu, L. Ma, M. Liu, G. Liu, Y. Zhang and X. Lin, 2014. Oleanolic acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type M isoforms. PLoS ONE, Vol. 9. 10.1371/journal.pone.0091606.
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  16. Liu, J., L. Zheng, N. Wu, L. Ma, J. Zhong, G. Liu and X. Lin, 2014. Oleanolic acid induces metabolic adaptation in cancer cells by activating the AMP-activated protein kinase pathway. J. Agric. Food Chem., 62: 5528-5537.
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  17. Liu, J., L. Zheng, L. Ma, B. Wang and Y. Zhao et al., 2014. Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy. J. Nutr. Biochem., 25: 1154-1160.
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  18. Liu, J., L. Zheng, J. Zhong, N. Wu, G. Liu and X. Lin, 2014. Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways. Oncol. Rep., 32: 567-572.
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  19. Liu, J., L. Ma, N. Wu, G. Liu, L. Zheng and X. Lin, 2014. Aplysin sensitizes cancer cells to TRAIL by suppressing P38 MAPK/survivin pathway. Mar. Drugs, 12: 5072-5088.
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  20. Liu, H., J.C. Schmitz, J. Wei, S. Cao and J.H. Beumer et al., 2014. Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis. Oncol. Res. Featuring Preclin. Clin. Cancer Ther., 21: 247-259.
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  21. Liu, G., M. Liu, J. Wei and X. Lin, 2014. CS5931, a novel polypeptide in Ciona savignyi, represses angiogenesis via inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). Mar. Drugs, 12: 1530-1544.
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  22. Zheng, L., X. Lin, N. Wu, M. Liu and Y. Zheng et al., 2013. Targeting cellular apoptotic pathway with peptides from marine organisms. Biochim. Biophys. Acta (BBA)-Rev. Cancer, 1836: 42-48.
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  23. Zhao, J., J. Wei, M. Liu, L. Xiao and N. Wu et al., 2013. Cloning, characterization and expression of a cDNA encoding a granulin-like polypeptide in Ciona savignyi. Biochimie, 95: 1611-1619.
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  24. Xiao, L., H. Liu, N. Wu, M. Liu, J. Wei, Y. Zhang and X. Lin, 2013. Characterization of the high cytochalasin E and rosellichalasin producing-Aspergillus sp. nov. F1 isolated from marine solar saltern in China. World J. Microbiol. Biotechnol., 29: 11-17.
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  25. Wu, N., X. Lin, X. Zhao, L. Zheng and L. Xiao et al., 2013. MiR-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independent pathways. Br. J. Cancer, 109: 2853-2863.
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  26. Wang, H., J. Wei, N. Wu, M. Liu and C. Wang et al., 2013. Mere15, a novel polypeptide from Meretrix meretrix, inhibits adhesion, migration and invasion of human lung cancer A549 cells via down-regulating MMPs. Pharm. Biol., 51: 145-151.
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  27. Liu, H., L. Xiao, J. Wei, J.C. Schmitz and M. Liu et al., 2013. Identification of Streptomyces sp. nov. WH26 producing cytotoxic compounds isolated from marine solar saltern in China. World J. Microbiol. Biotechnol., 29: 1271-1278.
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  28. Zhao, X., N. Wu, L. Ding, M. Liu, H. Liu and X. Lin, 2012. Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment. FEBS Lett., 586: 1220-1225.
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  29. Wu, N., L. Xiao, X. Zhao, J. Zhao and J. Wang et al., 2012. miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2. FEBS Lett., 586: 3831-3839.
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  30. Wei, J., H. Liu, M. Liu, N. Wu and J. Zhao et al., 2012. Oleanolic acid potentiates the antitumor activity of 5-fluorouracil in pancreatic cancer cells. Oncol. Rep., 28: 1339-1345.
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  31. Wang, C., M. Liu, L. Cheng, J. Wei, N. Wu, L. Zheng and X. Lin, 2012. A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma. Exp. Biol. Med., 237: 442-450.
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  32. Tang, D., H. Zhu, J. Wu, H. Chen and Y. Zhang et al., 2012. Silencing myostatin gene by RNAi in sheep embryos. J. Biotechnol., 158: 69-74.
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  33. Liu, M., X. Zhao, J. Zhao, L. Xiao and H. Liu et al., 2012. Induction of apoptosis, G0/G1 phase arrest and microtubule disassembly in K562 leukemia cells by Mere15, a novel polypeptide from Meretrix meretrix Linnaeus. Mar. Drugs, 10: 2596-2607.
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  34. Liu, M., W. Zhang, J. Wei, L. Qiu and X. Lin, 2012. Marine bromophenol bis (2,3-dibromo-4,5-dihydroxybenzyl) ether, induces mitochondrial apoptosis in K562 cells and inhibits topoisomerase I in vitro. Toxicol. Lett., 211: 126-134.
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  35. Cheng, L., C. Wang, H. Liu, F. Wang and L. Zheng et al., 2012. A novel polypeptide extracted from Ciona savignyi induces apoptosis through a mitochondrial-mediated pathway in human colorectal carcinoma cells. Clin. Colorectal Cancer, 11: 207-214.
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  36. Wu, N., X. Zhao, M. Liu, H. Liu and W. Yao et al., 2011. Role of microRNA-26b in glioma development and its mediated regulation on EphA2. PLoS ONE, Vol. 6. 10.1371/journal.pone.0016264.
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  37. Wang, C.C., H.Z. Liu, M. Liu, Y.Y. Zhang, T.T. Li and X.K. Lin, 2011. Cytotoxic metabolites from the soil-derived fungus Exophiala pisciphila. Molecules, 16: 2796-2801.
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  38. Liu, M., W. Zhang, J. Wei and X. Lin, 2011. Synthesis and α-glucosidase inhibitory mechanisms of bis (2,3-dibromo-4,5-dihydroxybenzyl) ether, a potential marine bromophenol α-glucosidase inhibitor. Mar. Drugs, 9: 1554-1565.
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  39. Liu, M., P.E. Hansen and X. Lin, 2011. Bromophenols in marine algae and their bioactivities. Mar. Drugs, 9: 1273-1292.
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  40. Cheng, L., M. Liu, C. Wang, H. Liu, Y. Zhang and X. Lin, 2011. CI431, an aqueous compound from Ciona intestinalis L., induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells. Evid.-Based Complement. Altern. Med., Vol. 2011. 10.1155/2011/292873.
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  41. Zhao, X., M. Liu, N. Wu, L. Ding, H. Liu and X. Lin, 2010. Recovery of recombinant zebrafish p53 protein from inclusion bodies and its binding activity to p53 mRNA in vitro. Protein Expression Purif., 72: 262-266.
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  42. Zhang, Y., S. Yang, M. Liu, C. Song and N. Wu et al., 2010. Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos. PLoS ONE, Vol. 5. 10.1371/journal.pone.0010618.
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  43. Liu, M., W. Zhang, L. Qiu and X. Lin, 2010. Synthesis of butyl-isobutyl-phthalate and its interaction with α-glucosidase in vitro. J. Biochem., 149: 27-33.
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  44. Lin, X., M. Liu, C. Hu and D.J. Liao, 2010. Targeting cellular proapoptotic molecules for developing anticancer agents from marine sources. Curr. Drug Targets, 11: 708-715.
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  45. Chen, L., G. Wang, T. Bu, Y. Zhang, Y. Wang, M. Liu and X. Lin, 2010. Phylogenetic analysis and screening of antimicrobial and cytotoxic activities of moderately halophilic bacteria isolated from the Weihai Solar Saltern (China). World J. Microbiol. Biotechnol., 26: 879-888.
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  46. Bu, T., M. Liu, L. Zheng, Y. Guo and X. Lin, 2010. α-glucosidase inhibition and the in vivo hypoglycemic effect of butyl-isobutyl-phthalate derived from the Laminaria japonica rhizoid. Phytother. Res., 24: 1588-1591.
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  47. Yang, S.L., S. Yan, R.L. Niu and X. Lin, 2009. VEGF gene silencing by cytomegalovirus promoter driven ShRNA expression vector results in vascular development defects in Zebrafish. Russian J. Genet., 45: 1040-1046.
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  48. Ning, X., J. Zhao, Y. Zhang, S. Cao, M. Liu, P. Ling and X. Lin, 2009. A novel anti-tumor protein extracted from Meretrix meretrix Linnaeus induces cell death by increasing cell permeability and inhibiting tubulin polymerization. Int. J. Oncol., 35: 805-812.
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  49. Zheng, L., Z. Wang, R.L. Niu, C.X. Hu and X. Lin, 2007. A novel peptide from shark cartilage with potent antiangiogenesis activity. Cancer Biol. Ther., 6: 775-780.
  50. Wang, Z., L.H. Zheng, S.L. Yang, R.L. Niu, E. Chu and X. Lin, 2007. N-acetylchitooligosaccharide is a potent angiogenic inhibitor both in vivo and in vitro. Biochem. Biophys. Res. Commun., 357: 26-31.
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  51. Thakur, A., K. Rahman, J. Wu, X. Lin and H. Nassar et al., 2007. Aberrant expression of X-linked genes RbAp46, Rsk4 and Cldn2 in breast cancer. Mol. Cancer Res., 5: 171-181.
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  52. Du, C., R. Niu, E. Chu, P. Zhang and X. Lin, 2006. Sequence analysis and functional study of thymidylate synthase from zebrafish, Danio rerio. J. Biochem., 139: 913-920.
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