Dr. Dong Xie
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Dr. Dong Xie

Professor
Institute of Nutritional Science, China

Highest Degree
Ph.D. in Molecular Biology from University of South Carolina, USA

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Area of Interest:

Biomedical Sciences
100%
Gastroenterology
62%
Cancer Research
90%
Immunology
75%
Pathology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Yue-Zhen, D., Y. Fan, L. Jing-Jing, M. Zheng-Fa and D. Xie et al., 2012. RACK1 Suppresses Gastric Tumorigenesis by Stabilizing the β-Catenin Destruction Complex. Gastroenterology, 142: 812-823.e15.
    PubMed  |  Direct Link  |  
  2. Yang, P., Q.J. Li, Y. Feng, Y. Zhang, and D. Xie et al., 2012. TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma. Can. Cell, 22: 291-303.
    PubMed  |  Direct Link  |  
  3. Shuo S., D. Yue-Zhen, Z. Jiang-Sha, J. Xiao-Dan and D. Xie et al. 2012. RACK1 Promotes Non-small-cell Lung Cancer Tumorigenicity through Activating Sonic Hedgehog Signaling Pathway. J. Biol. Chem., 10.1074/jbc.M111.315416 jbc.M111.315416..
    CrossRef  |  
  4. Guo, L., J. Xiao-Dan, G. Hong, Z. Jiang-Sha and D. Xie et al., 2012. EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex. Nat. Commun., 10.1038/ncomms1675.
    CrossRef  |  
  5. Ji, X.D., G. Li, Y.X. Feng, J.S. Zhao and D. Xie et al ., 2011. EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration. Can. Res., 71: 1156-1166.
    CrossRef  |  PubMed  |  Direct Link  |  
  6. Feng, Y.X., T. Wang, Y.Z. Deng, P. Yang and D. Xie et al., 2011. Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model. Hepatology, 53: 483-492.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Ying, H., L. Yang, G. Qiao, Z. Li and D. Xie et al., 2010. Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation. J. Immunol., 185: 1375-1378.
    CrossRef  |  PubMed  |  
  8. Yin, D., W. Chen, J. O'Kelly, D.Lu and D. Xie et al., 2010. Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme. Int. J. Can., 127: 2257-2267.
    CrossRef  |  PubMed  |  Direct Link  |  
  9. Xie, J.J., L.Y., Xu, J.Y. Wu, Z.Y. Shen and D. Xie et al., 2010. Involvement of CYR61 and CTGF in the Fascin-Mediated Proliferation and Invasiveness of Esophageal Squamous Cell Carcinomas Cells. Am. J. Pathol., 176: 939-951.
    CrossRef  |  PubMed  |  
  10. Wang, T., H.S. Hu, Y.X. Feng, J. Shi and D. Xie et al., 2010. Characterisation of a novel cell line (CSQT-2) with high metastatic activity derived from portal vein tumour thrombus of hepatocellular carcinoma. Br. J. Can., 102: 1618-1626.
    PubMed  |  Direct Link  |  
  11. Wang, L.D., F.Y. Zhou, X.M. Li, L.D. Sun and D. Xie et al., 2010. Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat. Genet., 42: 759-763.
    PubMed  |  Direct Link  |  
  12. Qiu, Y., T. Mao, Y. Zhang, M. Shao and D. Xie et al., 2010. A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci. Signal., 3: 106-106.
    PubMed  |  Direct Link  |  
  13. Nan, L., W. Guo, J. Shi, J. Xue and D. Xie et al., 2010. Expression of the chemokine receptor CXCR4 in human hepatocellular carcinoma and its role in portal vein tumor thrombus. J. Exp. Clin. Can. Res., 29: 156-156.
    CrossRef  |  
  14. Lu, X.F., E.M. Li, Z.P. Du, J.J. Xie and D. Xie et al., 2010. Specificity protein 1 regulates fascin expression in esophageal squamous cell carcinoma as the result of the epidermal growth factor/extracellular signal-regulated kinase signaling pathway activation. Cell. Mo. Life Sci., 67: 3313-3329.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Feng, Y.X., J.S. Zhao, J.J. Li, T. Wang, S.Q. Cheng and D. Xie et al., 2010. Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway 120. Hepatology, 51: 535-544.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Chen, P., P. Hu, D. Xie, Y. Qin, F. Wang and H. Wang, 2010. Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Can. Res. Treat., 121: 469-477.
    CrossRef  |  
  17. Cai, Z., J.S. Zhao, J.J. Li, D.N. Peng and D. Xie et al., 2010. A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. Mol. Cell. Proteomics, 9: 2617-2928.
    CrossRef  |  PubMed  |  
  18. Zhou, W., X.L. Ye, Z.J. Sun, X.D. Ji, H.X. Chen, D. Xie, 2009. Overexpression of degenerative spermatocyte homolog 1 up-regulates the expression of cyclin D1 and enhances metastatic efficiency in esophageal carcinoma Eca109 cells. Mol. Carcinog., 48: 886-894.
    CrossRef  |  PubMed  |  Direct Link  |  
  19. Li, J.J., R.Z. Qi, G.K.H. Ng and D. Xie, 2009. Proteomics in gastric cancer research: benefits and challenges. Proteomics Clin. Appl., 3: 185-196.
    CrossRef  |  
  20. Li, J.J., D.P. Liu, G. Liu and D. Xie, 2009. EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor. Oncogene, 16: 1759-1768.
    PubMed  |  Direct Link  |  
  21. Wang, Y., D.P. Liu, P.P. Chen, X.J. Tong and D. Xie, 2008. Negative Feedback Regulation of IFN-γ Pathway by IFN Regulatory Factor 2 in Esophageal Cancers. Can. Res., 68: 1136-1143.
    CrossRef  |  
  22. Sun, Z.J., Y. Wang, Z. Cai, P.P. Chen, X.J. Tong and D. Xie, 2008. Involvement of Cyr61 in growth, migration, and metastasis of prostate cancer cells. Br. J. Can., 99: 1656-1667.
    PubMed  |  Direct Link  |  
  23. Lu, F., H. Chen, C. Zhou, S. Liu and D. Xie et al., 2008. T-type Ca2+ channel expression in human esophageal carcinomas: a functional role in proliferation. Cell Calcium, 43: 49-58.
    CrossRef  |  PubMed  |  
  24. J.J., Li , C. Huang and D. Xie, 2008. Anti-obesity effects of conjugated linoleic acid, docosahexaenoic acid, and eicosapentaenoic acid. Mol. Nutr. Food Res., 52: 631-645.
    CrossRef  |  PubMed  |  
  25. Chen, P., J. Liang, Z. Wang, X. Zhou and D. Xie et al., 2008. Association of common PALB2 polymorphisms with breast cancer risk: a case-control study. Clin. Can. Res., 14: 5931-5937.
    CrossRef  |  PubMed  |  
  26. Wang, Y., D.P. Liu, P.P. Chen, H.P. Koeffler, X.J. Tong and D. Xie, 2007. Involvements of interferon regulatory factor-1 and -2 in the formation and progression of human esophageal cancers. Cancer Res., 67: 2535-2543.
  27. Liu, D.P., Y. Wang, H.P. Koeffler and D. Xie, 2007. Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK. Int. J. Oncol., 30: 865-871.
    Direct Link  |  
  28. Liu, D.P., R.Z. Qi, Y. Wang, P.P. Chen, H.P. Koeffler and D. Xie, 2007. Discovery of stage-related proteins in esophageal squamous cell carcinoma using proteomic analysis. Proteomics-Clinical Appli., 1: 312-320.
    CrossRef  |  
  29. Li, J.J. and D. Xie, 2007. Cleavage of Focal Adhesion Kinase (FAK) is essential in adipocyte differentiation. Biochem. Biophys. Res. Commun., 357: 648-654.
    CrossRef  |  
  30. Deng, Y.Z., Chen, P.P., Y. Wang, D. Yin and H.P. Koeffler et al., 2007. Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through β-catenin-T-cell factor/Lef signaling. J. Biol. Chem., 282: 36571-36581.
    CrossRef  |  
  31. Chen, P.P., W.J. Li, Y. Wang, S. Zhao, D.Y. Li, L.Y. Feng and D. Xie, 2007. Expression of Cyr61, CTGF and WISP-1 correlates with clinical features of lung cancer. PLoS ONE, Vol. 6. 10.1371/journal.pone.0000534.
    CrossRef  |  
  32. Yin, D., D. Xie, S. Sakajiri, C.W. Miller and H. Zhu et al., 2005. DLK1: Increased expression in gliomas and associated with oncogenic activities. Oncogne, 25: 1852-1861.
    Direct Link  |  
  33. Gery, S., D. Xie, D. Yin, H. Gabra nd C. Miller et al., 2005. Ovarian carcinomas: CCN genes are aberrantly expressed and CCN1 promotes proliferation of these cells. Clin. Cancer Res., 11: 7243-7254.
    CrossRef  |  Direct Link  |  
  34. Yin, D., D. Xie, S. DeVos, G. Liu, C. Miller, K. Black and H.P. Koeffler, 2004. Imprinting status of DLK1 gene in brain tumors and lymphomas. Int. J. Oncol., 24: 1011-1016.
    Direct Link  |  
  35. Xie, D., D. Yin, X. Tong, J. O'Kelly and C. Miller et al., 2004. Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and β-catenin-TCF/Lef signaling pathways. Cancer Res., 64: 1987-1996.
    CrossRef  |  
  36. Xie, D., D. Yin, H. Wang, R. Elashoff, K. Black and H.P. Koeffler, 2004. Levels of expression of Cyr61 and CTGF are prognostic for tumor progression and survival of individuals with Gliomas. Clin. Cancer Res., 10: 2072-2081.
    CrossRef  |  
  37. Tong, X., J. O'Kelly, D. Xie, A. Mori and N. Lemp et al., 2004. Cyr61 suppresses the growth of non-small-cell lung cancer cells via the β-catenin-c-myc-p53 pathway. Oncogene, 23: 4847-4855.
    Direct Link  |  
  38. Liu, G.T., J.S. Yu, G. Zeng, D. Yin, D. Xie, K.L. Black and H. Ying, 2004. AIM-2: A novel tumor antigen is expressed and presented by human glioma cells. J. Immunotherapy, 27: 220-226.
    Direct Link  |  
  39. Yin, D., D. Xie, W.K. Hofmann, K. Asotra, R. Wong, K.L. Black and H.P. Koeffler, 2003. Promoter hypermethylation of DNA repair gene O6-methylguanine-DNA methyltransferase is associated with its Downregulation and GC to A:T mutation of p53 in brain tumors. Mol. Carcinog., 36: 23-31.
  40. Tong, X., D. Xie, W. Roth, J. Reed and H.P. Koeffler, 2003. NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. Int. J. Oncol., 22: 1357-1362.
    Direct Link  |  
  41. Gery, S., D. Yin, D. Xie, K. Black and H.P. Koeffler, 2003. TMEFF1 and brain tumors. Oncogene, 22: 2723-2727.
    CrossRef  |  
  42. Yin, D., D. Xie, W.K. Hofmann, C.W. Miller, K.L. Black and H.P. Koeffler, 2002. Methylation, expression and mutation analysis of the cell cycle control genes in human brain tumors. Oncogene, 21: 8372-8378.
    Direct Link  |  
  43. Xie, D., A. Jauch, C.W. Miller, C.R. Bartram and H.P. Koeffler, 2002. Discovery of over-expressed genes and genetic alterations in breast cancer cells using a combination of suppression subtractive hybridization, multiplex FISH and comparative genomic hybridization. Int. J. Oncol., 21: 499-507.
    Direct Link  |  
  44. Szalai, G., D. Xie, M. Wassenich, M. Veres and J.D. Ceci et al., 2002. Distal and proximal cis-linked sequences are needed for the total expression phenotype of the mouse alcohol dehydrogenase 1 (Adh1) gene. Gene, 291: 259-270.
    CrossRef  |  
  45. Xie, D., K. Nakachi, H. Wang, R. Elashoff and H.P. Koeffler, 2001. Elevated levels of CTGF, WISP-1 and Cyr61 in primary breast cancers associated with more advanced features. Cancer Res., 61: 8917-8923.
    Direct Link  |  
  46. Xie, D., C.W. Miller, J. O'Kelly, K. Nakachi and A. Sakashita et al., 2001. Breast cancer: Cyr61 is over-expressed, estrogen inducible and associated with more advanced disease. J. Biol. Chem., 276: 14187-14194.
    Direct Link  |  
  47. Tong, X., D. Xie, J. O'Kelly, C.W. Miller, C. Muller-Tidow and H.P. Koeffler, 2001. Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer. J. Biol. Chem., 276: 47709-47714.
    PubMed  |  Direct Link  |  
  48. Hofmann, W.K., S. Takeuchi, D. Xie, C.W. Miller, D. Hoelzer and H.P. Koeffer, 2001. Frequent loss of heterozygosity in the region of D1S450 at 1p36.2 in myelodysplastic syndromes. Leukemia Res., 10: 855-858.
    CrossRef  |  
  49. Xie, D., W.K. Hofmann, N. Mori, C. Miller, D. Hoelzer and H.P. Koeffler, 2000. Allelotype analysis of the myelodysplastic syndrome. Leukemia, 14: 805-810.
    Direct Link  |  
  50. Xie, D., P. Narasimhan, Y.W. Zheng, M. Dewey and M.R. Felder, 1996. Ten Kilobases of 5'-flanking region confers proper regulation of the mouse alcohol dehydrogenase (Adh-1) gene in kidney and adrenal of transgenic mice. Gene, 181: 173-178.
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