Dr. Shaoyong Ke
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Dr. Shaoyong Ke

Research Scientist
National Biopesticide Engineering Research Center, Hubei Academy of Agricultural Science , Wuhan , 430064 , People's Republic of China

Highest Degree
Ph.D. in Applied Chemistry from East China University of Science & Technology, China

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Area of Interest:

Chemistry
100%
Applied Chemistry
62%
Drug Discovery
90%
Multicomponents Reaction
75%
Organic Chemistry
55%

Research Publications in Numbers

Books
0
Chapters
1
Articles
73
Abstracts
0

Selected Publications

  1. Ke, S., T. Xu, Y. Min, Z. Wan, Z. Yang and K. Wang, 2021. Marine alkaloid pityriacitrin and its analogues: Discovery, structures, synthetic methods and biological properties. Mini Rev. Med. Chem., 21: 233-244.
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  2. Song, D., X. Cao, W. Huang and S. Ke, 2020. Design, synthesis and biological evaluation of stilbene derivatives containing a 1,3-benzodioxole moiety. ChemistrySelect, 5: 13563-13568.
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  3. Shi, L., Z. Wu, Y. Zhang, Z. Zhang and W. Fang et al., 2020. Herbicidal secondary metabolites from actinomycetes: Structure diversity, modes of action, and their roles in the development of herbicides. J. Agric. Food Chem., 68: 17-32.
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  4. Huang, D., S. Wang, D. Song, X. Cao, W. Huang and S. Ke, 2020. Discovery of γ-lactam alkaloid derivatives as potential fungicidal agents targeting steroid biosynthesis. J. Agric. Food Chem., 68: 14438-14451.
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  5. Xu, T., L. Shi, Y. Zhang, K. Wang, Z. Yang and S. Ke, 2019. Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues. Eur. J. Med. Chem., 168: 293-300.
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  6. Wang, S., L. Bao, D. Song, J. Wang, X. Cao and S. Ke, 2019. Amino acid-oriented poly-substituted heterocyclic tetramic acid derivatives as potential antifungal agents. Eur. J. Med. Chem., 179: 567-575.
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  7. Ke, S., Z. Zhang, M. Liu, W. Fang and D. Huang et al., 2019. Synthesis and bioevaluation of novel steroidal isatin conjugates derived from epiandrosterone/androsterone. J. Enzyme Inhib. Med. Chem., 34: 1607-1614.
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  8. Ke, S., Z. Zhang, L. Shi, M. Liu and W. Fang et al., 2019. An efficient synthesis and bioactivity evaluation of oxazole-containing natural hinduchelins A-D and their derivatives. Org. Biomol. Chem., 17: 3635-3639.
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  9. Huang, D., F. Qiu, Z. Zhang, L. Shi, C. Cao and S. Ke, 2019. Synthesis and antifungal activity of substituted 2-aryl benzimidazoles derivatives. J. Heterocyclic Chem., 56: 2494-2498.
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  10. Ke, S., N. Li, T. Ke, L. Shi and Z. Zhang et al., 2018. Synthesis and evaluation of steroidal thiazoline conjugates as potential antiviral agents. Future Med. Chem., 10: 2589-2605.
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  11. Li, S., H. Li, C. Chen, X. Yue, X. Cao and S. Ke, 2013. Novel aroylhydrazine-amide derivatives bearing pyridine core: synthesis, characterisations and selective colorimetric recognition properties. Supramol. Chem., 25: 384-392.
    CrossRef  |  
  12. Ke, S., Z.G. Zhang, T. Long, Y. Liang and Z.W. Yang, 2013. Novel salicylamide derivatives incorporating neonicotinoid pharmacophore: Design, synthesis, characterization and biological evaluation. Med. Chem. Res., 22: 3621-3628.
    CrossRef  |  
  13. Ke, S., Y. Wei, Z. Yang, K. Wang, Y. Liang and L. Shi, 2013. Novel cycloalkylthiophene-imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation. Bioorg. Med. Chem. Lett., 23: 5131-5134.
    CrossRef  |  
  14. Ke, S., Y. Wei, L. Shi and Yang Q., Z. Yang, 2013. Synthesis of novel steroid derivatives derived from dehydroepiandrosterone as potential anticancer agents. Anticancer Agents Med. Chem., 13: 1291-1298.
    PubMed  |  
  15. Shi, L., R. Hu, Y. Wei, Y. Liang, Z. Yang and S. Ke, 2012. Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation. Eur. J. Med. Chem., 54: 549-556.
    CrossRef  |  
  16. Li, S., X. Cao, C. Chen and S. Ke, 2012. Novel salicylic acid-oriented thiourea-type receptors as colorimetric chemosensor: Synthesis, characterizations and selective naked-eye recognition properties. Spectrochim. Acta Part A: Mol. Biomol. Spectrosc., 96: 18-23.
    CrossRef  |  
  17. Ke, S., L. Shi, X. Cao, Q. Yang, Y. Liang and Z. Yang, 2012. Heterocycle-functional gramine analogues: Solvent-and catalyst-free synthesis and their inhibition activities against cell proliferation. Eur. J. Med. Chem., 54: 248-254.
    CrossRef  |  
  18. Ke, S., Y.N. Zhang, W. Shu, Z. Zhang and L. Shi et al., 2011. Structural diversity-guided convenient construction of functionalized polysubstituted butenolides and lactam derivatives. C. R. Chim., 14: 1071-1079.
    CrossRef  |  
  19. Ke, S., X. Cao, Y. Liang, K. Wang and Z. Yang, 2011. Synthesis and biological properties of dihydro-oxadiazine-based heterocyclic derivatives. Mini Rev. Med. Chem., 11: 642-657.
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  20. Cao, X., C. Chen, W. Lu and S. Ke, 2011. Chiralβ-arylalkyl-1 H-1, 2, 4-triazoles as demethylase inhibitors: Biological evaluation and its stereoselective interaction with sterol 14α-demethylase from Penicillium digitatum. Pestic. Biochem. Phys., 99: 189-193.
    CrossRef  |  
  21. Ke, S., T.T. Sun, Z.G. Zhang, Y.N. Zhang, Y. Liang, K. Wang and Z. Yang, 2010. Spirodiclofen analogues as potential lipid biosynthesis inhibitors: A convenient synthesis, biological evaluation and structure-activity relationship. Bull. Korean Chem. Soc., 31: 2315-2321.
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  22. Cao, X.F., T.T. Sun and S. Ke, 2010. Progress in the studies on synthesis and biological properties of butenolide and its derivatives. 30 Chin. J. Org. Chem.,: 1113-1125.
  23. Ke, S.Y., X.H. Qian, F.Y. Liu, N. Wang, Q. Yang and Z. Li, 2009. Novel 4 H-1, 3, 4-oxadiazin-5 (6 H)-ones with hydrophobic and long alkyl chains: Design, synthesis and bioactive diversity on inhibition of monoamine oxidase, chitin biosynthesis and tumor cell. Eur. J. Med. Chem., 44: 2113-2121.
    CrossRef  |  
  24. Ke, S., X. Qian, F. Liu, N. Wang, F. Fan, Z. Li and Q. Yang, 2009. Diacylhydrazine derivatives as novel potential chitin biosynthesis inhibitors: Design, synthesis and structure-activity relationship. Eur. J. Med. Chem., 44: 2985-2993.
    CrossRef  |  
  25. Ke, S., F. Liu, N. Wang, Q. Yang and X. Qian, 2009. 1, 3, 4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design, synthesis and biological evaluation. Bioorg. Med. Chem. Lett., 19: 332-335.
    CrossRef  |  
  26. Ke, S., Z. Li and X. Qian, 2008. 1, 3, 4-Oxadiazole-3 (2 H)-carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: Synthesis, evaluation and role of urea moiety. Bioorg. Med. Chem., 16: 7565-7572.
    CrossRef  |  
  27. Ke, S.Y. and S.J. Xue, 2006. Synthesis and herbicidal activity of N-(o-fluorophenoxyacetyl) thioureas derivatives and related fused heterocyclic compounds. Arkivoc, 10: 63-68.
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  28. Xue, S., S. Ke, L. Yan, Z. Cai and Y. Wei, 2005. A trifluoromethyl substituted organoimido derivative of the hexametalate cluster: Synthesis, crystal structure and bioactivity of [Mo 6 O 17(NAr) 2] 2−(Ar= o-CF 3 C 6 H 4). J. Inorg. Biochem., 99: 2276-2281.
    CrossRef  |