Dr. Jianwen Liu
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Dr. Jianwen Liu

Professor
East China University of Science and Technology, China

Highest Degree
Ph.D. in Applied Biosciences from Hiroshima Prefectural University, Japan

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Area of Interest:

Biomedical Sciences
100%
Chemotherapy
62%
Anticancer Materials Filtration
90%
Anticancer Activity
75%
Cancer Chemotherapy
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Zhou, L., L. Sun, H. Wu, L. Zhang, M. Chen, J. Liu and R. Zhong, 2013. Oridonin ameliorates lupus-like symptoms of MRLlpr/lpr mice by inhibition of B-cell activating factor (BAFF). Eur. J. Pharmacol., 715: 230-237.
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  2. Zheng, Y., V. Le, Z. Cheng, S. Xie, H. Li, J. Tian and J. Liu, 2013. Development of rapid and highly sensitive HSPA1A promoter-driven luciferase reporter system for assessing oxidative stress associated with low-dose photodynamic therapy. Cell Stress Chaperones, 18: 203-213.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Xu, K., X. Liang, D. Cui, Y. Wu, W. Shi and J. Liu, 2013. MiR-1915 inhibits Bcl-2 to modulate multidrug resistance by increasing drug-sensitivity in human colorectal carcinoma cells. Mol. Carcinogen., 52: 70-78.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Wang, Z., X. Liang, Z. Cheng, Y. Xu and P. Yin et al., 2013. Induction of apoptosis and suppression of ERCC1 expression by the potent amonafide analogue 8-c in human colorectal carcinoma cells. Anticancer Drugs, 24: 355-365.
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  5. Shen, K., H. Zhang, L. Sun, Y. Xu, X. Qian and J. Liu, 2013. A ROS-mediated lysosomal-mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human Hela cervix carcinoma cells. Cancer let., 333: 229-238.
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  6. Shao, J., Y. Li, Z. Wang, M. Xiao and P. Yin et al., 2013. 7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-κB in LPS-stimulated RAW264.7 macrophages. Int. Immunopharmacol., 17: 216-228.
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  7. Liang, L., S. Xie, L. Jiang, H. Jin, S. Li and J. Liu, 2013. The combined effects of hematoporphyrin monomethyl ether-SDT and doxorubicin on the proliferation of QBC939 Cell Lines. Ultrasound Med. Boil., 39: 146-160.
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  8. Jin, H., L. Liu, W. Deng, Y. Lu, J. Tian, H. Li and J. Liu, 2013. HDAC inhibitor DWP0016 suppresses miR-22 to induce growth inhibition and apoptosis via p53-independent PTEN activation in neuroblastoma SH-SY5Y cells. Process Biochem., 48: 1133-1142.
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  9. Jin, H., L. Liang, L. Liu, W. Deng and J. Liu, 2013. HDAC inhibitor DWP0016 activates p53 transcription and acetylation to inhibit cell growth in U251 glioblastoma cells. J. Cell. Biochem., 114: 1498-1509.
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  10. Xu, Y., Z. Jiang, P. Yin, Q. Li and J. Liu, 2012. Role for Class I histone deacetylases in multidrug resistance. Exp. Cell. Res., 318: 117-186.
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  11. Xu, K., X. Liang, K. Shen, L. Sun and D. Cui et al., 2012. MiR-222 modulates multidrug resistance in human colorectal carcinoma by down-regulating ADAM-17. Exp. Cell. Res., 318: 2168-2177.
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  12. Shen, K., Q. Liang, K. Xu, D. Cui and L. Jiang et al., 2012. MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type I insulin-like growth factor receptor. Biochem. Pharmacol., 84: 320-330.
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  13. Shen, K., D. Cui, L. Sun, Y. Lu, M. Han and J. Liu, 2012. Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression. J. Cell. Biochem., 113: 2086-2097.
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  14. Shao, J., Y. Li, K. Shen, B. Lin and Y. Xu et al., 2012. 7b, a novel amonafide analog, inhibited proliferation and phorbol 12-myristate 13-acetate/phytohemagglutinin-induced inflammatory responses of Jurkat T cells via p73-dependent pathway and decrease of nuclear factor-κB DNA-binding, respectively. Leuk Lymphoma, 54: 359-371.
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  15. Li, Y., J. Shao, K. Shen, Y. Xu, J. Liu and X. Qian, 2012. E2F1-dependent pathways are involved in amonafide analogue 7-d-induced DNA damage, G2/M arrest, and apoptosis in p53-deficient K562 cells. J. Cell. Biochem., 113: 3165-3177.
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  16. Ke, X., L. Xin, S. Ke, C. Daling and Z. Yuanhong et al., 2012. miR-297 modulates multidrug resistance in human colorectal carcinoma by down-regulating MRP-2. Biochem. J., 446: 291-300.
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  17. Jiang, L., Z. Cheng, S. Qiu, Z. Que and W. Bao et al., 2012. Altered let-7 expression in Myasthenia gravis and let-7c mediated regulation of IL-10 by directly targeting IL-10 in Jurkat cells. Int. immunopharmacol., 14: 217-223.
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  18. Xu, K., X. Liang, F. Wang, L. Xie, Y. Xu, J. Liu and X. Qian, 2011. Induction of G2/M phase arrest and apoptosis by potent antitumor APCA in human cervix carcinoma cells. Anticancer Drugs., 22: 875-885.
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  19. Wang, F., C. Jiao, J. Liu, H. Yuan, M. Lan and F. Gao, 2011. Oxidative mechanisms contribute to nanosize silican dioxide-induced developmental neurotoxicity in PC12 cells. Toxicol. in Vitro, 25: 1548-1556.
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  20. Sun, L., L. Zhou, M. Chen, R. Zhong and J. Liu, 2011. Amelioration of systemic lupus erythematosus by withangulatin A in MRL/lpr mice. J. Cell. Biochem., 112: 2376-2382.
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  21. Sun, L., J. Liu, P. Liu, Y. Yu, L. Ma and L. Hu, 2011. Immunosuppression effect of Withangulatin A from Physalis angulata via heme oxygenase 1-dependent pathways. Process Biochem., 46: 482-488.
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  22. Lin, B., Z. Chen, Y. Xu, H. Zhang, J. Liu and X. Qian, 2011. 7-b, a novel amonafide analogue, cause growth inhibition and apoptosis in Raji cells via a ROS-mediated mitochondrial pathway. Leuk Res., 35: 646-656.
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  23. Liang, X., L. Guo, K. Xu, T. Jin, Y. Wu, P. Liu and J. Liu, 2011. Synthesis of immunomagnetic nanoparticles and their use for breast cancer cell separation. Adv. Sci. Lett., 4: 1-5.
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  24. Liang, X., K. Xu, Y. Xu, J. Liu and X. Qian, 2011. B1-induced caspase-independent apoptosis in MCF-7 cells is mediated by down-regulation of Bcl-2 via p53 binding to P2 promoter TATA box. Toxicol. Applied pharmacol., 256: 52-61.
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  25. Liang, X., A. Wu, Y. Xu, K. Xu, J. Liu and X. Qian, 2011. B1, a novel naphthalimide-based visible light activatable photonuclease, induces cell cycle arrest and apoptosis via Chk2-p53 pathway in HeLa cells. Invest New Drugs, 29: 646-658.
  26. Jiang, Z., T. Jin, F. Gao, J. Liu, J. Zhong and H. Zhao, 2011. Effects of Ganoderic acid Me on inhibiting multidrug resistance and inducing apoptosis in multidrug resistant colon cancer cells. Process Biochem., 46: 1307-1314.
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  27. Yu, Y., L. Sun, L. Ma, J. Li, L. Hu and J. Liu, 2010. Investigation of the immunosuppressive activity of physalin H on T lymphocytes. Int. Immunopharmacol., 10: 290-297.
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  28. Ye, Y., J. Liu, M. Chen, L. Sun and M. Lan, 2010. In vitro toxicity of silica nanoparticles in myocardial cells. Environ. Toxicol. Pharmacol., 29: 131-137.
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  29. Ye, Y., J. Liu, M. Chen, L. Sun and M. Lan, 2010. In vitro toxicity of silica nanomaterials in myocardial H9c2(2-1) cells. Toxicol. in Vitro, 24: 751-758.
  30. Xu, Y., Z. Jiang, G. Ji and J. Liu, 2010. Inhibition of bone metastasis from breast carcinoma by rosmarinic acid. Acid Planta Med., 76: 956-962.
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  31. Xu, Y., G. Xu, L. Liu, D. Xu and J. Liu, 2010. Anti-invasion effect of rosmarinic acid via the extracellular signal-regulated kinase and oxidation-reduction pathway in Ls174-T cells. J. Cell Biochem., 111: 370-379.
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  32. Xu, K., X. Liang, F. Gao, J. Zhong and J. Liu, 2010. Antimetastatic effect of ganoderic acid T in vitro through inhibition of cancer cell invasion. Process Biochem., 45: 1261-1267.
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  33. Sun, L., J. Liu, D. Cui, J. Li, Y. Yu, L. Ma and L. Hu, 2010. Anti-inflammatory function of Withangulatin A by targeted inhibiting COX-2 expression via MAPK and NF-κB pathways. J. Cell. Biochem., 109: 532-541.
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  34. Liang, X., Y. Xu, K. Xu, J. Liu and X. Qian, 2010. B1, a novel amonafide analogue, overcomes the resistance conferred by Bcl-2 in human promyelocytic leukemia HL60 cells. Mol. Cancer Res., 8: 1619-1632.
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  35. Chen, Z., X. Liang, H. Zhang, H. Xie and Liu et al., 2010. A new class of naphthalimide-based antitumor agents that inhibit topoisomerase II and induce lysosomal membrane permeabilization and apoptosis. J. Med. Chem., 53: 2589-2600.
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  36. Chen, N.H., J.W. Liu and J.J. Zhong, 2010. Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression. Pharmacol. Rep., 62: 150-163.
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  37. Chen, M.C., Y.Y. Ye, G. Ji and J.W. Liu, 2010. Hesperidin upregulates heme oxygenase-1 to attenuate hydrogen peroxide-induced cell damage in hepatic L02 cells. J. Agric. Food Chem., 58: 3330-3335.
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  38. Chen, M., H. Gu, Y. Ye, B. Lin and L. Sun et al., 2010. Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes. Food Chem. Toxicol., 48: 2980-2987.
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  39. Zheng, P., G. Ji, Z. Ma, T. Liu and L. Xin et al., 2009. Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways. Am. J. Chin. Med., 37: 69-83.
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  40. Xie, L., Y. Xiao, F. Wang, Y. Xu and X. Qian et al., 2009. Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: Synthesis, cytotoxicity, DNA-binding and cell cycle evaluation. Bioorganic Med. Chem., 17: 7615-7621.
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  41. Wang, J., A. Wu, Y. Xu, J. Liu and X. Qian, 2009. M2-A induces apoptosis and G2-M arrest via inhibiting PI3K/Akt pathway in HL60 cells. Can. Lett., 283: 193-202.
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  42. Liang, X., K. Xu, J. Xu, W. Chen, H. Shen and J. Liu, 2009. Preparation of immunomagnetic nanoparticles and their application in the separation of mouse CD34+ hematopoietic stem cells. J. Magnetism Magnetic Mater., 321: 1885-1888.
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  43. Huang, C.F., L. Ma, L.J. Sun, M. Ali, M. Arfan, J.W. Liu and L.H. Hu, 2009. Immunosuppressive withanolides from Withania coagulans. Chem. Biodiversity, 6: 1415-1426.
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  44. Hu, B., J. Pan, H.L. Yu, J.W. Liu and J.H Xu, 2009. Immobilization of Serratia marcescens lipase onto amino-functionalized magnetic nanoparticles for repeated use in enzymatic synthesis of diltiazem intermediate. Process Biochem., 44: 1019-1024.
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  45. Fang, Y.S., D.M. Shan, J.W. Liu, W. Xu, C.L. Li and H.Z. Wu, 2009. Effect of compounds extracted from fructus aurantii immaturus and radix paeoniae alba on gastrointestinal movement. Planta Med., 75: 24-31.
  46. Xu, W., J. Liu, C. Li, H.Z. Wu and Y.W. Liu, 2008. Kaempferol-7-O-β-d-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner. Cancer Lett., 264: 229-240.
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  47. Xing, X., H. Wu, X. Wang, Y. Huang and Q. Li et al., 2008. Inhibition of tumor cell proliferation by Coleon C. J. Chem., 20: 238-245.
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  48. Wu, H., X. Liang, Y. Fang, X. Qin, Y. Zhang and J. Liu, 2008. Resveratrol inhibits hypoxia-induced metastasis potential enhancement by restricting hypoxia-induced factor-1α expression in colon carcinoma cells. Biomed. Pharmacother., 62: 613-621.
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  49. Shan, D., Y. Fang, Y. Ye and J. Liu, 2008. EGCG reducing the susceptibility to cholesterol gallstone formation through the regulation of inflammation. Biomed. Pharmacother., 62: 677-683.
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  50. Ott, I., Y. Xu, J. Liu, M. Kokoschka, M. Harlos, W.S. Sheldrick and X. Qian, 2008. Sulfur-substituted naphthalimides as photoactivatable anticancer agents: DNA interaction, fluorescence imaging, and phototoxic effects in cultured tumor cells. Bioorganic Med. Chem., 16: 7107-7116.
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  51. Hu, A.P., J.M. Du, J.Y. Li and J.W. Liu, 2008. Oridonin promotes CD4+/CD25+ Treg differentiation, modulates Th1/Th2 balance and induces HO-1 in rat splenic lymphocytes. Inflammation Res., 57: 163-170.
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  52. Duan, L., Y. Xu, X. Qian, F. Wang, J. Liu and T. Cheng, 2008. Highly selective fluorescent chemosensor with red shift for cysteine in buffer solution and its bioimage: Symmetrical naphthalimide aldehyde. Tetrahedron Lett., 49: 6624-6627.
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  53. Chen, N.H., J.W. Liu and J.J. Zhong, 2008. Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression. J. Pharmacol. Sci., 108: 212-216.
    CrossRef  |  PubMed  |  Direct Link  |  
  54. Changlong, L., W. Hezhen, H. Yongping, Y. Yanfang, L. Yanwen and L. Jianwen, 2008. 6-O-Angeloylenolin induces apoptosis through a mitochondrial/caspase and NF-κB pathway in human leukemia HL60 cells. Biomed. Pharmacother., 62: 401-409.
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  55. Yuan, L.L., G.P. Gan, H.Z. Wu, H.Z. Zhang and C.L. Li et al., 2007. A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines. J. Ethnopharmacol., 113: 115-124.
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  56. Wang, G., J. Zhao, J. Liu, Y. Huang, J.J. Zhong and W. Tang, 2007. Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo. Int. Immunopharmacol., 7: 864-870.
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  57. Liu, J., F. Yang, Y. Zhang and J. Li, 2007. Studies on the cell-immunosuppressive mechanism of Oridonin from Isodon serra. Int. Immunopharmacol., 7: 945-954.
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  58. Li, T., J. Liu, X. Zhang and G. Ji, 2007. Antidiabetic activity of lipophilic (−)-epigallocatechin-3-gallate derivative under its role of α-glucosidase inhibition. Biomed. Pharmacotherapy, 61: 91-96.
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  59. Cao, Y., J.W. Liu, Y.J. Yu, P.Y. Zheng, X.D. Zhang, T. Li and M.C. Guo, 2007. Synergistic protective effect of picroside II and NGF on PC12 cells against oxidative stress induced by H2O2. Pharmacol. Rep., 59: 573-579.
    PubMed  |  Direct Link  |  
  60. Zhang, S., G. Ji and J. Liu, 2006. Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin. J. Nutr. Biochem., 17: 485-491.
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  61. Liu, J., X. Zhang, F. Yang, T. Li, D. Wei and Y. Ren, 2006. Antimetastatic effect of a lipophilic ascorbic acid derivative with antioxidation through inhibition of tumor invasion. Cancer Chemotherapy Pharmacol., 57: 584-590.
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  62. Ji, G., L. Wang, S.H. Zhang, J.W. Liu, P.Y. Zheng and T. Liu, 2006. Effect of Chinese medicine Qinggan Huoxuefang on inducing HSC apoptosis in alcoholic liver fibrosis rats. World J. Gastroenterol., 12: 2047-2052.
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  63. Zhang, Y., J. Liu, W. Jia, A. Zhao and T. Li, 2005. Distinct immunosuppressive effect by Isodon serra extracts. Int. Immunopharmacol., 5: 1957-1965.
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  64. Zhang, J., Y. Shen, J. Liu and D. Wei, 2005. Antimetastatic effect of prodigiosin through inhibition of tumor invasion. Biochem. Pharmacol., 69: 407-414.
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  65. Ye, C.L., J.W. Liu, D.Z. Wei, Y.H. Lu and F. Qian, 2005. In vivo antitumor activity by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone in a solid human carcinoma xenograft model. Cancer Chemother. Pharmacol., 56: 70-74.
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  66. Yang, J., D. Wei and J. Liu, 2005. Repressions of MMP-9 expression and NF-κB localization are involved in inhibition of lung carcinoma 95-D cell invasion by (-)-epigallocatechin-3-gallate. Biom. Pharm., 59: 98-103.
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  67. Xin, X., J. Zhong, D. Wei and J. Liu, 2005. Protection effect of 20(S)-ginsenoside Rg2 extracted from cultured Panax notoginseng cells on hydrogen peroxide-induced cytotoxity of human umbilical cord vein endothelial cells in vitro. Process Biochem., 40: 3202-3205.
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  68. Mei, Y., D. Wei and J. Liu, 2005. Modulation effect of tea polyphenol toward N-methyl-N'-nitro-N-nitrosoguanidine-induced precancerous gastric lesion in rats. J. Nutr. Biochem., 16: 172-177.
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  69. Zhao, A.H., Y. Zhang, Z.H. Xu, J.W. Liu and W. Jia, 2004. Immunosuppressive ent-Kaurene Diterpenoids from Isodon serra. Helvetica Chim. Acta, 87: 3160-3166.
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  70. Zhang, Q., D. Wei and J. Liu, 2004. In vivo reversal of doxorubicin resistance by (-)-epigallocatechin gallate in a solid human carcinoma xenograft. Cancer Lett., 208: 179-186.
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  71. Ye, C.L., J.W. Liu, D.Z. Wei, Y.H. Lu and F. Qian, 2004. In vitro anti-tumor activity of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone against six established human cancer cell lines. Pharmacol. Res., 50: 505-510.
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  72. Ren, Y., X. Zhan, D. Wei and J. Liu, 2004. In vitro reversal MDR of human carcinoma cell line by an antisense oligodeoxynucleotide-doxorubicin conjugate. Biomed. Pharm., 58: 520-526.
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  73. Mei, Y., F. Qian, D. Wei and J. Liu, 2004. Reversal of cancer multidrug resistance by green tea polyphenols. J. Pharm. Pharmacol., 56: 1307-1314.
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  74. Fan, S., D. Wei, J. Liu, X. Xin, W. Tong and N. Miwa, 2004. Ascorbic acid-2-o-phosphate-6-o-palmitate protecting the human umbilical cord vein endothelial cells against hydrogen peroxide and tert-butyl hydroperoxide induced cytotoxicity. Biomed. Pharm., 58: 205-211.
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  75. Wei, D., Y. Mei and J. Liu, 2003. Quantification of doxorubicin and validation of reversal effect of tea polyphenols on multidrug resistance in human carcinoma cells. Biotechnol. Lett., 25: 291-294.
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  76. Mei, Y., D. Wei and J. Liu, 2003. Reversal of cancer multidrug resistance by tea polyphenol in KB cells. J. Chemotherapy, 15: 260-265.
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  77. Liu, J.W., D.Z. Wei, C.B. Du and J.J. Zhong, 2003. Enhancement of fibrinolytic activity of bovine aortic endothelial cells by ginsenoside Rb2. Acta Pharmacol. Sin., 24: 102-108.
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  78. Du, C.B., J.W. Liu, W. Su, Y.H. Ren and D.Z. Wei, 2003. The protective effect of ascorbic acid derivative on PC12 cells: Involvement of its ROS scavenging ability. Life Sci., 74: 771-780.
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  79. Liu, J.W., D.Z. Wei, C.B. Du and N. Miwa, 2002. Study on the mechanism of inhibition of tumor cell motility by ascorbic acid derivatives. Shi Yan Sheng Wu Xue Bao, 35: 82-88.
    PubMed  |