Dr. Chin  Kun Wang
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Dr. Chin Kun Wang

Distinguished professor
Chung Shan Medical University, Taiwan


Highest Degree
Ph.D. in Biomedicine from National Taiwan University College of Medicine, Taiwan

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Area of Interest:

Biomedical Sciences
100%
Clinical Medicine
62%
Drug Target
90%
Drug Delivery
75%
Biomedical Genetics
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Yen, C.H., H.F. Chiu, S.Y. Huang, Y.Y. Lu and Y.C. Han et al., 2018. Beneficial effect of Burdock complex on asymptomatic Helicobacter pylori‐infected subjects: A randomized, double‐blind placebo‐controlled clinical trial. Helicobacter, Vol. 23. 10.1111/hel.12469.
    CrossRef  |  Direct Link  |  
  2. Venkatakrishnan, K., H.F. Chiu, J.C. Cheng, Y.H. Chang and Y.Y. Lu et al., 2018. Comparative studies on the hypolipidemic, antioxidant and hepatoprotective activities of catechin-enriched green and oolong tea in a double-blind clinical trial. Food Funct., 9: 1205-1213.
    CrossRef  |  Direct Link  |  
  3. Lu, T.M., H.F. Chiu, Y.Y. Lu, Y.C. Han and Y.C. Shen et al., 2018. Efficacy of fermented goat milk on blood pressure in prehypertensive adults: A randomized, placebo-controlled, clinical trial. J. Food Biochem., Vol. 42. 10.1111/jfbc.12474.
    CrossRef  |  
  4. Lu, M.C., H.F. Chiu, C.P. Lin, Y.C. Shen, K. Venkatakrishnan and C.K. Wang, 2018. Anti-Helicobacter pylori effect of various extracts of Ixeris chinensis on inflammatory markers in human gastric epithelial AGS cells. J. Herbal Med., 11: 60-70.
    CrossRef  |  Direct Link  |  
  5. Chiua, H.F., Y.C. Shen, K. Venkatakrishnanc and C.K. Wang, 2018. Popular functional foods and nutraceuticals with lipid lowering activity and in relation to cardiovascular disease, dyslipidemia and related complications: An overview. J. Food Bioactives, 2: 16-27.
    CrossRef  |  Direct Link  |  
  6. Chiu, H.F., S.C. Hsiao, Y.Y. Lu, Y.C. Han, Y.C. Shen, K. Venkatakrishnan and C.K. Wang, 2018. Efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial. J. Food Drug Anal., 26: 309-317.
  7. Yen, C.H., H.F. Chiu, C. Wu, Y.Y. Lu and Y.C. Han et al., 2017. Beneficial efficacy of various propolis extracts and their digestive products by in vitro simulated gastrointestinal digestion. LWT-Food Sci. Technol., 84: 281-289.
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  8. Wang, Y.R., S.F. Liu, Y.C. Shen, C.L. Chen, C.N. Huang, T.M. Pan and C.K. Wang, 2017. A randomized, double-blind clinical study to determine the effect of ANKASCIN 568 plus on blood glucose regulation. J. Food Drug Anal., 25: 409-416.
    CrossRef  |  Direct Link  |  
  9. Chiu, H.F., Y.J. Chen, Y.Y. Lu, Y.C. Han, Y.C. Shen, K. Venkatakrishnan and C.K. Wang, 2017. Regulatory efficacy of fermented plant extract on the intestinal microflora and lipid profile in mildly hypercholesterolemic individuals. J. Food Drug Anal., 25: 819-927.
    CrossRef  |  Direct Link  |  
  10. Chiu, H.F., Y.C. Huang, Y.Y. Lu, Y.C. Han and Y.C. Shen et al., 2017. Regulatory/modulatory effect of prune essence concentrate on intestinal function and blood lipids. Pharm. Biol., 55: 974-979.
    CrossRef  |  Direct Link  |  
  11. Chiu, H.F., Y. Cheng, Y.Y. Lu, Y.C. Han, Y.C. Shen, K. Venkatakrishnan and C.K. Wang, 2017. Anti‐mutagenicity, hypouricemic and antioxidant activities of alkaloids from vinegar and mei vinegar. J. Food Biochem., Vol. 41. 10.1111/jfbc.12373.
    CrossRef  |  Direct Link  |  
  12. Chiu, H.F., S.R. Huang, Y.Y. Lu, Y.C. Han, Y.C. Shen, K. Venkatakrishnan and C.K. Wang,\ 2017. Antimutagenicity, antibacteria and water holding capacity of chitosan from Luffa aegyptiaca Mill and Cucumis sativus L. J. Food Biochem., Vol. 41. 10.1111/jfbc.12362.
    CrossRef  |  Direct Link  |  
  13. Chiu, H.F., J.Y. Liao, Y.Y. Lu, Y.C. Han and Y.C. Shen et al., 2017. Anti‐proliferative, anti‐inflammatory and pro‐apoptotic effects of Dunaliella salina on human KB oral carcinoma cells. J. Food Biochem., Vol. 41. 10.1111/jfbc.12349.
    CrossRef  |  Direct Link  |  
  14. Chiu, H.F., H.Y. Fu, Y.Y. Lu, Y.C. Han and Y.C. Shen et al., 2017. Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: A randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers. Pharm. Biol., 55: 1041-1046.
    CrossRef  |  Direct Link  |  
  15. Chiu, H.F., C.S. Yang, H.I. Chi, Y.C. Han, Y.C. Shen, K. Venkatakrishnan and C.K. Wang, 2017. Cyclooxygenase-2 expression in oral precancerous and cancerous conditions and its inhibition by caffeic acid phenyl ester-enriched propolis in human oral epidermal carcinoma KB cells. Arch. Biol. Sci., 69: 83-91.
    CrossRef  |  Direct Link  |  
  16. Chiu, H.F., B.K. Chen, Y.Y. Lu, Y.C. Han and Y.C. Shen et al., 2017. Hypocholesterolemic efficacy of royal jelly in healthy mild hypercholesterolemic adults. Pharm. Biol., 55: 497-502.
    CrossRef  |  Direct Link  |  
  17. Chang, H.H., H.F. Chiu, Y.C. Han, I.H. Chen, Y.C. Shen, K. Venkatakrishnan and C.K. Wang, 2017. Photoprotective effects of cranberry juice and its various fractions against blue light-induced impairment in human retinal pigment epithelial cells. Pharm. Biol., 55: 571-580.
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  18. Peng, M.L., H.F. Chiu, H. Chou, H.J. Liao and S.T. Chen et al., 2016. Influence/impact of lutein complex (marigold flower and wolfberry) on visual function with early age-related macular degeneration subjects: A randomized clinical trial. J. Funct. Foods, 24: 122-130.
    CrossRef  |  
  19. Law, Y.Y., H.F. Chiu, H.H. Lee, Y.C. Shen, K. Venkatakrishnan and C.K. Wang, 2016. Consumption of onion juice modulates oxidative stress and attenuates the risk of bone disorders in middle-aged and post-menopausal healthy subjects. Food Funct., 7: 902-912.
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  20. Chiu, H.F., Y.H. Wu, Y.C. Shen, S.J. Wang, K. Venkatakrishnan and C.K. Wang, 2016. Antioxidant and physiological effects of Si-Wu-Tang on skin and liver: A randomized, double-blind, placebo-controlled clinical trial. Chinese Med., 11: 30-39.
    CrossRef  |  
  21. Chiu, H.F., T.Y. Lin, Y.C. Shen, K. Venkatakrishnan and C.K. Wang, 2016. Improvement of green tea polyphenol with milk on skin with respect to antioxidation in healthy adults: A double-blind placebo-controlled randomized crossover clinical trial. Food Funct., 7: 893-901.
    CrossRef  |  
  22. Yen, H.F., C.T. Hsieh, F.R. Chang and C.K. Wang, 2015. In vitro anti-diabetic effect and chemical component analysis of 29 essential oils products. J. Food Drug Anal., 23: 124-129.
    CrossRef  |  Direct Link  |  
  23. Lu, T.M., H.F. Chiu, Y.C. Shen, C.C. Shen, K. Venkatakrishhan and C.K. Wang, 2015. Hypocholesterolemic efficacy of quercetin rich onion juice in healthy mild hypercholesterolemic adults: A pilot study. Plant Foods Hum. Nutr., 70: 395-400.
    CrossRef  |  Direct Link  |  
  24. Huang, H.L., C.T. Liu, M.C. Chou, C.H. Ko and C.K. Wang, 2015. Noni (Morinda citrifolia L.) fruit extracts improve colon microflora and exert anti-inflammatory activities in Caco-2 cells. J. Med. Foods, 18: 663-676.
    CrossRef  |  Direct Link  |  
  25. Chiu, H.F., J.D. Lian, P.C. Chang, C.C. Lan and C.K. Wang, 2015. Study of dietary supplement with compound proteins on the improvement of nutrition of dialysis patients. Pak. J. Nutr., 14: 353-357.
    CrossRef  |  
  26. Chiu, H.F., Y.C. Shen, T.Y. Huang, K. Venkatakrishnan and C.K. Wang, 2015. Cardioprotective efficacy of red wine extract of onion in healthy hypercholesterolemic subjects. Phytother. Res., 30: 380-385.
    CrossRef  |  
  27. Huang, H.L., C.H. Ko, Y.Y. Yan and C.K. Wang, 2014. Antiadhesion and anti-inflammation effects of noni (Morinda citrifolia) fruit extracts on AGS cells during Helicobacter pylori infection. J. Agric. Food Chem., 62: 2374-2383.
    CrossRef  |  Direct Link  |  
  28. Yan, Y.Y., Y.W. Wang, S.L. Chen, S.R. Zhuang and C.K. Wang, 2013. Anti-inflammatory effects of phenolic crude extracts from five fractions of Corchorus Olitorius L. Food Chem., 138: 1008-1014.
    CrossRef  |  
  29. Zhuang, S.R., Y.Y. Yan and C.K. Wang, 2012. Effects of nutritional intervention to improve nutritional status and blood lipids for home-care diabetes patients. Nutr. Sci., 37: 85-92.
  30. Zhuang, S.R., H.F. Chiu, S.L. Chen, J.H. Tsai and M.Y. Lee et al., 2012. Effects of a Chinese medical herbs complex on cellular immunity and toxicity-related conditions of breast cancer patients. Br. J. Nutr., 107: 712-718.
    Direct Link  |  
  31. Yen, H.F., S.Y. Wang, C.C. Wu, W.Y. Lin, T.Y. Wu and C.K. Wang, 2012. Cytotoxicity, anti-platelet aggregation assay and chemical components analysis of thirty-eight kinds of essential oils. J. Food Drug Anal., 20: 478-483.
    CrossRef  |  Direct Link  |  
  32. Jin, S.Y., Y.C. Shen, N.C. Yang, C.C. Li, C.K. Wang, S.L. Chen and C.Y. Chang, 2012. Effects of extracts from green tea and black tea on quality of precooked chicken meat. Nutr. Sci. J., 37: 25-35.
  33. Jin, S.Y., F.J. Tan, K.S. Liu, C.K. Wang, Y.C. Shen and C.Y. Chang, 2012. Implementation of the hazard analysis and critical control point(HACCP) system of an enteral feeding system at a private local hospital in taichung of Taiwan. J. Food Drug Anal., 20: 705-710.
  34. Improvement of liver function in humans using a mixture of Schisandra fruit extract and sesamin, 2012. Improvement of liver function in humans using a mixture of Schisandra fruit extract and sesamin. Phytother. Res., 27: 368-373.
    CrossRef  |  PubMed  |  Direct Link  |  
  35. Tsao, L.Y., S.R. Zhuang, H.F. Chiu and C.K. Wang, 2011. Intervention of extract of ganodermalucidum, codonopsispilosula and angelicaesinensis on the nutritional status and life quality of cancer patients. Taiwan J. Dietetics, 3: 15-24.
  36. Lee, Y.C., J.T. Lin, C.K. Wang, C.H. Chen and D.J. Yang, 2011. Antiproliferative effects of fractions of furostanol and spirostanol glycosides from yam (Dioscorea pseudojaponica yamamoto) and diosgenin on cancer and normal cells and their apoptotic effects for mcf-7 cells. J. Food Biochem., 36: 75-85.
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  37. Ho, M.C. and C.K. Wang, 2011. The effect of betel nut chewing on contour and object masking. Atten. Percept. Psychophys., 73: 2583-2593.
    CrossRef  |  PubMed  |  Direct Link  |  
  38. Chiu, H.F., Y.C. Shen, C.C. Chang and C.K. Wang, 2011. Effect of acid-electrolyzed water on bacteria of upper respiratory tract infections. Nutr. Sci. J., 36: 42-49.
    Direct Link  |  
  39. Shen, Y.C., H.C. Ko, Y.C. Huang, S.L. Chen and C.K. Wang, 2010. Effect of inulin containing fermented milk administration on human intestinal bacterial flora. Nutr. Sci. J., 35: 77-86.
    Direct Link  |  
  40. Ho, M.C. and C.K. Wang, 2010. Can betel nut chewing affect the UFOV size after sleep deprivation. Chin. J. Psychol., 52: 445-456.
    Direct Link  |  
  41. Zhuang, S.R., S.L. Chen, J.H. Tsai, C.C. Huang and T.C. Wu et al., 2009. Effect of citronellol and the Chinese medical herb complex on cellular immunity of cancer patients receiving chemotherapy/radiotherapy. Phytother. Res., 23: 785-790.
    CrossRef  |  PubMed  |  Direct Link  |  
  42. Liu, S.C., J.T. Lin, C.K. Wangc, H.Y. Chen and D.J. Yang, 2009. Antioxidant properties of various solvent extracts from lychee (Litchi chinenesis Sonn.) flowers. Food Chem., 114: 577-581.
    CrossRef  |  Direct Link  |  
  43. Shen, Y.C., S.L. Chen, S.R. Zhuang and C.K. Wang, 2008. Contribution of tomato phenolics to suppression of COX-2 expression in KB Cells. J. Food Sci., 73: C1-C10.
    CrossRef  |  PubMed  |  Direct Link  |  
  44. Wu, M.K., C.Y. Huang, Y.J. Liou, C.K. Wang and S.D. Lee, 2007. Glucose-insulin homeostasis, lipid profiles and GH-IGF-IGFBP axis in clozapine-treated schizophrenic obesity versus non-psychiatric obesity. Int. J. Obesity, 32: 436-442.
    CrossRef  |  
  45. Wu, M.K., C.K. Wang, Y.M. Bai, C.Y. Huang and S.D. Lee, 2007. Outcomes of obese, clozapine-treated inpatients with schizophrenia placed on a six-month diet and physical activity program. Psychiatric Serv., 58: 544-550.
    CrossRef  |  
  46. Wang, C.K., H.Y. Fu and M. Chiang, 2007. Cardiovascular diseases prevention of cranberry vinegar. Nutr. Sci. J., 32: 108-118.
  47. Shen, Y.C., S.L. Chen and C.K. Wang, 2007. Contribution of tomato phenolics to antioxidation and down-regulation of blood lipids. J. Agric. Food Chem., 55: 6475-6481.
    CrossRef  |  PubMed  |  Direct Link  |  
  48. Lee, S.D., W.W. Kou, J.A. Lin, Y.F. Chu and C.K. Wang et al., 2007. Effects of long-term intermittent hypoxia on mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts. Int. J. Cardiol., 116: 348-356.
    CrossRef  |  Direct Link  |  
  49. Cadée, J.A., C.Y. Chang, C.N. Huang, S.L. Chen and C.K. Wang, 2007. Bovine casein hydrolysate (c12 Peptide) reduces blood pressure in prehypertensive subjects. Am. J. Hypertens., 20: 1-5.
    CrossRef  |  PubMed  |  Direct Link  |  
  50. Lu, C.C. and C.K. Wang, 2006. Effect of cranberry juice on oxidation in vitro and human study. Polyphenols Commun., 6: 425-426.
  51. Lee, S.D., C.C. Wu, W.W. Kuo, J.A. Lin and J.M. Hwang et al., 2006. Porphyromonas gingivalis-related cardiac cell apoptosis was majorly co-activated by p38 and extracellular signal-regulated kinase pathways. J. Periodontal Res., 41: 39-46.
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  52. Chao, P.C., C.H. Yen, C.N. Huang and C.K. Wang, 2006. Comparison of short-term MUFA and PUFA-rich diets on blood lipid levels in NG Tube-fed elderly patients. Taiwan Geriatrics Gerontol, 2: 92-103.
    Direct Link  |  
  53. Wang, C.K., S.L. Chen and W.J. Lee, 2004. Inhibition of melanin formation and hyperpigmentation by Piper betle leaf polyphenols. Polyphenols Commun., 4: 827-828.
  54. Shen, Y.C., S.L. Chen and C.K. Wang, 2004. The promotion of tomato phenolics on the stability and biological activities of lycopene. Polyphenols Commun., 4: 431-432.
  55. Lin, C.K., S.L. Chen and C.K. Wang, 2004. Study on the proliferation and cyclooxygenase II activity of carcinoma cells by tomato residue polyphenols. Nutr. Sci. J., 29: 31-37.
    Direct Link  |  
  56. Chen, S.L., C.W. Cheng and C.K. Wang, 2003. Effect of Constituents of betel quid on the formation of 8-OH-dG. Chung Shan Med. J., 14: 25-35.
    Direct Link  |  
  57. Chen, S.L., C.K. Wang and Y.H. Sun, 2002. The characteristics and biological activities of the phenolics of tomato residues. Polyphenols Commun., 2: 181-182.
  58. Wang, C.K., S.L. Chen and M.G. Wu, 2001. Inhibitory effect of betel quid on the volatility of methyl mercaptan. J. Agric. Food Chem., 49: 1979-1983.
    PubMed  |  Direct Link  |  
  59. Chen, S.L., M.L. Yang, S.H. Yang, L.C. Yang and M.H. Chen et al., 2000. Effects of crude phenolic extract of areca nut on cultured human gingival fibroblasts. Chin. Dent. J., 19: 23-34.
  60. Wang, C.K., H.Y. Su and C.K. Lii, 1999. Chemical composition and toxicity of Taiwanese betel quid extract. Food Chem. Toxicol., 37: 135-144.
    PubMed  |  Direct Link  |  
  61. Wang, C.K., W.H. Lee and C.H. Peng, 1997. Contents of phenolics and alkaloids in Areca catechu during maturation. J. Agric. Food Chem., 45: 1185-1188.
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  62. Wang, C.K. and L.S. Hwang, 1997. Effect of betel quid on catecholamine secretion from adrenal chromaffin cells. Proc. Nati. Sci. Counc. Repub. China. B., 21: 129-136.
    PubMed  |  Direct Link  |  
  63. Wang, C.K. and W.H. Lee, 1996. Separation, characteristics, and biological activities of phenolics in areca fruit. J. Agric. Food Chem., 44: 2014-2019.
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  64. Wang, C.K. and M.J. Wu, 1996. The separation of phenolics from Piper betle leaf and the effect on the mutagenicity of arecoline. J. Chin. Agric. Chem. Soc., 34: 638-647.
  65. Wang, C.K. and C.H. Peng, 1996. The mutagenicities of alkaloids and N-nitrosoguvacoline from betel quid. Mutat. Res., 360: 165-171..
    PubMed  |  Direct Link  |  
  66. Wang, C.K.N. and L.S.N. Hwang, 1993. Study on the separation and hydrolysis of alkaloids from betel nut. Food Sci., 20: 514-526.
    Direct Link  |  
  67. Wang, C.K.N. and L.S.N. Hwang, 1993. Separation of safrole from Piper betle flower. J. Chin. Agric. Chem. Soc., 31: 566-569.
    Direct Link  |  
  68. Wang, C.K.N. and L.S.N. Hwang, 1993. Phenolic compounds of betel quid chewing juice. Food Sci., 20: 458-471.
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  69. Wang, C.K.N. and L.S.N. Hwang, 1993. Analysis of the phenolic compounds in betel quid. J. Chin. Agric. Chem. Soc., 31: 623-632.
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  70. Hwang, L.S., C.K. Wang, M.J. Sheu and L.S. Kao, 1992. Phenolic compounds of piper betle flower as flavoring and neuronal activity modulating agents. ACS Symp. Ser., 506: 200-213.
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  71. Yen, G.C., C.K. Wang and P.D. Duh, 1990. Antioxidative activity of maillard reaction products prepared from peanut protein with sugars. J. Chinese Agric. Chem. Soc., 28: 285-295.