Dr. Yusuf  Ozturk

Dr. Yusuf Ozturk

Professor
Anadolu University, Turkey


Highest Degree
Ph.D. in Pharmacology Sciences from Graduate Institute of Health, Turkey

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Area of Interest:

Pharmacology and Toxicology
100%
Pharmaceutical Sciences
62%
Hypericum Perforatum
90%
Neuropharmacology
75%
Cancer Chemotherapy
55%

Selected Publications

  1. Ozturk, Y., O.D. Can and U. Demir-Ozkay, 2018. Role of St.-John's Wort (Hypericum perforatum L.) in the Management of Diabetes and Neurological Disorders. In: Herbs for Diabetes and Neurological Disease Management: Research and Advancements, Kumar, V. and A. Veeranjaneyulu (Eds.). Chapter 1, Apple Academic Press, Waretown, NJ., USA., ISBN-13: 9781771885881, pp: 1-21.

  2. Gencer, H.K., U.A. Cevik, S. Levent, B. Saglik and B. Korkut et al., 2017. New benzimidazole-1,2,4-triazole hybrid compounds: Synthesis, anticandidal activity and cytotoxicity evaluation. Molecules, Vol. 22, No. 4. 10.3390/molecules22040507.
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  3. Dikmen, M., E. Kaya-Tilki, S. Engur and Y. Ozturk, 2017. Neuritogenic activity of epigallocatechin gallate and curcumin combination on rat adrenal pheochromocytoma cells. Fresenius Environ. Bull., 26: 4726-4733.
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  4. Can, O.D., N. Turan, U.D. Ozkay and Y. Ozturk, 2017. Antidepressant-like effect of gallic acid in mice: Dual involvement of serotonergic and catecholaminergic systems. Life Sci., 190: 110-117.
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  5. Mustafa, A.M., F. Maggi, F. Papa, E. Kaya, M. Dikmen and Y. Ozturk, 2016. Isofuranodiene: A neuritogenic compound isolated from wild celery (Smyrnium olusatrum L., Apiaceae). Food Chem., 192: 782-787.
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  6. Kaya-Tilki, E., M. Dikmen and Y. Ozturk, 2016. Effects of DNMT and HDAC inhibitors (RG108 and Trichostatin A) on NGF-induced neurite outgrowth and cellular migration. Int. J. Pharmacol., 12: 351-360.
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  7. Engur, S., M. Dikmen and Y. Ozturk, 2016. Comparison of antiproliferative and apoptotic effects of a novel proteasome inhibitor MLN2238 with bortezomib on K562 chronic myeloid leukemia cells. Immunopharmacol. Immunotoxicol., 38: 87-97.
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  8. Ucel, U.I., O.D. Can, U.D. Ozkay and Y. Ozturk, 2015. Antihyperalgesic and antiallodynic effects of mianserin on diabetic neuropathic pain: A study on mechanism of action. Eur. J. Pharmacol., 756: 92-106.
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  9. Ozkay, U.D., E. Soztutar, O.D. Can, U.I. Ucel, Y. Ozturk and E. Ulupinar, 2015. Effects of long-term agomelatine treatment on the cognitive performance and hippocampal plasticity of adult rats. Behav. Pharmacol., 26: 469-480.
    CrossRef  |  Direct Link  |  

  10. Mustafa, A.M., G. Caprioli, M. Dikmen, E. Kaya and F. Maggi et al., 2015. Evaluation of neuritogenic activity of cultivated, wild and commercial roots of Gentiana lutea L. J. Funct. Foods, 19: 164-173.
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  11. Bektas, N., R. Arslan and Y. Ozturk, 2014. Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy. Life Sci., 95: 9-13.
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  12. Ozkay, U.D., L. Yurttas, Y. Ozkay, U.I. Ucel, O.D. Can and Y. Ozturk, 2013. Synthesis of new 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluation of their antidepressant-like effects. Arch. Pharmacal Res., 36: 802-811.
    CrossRef  |  Direct Link  |  

  13. Ozkay, U.D., O.D. Can, Y. Ozkay and Y. Ozturk, 2012. Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits. Pharmacol. Rep., 64: 834-847.
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  14. Can, O.D., E. Ulupinar, U.D. Ozkay, B. Yegin and Y. Ozturk, 2012. The effect of simvastatin treatment on behavioral parameters, cognitive performance and hippocampal morphology in rats fed a standard or a high-fat diet. Behav. Pharmacol., 23: 582-592.
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  15. Bektas, N. and Y. Ozturk, 2012. Effect of phenolic acids on functions of rat aorta, vas deferens and on metabolic changes in streptozotocin-induced diabetes. Indian J. Pharmacol., 44: 184-188.
    CrossRef  |  PubMed  |  Direct Link  |  

  16. Ozturk, Y. and N. Ozturk, 2011. Interesting linkage between wound healing and hepatoprotective activities. Chemico-Biol. Interact., 190: 191-191.
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  17. Ozden, O, H. Kayir, Y. Ozturk and T. Uzbay, 2011. Agmatine blocks ethanol-induced locomotor hyperactivity in male mice. Eur. J. Pharmacol., 659: 26-29.
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  18. Dikmen, M., Y. Ozturk, G. Sagratini, M. Ricciutelli, S. Vittori and F. Maggi, 2011. Evaluation of the wound healing potentials of two subspecies of Hypericum perforatum on cultured NIH3T3 fibroblasts. Phytotherapy Res., 25: 208-211.
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  19. Dikmen, M., N. Ozturk and Y. Ozturk, 2011. The antioxidant potency of Punica granatum L. fruit peel reduces cell proliferation and induces apoptosis on breast cancer. J. Med. Food, 14: 1638-1646.
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  20. Can, O.D., Y. Ozturk, N. Ozturk, G. Sagratini, M. Ricciutelli, S. Vittori and F. Maggi, 2011. Effects of treatment with St. John`s Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats. Fitoterapia, 82: 576-584.
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  21. Can, O.D., Y. Ozturk and U.D. Ozkay, 2011. Effects of insulin and St. John's Wort treatments on anxiety, locomotory activity, depression and active learning parameters of streptozotocin-diabetic rats. Planta Med., 77: 1970-1976.
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  22. Babanli, A., A. Gunes and Y. Ozturk, 2011. A computer experiment model to investigate the effects of drug dosage in animals, for use in pharmacological education and research. Altern. Lab. Anim., 39: 519-525.
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  23. Arslan, R., Z. Bor, N. Bektas, A.H. Mericli and Y. Ozturk, 2011. Antithrombotic effects of ethanol extract of Crataegus orientalis in the carrageenan-induced mice tail thrombosis model. Thrombosis Res., 127: 210-213.
    CrossRef  |  PubMed  |  Direct Link  |  

  24. Dikmen, M., Z. Canturk, Y. Ozturk and Y. Tunali, 2010. Investigation of the apoptotic effect of curcumin in Human Leukemia HL-60 cells by using flow Cytometry. Cancer Biotherapy Radiopharm., 25: 749-755.
    CrossRef  |  PubMed  |  Direct Link  |  

  25. Can, O.D., U.D. Ozkay, N. Ozturk and Y. Ozturk, 2010. Effects of Hawthorn seed and pulp extracts on the central nervous system. Pharm. Biol., 48: 924-931.
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  26. Arslan, R., N. Bektas and Y. Ozturk, 2010. Antinociceptive activity of methanol extract of fruits of Capparis ovata in mice. J. Ethnopharmacol., 131: 28-32.
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  27. Gunes, A., Y. Ozturk and A. Babanli, 2009. An in vivo database model for pharmacological and physiological dosage for experimental animals. Comput. Biol. Med., 39: 590-594.
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  28. Can, O.D., U.D. Ozkay, Z.A. Kaplancikli and Y. Ozturk, 2009. Effects of some 1,3,5-trisubstitued-2-pyrazoline derivatives on depression and anxiety parameters of mice. Arch. Pharm. Res., 32: 1293-1299.
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  29. Sagratini, G, M. Ricciutelli, S. Vittori, N. Ozturk, Y. Ozturk and F. Maggi, 2008. Phytochemical and antioxidant analysis of eight Hypericum taxa from Central Italy. Fitoterapia, 79: 210-213.
    CrossRef  |  PubMed  |  Direct Link  |  

  30. Ozturk, Y. and N. Ozturk, 2008. Opportunities and threats for biological screening of medicinal plants: Importance for the pharmaceutical industries in developing countries. World Rev. Sci. Technol. Sustainable Dev., 5: 124-139.
    CrossRef  |  Direct Link  |  

  31. Uzbay, I.T., I. Coskun, H. Kayir, N. Ozturk and Y. Ozturk, 2007. Extract of Hypericum perforatum blocks caffeine-induced locomotor activity in mice: A possible role of nitric oxide. Phytotherapy Res., 21: 415-419.
    CrossRef  |  PubMed  |  Direct Link  |  

  32. Ozturk, N., S. Korkmaz-Cetin and Y. Ozturk, 2007. Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts. J. Ethnopharmacol., 111: 33-39.
    CrossRef  |  PubMed  |  Direct Link  |  

  33. Ozturk, Y., S. Aydin, R. Beis and T. Herekman-Demir, 2006. The involvement of endogenous opioid mechanisms in the antinociceptive effects induced by antidepressant drugs, desipramine and trimipramine. Pharmacol. Biochem. Behav., 83: 592-597.
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  34. Ozturk, Y. and S. Aydin, 2006. Effects of streptozotocin-induced diabetes and insulin on calcium responsiveness of the rat vas deferens. Life Sci., 78: 1084-1090.
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  35. Ozturk, N., S. Korkmaz, Y. Ozturk and K.H.C. Baser, 2006. Effects of gentiopicroside, sweroside and swertiamarine, secoiridoids from Gentian (Gentiana lutea ssp. symphyandra), on cultured chicken embryonic fibroblasts. Planta Med., 72: 289-294.
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  36. Coskun, I., I.T. Uzbay, N. Ozturk and Y. Ozturk, 2006. Attenuation of ethanol withdrawal syndrome by extract of Hypericum perforatum in Wistar rats. Fundam. Clin. Pharmacol., 20: 481-488.
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  37. Ozturk, N., K.H.C. Baser, S. Aydin, Y. Ozturk and I. Calis, 2002. Effects of Gentiana lutea ssp. symphyandra on the central nervous system in mice. Phytother. Res., 16: 627-631.
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  38. Ozturk, Y., 2001. Kinin receptors and their antagonists as novel therapeutic agents. Curr. Pharm. Des., 7: 135-161.
    PubMed  |  Direct Link  |  

  39. Korkmaz, S., H. Zeytinoglu, M. Zeytinoglu, S. Aydin, Y. Ozturk and K.H.C. Baser, 2000. Testing wound-healing activity in T15 fibroblast cultures : A morphometric analysis. Altern. Lab. Anim., 28: 41-51.
    Direct Link  |  

  40. Ozturk, Y., S. Aydin, A.T. Ozcelikay, V.M. Altan and N. Yildizoglu-Ari, 1997. Calmodulin content and in vitro contractility of duodenum from streptozotocin-induced diabetic rats: Effects of insulin therapy and calmodulin antagonism. Eur. J. Pharmacol., 321: 59-65.
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  41. Gur, S., N. Ari and Y. Ozturk, 1997. Increased responses to adenosine in isolated left atria from streptozotocin-diabetic rats: Evidence for the involvement of hypothyroidism. J. Cardiovasc. Pharmacol., 29: 174-179.
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  42. Ozturk, Y., V.M. Altan and N. Yildizoglu-Ari, 1996. Effects of experimental diabetes and insulin on smooth muscle functions. Pharmacol. Rev., 48: 69-112.
    PubMed  |  Direct Link  |  

  43. Aydin, S., Y. Ozturk, V.M. Altan, N. Yildizoglu-Ari and A.T. Ozcelikay, 1996. Effect of insulin treatment on smooth muscle calmodulin levels in rats with long-term streptozotocin-diabetes. Mol. Cell. Endocrinol., 116: 67-71.
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  44. Ozturk, Y., S. Aydin, V.M. Altan, N. Yildizoglu-Ari and A.T. Ozcelikay, 1994. Effect of short and long term streptozotocin diabetes on smooth muscle calmodulin levels in the rat. Cell Calcium, 16: 81-86.
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  45. Ozturk, Y., S. Aydin, M. Kosar and K.H.C. Baser, 1994. Endothelium-dependent and independent effects of garlic on rat aorta. J. Ethnopharmacol., 44: 109-116.
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  46. Ozcelikay, A.T., C. Pekiner, N. Ari, Y. Ozturk, A. Ozuari and V.M. Altan, 1994. The effect of vanadyl treatment on vascular responsiveness of streptozotocin-diabetic rats. Diabetologia, 37: 572-578.
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  47. Ozturk, Y., V.M. Altan, N. Yidizoglu-Ari and O. Altınkurt, 1993. Bradykinin receptors in intestinal smooth muscles and their post-receptor events related to calcium. Mediat. Inflamm., 2: 309-315.
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  48. Ozcelikay, A.T., V.M. Altan, N. Yildizoglu-Ari, O. Altinkurt, F. Onur and Y. Ozturk, 1993. Basal and histamine-induced gastric acid secretion in alloxan diabetic rats. Gen. Pharmacol., 24: 121-126.
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  49. Ozturk, Y., V.M. Altan, A.T. Ozcelikay and N. Yildizoglu-Ari, 1992. Beneficial effect of insulin on the decreased gastrointestinal β-adrenergic responses in streptozotocin-diabetic rats: A contributing role of protein biosynthesis. Arch. Int. Pharmacodyn. Ther., 317: 81-92.
    PubMed  |  

  50. Ozturk, Y., V.M. Altan and N. Yildizoglu-Ari, 1992. β-Adrenergic responsiveness of the gastrointestinal tract in diabetic rats. Pharmacol. Toxicol., 71: 250-253.
    CrossRef  |  Direct Link  |  

  51. Ozturk, Y., A.T. Ozcelikay, V.M. Altan and O. Altinkurt, 1991. Linear modeling of the effect of intravenous histamine infusion on rat gastric acid secretion: A biostatistical evaluation by splitting the time-effect curves. Methods Findings Exp. Clin. Pharmacol., 13: 463-469.
    PubMed  |  

  52. Ozturk, Y., O. Altinkurt, N. Yildizoglu-Ari and V.M. Altan, 1990. Evaluation of contraction time and recovery period as a parameter in the calcium antagonistic action on the K+-depolarized rat duodenum. J. Pharm. Pharmacol., 42: 874-877.
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  53. Ozturk, Y., N. Yildizoglu-Ari, A. Ozuari, A.T. Ozcelikay and V.M. Altan, 1990. Decreased β-adrenergic responses of rat small intestine due to non-insulin-dependent diabetes. Diabetes Res. Clin. Pract., 9: 123-127.
    CrossRef  |  Direct Link  |  

  54. Ozcelikay, A.T., O. Altinkurt, Y. Ozturk, N. Yildizoglu-Ari and V.M. Altan, 1990. Biostatistical modeling of the effect of intravenous histamine-infusion on the rat gastric acid secretion. J. Pharmacol. Methods, 24: 241-250.
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  55. Karasu, C., Y. Ozturk, N. Altan, N. Yildizoglu-Ari, C. Ikizler and V.M. Altan, 1990. Thyroid hormones mediated effect of insulin on alloxan diabetic rat atria. Gen. Pharmacol.: Vasc. Syst., 21: 735-740.
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  56. Altinkurt, O. and Y. Ozturk, 1990. Bradykinin receptors in isolated rat duodenum. Peptides, 11: 39-44.
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  57. Altinkurt, O. and Y. Ozturk, 1989. Approaches to the mechanism of relaxing effect of vitamin K3 on smooth muscle. Arch. Int. Pharmacodyn. Ther., 299: 232-240.
    PubMed  |  

  58. Altan, M., N. Yildizoglu and Y. Ozturk, 1987. Decreased gastro-intestinal responses to certain agonists in streptozotocin- and alloxan-diabetic rats in vitro. Pharmacology, 34: 143-148.
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