Dr. Ahmet Ozer Sehirli
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Dr. Ahmet Ozer Sehirli

Associate Professor
Department of Medical Pharmacology, Marmara University, Istanbul, Turkiye

Highest Degree
Ph.D. in Pharmacology from Marmara University, Turkiye

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Biography

I was born in Istanbul on March 26th, 1975. I graduated from Kabataş High School in 1992 and Marmara University Faculty of Pharmacy in 1998. I completed his master's degree in Pharmacology at Marmara University Institute of Health Sciences in 2001 and completed the same field doctor in 2006. In 2007, I became an instructor and in 2008 I became an assistant profess. I am an associated professorfor 2 years. 113 international and 266 national publications published in SCI journals; There are 55 international and 39 national publications presented in various scientific meetings and congresses. There are 6332 citations in these publications. I taught at Marmara University Faculty of Pharmacy, Faculty of Health Sciences (Nursing, Midwifery and Physical Therapy and Rehabilitation Departments), Okan University Faculty of Health Sciences and served in various commissions. Part-time in 2013-2014 and full status from 2014-2015 (in the framework of the current Cultural Agreement between the Turkish Republic of Northern Cyprus and the Republic of Turkey) was assigned to the Near East University Faculty of Dentistry.

Area of Interest:

Pharmacology and Toxicology
100%
Inflammatory Disorders
62%
Pulmonary Toxicology
90%
Oxidative Stress
75%
Drug Toxicity
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
160
Abstracts
0

Selected Publications

  1. Çakmak, G.Y. and A.Ö. Şehirli, 2022. Treatment of behçet’ s disease and current approaches. J. Fac. Pharm. Ankara Univ., 46: 619-650.
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  2. Paksoy, T., G. Ustaoğlu, A.Ö. Şehirli, R.B.K. Ünsal and S. Sayıner et al., 2022. Evaluation of the oxytocin effect in a rat model with experimental periodontitis. Naunyn-Schmiedeberg's Arch. Pharmacol., 395: 1599-1608.
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  3. Küçük, M., U. Aksoy and A.Ö. Şehirli, 2022. Possible protective effects of the Bmal1 gene and melatonin on the prognosis of apical periodontitis. Med. Hypotheses, Vol. 162. 10.1016/j.mehy.2022.110806.
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  4. Koca-Ünsal, R.B., A.Ö. Şehirli, S. Sayıner and U. Aksoy, 2022. Relationship of NLRP3 inflammasome with periodontal, endodontic and related systemic diseases. Mol. Biol. Rep., 49: 11123-11132.
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  5. Haskologlu, I.C., E. Erdag, S. Sayiner, N. Abacioglu and A.O. Sehirli, 2022. Melatonin and REGN-CoV2 combination as a vaccine adjuvant for Omicron variant of SARS-CoV-2. Mol. Biol. Rep., 49: 4061-4068.
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  6. Gültekin, Ç., S. Sayiner, Ş. Çetinel and A.Ö. Şehirli, 2022. Does Ambroxol alleviate kidney ischemia-reperfusion injury in rats? Iran. J. Basic Med. Sci., 25: 1037-1041.
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  7. Gultekin, C., A.O. Sehirli, S. Cetinel and S. Sayiner, 2022. Could ambroxol reduce cytokines in hepatic ischemia-reperfusion injury in rats? Bratislava Med. J., 123: 381-384.
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  8. Gençosman, S., D. Ceylanlı, A.Ö. Şehirli, K. Teralı, F. Bölükbaşı, Ş. Çetinel and S. Sayıner, 2022. Investigation of the possible protective effect of N-acetylcysteine (NAC) against irinotecan (CPT-11)-induced toxicity in rats. Antioxidants, Vol. 11. 10.3390/antiox11112219.
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  9. Fersahoğlu, M.M., E. Özkan, A. Velioğlu-Öğünç, S. Sayıner, F. Ercan, Ö.T.Ç. Kaya and A.Ö. Şehirli, 2022. Impact of pycnogenol on acetaminophen-induced hepatorenal damage. Biointerface Res. Appl. Chem., 12: 8070-8080.
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  10. Chukwunyere, U., M. Mercan, A.O. Sehirli and N. Abacioglu, 2022. Possible cytoprotective mechanisms of oxytocin against 5-fluorouracil-induced gastrointestinal mucositis. Mol. Biol. Rep., 49: 4055-4059.
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  11. Bilginaylar, K., A. Aykac, S. Sayiner, H. Özkayalar and A.Ö. Şehirli, 2022. Evaluation of the antiapoptotic and anti-inflammatory properties of chitosan in methotrexate-induced oral mucositis in rats. Mol. Biol. Rep., 49: 3237-3245.
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  12. Aykaç, A., H. Şah, A. Kükner, S. Sayıner and A.Ö. Şehirli, 2022. Effects of chitosan on cisplatin-induced hepatorenal toxicity in an animal model. Istanbul Med. J., 23: 183-188.
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  13. Şehirli, A.Ö., U. Aksoy, R.B. Koca-Ünsal and S. Sayıner, 2021. Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin. Med. Hypotheses, Vol. 151. 10.1016/j.mehy.2021.110588.
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  14. Şehirli, A.Ö., S. Sayiner, G. Savtekin and A. Velioğlu-Öğünç, 2021. Protective effect of bromelain on corrosive burn in rats. Burns, 47: 1352-1358.
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  15. Yüksel, A., M. Tilki, V.M. Kara, A.Ö. Sehirli and S. Özkara, 2021. Effects of different resuscitation fluids on early lung ischaemia-reperfusion injury and inflammatory response: an experimental study. Kocaeli Med. J., 10: 126-132.
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  16. Serkan, S., V.O. Ayliz and S.A. Ozer, 2021. Bromelain: a potential therapeutic application in SARS-CoV-2 infected patients. Ann. Antivirals Antiretrovirals, 5: 015-018.
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  17. Sehirli, A.Ö., U. Chukwunyere, U. Aksoy, S. Sayiner and N. Abacioglu, 2021. The circadian clock gene bmal1: role in COVID-19 and periodontitis. Chronobiol. Int., 38: 779-784.
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  18. Sehirli, A.O., S. Sayıner, U. Chukwunyere and N. Serakinci, 2021. Role of melatonin in angiotensin and aging. Molecules, Vol. 26. 10.3390/molecules26154666.
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  19. Sehirli, A.O. and S. Sayu0131ner, 2021. Daylight is critical to preserve 5-methoxytryptophol levels in suspected and confirmed COVID-19 patients. Med. Hypotheses, 10.1016/j.mehy.2021.110504.
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  20. Sayıner, S., A.Ö. Şehirli and N. Serakıncı, 2021. Alpha lipoic acid as a potential treatment for COVID-19-A hypothesis. Curr. Top. Nutraceutical Res., 19: 172-175.
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  21. Sayiner, S., M. Altaş, G. Camkerten, A.Ö. Şehirli, N. Paksoy, B.M. Balkan and G.Ş. Soran, 2021. Kidney tissue selenium levels of Toxocara canis infected mice given Nigella sativa. J. Adv. VetBio Sci. Tech., 6: 278-283.
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  22. Mercan, M., A.O. Sehirli, U. Chukwunyere and N. Abacu0131oglu, 2021. Acute kidney injury due to COVID-19 and the circadian rhythm. Med. Hypotheses, 10.1016/j.mehy.2020.110463.
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  23. Kermeoğlu, F., U. Aksoy, A. Sebai, G. Savtekin, H. Özkayalar, S. Sayıner and A.Ö. Şehirli, 2021. Anti-inflammatory effects of melatonin and 5-methoxytryptophol on lipopolysaccharide-induced acute pulpitis in rats. BioMed Res. Int., Vol. 2021. 10.1155/2021/8884041.
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  24. Gunay, E., , E. Ozkan, H.H. Abuoglu and A. Aykac et al., 2021. Protective effect of Nigella sativa oil against indomethacin-related small intestine and gastric mucosal damage in rats. Cyprus J. Med. Sci., 6: 8-12.
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  25. Gul, M., C. Akyuz, O. Sunamak, A. Ogunc and A. Sehirli, 2021. Effects of saint john`s wort extract on intestinal injury and apoptosis. Ann. Med. Res., 28: 1725-1730.
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  26. Chukwunyere, U., A.O. Sehirli and N. Abacioglu, 2021. COVID-19-related arrhythmias and the possible effects of ranolazine. Med. Hypotheses, Vol. 149. 10.1016/j.mehy.2021.110545.
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  27. Aykaç, A., D. Özbeyli, G. Pekol and A.Ö. Şehirli, 2021. Evaluation of the effects of donepezil, memantine and α-lipoic acid combined administration in amnesia rats on impaired cognitive functions in terms of behavioural, apoptotic, cholinergic and glutamatergic systems. Clin. Exp. Health Sci., 11: 733-741.
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  28. Aykac, A. and A.Ö. Sehirli, 2021. The function and expression of ATP-binding cassette transporters proteins in the Alzheimer's disease. Glob. Med. Genet., 8: 149-155.
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  29. Sehirli, A.O., S. Sayiner and N. Serakinci, 2020. Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147). Mol. Biol. Rep., 47: 8229-8233.
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  30. Sayiner, S., U.R. Fidanci, S. Kucukersan, G. Kismali and O. Meral et al., 2020. Vitamin a, calcium, phosphorus and magnesium status of heifers grazing in northern cyprus. Trop. Anim. Health Prod., 52: 1869-1874.
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  31. Ozer, A., 2020. The effect of resveratrol treatment on caveolin-3 expression and Na+/K+ atpase activity in rats with isoproterenol-induced myocardial injury. Northern Clinics Istanbul, 10.14744/nci.2020.97957.
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  32. Aykac, A., A.O. Sehirli and M.Z. Gu00f6ren, 2020. Evaluation of the effect of prazosin treatment on u03b1-2C adrenoceptor and apoptosis protein levels in the predator scent-induced rat model of post-traumatic stress disorder. J. Mol. Neurosci., 70: 1120-1129.
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  33. Ayka, A. and A.O. Sehirli, 2020. The role of the slc transporters protein in the neurodegenerative disorders. Clin. Psychopharmacol. Neurosci., 18: 174-187.
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  34. Sehirli, A.O., U. Aksoy, F. Kermeoglu, A. Kalender, G. Savtekin, H. Ozkayalar and S. Sayiner, 2019. Protective effect of alpha‐lipoic acid against apical periodontitis‐induced cardiac injury in rats. European journal of oral sciences. Eur. J. Oral. Sci., 127: 333-339.
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  35. Guden, D.S. and A.O. Sehirli, 2019. An overview of experimental models on ischemic heart diseases. Clin. Exp. Health Sci., 9: 358-365.
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  36. Aykac, A. and A.O. Sehirli, 2019. The effects of citalopram and low-dose risperidone on memory and anxiety in rats subjected to chronic immobilization stress. Psychiat. Clin. Psychopharmacol., 29: 244-251.
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  37. Atalay, S., B. Soylu, A. Aykaç, A.V. Öğünç and Ş. Çetinel et al., 2019. Protective effects of spironolactone against hepatic ischemia/reperfusion injury in rats. Turk. J. Surg., 35: 285-292.
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  38. Aksoy, U., G. Savtekin, A.O. Sehirli, F. Kermeoglu and A. Kalender et al., 2019. Effects of alpha‐lipoic acid therapy on experimentally induced apical periodontitis: A biochemical, histopathological and micro‐CT analysis. Int. Endodontic J., 52: 1317-1326.
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  39. Sehirli, A.O. and G. Savtekin, 2018. Pharmacologic effect of 5-methoxytryptophol. Cyprus J. Med. Sci., 3: 189-192.
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  40. Savtekin, G., N. Serakinci, C. Erzik, S. Cetinel and A.O. Sehirli, 2018. Effects of Circadian Rhythm Hormones Melatonin and 5-Methoxytryptophol on COXs, Raf-1 and STAT3. Int. J. Pharmacol., 14: 787-795.
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  41. Savtekin, G. and A.O. Sehirli, 2018. Rheumatoid arthritis in temporo-mandibular joint: A review. Niger. J. Clin. Pract., 21: 1243-1246.
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  42. Aykac, A., B. Karanlik and A.O. Sehirli, 2018. Protective effect of silk fibroin in burn injury in rat model. Gene, 641: 287-291.
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  43. Atalay, S., B. Soylu, A. Aykac, A.V. Ogunc and S. Cetinel et al., 2018. Protective effects of St. John's wort in the hepatic ischemia/reperfusion injury in rats. Turk. J. Surg., 34: 198-204.
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  44. Arpag, H., M. Gul, Y. Aydemir, N. Atilla and B. Yigitcan et al., 2018. Protective effects of alpha-lipoic acid on methotrexate-induced oxidative lung injury in rats. J. Invest. Surg., 31: 107-113.
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  45. Akyuz, E.Y., C. Akyuz, G. Kiziltan, A.O. Sehirli and S. Cetinel, 2018. The effects of oral nutritional formula enriched with arginine, omega 3 fatty acids and nucleotides on methotrexate-induced experimental intestinal mucositis. Prog. Nutr., 20: 248-256.
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  46. Akyuz, C., O. Uzun, O. Sunamak, A. Velioglu-Ogunc, S. Cetinel and A.O. Sehirli, 2018. The protective effect of spironolactone and role of the Na+/K+-ATPase pump on intestinal ischemia/reperfusion injury. Marmara Pharm. J., 22: 429-435.
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  47. Akyuz, C., N.F. Yasar, O. Uzun, K.D. Peker and O. Sunamak et al., 2018. Effects of melatonin on colonic anastomosis healing following chemotherapy in rats. Singapore Med. J., 59: 545-549.
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  48. Kiran, D., O.E. Tok, A.O. Sehirli, A.M. Gokce and F. Ercan, 2017. The morphological and biochemical investigation of electromagnetic wave effects on urinary bladder in prenatal rats. Marmara Med. J., 30: 146-154.
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  49. Duran, A., S. Ciloglu, O. Sehirli, A. Yigit and H. Buyukdogan et al., 2017. Apocynin and dimethyl sulfoxide synergistically protect against ischemia-reperfusion injury in a rat hind limb ischemia-reperfusion model. Eur. J. Plast. Surg., 40: 507-512.
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  50. Beceren, A., A.O. Sehirli, G.Z. Omurtag, S. Arbak, P. Turan and G. Sener, 2017. Protective effect of N-Acetyl-L-Cysteine (NAC) on endosulfan-induced liver and kidney toxicity in rats. Int. J. Clin. Exp. Med., 10: 10031-10039.
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  51. Uzun, O., N.F. Yasar, C. Akyuz, K.D. Peker, A.O. Sehirli, S. Cetinel and M. Duman, 2016. Effects of ghrelin on colonic anastomosis following radiotherapy. Int. J. Clin. Exp. Med., 9: 16529-16534.
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  52. Sehirli, A.O., B. Satilmis, S. Tetik, S. Cetinel, B. Yegen, A. Aykac and G. Sener, 2016. Protective effect of betaine against burn-induced pulmonary injury in rats. Ulus Travma Acil Cerr. Derg., 22: 417-422.
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  53. Savtekin, G., M.S. Tuzum, L.O. Uyanik, A. Ayali and A.V. Ogunc et al., 2016. Effects of melatonin and 5-methoxytryptophol on synovial inflammation in the zymosan-induced rheumatoid arthritis in rats. Int. J. Clin. Exp. Med., 9: 7137-7144.
  54. Ozkan, N., A.O. Sehirli, M. Koc and S. Cetinel, 2016. Histomorphological changes of apelin treatment in renal tissue in doxorubicin-induced nephrotic syndrome model. Clin. Exp. Health Sci., 6: 20-27.
  55. Sehirli, A.O., S. Cetinel, N. Ozkan, S. Selman, S. Tetik, M. Yuksel and F.G. Dulger, 2015. St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or p-glycoproteins. J. Physiol. Pharmacol., 66: 203-214.
    PubMed  |  
  56. Rayaman, P., E. Rayaman, A. Cevikbas, R. Demirtunc, A.O. Sehirli, S.G. Alagoz and U.S. Gurer, 2015. Effect of antibiotics on polymorphonuclear leukocyte functions and myeloperoxidase activity, glutathione and malondialdehyde levels in allergic asthma. Polish J. Microbiol., 64: 69-72.
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  57. Kerimoglu, O., S. Sahbaz, O. Sehirli, Z.N. Ozdemır, S. Cetinel, B. Dortunc and G. Sener, 2015. Pharmacodynamıcal evaluatıon of matrıx type transdermal therapeutıc systems contaınıng captopril. Acta Poloniae Pharmaceut., 72: 799-806.
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  58. Kerimoglu, O., S. Sahbaz, A.O. Sehirli, B. Dortunc and G. Sener, 2015. Mechanical evaluation of matrix type transdermal therapeutic systems containing captopril. Marmara Pharmaceut. J., 19: 67-72.
  59. Cakir, T., C. Polat, A. Basturk, M. Gul and A. Aslaner et al., 2015. The effect of alpha lipoic acid on rat kidneys in methotrexate induced oxidative injury. Eur. Rev. Med. Pharmacol. Sci., 19: 2132-2139.
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  60. Cakir, T., A. Basturk, C. Polat, A. Aslaner and H. Durgut et al., 2015. Does alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats? Acta Cirurg. Brasil., 30: 247-252.
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  61. Aslaner, A., T. Cakir, B. Celik, U. Dogan and C. Akyuz et al., 2015. The protective effect of intraperitoneal medical ozone preconditioning and treatment on hepatotoxicity induced by methotrexate. Int. J. Clin. Exp. Med., 8: 13303-13309.
  62. Aslaner, A., T. Cakir, B. Celik, U. Dogan and B. Mayir et al., 2015. Does intraperitoneal medical ozone preconditioning and treatment ameliorate the methotrexate induced nephrotoxicity in rats? Int. J. Clin. Exp. Med., 8: 13811-13817.
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  63. Yalcin, M., O. Yiginer, M. Eroglu, O. Sehirli, U. Berber, F. Ozcelik and G. Sener, 2014. Effect of hyperbaric oxygen treatment in a rat model of abdominal aortic aneurysm. Undersea Hyp. Med. J. Undersea Hyperbaric Med. Society, 41: 9-15.
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  64. Saglam, E., A.O. Sehirli, E.N. Ozdamar, G. Contuk and S. Cetinel et al., 2014. Captopril protects against burn-induced cardiopulmonary injury in rats. Ulus Travma Acil Cerrahi Derg., 20: 151-160.
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  65. Sehirli, A.O., D. Koyun, S. Tetik, D. Ozsavcı and O. Yiginer et al., 2013. Melatonin protects against ischemic heart failure in rats. J. Pineal Res., 55: 138-148.
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  66. Savcun, G.Y., E. Ozkan, E. Dulundu, U. Topaloglu and A.O. Sehirli et al., 2013. Antioxidant and anti-inflammatory effects of curcumin against hepatorenal oxidative injury in an experimental sepsis model in rats. Ulusal Travma Acil Cerr. Dergisi, 19: 507-515.
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  67. Saglam, I.Y., E.N. Ozdamar, E. Demiralay, A.O. Sehirli, G. Sener and E. Saglam, 2013. The effect of captopril on brain apoptosis after burn injury in rats. Turk. Neurosurg., 23: 366-371.
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  68. Tozan-Beceren, A., A.O. Sehirli, E. Eksioglu-Demiralp, G. Sener and G.Z. Omurtag, 2012. Melatonin protects against acrylamide-induced oxidative tissue damage in rats. Marmara Pharmaceut. J., 16: 134-142.
  69. Ozkan, E., C. Akyuz, E. Dulundu, U. Topaloglu, A.O. Sehirli, F. Ercan and G. Sener, 2012. Protective effects of lycopene on cerulein-induced experimental acute pancreatitis in rats. J. Surg. Res., 176: 232-238.
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  70. Avci, G., H. Kadioglu, A.O. Sehirli, S. Bozkurt, O. Guclu, E. Arslan and S.K. Muratli, 2012. Curcumin protects against ischemia/reperfusion injury in rat skeletal muscle. J. Surg. Res., 172: e39-e46.
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  71. Alturfan, A.A., A. Tozan-Beceren, A.O. Sehirli, E. Demiralp, G. Sener and G.Z. Omurtag, 2012. Resveratrol ameliorates oxidative DNA damage and protects against acrylamide-induced oxidative stress in rats. Molecular Biol. Rep., 39: 4589-4596.
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  72. Sehirli, O., B. Unlu, S. Cetinel, S. Tetik, E. Sener and G. Sener, 2011. Etanercept protects remote organ damage in a rat model of thermal injury. Marmara Eczacılık Dergisi. Cilt, 3: 118-124.
  73. Emekli-Alturfan, E., A. Yarat, T. Tunali-Akbay, F. Isik and G. Yenidogan, 2011. Effect of black cumin (Nigella sativa) seed oil on gastric tissue in experimental colitis. Adv. Environ. Biol., 5: 483-490.
  74. Cakir, T., E. Ozkan, E. Dulundu, U. Topaloglu and A.O. Sehirli et al., 2011. Caffeic acid phenethyl ester (CAPE) prevents methotrexate-induced hepatorenal oxidative injury in rats. J. Pharm. Pharmacol., 63: 1566-1571.
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  75. Bulut, N.E., E. Ozkan, O. Ekinci, E. Dulundu and U. Topaloglu et al., 2011. Beneficial effects of alpha lipoic acid on cerulein-induced experimental acute pancreatitis in rats. Turk. J. Trauma Emergency Surg., 17: 383-389.
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  76. Tunali-Akbay, T., O. Sehirli, F. Ercan and G. Sener, 2010. Resveratrol protects against methotrexate-induced hepatic injury in rats. J. Pharm. Pharmaceut. Sci., 13: 303-310.
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  77. Toklu, H.Z., O. Sehirli, M. Ersahin, S. Suleymanoglu and O. Yiginer et al., 2010. Resveratrol improves cardiovascular function and reduces oxidative organ damage in the renal, cardiovascular and cerebral tissues of two‐kidney, one‐clip hypertensive rats. J. Pharmacy Pharmacol., 62: 1784-1793.
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  78. Toklu, H., O. Sehirli, H. Sahin, S. Cetinel, B.C. Yegen and G. Sener, 2010. Resveratrol supplementation protects against chronic nicotine-induced oxidative damage and organ dysfunction in the rat urogenital system. Marmara Eczacılık Dergisi cilt, 14: 53-60.
  79. Sehirli, A.O. and G. Sener, 2010. Protective effect of erdosteine against naphthalene-induced oxidative stress in rats. Marmara Pharmaceut. J., 14: 67-73.
  80. Ozkan, E., S. Yardimci, E. Dulundu, U. Topaloglu and O. Sehirli et al., 2010. Protective potential of montelukast against hepatic ischemia/reperfusion injury in rats. J. Surg. Res., 159: 588-594.
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  81. Ozkan, E., C. Akyuz, A.O. Sehirli, U. Topaloglu, F. Ercan and G. Sener, 2010. Montelukast, a selective cysteinyl leukotriene receptor 1 antagonist, reduces cerulein-induced pancreatic injury in rats. Pancreas, 39: 1041-1046.
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  82. Eksioglu‐Demiralp, E., E.R. Kardas, S. Ozgul, T. Yagci and H. Bilgin et al., 2010. Betulinic acid protects against ischemia/reperfusion‐induced renal damage and inhibits leukocyte apoptosis. Phytother. Res., 24: 325-332.
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  83. Velioglu-Ogunc, A., O. Sehirli, H.Z. Toklu, H. Ozyurt and A. Mayadagli et al., 2009. Resveratrol protects against irradiation-induced hepatic and ileal damage via its anti-oxidative activity. Free Rad. Res., 43: 1060-1071.
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  84. Uzun, M.A., N. Koksal, S. Aktas, Y. Gunerhan, H. Kadioglu, N. Dursun and A.O. Sehirli, 2009. The effect of ursodeoxycholic acid on liver regeneration after partial hepatectomy in rats with non‐alcoholic fatty liver disease. Hepatol. Res., 39: 814-821.
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  85. Uzun, M.A., N. Koksal, H. Kadioglu, Y. Gunerhan, S. Aktas, N. Dursun and A.O. Sehirli, 2009. Effects of N-acetylcysteine on regeneration following partial hepatectomy in rats with nonalcoholic fatty liver disease. Surg. Today, 39: 592-597.
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  86. Toklu, H.Z., O. Sehirli, H. Ozyurt, A.A. Mayadagli and E. Eksioglu-Demiralp et al., 2009. Punica granatum peel extract protects against ionizing radiation-induced enteritis and leukocyte apoptosis in rats. J. Radiat. Res., 50: 345-353.
    PubMed  |  
  87. Tatlidede, E., O. Sehirli, A. Velioglu-Ogunc, S. Cetinel and B.C. Yegen ey al., 2009. Resveratrol treatment protects against doxorubicin-induced cardiotoxicity by alleviating oxidative damage. Free Radic Res., 23: 1-11.
  88. Sehirli, A.O., G. Sener and F. Ercan, 2009. Protective effects of pycnogenol against ischemia reperfusion-induced oxidative renal injury in rats. Renal Failure, 31: 690-697.
    CrossRef  |  
  89. Sehirli, A.O., E. Tatlidede, M. Yuksel, S. Cetinel and C. Erzik et al., 2009. Protective effects of alpha-lipoic acid against oxidative injury in TNBS-induced colitis. Erciyes Med. J., 31: 15-26.
  90. Kara, M., G. Tellioglu, O. Sehirli, M. Yildar and O. Krand et al., 2009. Evaluation of gadolinium pre-treatment with or without splenectomy in the setting of renal ischemia reperfusion injury in rats. Renal Failure, 31: 956-963.
    CrossRef  |  
  91. Ersahin, M., O. Sehirli, H.Z. Toklu, S. Suleymanoglu and E. Emekli-Alturfan et al., 2009. Melatonin improves cardiovascular function and ameliorates renal, cardiac and cerebral damage in rats with renovascular hypertension. J. Pineal Res., 47: 97-106.
    CrossRef  |  Direct Link  |  
  92. Akyuz, C., A.O. Sehirli, U. Topaloglu, A.V. Ogunc, S. Cetinel and G. Sener, 2009. Protective effects of proanthocyanidin on cerulein-induced acute pancreatic inflammation in rats. Gastroenterol. Res., 2: 20-28.
    CrossRef  |  Direct Link  |  
  93. Şehirli, Ö., A. Tozan, G.Z. Omurtag, S. Cetinel, G. Contuk, N. Gedik and G. Şener, 2008. Protective effect of resveratrol against naphthalene-induced oxidative stress in mice. Ecotoxicol. Environ. Saf., 71: 301-308.
    CrossRef  |  Direct Link  |  
  94. Sehirli, O., Y. Ozel, E. Dulundu, U. Topaloglu, F. Ercan and G. Sener, 2008. Grape seed extract treatment reduces hepatic ischemia-reperfusion injury in rats. Phytother. Res., 22: 43-48.
    CrossRef  |  Direct Link  |  
  95. Sehirli, O., E. Tatlidede, M. Yuksel, C. Erzik, S. Cetinel, B.C. Yegen and G. Sener, 2008. Antioxidant effect of alpha-lipoic acid against ethanol-induced gastric mucosal erosion in rats. Pharmacology, 81: 173-180.
    CrossRef  |  Direct Link  |  
  96. Sehirli, O., E. Sener, S. Cetinel, M. Yuksel, N. Gedik and G. Sener, 2008. α‐lipoic acid protects against renal ischaemia-reperfusion injury in rats. Clin. Exp. Pharmacol. Physiol., 35: 249-255.
    CrossRef  |  
  97. Sehirli, O., E. Sener, G. Sener, S. Cetinel, C. Erzik and B.C. Yegen, 2008. Ghrelin improves burn-induced multiple organ injury by depressing neutrophil infiltration and the release of pro-inflammatory cytokines. Peptides, 29: 1231-1240.
    CrossRef  |  
  98. Omurtag, G.Z., A. Tozan, A.O. Sehirli and G. Sener, 2008. Melatonin protects against endosulfan-induced oxidative tissue damage in rats. J. Pineal. Res., 44: 432-438.
    CrossRef  |  PubMed  |  
  99. Tunali‐Akbay, T., G. Sener, H. Salvarli, O. Sehirli and A. Yarat, 2007. Protective effects of Ginkgo biloba extract against mercury (II)‐induced cardiovascular oxidative damage in rats. Phytother. Res., 21: 26-31.
    CrossRef  |  
  100. Tozan, A., O. Sehirli, G.Z. Omurtag, S. Cetinel, N. Gedik and G. Sener, 2007. Ginkgo biloba extract reduces naphthalene‐induced oxidative damage in mice. Phytother. Res., 21: 72-77.
    CrossRef  |  Direct Link  |  
  101. Toklu, H.Z., O. Sehirli, G. Sener, M.U. Dumlu, F. Ercan, N. Gedik and V. Gokmen, 2007. Pomegranate peel extract prevents liver fibrosis in biliary-obstructed rats. J. Pharm. Pharmacol., 59: 1287-1295.
    CrossRef  |  Direct Link  |  
  102. Sener, G., O. Sehirli, H. Toklu, F. Ercan and I. Alican, 2007. Montelukast reduces ischaemia/reperfusion‐induced bladder dysfunction and oxidant damage in the rat. J. Pharm. Pharmacol., 59: 837-842.
    CrossRef  |  Direct Link  |  
  103. Sener, G., O. Sehirli, A. Tozan, A. Velioglu-Ovunc, N. Gedik and G.Z. Omurtag, 2007. Gingko biloba extract protects against mercury (II)-induced oxidative tissue damage in rats. Food Chem. Toxicol., 45: 543-550.
    PubMed  |  
  104. Sener, G., N. Topaloglu, A.O. Sehirli, F. Ercan and N. Gedik, 2007. Resveratrol alleviates bleomycin-induced lung injury in rats. Pulmonary Pharmacol. Therapeut., 20: 642-649.
    CrossRef  |  
  105. Sener, G., H. Aksoy, O. Sehirli, M. Yuksel and C. Aral et al., 2007. Erdosteine prevents colonic inflammation through its antioxidant and free radical scavenging activities. Digestive Dis. Sci., 52: 2122-2132.
    Direct Link  |  
  106. Sener, G., A.O. Sehirli, N. Gedik and G.A. Dulger, 2007. Rosiglitazone a PPAR-γ ligand protects aganist burn-induced oxidative injury of remote organs. Burns, 33: 587-593.
    CrossRef  |  PubMed  |  Direct Link  |  
  107. Sener, G., A.O. Sehirli, H.Z. Toklu, M. Yuksel, F. Ercan and N. Gedik, 2007. Erdosteine treatment attenuates oxidative stress and fibrosis in experimental biliary obstruction. Pediatr. Surg. Int., 23: 233-241.
    Direct Link  |  
  108. Sener, G., A. Sakarcan, O. Sehirli, E. Eksioglu-Demiralp and E. Sener et al., 2007. Chronic renal failure-induced multiple-organ injury in rats is alleviated by the selective CysLT1 receptor antagonist montelukast. Prostag. Lipid Mediat., 83: 257-267.
    CrossRef  |  PubMed  |  
  109. Sehirli, O., A. Sakarcan, A. Velioglu-Ogunc, S. Cetinel, N. Gedik, B.C. Yegen and G. Sener, 2007. Resveratrol improves ifosfamide-induced Fanconi syndrome in rats. Toxicol. Applied Pharmacol., 222: 33-41.
    CrossRef  |  Direct Link  |  
  110. Dulundu, E., Y. Ozel, U. Topaloglu, O. Sehirli, F. Ercan, N. Gedik and G. Sener, 2007. Alpha-lipoic acid protects against hepatic ischemia-reperfusion injury in rats. Pharmacology, 79: 163-170.
    CrossRef  |  
  111. Toklu, H.Z., A.O. Sehirli, A. Velioglu-Ogunc, S. Cetinel and G. Sener, 2006. Acetaminophen-induced toxicity is prevented by β-d-glucan treatment in mice. Eur. J. Pharmacol., 543: 133-140.
    CrossRef  |  
  112. Sener, G.Z., G. Omurtag, O. Sehrirli, A. Tozan, M. Yuksel, F. Ercan and N. Gedik, 2006. Protective effects of Ginkgo biloba against acetaminophen-induced toxicity in mice. Mol. Cell Biochem., 283: 39-45.
    Direct Link  |  
  113. Sener, G., O. Sehirli, A. Velioglu-Ogunc, S. Cetinel, N. Gedik, M. Caner, A. Sakarcan and B.C. Yegen, 2006. Montelukast protects against renal ischemia/reperfusion injury in rats. Pharmacol. Res., 54: 65-71.
    CrossRef  |  
  114. Sener, G., O. Sehirli, A. Velioglu-Ogunc, Ercan, F., G. Erkanli, N. Gedik and B.C. Yegen, 2006. Propylthiouracil (PTU)-induced hypothyroidism alleviates burn-induced multiple organ injury. Burns, 32: 728-736.
    CrossRef  |  
  115. Sener, G., L. Kabasakal, O. Sehirli, F. Ercan and N. Gedik, 2006. 2-Mercaptoethane sulfonate (MESNA) protects against biliary obstruction-induced oxidative damage in rats. Hepatol. Res., 35: 140-146.
    CrossRef  |  Direct Link  |  
  116. Sener, G., H.Z. Toklu, A.O. Sehirli, A. Velioglu-Ogunc, S. Cetinel and N. Gedik, 2006. Protective effects of resveratrol against acetaminophen-induced toxicity in mice. Hepatol. Res., 35: 62-68.
    CrossRef  |  Direct Link  |  
  117. Sener, G., G. Sert, A.O. Sehirli, S. Arbak, N. Gedik and G. Ayanoglu‐Dulger, 2006. Melatonin protects against pressure ulcer‐induced oxidative injury of the skin and remote organs in rats. J. Pineal Res., 40: 280-287.
    CrossRef  |  Direct Link  |  
  118. Sener, G., G. Sert, A.O. Sehirli, S. Arbak, B. Uslu, N. Gedik and G. Ayanoglu-Dulger, 2006. Pressure ulcer-induced oxidative organ injury is ameliorated by β-glucan treatment in rats. Int. Immunopharmacol., 6: 724-732.
    CrossRef  |  Direct Link  |  
  119. Sener, G., Y. Ipci, F. Ercan, N. Gedik and B.C. Yegen, 2005. Aqueous garlic extract alleviates ischaemia‐reperfusion‐induced oxidative hepatic injury in rats. J. Pharm. Pharmacol., 57: 145-150.
    CrossRef  |  Direct Link  |  
  120. Sener, G., O. Sehirli, Y. Ipci, S. Cetinel, E. Cikler, N. Gedik and I. Alican, 2005. Protective effects of taurine against nicotine-induced oxidative damage of rat urinary bladder and kidney. Pharmacology, 74: 37-44.
    CrossRef  |  
  121. Sener, G., O. Sehirli, S. Cetinel, S. Midillioglu, N.Gedik and G. Ayanoglu‐Dulger, 2005. Protective effect of taurine against alendronate‐induced gastric damage in rats. Fundamental Clin. Pharmacol., 19: 93-100.
    CrossRef  |  Direct Link  |  
  122. Sener, G., O. Sehirli, S. Cetinel, F. Ercan, M. Yuksel, N. Gedik and B.C. Yegen, 2005. Amelioration of sepsis-induced hepatic and ileal injury in rats by the leukotriene receptor blocker montelukast. Prostaglandins Leukotrienes Essential Fatty Acids, 73: 453-462.
    CrossRef  |  Direct Link  |  
  123. Sener, G., O. Sehirli, S. Cetinel, B.G. Yegen, N. Gedik and G. Ayanoglu-Dulger, 2005. Protective effects of MESNA (2-mercaptoethane sulphonat) against acetaminophen induced hepatorenal oxidative damage in mice. J. Applied Toxicol., 25: 20-29.
    CrossRef  |  PubMed  |  Direct Link  |  
  124. Sener, G., O. Sehirli, F. Ercan, S. Sirvanci, N. Gedik and A. Kacmaz, 2005. Protective effect of mesna (2-mercaptoethane sulfonate) against hepatic ischemia/reperfusion injury in rats. Surg. Today, 35: 575-580.
    CrossRef  |  PubMed  |  Direct Link  |  
  125. Sener, G., E. Sener, O. Sehirli, A.V. Ogunc, S. Cetinel, N. Gedik and A. Sakarcan, 2005. Ginkgo biloba extract ameliorates ischemia reperfusion-induced renal injury in rats. Pharmacol. Res., 52: 216-222.
    CrossRef  |  Direct Link  |  
  126. Sener, G., A.O. Sehirli, Y. Ipci, S. Cetinel, E. Cikler, N. Gedik and I. Alican, 2005. Taurine treatment protects against chronic nicotine-induced oxidative changes. Fundam. Clin. Pharmacol., 19: 155-164.
    CrossRef  |  
  127. Sener, G., A.O. Sehirli, Y. Ipci, S. Cetinel, E. Cikler and N. Gedik, 2005. Chronic nicotine toxicity is prevented by aqueous garlic extract. Plant Foods Hum. Nutr., 60: 77-86.
    CrossRef  |  Direct Link  |  
  128. Sakarcan, A., O. Sehirli, A. Velioglu-Ovunc, F. Ercan, G. Erkanl, N. Gedik and G. Sener, 2005. Ginkgo biloba extract improves oxidative organ damage in a rat model of thermal trauma. J. Burn Care Res., 26: 515-524.
    CrossRef  |  Direct Link  |  
  129. Omurtag, G.Z., F.D. Guranlioglu, O. Sehirli, S. Arbak, B. Uslu, N. Gedik and G. Sener, 2005. Protective effect of aqueous garlic extract against naphthalene‐induced oxidative stress in mice. J. Pharm. Pharmacol., 57: 623-630.
    CrossRef  |  
  130. Nursal, G., K. Levent, O. Xehirli, E. Feriha S.V. Serap, K. Meral and M. Goksel, 2005. Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats. Life Sci., 76: 2593-2606.
    Direct Link  |  
  131. Kacmaz, A., E.Y. User, A.O. Sehirli, M. Tilki, S. Ozkan and G. Sener, 2005. Protective effect of melatonin against ischemia/reperfusion-induced oxidative remote organ injury in the rat. Surg. Today, 35: 744-750.
    CrossRef  |  PubMed  |  
  132. Kabasakal, L., O. Sehirli, S. Cetinel, E. Cikler, N. Gedik and G. Sener, 2005. Protective effect of aqueous garlic extract against renal ischemia/reperfusion injury in rats. J. Med. Food, 8: 319-326.
    CrossRef  |  Direct Link  |  
  133. Cetiner, M., G. Sener, A.O. Sehirli, E. Eksioglu-Demiralp and F. Ercan et al., 2005. Taurine protects against methotrexate-induced toxicity and inhibits leukocyte death. Toxicol. Applied Pharmacol., 209: 39-50.
    CrossRef  |  
  134. Sener, G., O. Sehirli, G. Erkanli, S. Cetinel, N. Gedik and B. Yegen, 2004. 2-Mercaptoethane sulfonate (MESNA) protects against burn-induced renal injury in rats. Burns, 30: 557-564.
    CrossRef  |  Direct Link  |  
  135. Sener, G., O. Sehirli, B.C. Yegen, S. Cetinel, N. Gedik and A. Sakarcan, 2004. Melatonin attenuates ifosfamide‐induced Fanconi syndrome in rats. J. Pineal Res., 37: 17-25.
    CrossRef  |  
  136. Kabasakal, L., A.O. Sehirli, S. Cetinel, E. Cikler, N. Gedik and G. Sener, 2004. Mesna (2-mercaptoethane sulfonate) prevents ischemia/reperfusion induced renal oxidative damage in rats. Life Sci., 75: 2329-2340.
    CrossRef  |  Direct Link  |  
  137. Sener, G., O. Tosun, A. Kacmaz, S. Arbak, Y. Ersoy and G. Ayanoglu-Dulger, 2003. Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life Sci., 72: 2707-2718.
    CrossRef  |  
  138. Sener, G., H. Satyroglu, A.O. Sehirli and A. Kacmaz, 2003. Protective effect of aqueous garlic extract against oxidative organ damage in a rat model of thermal injury. Life Sci., 73: 81-91.
    CrossRef  |  Direct Link  |  
  139. Sener, G., A.O. Sehirli, K. Paskaloglu, G.A. Dulger and I. Alican, 2003. Melatonin treatment protects against ischemia/reperfusion‐induced functional and biochemical changes in rat urinary bladder. J. Pineal Res., 34: 226-230.
    CrossRef  |  Direct Link  |  
  140. Sener, G., A.O. Sehirli, H. Satiroglu, A. Kacmaz, G. Ayanoglu-Dulger and B.C. Yegen, 2003. Octreotide improves burn-induced intestinal injury in the rat. Peptides, 24: 123-127.
    CrossRef  |  
  141. Sener, G., A.O. Sehirli and G. Ayanoglu-Dulger, 2003. Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice: A comparative study. J. Pineal. Res., 35: 61-68.
    CrossRef  |  PubMed  |  Direct Link  |  
  142. Sener, G., A.O. Sehirli and G. Ayanog lu-Dulger, 2003. Melatonin protects against mercury(II)-induced oxidative tissue damage in rats. Pharmacol. Toxicol., 93: 290-296.
    CrossRef  |  Direct Link  |  
  143. Sehirli, A.O., G. Sener, H. Satiroglu and G. Ayanoglu-Dulger, 2003. Protective effect of N-acetylcysteine on renal ischemia/reperfusion injury in the rat. J. Nephrol., 16: 75-80.
    Direct Link  |  
  144. Jahovic, N., H. Cevik, A.O. Sehirli, B.C. Yegen and G. Sener, 2003. Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats. J. Pineal Res., 34: 282-287.
    CrossRef  |  Direct Link  |  
  145. Cetinel, S., F. Ercan, S. Sirvanci, O. Sehirli, Y. Ersoy, T. San and G. Sener, 2003. The ameliorating effect of melatonin on protamine sulfate induced bladder injury and its relationship to interstitial cystitis. J. Urol., 169: 1564-1568.
    CrossRef  |  Direct Link  |  
  146. Sener, G., K. Paskaloglu, A.O. Sehirli, G.A. Dulger and I. Alican, 2002. The effects of melatonin on ischemia-reperfusion induced changes in rat corpus cavernosum. J. Urol., 167: 2624-2627.
    CrossRef  |  Direct Link  |  
  147. Sener, G., A.O. Sehirli, M. Keyer‐Uysal, S. Arbak, Y. Ersoy and B.C. Yegen, 2002. The protective effect of melatonin on renal ischemia-reperfusion injury in the rat. J. Pineal Res., 32: 120-126.
    CrossRef  |  Direct Link  |  
  148. Sener, G., A.O. Sehirli, H.Z. Altunbas, Y. Ersoy, K. Paskalylu, S. Arbak and G. Ayanoglu-Dulger, 2002. Melatonin protects against gentamicin-induced nephrotoxicity in rats. J. Pineal Res., 32: 231-236.
    CrossRef  |  
  149. Sener, G., A.O. Sehirli, H. Satıroglu, M. Keyer-Uysal and B.C. Yegen, 2002. Melatonin improves oxidative organ damage in a rat model of thermal injury. Burns, 28: 419-425.
    CrossRef  |  Direct Link  |  
  150. Sener, G., A.O. Sehirli, H. Satiroglu, U.M. Keyer and B.C. Yegen, 2002. Melatonin prevents oxidative kidney damage in a rat model of thermal injury. Life Sci., 70: 2977-2985.
    CrossRef  |