Dr. Dilek  Telci
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Dr. Dilek Telci

Professor
Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey


Highest Degree
Ph.D. in Biotechnology from Nottingham Trent University, Nottingham UK

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Area of Interest:

Biomedical Sciences
100%
Biology
62%
Biotechnology
90%
Cell Biology
75%
Molecular Genetics
55%

Research Publications in Numbers

Books
0
Chapters
5
Articles
55
Abstracts
62

Selected Publications

  1. Rencuzogulları, O., P.O. Yerlikaya, A.C. Gürkan, E.D. Arısan and D. Telci, 2019. Palbociclib, a selective CDK4/6 inhibitor, restricts cell survival and epithelial‐mesenchymal transition in Panc‐1 and MiaPaCa‐2 pancreatic cancer cells. J. Cell. Biochem. 10.1002/jcb.29249.
    CrossRef  |  Direct Link  |  
  2. Nezir, A.E., B. Ulukan and D. Telci, 2019. Transglutaminase 2: The maestro of the oncogenic mediators in renal cell carcinoma. Med. Sci., Vol. 7, No. 2. 10.3390/medsci7020024.
    CrossRef  |  Direct Link  |  
  3. Nayman, A.H., H. Siginc, E. Zemheri, F. Yencilek, A. Yildirim and D. Telci, 2019. Dual-ınhibition of mTOR and Bcl-2 enhances the anti-tumor effect of everolimus against renal cell carcinoma ın vitro and ın vivo. J. Cancer, 10: 1466-1478.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Kurt-Celep, İ., E. Celep, S. Akyüz, Y. İnan and T.H. Barak et al., 2019. Hypericum olympicum L. recovers DNA damage and prevents MMP-9 activation induced by UVB in human dermal fibroblasts. J. Ethnopharmacol., Vol. 246. 10.1016/j.jep.2019.112202.
    CrossRef  |  Direct Link  |  
  5. Kara, A., N. Ozturk, G. Esendagli, U.U. Ozkose and S. Gulyuz et al., 2018. Development of novel self-assembled polymeric micelles from partially hydrolysed poly (2-ethyl-2-oxazoline)-co-PEI-b-PCL block copolymer as non-viral vectors for plasmid DNA in vitro transfection. Artif. Cells Nanomed. Biotechnol., 10.1080/21691401.2018.1491478.
    CrossRef  |  Direct Link  |  
  6. Gulyuz, S., U.U. Ozkose, P. Kocak, D. Telci, O. Yilmaz and M.A. Tasdelen, 2018. In-vitro cytotoxic activities of poly(2-ethyl-2-oxazoline)-based amphiphilic block copolymers prepared by CuAAC click chemistry. Express Polym. Lett., 12: 146-158.
  7. Dogan, A., S. Demirci, D. Telci, S. Canikyan, M. Kongur, B. Dede and F. Sahin, 2018. Anticancer activity of Schiff base-Poloxamer P85 combination against kidney cancer. Int. Urol. Nephrol., 50: 247-255.
    CrossRef  |  Direct Link  |  
  8. Bagatur, Y., A.Z.I. Akulke, A. Bihorac, M. Erdem and D. Telci, 2018. Tissue transglutaminase expression is necessary for adhesion, metastatic potential and cancer stemness of renal cell carcinoma. Cell Adhesion Migrat., 12: 138-151.
    CrossRef  |  Direct Link  |  
  9. Demirci, S., A. Dogan, N.B. Turkmen, D. Telci, A.A. Rizvanov and F. Sahin, 2017. Schiff base-Poloxamer P85 combination demonstrates chemotherapeutic effect on prostate cancer cells in vitro. Biomed. Pharmacoth., 86: 492-501.
    CrossRef  |  Direct Link  |  
  10. Demirci, S., A. Dogan, N.B. Turkmen, D. Telci and A.B. Caglayan et al., 2017. Poloxamer P85 increases anticancer activity of Schiff base against prostate cancer in vitro and in vivo. Anti-Cancer Drugs, 28: 869-879.
    CrossRef  |  Direct Link  |  
  11. Balkan, I.A., A.Z.I. Akulke, Y. Bagatur, D. Telci, A.C. Goren, H. Kirmizibekmez and E. Yesilada, 2017. Sambulin A and B, non-glycosidic iridoids from Sambucus ebulus, exert significant in vitro anti-inflammatory activity in LPS-induced RAW 264.7 macrophages via inhibition of MAPKs's phosphorylation. J. Ethnopharmacol., 206: 347-352.
    CrossRef  |  Direct Link  |  
  12. Kocak, P., S. Canikyan, M. Batukan, R. Attar, F. Sahin and D. Telci, 2016. Comparison of enzymatic and nonenzymatic isolation methods for endometrial stem cells. Turk. J. Biol., 40: 1081-1089.
    Direct Link  |  
  13. Dogan, A., S. Demirci, N.B. Turkmen, A.B. Caglayan and S. Aydin et al., 2016. Schiff base‐poloxamer P85 combination prevents prostate cancer progression in C57/Bl6 mice. Prostate, 76: 1454-1463.
    CrossRef  |  Direct Link  |  
  14. Erdem, S., G. Yegen, D. Telci, I. Yildiz and T. Tefik et al., 2015. The increased transglutaminase 2 expression levels during initial tumorigenesis predict increased risk of metastasis and decreased disease-free and cancer-specific survivals in renal cell carcinoma. World J. Urol., 33: 1553-1560.
    CrossRef  |  Direct Link  |  
  15. Demirci, S., A. Dogan, N. Basak, D. Telci and B. Dede et al., 2015. A schiff base derivative for effective treatment of diethylnitrosamine-induced liver cancer in vivo. Anti-Cancer Drugs, 26: 555-564.
    Direct Link  |  
  16. Erdem, M., S. Erdem, O. Sanli, H. Sak, I. Kilicaslan, F. Sahin and D. Telci, 2014. Up-regulation of TGM2 with ITGB1 and SDC4 is important in the development and metastasis of renal cell carcinoma. Urol. Oncol., 32: e13-e25.
    CrossRef  |  Direct Link  |  
  17. Dogan, A., N. Basak , S. Demirci, D. Telci and B. Dede et al., 2014. A novel Schiff base derivative for effective treatment of azoxymethane induced colon cancer. Int. J. Pharm. Sci. Res., 5: 3544-3550.
  18. Aysan, E., O.F. Bayrak, E. Aydemir, D. Telci, F. Sahin, C. Yardimci and M. Muslumanoglu, 2013. Cancer preventive effects of whole cell type ımmunization against mice ehrlich tumors. Asian. Pac. J. Cancer Prev., 14: 3515-3519.
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  19. Aysan, E., F. Sahin, D. Telci, M. Erdem, M. Muslumanoglu, E. Yardimci and H. Bektasoglu, 2013. Mechanism of body weight reducing effect of oral boric acid intake. Int. J. Endocrinol., Vol. 2013. 10.1155/2013/914651.
    CrossRef  |  Direct Link  |  
  20. Tanriverdi, O., D. Telci, M. Aydin, I.D. Ekici, C. Miroglu and K. Sarica, 2012. Hyperoxaluria-induced tubular ischemia: The effects of verapamil and vitamin E on apoptotic changes with an emphasis on renal papilla in rat model. Urol. Res., 40: 17-25.
    CrossRef  |  Direct Link  |  
  21. Sarica, K., H. Aydin, F. Yencilek, D. Telci and B.Yilmaz, 2012. Human umbilical vein endothelial cells accelerate oxalate-induced apoptosis of human renal proximal tubule epithelial cells in co-culture system which is prevented by pyrrolidine dithiocarbamate. Urol. Res., 40: 461-466.
    CrossRef  |  Direct Link  |  
  22. Wang, Z., D. Telci and M. Griffin, 2011. Importance of syndecan-4 and syndecan-2 in osteoblast cell adhesion and survival mediated by a tissue transglutaminase-fibronectin complex. Exp. Cell Res., 317: 367-381.
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  23. Telci, D., A.U. Dogan, E. Ozbek, E.C. Polat and A. Simsek et al., 2011. KLOTHO gene polymorphism of G395A is associated with kidney stones. Am. J. Nephrol., 33: 337-343.
    Direct Link  |  
  24. Aysan, E., F. Sahin, D. Telci, M.E. Yalvac, S.H. Emre, C. Karaca and M. Muslumanoglu, 2011. Body weight reducing effect of oral boric acid intake. Int. J. Med. Sci., 8: 653-658.
    Direct Link  |  
  25. Wang, Z., R.J. Collighan, S.R. Gross, E.H. Danen, G. Orend, D. Telci and M. Griffin, 2010. RGD-independent cell adhesion via a tissue transglutaminase-fibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 and α5β1 integrin co-signalling. J. Biol. Chem., 10.1074/jbc.M110.123703.
    CrossRef  |  Direct Link  |  
  26. Arisan, E.D., O. Kutuk, T. Tezil, C. Bodur, D. Telci and H. Basaga, 2010. Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells. Breast Cancer Res. Treatment, Vol. 119. 10.1007/s10549-009-0343-z.
    CrossRef  |  Direct Link  |  
  27. Telci, D., R.J. Collighan, H. Basaga and M. Griffin, 2009. Increased TG2 expression can result in induction of transforming growth factor beta1, causing increased synthesis and deposition of matrix proteins, which can be regulated by nitric oxide. J. Biol. Chem., 284: 29547-29558.
  28. Telci, D., Z. Wang, X. Li, E.A. Verderio and M.J. Humphries et al., 2008. Fibronectin-TG2 matrix rescues RGD-impaired cell adhesion through Syndecan-4 and 1 Integrin co-signaling. J. Biol. Chem., 283: 20937-20947.
  29. Telci, D. and M. Griffin, 2006. Tissue transglutaminase (TG2)-A wound response enzyme. Front. Biosci., 11: 867-882.
  30. Verderio, E.A., D. Telci, A. Okoye, G. Melino and M. Griffin, 2003. A novel RGD-independent cell adhesion pathway mediated by fibronectin-bound tissue transglutaminase rescues cells from anoikis. J. Biol. Chem., 278: 42604-42614.