Dr. Dilek  Telci
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Dr. Dilek Telci

Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey

Highest Degree
Ph.D. in Biotechnology from Nottingham Trent University, Nottingham UK

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Area of Interest:

Biomedical Sciences
Cell Biology
Molecular Genetics

Research Publications in Numbers


Selected Publications

  1. Rencuzogulları, O., P.O. Yerlikaya, A.C. Gürkan, E.D. Arısan and D. Telci, 2019. Palbociclib, a selective CDK4/6 inhibitor, restricts cell survival and epithelial‐mesenchymal transition in Panc‐1 and MiaPaCa‐2 pancreatic cancer cells. J. Cell. Biochem. 10.1002/jcb.29249.
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  2. Nezir, A.E., B. Ulukan and D. Telci, 2019. Transglutaminase 2: The maestro of the oncogenic mediators in renal cell carcinoma. Med. Sci., Vol. 7, No. 2. 10.3390/medsci7020024.
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  3. Nayman, A.H., H. Siginc, E. Zemheri, F. Yencilek, A. Yildirim and D. Telci, 2019. Dual-ınhibition of mTOR and Bcl-2 enhances the anti-tumor effect of everolimus against renal cell carcinoma ın vitro and ın vivo. J. Cancer, 10: 1466-1478.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Kurt-Celep, İ., E. Celep, S. Akyüz, Y. İnan and T.H. Barak et al., 2019. Hypericum olympicum L. recovers DNA damage and prevents MMP-9 activation induced by UVB in human dermal fibroblasts. J. Ethnopharmacol., Vol. 246. 10.1016/j.jep.2019.112202.
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  5. Kara, A., N. Ozturk, G. Esendagli, U.U. Ozkose and S. Gulyuz et al., 2018. Development of novel self-assembled polymeric micelles from partially hydrolysed poly (2-ethyl-2-oxazoline)-co-PEI-b-PCL block copolymer as non-viral vectors for plasmid DNA in vitro transfection. Artif. Cells Nanomed. Biotechnol., 10.1080/21691401.2018.1491478.
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  6. Gulyuz, S., U.U. Ozkose, P. Kocak, D. Telci, O. Yilmaz and M.A. Tasdelen, 2018. In-vitro cytotoxic activities of poly(2-ethyl-2-oxazoline)-based amphiphilic block copolymers prepared by CuAAC click chemistry. Express Polym. Lett., 12: 146-158.
  7. Dogan, A., S. Demirci, D. Telci, S. Canikyan, M. Kongur, B. Dede and F. Sahin, 2018. Anticancer activity of Schiff base-Poloxamer P85 combination against kidney cancer. Int. Urol. Nephrol., 50: 247-255.
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  8. Bagatur, Y., A.Z.I. Akulke, A. Bihorac, M. Erdem and D. Telci, 2018. Tissue transglutaminase expression is necessary for adhesion, metastatic potential and cancer stemness of renal cell carcinoma. Cell Adhesion Migrat., 12: 138-151.
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  9. Demirci, S., A. Dogan, N.B. Turkmen, D. Telci, A.A. Rizvanov and F. Sahin, 2017. Schiff base-Poloxamer P85 combination demonstrates chemotherapeutic effect on prostate cancer cells in vitro. Biomed. Pharmacoth., 86: 492-501.
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  10. Demirci, S., A. Dogan, N.B. Turkmen, D. Telci and A.B. Caglayan et al., 2017. Poloxamer P85 increases anticancer activity of Schiff base against prostate cancer in vitro and in vivo. Anti-Cancer Drugs, 28: 869-879.
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  11. Balkan, I.A., A.Z.I. Akulke, Y. Bagatur, D. Telci, A.C. Goren, H. Kirmizibekmez and E. Yesilada, 2017. Sambulin A and B, non-glycosidic iridoids from Sambucus ebulus, exert significant in vitro anti-inflammatory activity in LPS-induced RAW 264.7 macrophages via inhibition of MAPKs's phosphorylation. J. Ethnopharmacol., 206: 347-352.
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  12. Kocak, P., S. Canikyan, M. Batukan, R. Attar, F. Sahin and D. Telci, 2016. Comparison of enzymatic and nonenzymatic isolation methods for endometrial stem cells. Turk. J. Biol., 40: 1081-1089.
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  13. Dogan, A., S. Demirci, N.B. Turkmen, A.B. Caglayan and S. Aydin et al., 2016. Schiff base‐poloxamer P85 combination prevents prostate cancer progression in C57/Bl6 mice. Prostate, 76: 1454-1463.
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  14. Erdem, S., G. Yegen, D. Telci, I. Yildiz and T. Tefik et al., 2015. The increased transglutaminase 2 expression levels during initial tumorigenesis predict increased risk of metastasis and decreased disease-free and cancer-specific survivals in renal cell carcinoma. World J. Urol., 33: 1553-1560.
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  15. Demirci, S., A. Dogan, N. Basak, D. Telci and B. Dede et al., 2015. A schiff base derivative for effective treatment of diethylnitrosamine-induced liver cancer in vivo. Anti-Cancer Drugs, 26: 555-564.
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  16. Erdem, M., S. Erdem, O. Sanli, H. Sak, I. Kilicaslan, F. Sahin and D. Telci, 2014. Up-regulation of TGM2 with ITGB1 and SDC4 is important in the development and metastasis of renal cell carcinoma. Urol. Oncol., 32: e13-e25.
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  17. Dogan, A., N. Basak , S. Demirci, D. Telci and B. Dede et al., 2014. A novel Schiff base derivative for effective treatment of azoxymethane induced colon cancer. Int. J. Pharm. Sci. Res., 5: 3544-3550.
  18. Aysan, E., O.F. Bayrak, E. Aydemir, D. Telci, F. Sahin, C. Yardimci and M. Muslumanoglu, 2013. Cancer preventive effects of whole cell type ımmunization against mice ehrlich tumors. Asian. Pac. J. Cancer Prev., 14: 3515-3519.
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  19. Aysan, E., F. Sahin, D. Telci, M. Erdem, M. Muslumanoglu, E. Yardimci and H. Bektasoglu, 2013. Mechanism of body weight reducing effect of oral boric acid intake. Int. J. Endocrinol., Vol. 2013. 10.1155/2013/914651.
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  20. Tanriverdi, O., D. Telci, M. Aydin, I.D. Ekici, C. Miroglu and K. Sarica, 2012. Hyperoxaluria-induced tubular ischemia: The effects of verapamil and vitamin E on apoptotic changes with an emphasis on renal papilla in rat model. Urol. Res., 40: 17-25.
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  21. Sarica, K., H. Aydin, F. Yencilek, D. Telci and B.Yilmaz, 2012. Human umbilical vein endothelial cells accelerate oxalate-induced apoptosis of human renal proximal tubule epithelial cells in co-culture system which is prevented by pyrrolidine dithiocarbamate. Urol. Res., 40: 461-466.
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  22. Wang, Z., D. Telci and M. Griffin, 2011. Importance of syndecan-4 and syndecan-2 in osteoblast cell adhesion and survival mediated by a tissue transglutaminase-fibronectin complex. Exp. Cell Res., 317: 367-381.
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  23. Telci, D., A.U. Dogan, E. Ozbek, E.C. Polat and A. Simsek et al., 2011. KLOTHO gene polymorphism of G395A is associated with kidney stones. Am. J. Nephrol., 33: 337-343.
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  24. Aysan, E., F. Sahin, D. Telci, M.E. Yalvac, S.H. Emre, C. Karaca and M. Muslumanoglu, 2011. Body weight reducing effect of oral boric acid intake. Int. J. Med. Sci., 8: 653-658.
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  25. Wang, Z., R.J. Collighan, S.R. Gross, E.H. Danen, G. Orend, D. Telci and M. Griffin, 2010. RGD-independent cell adhesion via a tissue transglutaminase-fibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 and α5β1 integrin co-signalling. J. Biol. Chem., 10.1074/jbc.M110.123703.
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  26. Arisan, E.D., O. Kutuk, T. Tezil, C. Bodur, D. Telci and H. Basaga, 2010. Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells. Breast Cancer Res. Treatment, Vol. 119. 10.1007/s10549-009-0343-z.
    CrossRef  |  Direct Link  |  
  27. Telci, D., R.J. Collighan, H. Basaga and M. Griffin, 2009. Increased TG2 expression can result in induction of transforming growth factor beta1, causing increased synthesis and deposition of matrix proteins, which can be regulated by nitric oxide. J. Biol. Chem., 284: 29547-29558.
  28. Telci, D., Z. Wang, X. Li, E.A. Verderio and M.J. Humphries et al., 2008. Fibronectin-TG2 matrix rescues RGD-impaired cell adhesion through Syndecan-4 and 1 Integrin co-signaling. J. Biol. Chem., 283: 20937-20947.
  29. Telci, D. and M. Griffin, 2006. Tissue transglutaminase (TG2)-A wound response enzyme. Front. Biosci., 11: 867-882.
  30. Verderio, E.A., D. Telci, A. Okoye, G. Melino and M. Griffin, 2003. A novel RGD-independent cell adhesion pathway mediated by fibronectin-bound tissue transglutaminase rescues cells from anoikis. J. Biol. Chem., 278: 42604-42614.