Dr. Nikhil Baban Ghate

Dr. Nikhil Baban Ghate

Senior Scientist
USC Norris Cancer Center, USA


Highest Degree
Ph.D. in Biochemistry from University of Calcutta, India

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Biography

Mr. Nikhil Baban Ghate is currently working as Senior Research Fellow at Bose Institute, India. He has completed his M.Sc./M.Sc. (Hons.) in Biotechnology from University of Pune, Pune, India. He is dynamic research Biologist/Chemist with exposure in free Radical Imbalance and the Pathological Consequences thereof. His area of research interest focuses on different aspects of Alternative Medicines with special emphasis on Development of Anticancer as well as Anti-Inflammatory Drugs. He has hands-on experience on In-vitro as well as In-vivo techniques, and 3+ years of labā€based training in Cell Biology, Molecular Biology and Biochemistry of Cancer Prognosis and Therapeutics, Esp. Alternative Approaches. He also worked on 3 research projects. He has published 23 research articles in journals and 9 research achievement published in news media contributed as author/co-author. He is also serving as peer reviewer for Pharmaceutical Biology and BMC Biological Research.

Area of Interest:

Pharmacology and Toxicology
100%
Hepatotoxicity
62%
Inflammation
90%
Medicinal Plants
75%
Cell Biology
55%

Selected Publications

  1. Ghate, N.B., D. Chaudhuri, S. Panja, S.S. Singh, G. Gupta, C.Y. Lee and N. Mandal, 2018. In vitro mechanistic study of the anti-inflammatory activity of a quinoline isolated from Spondias pinnata bark. J. Nat. Prod., 81: 1956-1961.
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  2. Basu, T., S. Panja, N.B. Ghate, D. Chaudhuri and N. Mandal, 2017. Antioxidant and antiproliferative effects of different solvent fractions from Terminalia belerica Roxb. fruit on various cancer cells. Cytotechnology, 69: 201-216.
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  3. Panja, S., N.B. Ghate and N. Mandal, 2016. A microalga, Euglena tuba induces apoptosis and suppresses metastasis in human lung and breast carcinoma cells through ROS-mediated regulation of MAPKs. Cancer Cell Int., Vol. 16. 10.1186/s12935-016-0330-5.
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  4. Gupta, G., A. Das, N.B. Ghate, T. Kim and J.Y. Ryu et al., 2016. Novel BODIPY-based Ru(II) and Ir(III) metalla-rectangles: Cellular localization of compounds and their antiproliferative activities. Chem. Commun., 52: 4274-4277.
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  5. Ghate, N.B., A. Das, D. Chaudhuri, S. Panja and N. Mandal, 2016. Sundew plant, a potential source of anti-inflammatory agents, selectively induces G2/M arrest and apoptosis in MCF-7 cells through upregulation of p53 and Bax/Bcl-2 ratio. Cell Death Discov., Vol. 2. 10.1038/cddiscovery.2015.62.
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  6. Chaudhuri, D., N.B. Ghate, S. Panja, T. Basu, A.K. Shendge and N. Mandal, 2016. Glycoside rich fraction from Spondias pinnata bark ameliorate iron overload induced oxidative stress and hepatic damage in Swiss albino mice. BMC Complement. Altern. Med., Vol. 16. 10.1186/s12906-016-1244-4.
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  7. Chaudhuri, D., N.B. Ghate, S. Panja and N. Mandal, 2016. Role of phenolics from Spondias pinnata bark in amelioration of iron overload induced hepatic damage in Swiss albino mice. BMC Pharmacol. Toxicol., Vol. 17. 10.1186/s40360-016-0077-6.
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  8. Hazra, B., R. Sarkar, D. Chaudhuri, N.B. Ghate, S. Panja and N. Mandal, 2015. Attenuation of iron overload induced liver toxicity by Hemidesmus indicus root in Swiss albino mice. Int. J. Pharma. Bio Sci., 6: 354-364.
  9. Ghate, N.B., D. Chaudhuri, A. Das, S. Panja and N. Mandal, 2015. An Antioxidant Extract of the Insectivorous Plant Drosera burmannii Vahl. Alleviates Iron-Induced Oxidative Stress and Hepatic Injury in Mice. PLos One, 10.1371/journal.pone.0128221.
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  10. Ghate, N.B., D. Chaudhuri and N. Mandal, 2015. Nerium indicum leaf alleviates iron- induced oxidative stress and hepatic injury in mice. Pharma. Biol., 53: 1066-1074.
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  11. Das, A., D. Chaudhuri, N.B. Ghate, S. Panja, A. Chatterjee and N. Mandal, 2015. Protective effect of Clerodendrum colebrookianum leaves against iron-induced oxidative stress and hepatotoxicity in Swiss albino mice. Indian J. Exp. Biol., 53: 281-291.
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  12. Chaudhuri, D., N.B. Ghate, S.S. Singh and N. Mandal, 2015. Methyl gallate isolated from Spondias pinnata exhibits anticancer activity against human glioblastoma by induction of apoptosis and sustained extracellular signal-regulated kinase 1/2 activation. Pharmacogn. Mag., 11: 269-276.
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  13. Chaudhuri, D., N.B. Ghate, S. Panja, A. Das and N. Mandal, 2015. Wild edible fruits of Prunus nepalensis Ser. (Steud), a potential source of antioxidants, ameliorate iron-overload induced hepatotoxicity and liver fibrosis in mice. PLos One, 10.1371/journal.pone.0144280.
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  14. Sarkar, R., N.B. Ghate and N. Mandal, 2014. Antioxidant activity of Tinospora cordifolia extract depends on the solvent system. J. Comput. Sci. Syst. Biol., Vol. 7. .
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  15. Panja, S., D. Chaudhuri, N.B. Ghate and N. Mandal, 2014. Phytochemical profile of a microalgae Euglena tuba and its hepatoprotective effect against iron-induced liver damage in Swiss albino mice. J. Appl. Microbiol., 117: 1776-1786.
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  16. Panja, S., D. Chaudhuri, N.B. Ghate and N. Mandal, 2014. In vitro assessment of phytochemicals, antioxidant and DNA protective potential of wild edible fruit Elaeagnus latifolia Linn. Fruits, 69: 303-314.
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  17. Ghate, N.B., D. Chaudhuri, S. Panja, T.B. Mallik, A. Das and N. Mandal, 2014. Antioxidants from Clerodendrum viscosum leaf play a role in anticancer activity against brain cancer. J. Cancer Sci. Ther., Vol. 6. .
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  18. Ghate, N.B., B. Hazra, R. Sarkar, D. Chaudhuri and N. Mandal, 2014. Alteration of Bax/Bcl-2 ratio contributes to Terminalia belerica-induced apoptosis in human lung and breast carcinoma. In vitro Cell. Dev. Biol. Anim., 50: 527-537.
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  19. Ghate, N.B., B. Hazra, R. Sarkar and N. Mandal, 2014. Heartwood Extract of Acacia catechu Induces Apoptosis in Human Breast Carcinoma by Altering Bax/Bcl-2 ratio. Pharmacognosy Magazine, 10: 27-33.
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  20. Ghate, N.B., B. Hazra, R. Sarkar and N. Mandal, 2014. In vitro anticancer activity of Spondias pinnata bark on human lung and breast carcinoma. Cytotechnology, 66: 209-218.
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  21. Das, A., D. Chaudhuri, N.B. Ghate, A. Chatterjee and N. Mandal, 2014. Phytochemical Analysis, Antioxidant and Anticancer Potential of Leaf Extracts from Edible Greater Yam, Dioscorea alata L., from North-East India. Int. J. Phytopharmacol., 5: 109-119.
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  22. Chaudhuri, D., N.B. Ghate, S. Panja, T.B. Mallik and N. Mandal, 2014. HPLC screening of Clerodendrum viscosum leaf extract show possible photochemical responsible for antioxidant and anticancer activities. J. Cancer Sci. Ther., Vol. 6. .
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  23. Chaudhuri, D., N.B. Ghate, S. Deb, S. Panja, R. Sarkar, J. Rout and N. Mandal, 2014. Assessment of the phytochemical constituents and antioxidant activity of a bloom forming algae. Euglena tuba BMC Biol. Res., 10.1186/0717-6287-47-24.
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  24. Hazra, B., R. Sarkar, N.B. Ghate, D. Chaudhuri and N. Mandal, 2013. Study on the protective effects of Katha (Heartwood extract of Acacia catechu) in iron-overload-induced liver damage. J. Environ. Pathol. Toxicol. Oncol., 32: 229-240.
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  25. Ghate, N.B., D. Chaudhuri, R. Sarkar, A.L. Sajem, S. Panja, J. Rout and N. Mandal, 2013. An antioxidant extract of tropical lichen, Parmotrema reticulatum, induces cell cycle arrest and apoptosis in breast carcinoma cell line MCF-7. PLos One, 10.1371/journal.pone.0082293.
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  26. Ghate, N.B., D. Chaudhuri and N. Mandal, 2013. In vitro assessment of Tinospora cordifolia stem for its antioxidant, free radical scavenging and DNA protective potentials. Int. J. Pharma. Bio Sci., 4: 373-388.
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  27. Das, A., D. Chaudhuri, N.B. Ghate, A. Chatterjee and N. Mandal, 2013. Comparative Assessment of Phytochemicals and Antioxidant Potential of Methanolic and Aqueous Extracts of Clerodendrum colebrookianum Walp. leaf from North-East India. Int. J. Pharm. Pharma. Sci., 5: 420-427.
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  28. Chaudhuri, D., N.B. Ghate, R. Sarkar and N. Mandal, 2012. Phytochemical Analysis and Evaluation of Antioxidant and Free Radical Scavenging Activity of Withania Somnifera Root. Asian J. Pharma. Clin. Res., 5: 193-199.
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