Dr. Viswas Raja Solomon

Dr. Viswas Raja Solomon

Research Scientist
University of Saskatchewan


Highest Degree
Ph.D. in Chemistry from Dr. Bhim Rao Ambedkar Open University Agra, India

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Biography

Dr. Raja Solomon Viswas was born in Aruppukottai, India. He received his bachelor’s degree in Pharmacy from the S. B. College of Pharmacy, the Tamilnadu Dr. M. G. R. Medical University, Chennai, India, and master’s degree in Pharmacy with specialization of Medicinal & Pharmaceutical chemistry from the S. G. S. Institute of Technology, the Rajiv Gandhi Technical University, Bhopal, India, under the direction of Prof. S. C. Chaturvedi. He completed his Ph.D. in the field of Medicinal Chemistry at the CSIR-Central Drug Research Institute (CDRI), Lucknow, India, under the guidance of Prof. S. B. Katti and then moved to Advanced Medical Research Institute of Canada/Health Science North, as an Ontario Government of Ministry of Research innovation postdoctoral fellow in the Prof. Hoyun Lee research group. He is presently working as a Research Scientist at the Dept of Medical Imaging at the University of Saskatchewan, Saskatoon with Prof. Humphrey Fonge. His research interests include (i) development of novel immune-SPECT/PET agents for cancer; (ii) development of novel targeted alpha therapy (TAT) agents for colorectal and breast cancer treatment (iii) design, synthesis, and biological evaluation of hybrid molecules for cancer drug discovery; and (iv) development of new synthetic methodologies for application in organic and bifunctional chelators synthesis.

Area of Interest:

Pharmacology and Toxicology
100%
Pharmaceutical Research
62%
Bioorganic and Medicinal Chemistry
90%
Cancer Immunotherapy
75%
In Vivo Molecular Imaging
55%

Selected Publications

  1. Solomon, V.R., V.J. Tallapragada, M. Chebib, G.A.R. Johnston and J.R. Hanrahan, 2019. GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators. Europe. J. Med. Chem., 171: 434-461.
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  2. Solomon, V.R., S. Pundir and H. Lee, 2019. Examination of novel 4-aminoquinoline derivatives designed and synthesized by a hybrid pharmacophore approach to enhance their anticancer activities. Sci. Rep., 10.1038/s41598-019-42816-4.
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  3. Solomon, V.R., E. Alizadeh, W. Bernhard, S.V. Hartimath, W. Hill, R. Chekol, K.M. Barreto, C.R. Geyer and H. Fonge, 2019. 111In- and 225Ac-labeled cixutumumab for imaging and α-particle radiotherapy of IGF-1R positive triple-negative breast cancer. Mol. Pharm., 16: 4807-4816.
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  4. Hartimath, S.V., E. Alizadeh, V.R. Solomon, R. Chekol, W. Bernhard, W. Hill, A.C. Parada, K. Barreto, C.R. Geyer and H. Fonge, 2019. Preclinical evaluation of 111In-Labeled PEGylated maytansine nimotuzumab drug conjugates in EGFR-positive cancer models. J. Nucl. Med., 60: 1103-1110.
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  5. Solomon, V.R., C. Gonzalez, E. Alizadeh, W. Bernhard, S.V. Hartimath, K. Barreto, C.R. Geyer and H. Fonge, 2018. 99mTc(CO)3+ labeled domain I/II-specific anti-EGFR (scFv)2 antibody fragment for imaging EGFR expression. Europe. J. Med. Chem., 157: 437-446.
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  6. Hajdu, I., A. Makhlouf, V.R. Solomon, D. Michel, M. Al-Dulaymi, K.M. Wasan, H. Fonge and I. Badea, 2018. A 89Zr-labeled lipoplex nanosystem for image-guided gene delivery: design, evaluation of stability and in vivo behavior. Int. J. Nanomed., Volume 13: 7801-7818.
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  7. Du, J.J., J.R. Hanrahan, V.R. Solomon, P.A. Williams, P.W. Groundwater, J. Overgaard, J.A. Platts and D.E. Hibbs, 2018. Exploring the binding of barbital to a synthetic macrocyclic receptor. A charge density study. J. Phys. Chem. A., 122: 3031-3044.
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  8. Chekol, R., V.R. Solomon, E. Alizadeh, W. Bernhard, D. Fisher, W. Hill, K. Barreto, J.F. DeCoteau, A.C. Parada, C.R. Geyer and H. Fonge, 2018. 89Zr-nimotuzumab for immunoPET imaging of epidermal growth factor receptor I. Oncotarget., 9: 17117-17132.
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  9. Alagarsamy, V., K. Chitra, G. Saravanan, V.R. Solomon, M.T. Sulthana and B. Narendhar, 2018. An overview of quinazolines: Pharmacological significance and recent developments. Eur. J. Med. Chem., 151: 628-685.
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  10. Solomon, V.R., S. Pundir, H.T. Le and H. Lee, 2017. Design and synthesis of novel quinacrine-[1,3]-thiazinan-4-one hybrids for their anti-breast cancer activity. Europe. J. Med. Chem., 143: 1028-1038.
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  11. Solomon, V.R., D. Almnayan and H. Lee, 2017. Design, synthesis and characterization of novel quinacrine analogs that preferentially kill cancer over non-cancer cells through the down-regulation of Bcl-2 and up-regulation of bax and bad. Europe. J. Med. Chem., 137: 156-166.
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  12. Naffaa, M.M., N. Absalom, V.R. Solomon, M. Chebib, D.E. Hibbs and J.R. Hanrahan, 2016. Investigating the role of loop c hydrophilic residue ‘T244’ in the binding site of ρ1 GABAC receptors via site mutation and partial agonism PLoS ONE 10.1371/journal.pone.0156618.
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  13. Pundir, S., H.Y. Vu, V.R. Solomon, R. McClure and H. Lee, 2015. VR23: a quinoline-sulfonyl hybrid proteasome inhibitor that selectively kills cancer via cyclin e-mediated centrosome amplification. Cancer Res., 75: 4164-4175.
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  14. Itoh, Y., K. Aihara, P. Mellini, T. Tojo, Y. Ota, H. Tsumoto, V.R. Solomon, P. Zhan, M. Suzuki, D. Ogasawara, A. Shigenaga, T. Inokuma, H. Nakagawa, N. Miyata, T. Mizukami, A. Otaka and T. Suzuki, 2015. Identification of SNAIL1 peptide-based irreversible lysine-specific demethylase 1-selective inactivators. J. Med. Chem., 59: 1531-1544.
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  15. Kadri, D., A.K. Crater, H. Lee, V.R. Solomon and S. Ananvoranich, 2014. The potential of quinoline derivatives for the treatment of Toxoplasma gondii infection. Exp. Parasitol., 145: 135-144.
    PubMed  |  
  16. Alagarsamy, V., B. Narendhar, M.T. Sulthana and V.R. Solomon, 2014. Design and synthesis of 3-(4-chlorophenyl)-2-(2-(4-substituted)-2-oxoethylthio) quinazolin-4 (3H)-one as antihistamine agents. Med. Chem. Res., 23: 4692-4699.
    Direct Link  |  
  17. Solomon, V.R., W. Haq, K. Srivastava, S.K. Puri, S.B. Katti, 2012. Design, Synthesis of 4-aminoquinoline derived thiazolidines and their antimalarial activity and heme polymerization inhibition studies. J. Enzyme Inhib. Med. Chem. 10.3109/14756366.2012.666537.
    CrossRef  |  PubMed  |  
  18. Solomon, V.R., W. Haq, K. Srivastava, S.K. Puri and S.B. Katti, 2012. Design and synthesis of 3-[(7-chloro-1-oxidoquinolin-4-ylamino)alkyl]-1,3-thiazolidin-4-ones as antimalarial agents. J. Enzyme Inhib. Med. Chem. .
    PubMed  |  
  19. Solomon, V.R. and H. Lee, 2012. Anti-breast cancer activity of heteroaryl chalcone derivatives. Biomed. Pharmacother., 66: 213-220.
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  20. Senthilraja, M., V. Alagarsamy and V.R. Solomon, 2012. 2,3-disubtituted thiazolidin-4-ones: Novel class of anticonvulsant agents. Lett. Drug Des. Discov., 9: 731-735.
  21. Patel, K., C. Karthikeyan, N.S.H.N. Moorthy, G.S. Deora, V.R. Solomon, H. Lee and P. Trivedi, 2012. Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents. Med. Chem. Res., 21: 1780-1784.
    CrossRef  |  
  22. Gokulan, P.D., B. Jayakar and V. Alagarsamy and V.R. Solomon, 2012. Synthesis and pharmacological investigation of 5-substituted-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid ethyl esters as new analgesic and anti-inflammatory agents. Arzneim.Forsch. .
    PubMed  |  
  23. Alagarsamy, V., B.A. Kumar, P. Parthiban, R.V. Sheorey and V.R. Solomon, 2012. Synthesis and antibacterial activity of some novel 1-(4-oxo-3-(3-methoxyphenyl)-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides. Anti-infective Agents. 10: 105-110.
    Direct Link  |  
  24. Solomon, V.R. and H. Lee, 2011. Quinoline is a privileged scaffold for cancer drug discovery. Curr. Med. Chem., 18: 1488-1508.
  25. Patel, K., C. Karthikeyan, V.R. Solomon, N.S.H.N. Moorthy and H. Lee et al., 2011. Synthesis of some coumarinyl chalcones and their antiproliferative activity against breast cancer cell lines. Lett. Drug Des. Discov., 8: 308-311.
    Direct Link  |  
  26. Alagarsamy, V., V.R. Solomon, P. Parthiban, R. Rajeshwari and G.V. Anjana, 2011. Synthesis and Analgesic, Anti-inflammatory Activities of 3-(3-Methoxyphenyl)-2-Substituted amino-quinazolin-4(3H)-ones. Med. Chem. Res., 20: 946-954.
    CrossRef  |  
  27. Solomon, V.R., W. Haq, M. Smilkstein, K. Srivastava, S.K. Puri and S.B. Katti, 2010. 4-Aminoquinoline derived antimalarials: Synthesis and heme polymerization inhibition studies. Eur. J. Med. Chem., 45: 4990-4996.
    PubMed  |  
  28. Solomon, V.R., C. Hu and H. Lee, 2010. Design and synthesis of chloroquine analogs for their anti-breast cancer property. Eur. J. Med. Chem., 45: 3916-3923.
    PubMed  |  
  29. Solomon, V.R., C. Hu and H. Lee, 2010. Design and synthesis of anti-breast cancer agents from 4-piperazinylquinoline: A hybrid pharmacophore approach. Bioorganic Med. Chem., 18: 1563-1572.
    CrossRef  |  
  30. Solomon, V.R., C. Hu adn H. Lee, 2010. Design and synthesis of CQ analogs for their anti-breast cancer property. Eur. J. Med. Chem., 45: 3916-3923.
    CrossRef  |  
  31. Hu, C., V.R. Solomon, P. Cano and H. Lee, 2010. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur. J. Med. Chem., 45: 705-709.
    CrossRef  |  PubMed  |  
  32. Alagarsamy, V., V.R. Solomon, P. Parthiban, R. Rajeshwari and G.V. Anjana, 2010. Synthesis and analgesic, Anti-inflammatory activities of 3-(3-Methoxyphenyl)-2-Substituted amino-quinazolin-4(3H)-ones. Med. Chem. Res., (In Press) 10.1007/s00044-010-9417-z.
    CrossRef  |  
  33. Solomon, V.R., C. Hu and H. Lee, 2009. Hybrid pharmacophore design and synthesis of isatin-benzothiazole analogs for their anti-breast cancer activity. Bioorg. Med. Chem., 17: 7585-7592.
    CrossRef  |  
  34. Solomon, V.R. and H. Lee, 2009. Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies. Eur. J. Pharm., 625: 220-223.
    CrossRef  |  Direct Link  |  
  35. Desphande, S., Solomon, V.R., S.B. Katti and Y.S. Prabhakar, 2009. Topological descriptors in modelling antimalarial activity: N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine as prototype. J. Enzyme Inhib. Med. Chem., 24: 94-104.
    CrossRef  |  PubMed  |  
  36. Alagarsamy, V., V.R. Solomon, R.V. Sheorey. R. Jayakumar, 2009. Synthesis of 3-(3-Ethylphenyl)-2-substituted amino-3H-quinazolin-4-ones as novel class of Analgesic and Anti-inflammatory agents. Chem. Biol. Drug Des., 73: 471-479.
    CrossRef  |  
  37. Alagarsamy, V., K. Kavitha, M. Rupeshkumar, V.R. Solomon, D.S. kumar, 2009. Synthesis and pharmacological investigation of novel 4-(3-ethylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones as new class of H1-antihistaminic agents. Acta Pharm., 59: 97-106.
    CrossRef  |  
  38. Alagarsamy, V., H.K. Sharma, P. Parthiban, J.C.H. Singh, S.T. Murugan and V.R. Solomon, 2009. 4-(3-Methoxyphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones: New class of H1-Antihistaminic agents veerachamy alagarsamy. Pharmazie, 64: 5-9.
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  39. Alagarsamy, V., D. Shankar, V.R. Solomon. R.V. Sheorey and P. Parthiban, 2009. Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agent. Acta Pharm., 59: 75-88.
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  40. Zhang, H., V.R. Solomon, C. Hu, G. Ulibarri and H. Lee, 2008. Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. Biomed. Pharmacotherapy, 62: 65-69.
    CrossRef  |  PubMed  |  
  41. Solomon, V.R., W. Haq, M. Smilkstein, K. Srivastava, S. Rajakumar, S.K. Puri and S.B. Katti, 2008. Synthesis and antimalarial activity of novel side chain modified antimalarial agents from 4-aminoquinoline. Med. Chem., 4: 446-451.
    CrossRef  |  PubMed  |  
  42. Hu, C., V.R. Solomon, G. Ulibarri and H. Lee, 2008. The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine. Bioorg. Med. Chem., 16: 7888-7893.
    CrossRef  |  PubMed  |  
  43. Alagarsamy, V., V.R. Solomon, R. Sankaranarayanan, P. Periyasamy, R. Deepa and T.D. Anandkumar, 2008. Synthesis of 3-(2-pyridyl)-2-Substituted-quinazolin-4(3H)-ones as new analgesic and Anti-inflammatory agents. Biomed. Pharmacother, 62: 454-461.
    CrossRef  |  PubMed  |  
  44. Alagarsamy, V., V.R. Solomon, M. Murugan, K. Dhanabal, P. Parthiban and G.V. Anjana, 2008. Design and synthesis of 3-(4-Ethylphenyl)-2-substitutedamino-3H-quinazolin-4-ones as novel class of analgesic and Anti-inflammatory agents. J. Enzyme Inhib. Med. Chem., 23: 839-847.
    CrossRef  |  PubMed  |  
  45. Alagarsamy, V., V.R. Solomon and S. Murugesan, 2008. Synthesis and pharmacological evaluation of some 3-(2-Methylphenyl)-2-Substituted amino-quinazolin-4(3H)-ones as analgesic and Anti-inflammatory agents. Arzneimittelforschung-Drug Res., 58: 174-181.
    PubMed  |  
  46. Alagarsamy, V., S. Meena, K.V. Ramseshu, V.R. Solomon and K. Thirumurugan, 2008. Synthesis, analgesic, anti-inflammatory and ulcerogenic index activities of novel 2-methylthio-3-substituted-5,6-dimethyl thieno [2,3-d] pyrimidin-4(3H)-ones. Drug Develop. Res., 69: 226-233.
    CrossRef  |  
  47. Alagarsamy, V., P. Parthiban, V.R. Solomon, K. Dhanabal, S. Murugesan, G. Saravanan and G.V. Anjana, 2008. Synthesis and pharmacological investigation of novel 4-(4-ethyl phenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones as new class of H1-antihistaminic agents. J. Heterocyclic Chem., 45: 709-715.
    CrossRef  |  
  48. Solomon, V.R., W. Haq, S.K. Puri, K. Srivastava and S.B. Katti, 2007. Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives. J. Med. Chem., 50: 394-398.
    CrossRef  |  PubMed  |  
  49. Alagarsamy, V., V.R. Solomon, R. Meena, K.V. Ramaseshu, K. Thirumurugan and S. Murugesan, 2007. Design and synthesis of 2-Methylthio-3-substituted-5,6-dimethylthieno [2,3-d] pyrimidin-4(3H)-ones as analgesic Anti-Inflammatory and antibacterial agents. Med. Chem., 3: 67-73.
    CrossRef  |  PubMed  |  
  50. Alagarsamy, V., V.R. Solomon, G. Deepa, P. Parthiban and G.V. Anjana, 2007. Synthesis and pharmacological investigation of 3-Subsituted-amino-2-methylsulfanyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-ones as analgesic and Anti-Inflammatory agents. Arch. Pharm., 340: 352-358.
    CrossRef  |  PubMed  |  
  51. Alagarsamy, V., V.R. Solomon and M. Murugan, 2007. Synthesis and pharmacological investigation of novel 4-benzyl-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H1-antihistaminic agents. Bioorg. Med. Chem., 15: 4009-4015.
    CrossRef  |  PubMed  |  Direct Link  |  
  52. Alagarsamy, V., V.R. Solomon and K. Dhanabal, 2007. Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-ones as analgesic, anti-inflammatory agents. Bioorg. Med. Chem., 15: 235-241.
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  53. Alagarsamy, V., S. Vijayakumar and V.R. Solomon, 2007. Synthesis of 2-Mercapto-3-substituted-5,6-dimethylthieno[2,3-d] pyrimidin-4(3H)-ones as new analgesic, Anti-inflammatory agents. Biomed. Pharmacotherapy, 61: 285-291.
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  54. Alagarsamy, V., S. Meena, K.V. Ramaseshu, V.R. Solomon, T.D. Kumar and K. Thirumurugan, 2007. Synthesis of novel 3-Butyl-2-Substituted Amino-3H-Quinazolin-4-ones as analgesic and Anti-inflammatory agents. Chem. Biol. Drug Des., 70: 254-260.
    CrossRef  |  PubMed  |  
  55. Alagarsamy, V., S. Meena, K.V. Ramaseshu, V.R. Solomon and T.D. Kumar, 2007. 4-Cyclohexyl-1-substituted-4H-[1,2,4]triazolo [4,3-a] quinazolin-5-ones: Novel Class of H1-antihistaminic agents. Chem. Biol. Drug Des., 70: 158-163.
    CrossRef  |  PubMed  |  
  56. Solomon, V.R., W. Haq, S.K. Puri, K. Srivastava and S.B. Katti, 2006. Design, synthesis and antimalarial activity of a new class of iron chelators. Med. Chem., 2: 1-6.
    CrossRef  |  PubMed  |  
  57. Alagarsamy, V., S. Meena, K.V. Ramseshu, V.R. Solomon, K. Thirumurugan, K. Dhanabal and M. Murugan, 2006. Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-4(3H)-ones. Eur. J. Med. Chem., 41: 1293-1300.
    CrossRef  |  PubMed  |  
  58. Alagarsamy, V., D. Shankar, V.R. Solomon, 2006. Synthesis of some novel 2-Mercapto-3-(substituted amino)-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-ones as analgesic and Anti-inflammatory agents. ARIKVOC, 16: 149-159.
    Direct Link  |  
  59. Solomon, V.R., S.K. Puri, K. Srivastava and S.B. Katti, 2005. Design and synthesis of new antimalarial agents from 4-aminoquinoline. Bioorg. Med. Chem., 13: 2157-2165.
    CrossRef  |  PubMed  |  
  60. Rawal, R.K., V.R. Solomon, Y.S. Prabhakar, S.B. Katti and E. De Clercq, 2005. Synthesis and QSAR studies on thiazolidinones as HIV-RT inhibitors. Combinatorial Chem. High-throughput Screening, 8: 439-443.
    PubMed  |  
  61. Prabhakar, Y.S., R.K. Rawal, M.K. Gupta, V.R. Solomon and S.B. Katti, 2005. Topological descriptors in modeling the HIV-RT inhibitory activityof 2-aryl-3-pyridyl-thiazolidin-4-one. Combinatorial Chem. High-Throughput Screening, 8: 431-437.
    PubMed  |  
  62. Alagarsamy, V., V.R. Solomon, R. Meena and K.V. Ramseshu, 2005. Synthesis, analgesic, Anti-inflammatory and antibacterial activities of some novel 2-Butyl-3-subtituted Quinazolin-4(3H)-ones. Biol. Pharmac. Bull., 28: 1091-1094.
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  63. Solomon, V.R., and S.C. Chaturvedi, 2004. QSAR Studies of diphenylpropionic acids based selective AT1 angiotensin II receptor antagonist as antihypertensive agents. Indian J. Heterocycl. Chem., 13: 373-396.
    Direct Link  |  
  64. Prabakar, Y.S., V.R. Solomon, R.K. Rawal, M.K.Gupta and S.B. Katti, 2004. CP-MLR/PLS directed structure activtity molecular modeling of the HIV-1 RT inhibitory activity of 2,3-Diaryl-1,3-thiazolidin-4-ones. QSAR Comb. Sci., 23: 234-244.
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  65. Alagarsamy, V., U.S. Pathak, V.R. Solomon, S. Meena, K.V. Rameshu and R. Rajesh, 2004. Anticancer, antibacterial and antifungal activites of some 2-substituted (1,3,4) thiadiazolo (2,3-b) tetrahydrobenzo (b) thieno (3,2-e) pyrimidines. Indian J. Heterocycl. Chem., 13: 347-350.
    Direct Link  |  
  66. Solomon, V.R. and S.C. Chaturvedi, 2003. Analysis of a series of new pyrazolidine-3,5-diones as selective AT1 angiotensin Ii receptor antagonists. Indian Pharm., 15: 53-58.
  67. Alagarsamy, V., U.S. Pathak, R. Venketeshperumal, S. Meena, K. Thirumurgan, V.R. Solomon and E. De Clercq, 2003. Anti HIV and antibacterial activites of 2-substituted thiadiazolo quinazolines. Indian J. Pharm. Sci., 65: 293-296.
    Direct Link  |  
  68. Alagarsamy, V., U.S. Pathak, R. Venketeshperumal, S. Meena, K. Thirumurgan, V. Raja Solomon and E. De Clercq, 2003. Anti HIV and antibacterial activites of 2-Subtituted thiadiazolo quinazolines. Indian J. Pharmac. Sci., 65: 293-296.
  69. Solomon, V.R., R.K. Sharma and S.C. Chaturvedi, 2002. Angiotensin antagonist: As antihypertensive agents. Indian Pharm., 1: 6-8.
  70. Alagarsamy, V., V.R. Solomon, G.V. Kavitha, V. Paluchamy and M.R. Chandran et al., 2002. Synthesis, analgesic, Anti-inflammatory and antibacterial activities of some novel 2-Phenyl-3-subtituted Quinazolin-4(3H)-ones. Biol. Pharmac. Bull., 25: 1432-1435.
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