Dr. Lokesh  Upadhyay

Dr. Lokesh Upadhyay

Professor and Director
Sarmila Institute of Medicinal Products and Research Academy, India


Highest Degree
PostDoc Fellow in Biochemistry and Immunology from Banaras Hindu University, India

Share this Profile

Biography

Dr. Lokesh Upadhyay is currently working as Professor & Head, Institute of BioMedical Education & Research, Mangalayatan University, Beswan, Aligarh. He has completed Postdoctoral Fellow in Biochemistry and Immunology from Banaras Hindu University, Varanasi, Uttar Pradesh, India. He is having 30 years research experience and 18 years teaching experience. His area of research interest focuses on Endocrinology, Neuroendocrinology, and Biotechnology. He has published 75 research articles in journals as well as 36 abstracts contributed as author/co-author. He has guided 10 PhD students, and 6 M. Pharm students projects. Dr. Lokesh received honors includes Biography was published in the 15th Edition of Marqus Whos Who in the World, Awarded membership of New York Academy of Sciences, USA, and Awarded Best Paper presentation Award. He also completed 10 research projects. He is member of Society of Biological Chemist, India, Science Congress Association, India, life member of Young Scientist Association, India, Endocrine Society of India, and member of New York Academy of Sciences, USA. He is also serving as technical editor for 8 international journals and reviewer for 10 international & national journals.

Area of Interest:

Biomedical Sciences
100%
Biochemistry
62%
Neuroendocrinology
90%
Endocrinology
75%
Immunology
55%

Education

1995

PostDoc Fellow

Banaras Hindu University, India

Biochemistry and Immunology

1983

M.Sc.

Ram Manohar Lohia Avadh University, India

Zoology, Endocrinology

1981

B.Sc.

Ram Manohar Lohia Avadh University, India

Zoology, Botany, Chemistry

Selected Publications

  1. Thirunavukkarasu, S.V., S. Venkataraman, S. Raja and L. Upadhyay, 2012. Neuroprotective effect of Manasamitra vatakam against aluminium induced cognitive impairment and oxidative damage in the cortex and hippocampus of rat brain. Drug Chem. Toxicol., 35: 104-115.
    CrossRef  |  Direct Link  |  

  2. Thirunavukkaras, S.V., L. Upadhyay and S. Venkataraman, 2012. Effect of manasamitra vatakam, an ayurvedic formulation, on Aluminium-induced neurotoxicity in rats. Trop. J. Pharm. Res., 11: 75-83.

  3. Shabi, M.M. and L. Upadhyay, 2012. Effect of myocardial ischemic reperfusion injury on lysosomal enzymes and electrolytes content of perfusate and cardiac tissue under the influence of Desmodium gangeticum L.: An in-vitro study. Int. J. Pharmacol., 8: 46-52.
    CrossRef  |  Direct Link  |  

  4. Saraswathi, R., L. Upadhyay, C. Vijaya and R. Venkatakrishnan, 2012. Synthesis and biological evaluation of isoniasid derivatives. Int. J. Institut. Pharm. Life Sci., 2: 105-110.

  5. Choudhury, M.K., S. Venkatraman and L. Upadhyay, 2012. Phytochemical analysis and peripheral glucose utilization activity determination of Steblus asper. Asian Pac. J. Trop. Biomed., 2: 656-661.
    CrossRef  |  Direct Link  |  

  6. Thirunavukkarasu, S.V., S. Venkataraman, S. Raja and L. Upadhyay, 2011. Protective effects of Manasamitra vatakam on aluminum-induced nephrotoxicity, oxidative stress and histological damage. Toxicol. Environ. Chem., 93: 1676-1692.
    CrossRef  |  Direct Link  |  

  7. Saraswathi, R., L. Upadhyay, R. Venkatakrishnan, R. Meera and P. Devi, 2011. Phytochemical investigation, analgesic and anti inflammatory activity of Abutilon indicum Linn. Int. J. Pharm. Pharm. Sci., 3: 154-156.
    Direct Link  |  

  8. Saraswathi, R., L. Upadhyay, A.B. Thandapani, R. Venkatakrishnan, R. Meera and P. Devi, 2011. Synthesis and pharmacological screening of N-substituted Amide ester derivatives and other derivatives of naproxen for anti inflammatory activity. Int. J. Drug Formulat. Res., 2: 237-248.

  9. Sararaswathi, R., L. Upadhyay, R. Venkatakrishnan, R. Meera and P. Devi, 2011. Phytochemical investigation and in-vitro cytotoxic studies on leaf extract of Costus ingneus. Int. J. Pharm. Sci., 3: 1011-1016.

  10. Upadhyay, L., 2010. Role of infochemicals in ecofriendly pest control. ENVIS For. Bull., 10: 107-113.

  11. Thirunavukkarasu, S.V., S. Venkataraman and L. Upadhyay, 2010. Effect of aluminium chloride on testicular function under the influence of manasamitra vatakam an indigenous drug formulation. Pharmacology, 1: 236-242.
    Direct Link  |  

  12. Thirunavukarasu, S.V., L. Upadhyay and S.V. Raman, 2010. Ameliorating effect of manasamitra vatakam an ayurvedic herbomineral prepration in AlCL3 indused cognitive dysfunction in rats. Biomedicine, 30: 40-47.

  13. Sararaswathi, R., L. Upadhyay, R. Venkatakrishnan, R. Meera and P. Devi, 2010. Isolation and evaluation of steroid from stem of Costus ingneus. J. Chem. Pharm. Res., 2: 444-448.

  14. Ratnaparakhi, M., G.P. Mohanta and L. Upadayay, 2010. Study of prescription practice for antipsychotic drugs by psychiatrists-a survey. Indian J. Pharm. Pract., 3: 23-27.
    Direct Link  |  

  15. Thirunavukkarasu, S.V., S. Venkataraman, J. Srikanth, K. Murali and L. Upadhyay, 2009. Effect of poly herbal formulation on cognitive deficits in aluminium-treated rats. Pharmacology, 3: 827-831.

  16. Theresal, R.L., L. Upadhyay and A. Thangathirupathy, 2009. Anti-inflammatory and analgesic activity of ethyl acetate extract of Nigella sativa Linn. Int. J. Pharmacol. Biol. Sci., 3: 21-27.

  17. Susan, E.A., M. Mishra and L. Upadhyay, 2009. Heavy metal toxicity and herbal plants. Biomedicine, 29: 305-311.

  18. Sararaswathi, R., L. Upadhyay and R.V. Krishnan, 2009. Phytochemical studies and anti-imicrobial activity of root extract of Sphaeranthus inducus. Int. J. Chem. Sci., 7: 844-850.

  19. Ratnaparkhi, M.P., G.P. Mohanta and L. Upadhyay, 2009. Review on: Fast dissolving ablet. J. Pharm. Res., 2: 5-12.
    Direct Link  |  

  20. Choudhury, M.K., S. Venkatraman and L. Upadhyay, 2009. Analysis of in vitro antioxidant potential of streblus asper leaves water extract. Biomedicine, 29: 259-262.

  21. Agrawal, A., M. Rastogi, R.P. Ojha, C.S. Sahayam, L. Upadhyay, G.V. Rajamanickam and G.P. Dubey, 2009. Obesity associated dementia among elderly-role of a plant based formulation. Indian J. Gerontol., 23: 145-166.

  22. Shabi, M.M. and L. Upadhyay, 2008. Myocardial ischemic reperfusion injury: A review in relation to clinical and pre-clinical studies. Biomedicine, 28: 241-251.

  23. Sararaswathi, R., L. Upadhyay and R.V. Krishnan, 2008. Anti-inflammatory activity of sphaeranthus inducus. Int. J. Chem. Sci., 7: 714-718.

  24. Jithendra, C., L. Upadhyay and T.E.G.K. Murthy, 2008. Protective role of curcumin in maximal electroshock induced seizures, memory impairment and neurotransmitters in rat brain. J. Pre-clin. Clin. Res., 2: 35-39.
    Direct Link  |  

  25. Chimakurthy, J., T.E.G.K. Murthy and L. Upadhyay, 2008. Effect of curcumin on sub-therapeutic doses of AED`S and long term memory in MES induced GTC type of seizures in rats. Res. J. Pharm. Technol., 1: 401-404.
    Direct Link  |  

  26. Chimakurthy, J., T.E.G.K. Murthy and L. Upadhyay, 2008. Effect of curcumin on neuroleptic drug induced catalepsy and memory disturbances. J. Pharm. Res., 1: 153-158.
    Direct Link  |  

  27. Upadhyay, L., A. Mehrotra and K. Tripathi, 2004. Effect of calcurosin (an indigeneous drug) in the management of urolithiasis. The Antiseptic, 101: 353-356.

  28. Upadhyay, L. and K. Tripathi, 2004. Clinical evaluation of the effect of JT-2000 in the management of osteoarthritis: A double blind pacebo cpntrolled trial. Medicine, 11: 31-36.

  29. Upadhyay, L., R. Srivastava, S.D. Dubey and K. Tripathi, 2003. Effect of Nerium indicum, Nerium odorum and Thevetia nerifolia cardiac function of frog heart. The Antiseptic, 100: 407-409.

  30. Upadhyay, L. and K. Tripathi, 2003. Clinical evaluation of herbal compound in the management of diabetes mellitus. The Antiseptic, 100: 67-69.

  31. Tripathi, K., J. Prakash and L. Upadhyay, 2003. Reno Vascular Hypertension. In: Text Book of Nephrology for the Asian Pacific Physicians, Mandal, A. and A. Agrawal (Eds.). Jaypee Brothers, New Delhi, India, pp: 97-110.

  32. Upadhyay, L., S.B. Deshpande and K. Tripathi, 2002. Effect of Mentat on contractile force and electrical activity of rat heart. The Antiseptic, 99: 464-465.
    Direct Link  |  

  33. Upadhyay, L., K. Tripathi and K.S. Kulkarani, 2001. A study of prostane in the treatment of benign prostatic hypertrophy. Phytother. Res., 15: 411-415.
    PubMed  |  

  34. Upadhyay, L., A. Mehrotra, A.K. Srivastava, N.P. Rai and K. Tripathi, 2001. An experimental study of some indigenous drug with special reference to hydraulic permeability. Indian J. Exp. Biol., 39: 1308-1310.
    PubMed  |  

  35. Upadhyay, L. and K. Tripathi, 1999. Effect of Lipan (an indigenous drug) on serum lipid profile in hyperlipidaemic patients. Antiseptic, 96: 177-180.

  36. Tripathi, K. and L. Upadhyay, 1998. Assessment of Carbonic anhydrase activity in blood by alteration in pH. Ind. J. Exp. Biol., 36: 940-942.
    Direct Link  |  

  37. Upadhyay, L. and K. Tripathi, 1997. Effect of bravobol on senile dementia. Indian Practitioner, 50: 1039-1041.

  38. Tripathi, K., M. Rai, P.S. Mishra, J.K. Agrawal and L. Upadhyay, 1997. Plasma renin activity in acute renal failure. Qut. J. Surg. Sci., 33: 21-25.

  39. Tripathi, K. and L. Upadhyay, 1996. Clinical evaluation of dashmool in various neurological disorders. J. Res. Ayurveda Siddha, 17: 85-90.
    Direct Link  |  

  40. Upadhyay, R.R., Usha and L. Upadhyay, 1995. Cirrhosis and dyspepsia caused by sun set yellow and brilliant blue in the liver of Hetropneustes fossilis. J. Ecotoxical. Environ. Monit., 4: 275-277.

  41. Upadhyay, R.R., Usha and L. Upadhyay, 1995. Carcinogenic effect of hair dye in the liver of Hetropneustes fossilis. J. Ecotoxicol. Environ. Moni., 5: 151-153.

  42. Upadhyay, R.R., A.K. Mukherjee, Usha and L. Upadhyay, 1995. Formation of marked basophilia by some synthetic compounds in liver of Heteropneustes fossilis. Ind. J. Exp. Biol., 33: 712-713.

  43. Upadhyay, R.R. and L. Upadhyay, 1995. 7, 12-dimethylbenzanthracene in high doses induces basophilia in the liver of Hetropneustes fossilis. J. Adv. Zool., 16: 125-126.

  44. Upadhyay, R.R. and L. Upadhyay, 1993. Development of marked basophilia in the liver of Heteropneustes fossilis by some selected chemicals. Curr. Sci., 65: 708-710.
    Direct Link  |  

  45. Upadhyay, L., J.K. Agrawal and G.P. Dubey, 1993. Effect of L-thyroxine and carbimazole on blood levels of biogenic amines in rat. Exp. Clin. Endocrinol., 101: 307-310.
    Direct Link  |  

  46. Upadhyay, L. and J.K. Agrawal, 1993. Effect of L-thyroxine and carbimazole on brain biogenic amines and amino acids in rat. Exp. Clin. Endocrinol., 19: 87-99.
    CrossRef  |  Direct Link  |  

  47. Upadhyay, L., J.K. Agrawal, G.P. Dubey and K.N. Udupa, 1992. Biogenic amines and thyrotoxicosis. Acta Endocrinol., 126: 315-318.
    CrossRef  |  Direct Link  |  

  48. Upadhyay, L., J.K. Agrawal and G.P. Dubey, 1992. Effect of iodine on brain content of Biogenic amines and thyroid hormones in rats. Ind. J. Cancer Biol. Res., 6: 9-15.

  49. Singh, R.P., L. Upadhyay and J.K. Agrawal, 1992. Plasma C-AMP and C-AMP, PDE activity in lymphoma patients. Ind. J. Cancer Biol. Res., 6: 5-8.

  50. Chandel, A.S., L. Upadhyay and J.K. Agrawal, 1992. Effect of temperature and pH on spontaneous adherence of sheep erythrocytes to human peripheral blood lymphocytes. Ind. J. Cancer Biol. Res., 6: 29-35.

  51. Upadhyay, L., R.P. Singh, S.R. Pathak, G.P. Dubey, J.K. Agrawal and K.N. Udupa, 1990. Effect of iodine on circulating levels of 5-HT and thyroid hormones in rat. Ind. J. Cancer Biol. Res., 3: 5-8.

  52. Upadhyay, L., A.K. Tiwari, A. Agrawal and G.P. Dubey, 1990. Stress-induced changes in brain level of biogenic amines modified by an indigenous drug. Activitas Nervosa Superior, 32: 128-129.
    Direct Link  |  

  53. Upadhyay, L., A.K. Tiwari, A. Agrawal and G.P. Dubey, 1990. Role of an indigenous drug geriforte on blood levels of biogenic amines and its significance in the treatment of anxiety neurosis. Activitas Nervosa Superior, 32: 1-5.

  54. Singh, R.P., L. Upadhyay, M. Shukla, K.N. Udupa and S.M. Pandey, 1990. Mechanism of the anticonvulsant action of the p-chloro-phenyliminel, 2,4-thiadiazolidin 3p-chlorophenylino-4p-chlorophenyl-5-imino-1,2,4-thia-diazolinine in rat. Ind. J. Cancer Biol. Res., 3: 1-5.

  55. Pathak, S.R., L. Upadhyay, R.H. Singh, G.P. Dubey and K.N. Udupa, 1990. Effect of Terminalia arjuna on autocoidal response and lipid profile of rabbit. Indian Drugs, 27: 221-227.

  56. Upadhyay, L., S.S. Shukla, A. Agrawal and G.P. Dubey, 1989. Changes in brain biogenic amines under influence of an indigenous drug, geriforte, following immobilization stress. Ind. J. Exp. Biol., 26: 911-912.
    Direct Link  |  

  57. Upadhyay, L., U. Agrawal, D.K. Rai, S.S. Shukla and G.P. Dubey, 1988. Circulating levels of histamine and histaminase under the influence of an indigenous drug Abana in chemically induced ischaemic heart disease. Curr. Med. Pract., 32: 115-124.
    Direct Link  |  

  58. Upadhyay, L., J.K. Agrawal, G.P. Dubey, R.C. Gupta and K.N. Udupa, 1988. Effect of iodine on circulating levels of histamine, histaminase and thyroid hormones in rat. Ind. J. Cancer Biol. Res., 1: 56-59.

  59. Shukla, S.S., L. Upadhyay, A. Agrawal and G.P. Dubey, 1986. Evaluation of microcirculation of the heart following oral administration of an indigenous drug ABANA (an experimental study). Probe, 26: 7-11.
    Direct Link  |  

  60. Agrawal, A., L. Upadhyay and G.P. Dubey, 1986. Role of herbomineral compound ABANA in the prevention of coronary heart disease. Probe, 26: 19-24.