Dr. Sanghapal D. Sawant
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Dr. Sanghapal D. Sawant

Senior Scientist
CSIR-Indian Institute of Integrative Medicine, India


Highest Degree
Ph.D. in Organic Synthesis and Medicinal Chemistry from CSIR-Indian Institute of Integrative Medicines, Jammu, India

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Area of Interest:

Biomedical Sciences
100%
Drug Discovery
62%
Bioactive Compounds
90%
Medicinal Chemistry
75%
Pharmaceutics
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
29
Abstracts
0

Selected Publications

  1. Saneja, A., D. Nayak, M. Srinivas, A. Kumar and V. Khare et al., 2017. Development and mechanistic insight into enhanced cytotoxic potential of hyaluronic acid conjugated nanoparticles in CD44 overexpressing cancer cells. Eur. J. Pharmaceut. Sci., 97: 79-91.
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  2. Venkateswarlu, V., S. Balgotra, K.A. Kumar, R.A. Vishwakarma and S.D. Sawant, 2015. Metal-free chemoselective ortho-C (sp2)-F bond hydroxylation and N-trifluoroacylation of fluoroarylamines for domino synthesis of 2-(N-Trifluoroacyl) aminophenols. Synlett, 26: 1258-1262.
  3. Venkateswarlu, V., K.A. Kumar, S. Gupta, D. Singh, R.A. Vishwakarma and S.D. Sawant, 2015. DMSO/I2 mediated C-C bond cleavage of α-ketoaldehydes followed by C-O bond formation: A metal-free approach for one-pot esterification. Org. Biomol. Chem., 13: 7973-7978.
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  4. Venkateswarlu, V., A.S. Pathania, K.A. Kumar, P. Mahajan and A. Nargotra et al., 2015. 4-(N-Phenyl-N'-substituted benzenesulfonyl)-6-(4-hydroxyphenyl) quinolines as inhibitors of mammalian target of rapamycin. Bioorg. Med. Chem., 23: 4237-4247.
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  5. Sawant, S.D., G.L. Reddy, M.I. Dar, M. Srinivas and G. Gupta et al., 2015. Discovery of novel pyrazolopyrimidinone analogs as potent inhibitors of phosphodiesterase type-5. Bioorg. Med. Chem., 23: 2121-2128.
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  6. Raghupathy, R., A.A. Anilkumar, A. Polley, P.P. Singh and M. Yadav et al., 2015. Transbilayer lipid interactions mediate nanoclustering of lipid-anchored proteins. Cell, 161: 581-594.
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  7. Munagala, G., K.R. Yempalla, S. Singh, S. Sharma and N.P. Kalia et al., 2015. Synthesis of new generation triazolyl-and isoxazolyl-containing 6-nitro-2, 3-dihydroimidazooxazoles as anti-TB agents: In vitro, structure-activity relationship, pharmacokinetics and in vivo evaluation. Org. Biomol. Chemistry, 13: 3610-3624.
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  8. Kumar, S., S.K. Guru, V. Venkateswarlu, F.A. Malik, R. Vishwakarma, D.S. Sawant and S. Bhushan, 2015. A novel quinoline based second-generation mTOR inhibitor that induces apoptosis and disrupts PI3K-Akt-mTOR signaling in human Leukemia HL-60 cells. Anti-Cancer Agents Med. Chem., 15: 1297-1304.
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  9. Kumar, K.A., V. Venkateswarlu, R.A. Vishwakarma and S.D. Sawant, 2015. A metal-free approach to carboxylic acids by oxidation of Alkyl, Aryl, or Heteroaryl Alkyl ketones or arylalkynes. Synthesis, 47: 3161-3168.
  10. Gul, T., H.M. Balkhi, G.L. Reddy, S.D. Sawant, A. Hamid and E. Haq, 2015. Effect of combination of Suberoylanilide hydroxamic acid and O2', O3', O5'-tri-acetyl-N6-(3-hydroxylaniline) adenosine on various obesity related markers in 3T3-L1 pre-adipocytic cell line. Int. J. Biol. Pharmaceut. Res., 6: 831-838.
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  11. Balgotra, S., V. Venkateswarlu, R.A. Vishwakarma and S.D. Sawant, 2015. Direct C-N bond cleavage of N-vinyl or N-allyl arylamines: A metal-free strategy for N-devinylation and N-deallylation. Tetrahedron Lett., 56: 4289-4292.
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  12. 6. Srinivas, M., A.D. Hudwekar, V. Venkateswarlu, G.L. Reddy, K.A. Kumar, R.A. Vishwakarma and S.D. Sawant, 2015. A metal-free approach for transamidation of amides with amines in aqueous media. Tetrahedron Lett., 56: 4775-4779.
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  13. Yadav, M., R. Raghupathy, V. Saikam, S. Dara and P.P. Singh et al., 2014. Synthesis of non-hydrolysable mimics of glycosylphosphatidylinositol (GPI) anchors. Org. Biomol. Chem., 12: 1163-1179.
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  14. Venkateswarlu, V., K.A. Kumar, S. Balgotra, G.L. Reddy, M. Srinivas, R.A. Vishwakarma and S.D. Sawant, 2014. C-H Oxygenation and N‐trifluoroacylation of arylamines under metal‐free conditions: A convenient approach to 2‐aminophenols and N‐trifluoroacyl‐ortho‐aminophenols. Chem.: A Eur. J., 20: 664-6645.
  15. Sawant, S.D., A.D. Hudwekar, K.A.A Kumar, V. Venkateswarlu, P.P. Singh and R.A. Vishwakarma, 2014. Ligand- and base-free synthesis of phenols by rapid oxidation of arylboronic acids using iron(III) oxide. Tetrahedron Lett., 55: 811-814.
  16. Reddy, G.L., S.K. Guru, M. Srinivas, A.S. Pathania and P. Mahajan et al., 2014. Synthesis of 5-substituted-1H-pyrazolo [4, 3-d] pyrimidin-7 (6H)-one analogs and their biological evaluation as anticancer agents: mTOR inhibitors. Eur. J. Med. Chem., 80: 201-208.
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  17. Sawant, S.D., M. Srinivas, K.A. Kumar, G.L. Reddy and P.P. Singh et al., 2013. Ligand-free C-N bond formation in aqueous medium using a reusable Cu-Mn bimetallic catalyst. Tetrahedron Lett., 54: 5351-5354.
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  18. Khazir, J., P.P. Singh, D.M. Reddy, I. Hyder and S. Shafi et al., 2013. Synthesis and anticancer activity of novel spiro-isoxazoline and spiro-isoxazolidine derivatives of α-santonin. Eur. J. Med. Chem., 63: 279-289.
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  19. Bharate, S.B., S.D. Sawant, P.P. Singh and R.A. Vishwakarma, 2013. Kinase inhibitors from marine origin. Chem. Rev., 113: 6761-6815.
  20. Singh, P.P., T. Thatikonda, K.A. Kumar, S.D. Sawant and B. Singh et al., 2012. Cu-Mn spinel oxide catalyzed regioselective halogenation of phenols and N-Heteroarenes. J. Org. Chem., 77: 5823-5828.
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  21. Singh, P.P., S. Gudup, H. Aruri, U. Singh and S. Ambala et al., 2012. New method for C-H arylation/alkylation at α-position of cyclic aliphatic ethers by iron-oxide mediated reaction. Org. Biomol. Chem., 10: 1587-1597.
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  22. Sawant, S.D., M. Srinivas, G.L. Reddy, V.V. Rao, P.P. Singh and R.A. Vishwakarma, 2012. One-pot multicomponent synthesis of medicinally important purine quinazolinone derivatives. Tetrahedron Lett., 53: 6195-6198.
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  23. Singh, P.P., S. Gudup, S. Ambala, U. Singh and S. Dadhwal et al., 2011. Iron oxide mediated direct C-H arylation/alkylation at α-position of cyclic aliphatic ethers. Chem. Commun., 47: 5852-5854.
  24. Saikam, V., R. Raghupathy, M. Yadav, V. Gannedi and P.P. Singh et al., 2011. Synthesis of new fluorescently labeled glycosylphosphatidylinositol (GPI) anchors. Tetrahedron Lett., 52: 4277-4279.
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  25. Reddy, D.M., N.A. Qazi, S.D. Sawant, A.H. Bandey and J. Srinivas et al., 2011. Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents. Eur. J. Med. Chem., 46: 3210-3217.
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  26. Sawant, S.D., P.P. Singh, N.A. Qazi and H.S. Kumar, 2007. Addition of allylindium bromide to nitrile oxides in aqueous media: Convenient synthesis of 5-methylisoxazolines. Chem. Lett., 36: 296-297.
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  27. Singh, P.P., P.B. Reddy, S.D. Sawant, S. Koul, S.C. Taneja and H.S. Kumar, 2006. Domino synthesis of indenols and alkyl-indene ethers under modified Vilsmeier conditions. Tetrahedron Lett., 47: 7241-7243.
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  28. Reddy, P.B., P.P. Singh, S.D. Sawant, S. Koul, S.C. Taneja and H.M.S. Kumar, 2006. Microwave promoted novel synthesis of indenols catalyzed by SiO2 in dry media. Arkivoc, 13: 142-146.
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  29. Kumar, H.M.S., P. Chakravarthy, S.D. Sawant, P.P. Singh, M. Shesha Rao and J.S. Yadav, 2005. Catalytic transfer hydrogenation reactions of PEG-bound succinyl esters. Tetrahedron Lett., 46: 3591-3593.
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