Dr. Mohammad  Husain

Dr. Mohammad Husain

Professor
Jamia Millia Islamia Central University, India


Highest Degree
PostDoc Fellow in Microbiology and Immunology from University of Arizona, USA

Share this Profile

Area of Interest:

Biomedical Sciences
100%
Physiology
62%
Rotavirus
90%
Virology
75%
Microbiology
55%

Education

1999

PostDoc Fellow

University of Arizona, USA

Microbiology and Immunology

Selected Publications

  1. Ganai, A.A. and M. Husain, 2017. Genistein attenuates D-GaIN induced liver fibrosis/chronicliver damage in rats by blocking the TGF-B/Smad signaling pathways. Chem. Biol. Interact., 261: 80-85.

  2. Nafis, S., K. Ponnusamy, M. Husain, R.K.B. Singh and R.N.K. Bamezai, 2016. Identification of key regulators and their controlling mechanism in a combinatorial apoptosis network: a systems biology approach. Mol. Biosyst., 12: 3357-3369.
    CrossRef  |  Direct Link  |  

  3. Misbah, M., G. Roy, M. Shahid, N. Nag, S. Kumar and M. Husain, 2016. Comparative analysis of drug resistance mutations in the human immunodeficiency virus reverse transcriptase gene in patients who are non-responsive, responsive and naive to antiretroviral therapy. Arch. Virol., 161: 1101-1113.
    CrossRef  |  Direct Link  |  

  4. Husain, M. and P. Gupta, 2016. Recent advances in HIV/AIDS. In: Holistic Approaches to Infectious Deseases. George, A., K.S. Joshy, M. Sebastian, O.S. Oluwafemi and S. Thomas, (Ed.). Apple Academic Press, USA., pp- 120.147.

  5. Haque, S., X. Lan, H. Wen, R. Lederman and A. Chawla et al., 2016. HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy. Am. J. Pathol., 186: 347-358.
    CrossRef  |  Direct Link  |  

  6. Ahmad, N., E. Matala, V.R.K. Yedavalli, T. Hahn and M. Husain, 2016. Characterization of human immunodeficiency virus type-1 involved in maternal-fetal transmission. In: Advances in Animal Virology. Jameel, S. and L. Villarreal, (Ed.). Science Inc., USA., pp- 351-370.
    Direct Link  |  

  7. Zaidi, S.L., S. Mittal, M.S. Rajala, F. Avecilla, M. Husain and A. Azam, 2015. Synthesis, characterization and antiamoebic activity of chalcones bearing N-substituted ethanamine tail. Eur. J. Med. Chem., 98: 179-189.
    CrossRef  |  Direct Link  |  

  8. Nafis, S., P. Kalaiarasan, R.K.B. Singh, M. Husain and R.N.K. Bamezai, 2015. Apoptosis regulatory protein-protein interaction demonstrates hierarchical scale-free fractal network. Briefings Bioinf., 16: 675-699.
    CrossRef  |  Direct Link  |  

  9. Ayasolla, K.R., P. Rai, S. Rahimipour, M. Husain, A. Malhotra and P.C. Singhal, 2015. Tubular cell phenotype in HIV-associated nephropathy: Role of phospholipid lysophosphatidic acid. Exp. Mol. Pathol., 99: 109-115.
    CrossRef  |  Direct Link  |  

  10. Gupta, P., M. Husain, C. Hans, H. Ram and S.S. Verma et al., 2014. Sequence heterogeneity in human immunodeficiency virus type 1 nef in patients presenting with rapid progression and delayed progression to AIDS. Arch. Virol., 159: 2303-2320.
    CrossRef  |  Direct Link  |  

  11. Chandel, N., K. Ayasolla, X. Lan, P. Rai and J. Mikulak et al., 2014. Renin modulates HIV replication in T cells. J. Leukocyte Biol., 96: 601-609.
    CrossRef  |  Direct Link  |  

  12. Rai, P., A. Plagov, X. Lan, N. Chandel and T. Singh et al., 2013. mTOR plays a critical role in p53-induced oxidative kidney cell injury in HIVAN. Am. J. Physiol. Renal Physiol., 305: 343-354.
    CrossRef  |  Direct Link  |  

  13. Rai, P., A. Plagov, D. Kumar, S. Pathak and K.R. Ayasolla et al., 2013. Rapamycin-induced modulation of HIV gene transcription attenuates progression of HIVAN. Exp. Mol. Pathol., 94: 255-261.
    CrossRef  |  Direct Link  |  

  14. Lan, X., P. Rai, N. Chandel, K. Cheng and R. Lederman et al., 2013. Morphine induces albuminuria by compromising podocyte integrity. PLoS One, 10.1371/journal.pone.0055748.
    CrossRef  |  Direct Link  |  

  15. Lan, X., K. Cheng, N. Chandel, R. Lederman and A. Jhaveri et al., 2013. High glucose enhances HIV entry into T cells through upregulation of CXCR4. J. Leukoc. Biol., 94: 769-777.
    CrossRef  |  Direct Link  |  

  16. Cheng, K., P. Rai, A. Plagov, X. Lan and P.W. Mathieson et al., 2013. Rapamycin-induced modulation of miRNA expression is associated with amelioration of HIV-associated nephropathy (HIVAN). Exp. Cell Res., 319: 2073-2080.
    CrossRef  |  Direct Link  |  

  17. Cheng, K., P. Rai, A. Plagov, X. Lan and A. Subrati et al., 2013. MicroRNAs in HIV-associated nephropathy (HIVAN). Exp. Mol. Pathol., 94: 65-72.
    CrossRef  |  Direct Link  |  

  18. Chandel, N., M. Husain, H. Goel, D. Salhan and X. Lan et al., 2013. VDR hypermethylation and HIV-induced T cell loss. J. Leukoc. Biol., 93: 623-631.
    CrossRef  |  Direct Link  |  

  19. Chandel, N., B. Sharma, M. Husain, D. Salhan and T. Singh et al., 2013. HIV compromises integrity of the podocyte actin cytoskeleton through downregulation of the vitamin D receptor. Am. J. Physiol. Renal Physiol., 304: 1347-1357.
    CrossRef  |  Direct Link  |  

  20. Bharadwaj, M., G. Roy, K. Dutta, M. Misbah, M. Husain and S. Hussain, 2013. Tackling hepatitis B virus-associated hepatocellular carcinoma-the future is now. Cancer Metastasis Rev., 32: 229-268.
    CrossRef  |  Direct Link  |  

  21. Vashistha, H., P.C. Singhal, A. Malhotra, M. Husain and P. Mathieson et al., 2012. Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney. Am. J. Physiol. Renal Physiol., 303: 1629-1640.
    CrossRef  |  Direct Link  |  

  22. Singh, P., H. Goel, M. Husain, X. Lan and J. Mikulak et al., 2012. Tubular cell HIV-entry through apoptosed CD4 T cells: A novel pathway. Virology, 434: 68-77.
    CrossRef  |  

  23. Salhan, D., M. Husain, A. Subrati, R. Goyal and T. Singh et al., 2012. HIV- induced kidney cell injury: role of ROS-induced downregulated vitamin D receptor. Am. J. Physiol. Renal Physiol., 303: 503-514.
    CrossRef  |  Direct Link  |  

  24. Salhan, D., A. Sagar, D. Kumar, R. Rattanavich and P. Rai et al., 2012. HIV-associated nephropathy: Role of AT(2)R. Cell. Signal., 24: 734-741.
    CrossRef  |  Direct Link  |  

  25. Rehman, S., N. Chandel, D. Salhan, P. Rai and B. Sharma et al., 2012. Ethanol and Vitamin D Receptor in T Cell Apoptosis. J. Neuroimmune Pharmacol., 8: 251-261.
    CrossRef  |  Direct Link  |  

  26. Rehman, S., M. Husain, A. Yadav, B.S. Kasinath, A. Malhotra and P.C. Singhal, 2012. HIV-1 promotes renal tubular epithelial cell protein synthesis: role of mTOR pathway. PLoS One, 10.1371/journal.pone.0030071.
    CrossRef  |  Direct Link  |  

  27. Chandel, N., B. Sharma, D. Salhan, M. Husain, A. Malhotra, S. Buch and P.C. Singhal, 2012. Vitamin D receptor activation and downregulation of renin-angiotensin system attenuate morphine- induced T cell apoptosis. Am. J. Physiol. Cell Physiol., 303: 607-615.
    CrossRef  |  Direct Link  |  

  28. Salhan, D., S. Pathak, M. Husain, P. Tandon and D. Kumar et al., 2011. HIV gene expression deactivates redox-sensitive stress response program in mouse tubular cells both in vitro and in vivo. Am. J. Physiol. Renal Physiol., 302: 129-140.
    CrossRef  |  Direct Link  |  

  29. Pathak, P., M.C. Sharma, C. Sarkar, P. Jha and V. Suri et al., 2010. Limb girdle muscular dystrophy type 2A in India: a study based on semi-quantitative protein analysis, with clinical and histopathological correlation. Neurol. India, 58: 549-554.
    CrossRef  |  Direct Link  |  

  30. Vashishtha, H., M. Husain, D. Kumar and P.C. Singhal, 2009. Tubular cell HIV-1 gp120 expression induces caspase 8 activation and apoptosis. Renal Fail., 31: 303-312.
    CrossRef  |  Direct Link  |  

  31. Husain, M., L.G. Meggs, H. Vashistha, S. Simoes and K.O. Griffiths et al., 2009. Inhibition of p66ShcA Longevity Gene Rescues Podocytes from HIV-1-induced Oxidative Stress and Apoptosis. J. Biol. Chem., 284: 16648-16658.
    CrossRef  |  Direct Link  |  

  32. Arora, S., M. Husain, H. Patni, L. Luan and F. Batliwala et al., 2009. Human immunodeficiency virus down regulates podocytes ApoE expression. Am. J. Physiol. Renal Physiol., 297: 653-661.
    CrossRef  |  Direct Link  |  

  33. Vashist, H., M. Husain, D. Kumar, A. Yadav, S. Arora and P.C. Singhal, 2008. HIV-1 expression induces tubular cell G2/M arrest and apoptosis. Renal Fail., 30: 655-664.
    CrossRef  |  Direct Link  |  

  34. Rosenstiel, P., T.T. Gruosso, A. Letourneau, J. Chan and M. Husain et al., 2008. HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells. Kidney Int., 74: 1049-1058.

  35. He, J.C., T.C. Lu, M. Fleet, M. Sunamoto and M. Husain et al., 2007. Retinoic Acid Inhibits HIV-1-Induced Podocyte Proliferation through the cAMP Pathway. J. Am. Soc. Nephrol., 18: 93-102.
    CrossRef  |  Direct Link  |  

  36. Zerhouni-Layachi, B., M. Husain, M.J. Ross, D. Marras and M. Sunamoto et al., 2006. Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy. AIDS, 20: 621-624.
    CrossRef  |  Direct Link  |  

  37. Ross, M.J., M.S. Wosnitzer, M.D. Ross, B. Granelli and G.L. Gusella et al., 2006. Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease. J. Am. Soc. Nephrol., 17: 996-1006.
    CrossRef  |  Direct Link  |  

  38. Ramakrishnan, R., M. Husain, A. Holzer, R. Mehta, V. Sundaravaradan and N. Ahmad, 2005. Evaluation of HIV type 1 rev gene diversity and functional domains following perinatal transmission. AIDS Res. Hum. Retroviruses, 21: 1035-1045.
    CrossRef  |  Direct Link  |  

  39. Husain, M,. V.D. D`Agati, J.C. He, M. Klotman and P.E. Klotman, 2005. HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. AIDS, 19: 1975-1980.
    Direct Link  |  

  40. Yedavalli, V.R.K., M. Husain, A. Horodner and N. Ahmad, 2004. Molecular characterization of HIV type 1 vpu genes from mother and infants after perinatal transmission. AIDS Res. Hum. Retroviruses, 17: 1089-1098.
    CrossRef  |  Direct Link  |  

  41. Husain, M., T. Hahn, R.K. Yedavalli and N. Ahmad, 2004. Characterization of HIV Type-1 tat sequences associated with perinatal transmission. AIDS Res. Hum. Retroviruses, 17: 765-773.
    CrossRef  |  Direct Link  |  

  42. He, J.C., M. Husain, M. Sunamoto, V.D. D`Agati, M.E. Klotman, R. Iyengar and P. Klotman, 2004. Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1, 2 pathways. J. Clin. Invest., 114: 643-651.
    Direct Link  |  

  43. Sunamoto, M., M. Husain, I.H. Gelman, E.J. Schwartz and P.E. Klotman, 2003. Podocyte dedifferentiation in a mouse model of HIV-associated nephropathy: Role of HIV-1 accessory genes. Kidney Int., 64: 1695-1701.

  44. Nelson, P.J., M. Sunamoto, M. Husain and I.H. Gelman, 2002. HIV-1 expression induces cyclin D1 expression and pRb phosphorylation in infected podocytes: cell cycle mechanisms contributing to the proliferative phenotype in HIV-associated nephropathy. BMC Microbiol., 2: 26-26.
    CrossRef  |  Direct Link  |  

  45. Husain, M., G.L. Gusella, M.E. Klotman, I.H. Gelman and M.D. Ross et al., 2002. HIV-1 Nef induces proliferation anchorage-independent growth in podocytes. J. Am. Soc. Nephrol., 13: 1806-1815.
    CrossRef  |  Direct Link  |