Dr. Ahmad Ali Shaik

Dr. Ahmad Ali Shaik

Post-doctoral Fellow
University of Toledo, USA


Highest Degree
Ph.D. in Organic Chemistry from Indian Institute of Chemical Technology, India

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Area of Interest:

Chemistry
100%
Analytical Chemistry
62%
Medicinal Chemistry
90%
Chemical Compound
75%
Drug Analysis
55%

Selected Publications

  1. Zhang, Y., A.A. Shaik, C. Xing, Y. Chai and L. Li et al., 2012. A Synthetic Decursin Analog with Increased In Vivo Stability Suppresses Androgen Receptor Signaling In Vitro and In Vivo. Invest. New Drugs, 30: 1820-1829.
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  2. Triolet, J., A.A. Shaik, D.D. Gallaher, M.G. O'Sullivan and C. Xing, 2012. Reduction in Colon Cancer Risk by Consumption of Kava or Kava Fractions in Carcinogen-Treated Rats. Nutr. Cancer, 64: 838-846.
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  3. Shaik, A.A., J. Tan, J. Lu and C. Xing, 2012. Economically Viable Efficient Synthesis of (±)-Methysticin: A Component in Kava Potentially Responsible for its Cancer Chemopreventive Activity. Arkivoc, 2012: 137-145.
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  4. Li, L., J. Zhang, A.A. Shaik, Y. Zhang and L. Wang et al., 2012. Quantitative Determination of Decursin, Decursinol Angelate, and Decursinol in Mouse Plasma and Tumor Tissue Using Liquid-Liquid Extraction and HPLC. Planta Medica, 78: 252-259.
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  5. Zhang, J., K. Nkhata, A.A. Shaik, L. Wang and L. Li et al., 2011. Mouse Prostate Proteome Changes Induced by Oral Pentagalloylglucose Treatment Suggest Targets for Cancer Chemoprevention. Curr. Cancer Drug Targets, 11: 787-798.
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  6. Li, L., A.A. Shaik, J. Zhang, K. Nhkata, L. Wang and Y. Zhang et al., 2011. Preparation of penta-o-galloyl-β-D-glucose from tannic acid and plasma pharmacokinetic analyses by liquid-liquid extraction and reverse-phase HPLC. Pharmaceutical Biomed. Anal., 54: 545-550.
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  7. Shaik, A.A., D.L. Hermanson and C. Xing, 2009. Identification of methysticin as a potent and non-toxic NF-κB inhibitor from kava, potentially responsible for kava`s chemopreventive activity. Bioorgranic. Med. Chem. Lett., 19: 5732-5736.
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  8. Kamal, A., M.S. Malik, S. Azeeza, S. Bajee and A.A. Shaik, 2009. Total synthesis of (R)- and (S)-turmerone and (7S,9R)-bisacumol by an efficient chemoenzymatic approach. Tetrahedron Asymmetry, 20: 1267-1271.
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  9. Kamal, A., M.S. Malik, A.A. Shaik and S. Azeeza, 2009. Lipase mediated resolution of γ-azidoalcohols in aqueous and organic media: Synthesis of (R)- and (S)-fluoxetine and duloxetine. J. Mol. Catalysis B Enzymatic, 58: 132-137.
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  10. Kamal, A., M.S. Malik, A.A. Shaik and A. Shaik, 2008. Synthesis of enantiomerically pure γ-azidoalcohols by lipase-catalyzed transesterification. Tetrahedron: Asymmetry, 19: 1078-1083.
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  11. Kamal, A., A. Shaik, M.S. Malik, A.A. Shaik and M.V. Rao, 2008. Efforts towards the development of new antitubercular agents: Potential for thiolactomycin based compounds. J. Pharmacy Pharm. Sci., 11: 56-80.
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  12. Kamal, A., M.S. Malik, A.A. Shaik and A. Shaik, 2007. Enantioselective synthesis of (R)- and (S)-curcumene and curcuphenol: an efficient chemoenzymatic route. Tetrahedron: Asymmetry, 18: 2547-2553.
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  13. Kamal, A., M.S. Malik, A.A. Shaik, A. Shaik, M. Sandbhor and M.S. Malik, 2006. Chemoenzymatic synthesis of (5S)- and (5R)-hydroxymethyl-3,5-dimethyl-4-(methoxymethoxy)-5H-thiophen-2-one: a precursor of thiolactomycin and determination of its absolute configuration. Tetrahedron: Asymmetry, 17: 2890-2895.
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  14. Kamal, A., A.A. Shaik, M. Sandbhor, M.S. Malik and A. Shaik, 2006. Chemoenzymatic synthesis of (3S,4R)- and (3R,4S)-3-methoxy-4-methylaminopyrrolidine. Tetrahedron: Asymmetry, 17: 2876-2883.
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  15. Kamal, A., M. Sandbhor, A.A. Shaik and M.S. Malik, 2005. A facile and convenient chemoenzymatic synthesis of optically active O-(4-methoxyphenyl)-glycidol and 1,2-diacyl-sn-glycerol. Tetrahedron: Asymmetry, 16: 1855-1859.
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  16. Kamal, A., A.A. Shaik, R. Sinha, J.S. Yadav and S.K. Arora, 2005. Antitubercular agents. Part 2: New thiolactomycin analogues active against Mycobacterium tuberculosis. Bioorg. Med. Chem. Lett., 15: 1927-1929.
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  17. Kamal, A., M. Sandbhor and A.A. Shaik, 2004. Chemoenzymatic synthesis of (S) and (R)-propranolol and sotalol employing one-pot lipase resolution protocol. Bioorg. Med. Chem. Lett., 14: 4581-4583.
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  18. Kamal, A., A.A. Shaik, M. Sandbhor, M.S. Malik and H. Kaga, 2004. Chemoenzymatic synthesis of (3S,4S)- and (3R,4R)-3-methoxy-4-methylaminopyrrolidine. Tetrahedron: Lett., 45: 8057-8059.
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  19. Kamal, A., A.A. Shaik, M. Sandbhor and M.S. Malik, 2004. Synthesis of enantiopure β-azidoalcohols from their ketoazides by reduction with NaBH4 in the presence of alumina and in situ lipase resolution. Tetrahedron: Asymmetry, 15: 935-939.
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  20. Kamal, A., A.A. Shaik, M. Sandbhor and M.S. Malik, 2004. Chemoenzymatic synthesis of (R)- and (S)-tembamide, aegeline and denopamine by a one-pot lipase resolution protocol. Tetrahedron: Asymmetry, 15: 3939-3944.
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  21. Kamal, A., M. Sandbhor, A.A. Shaik and V. Sravanthi, 2003. One-pot synthesis and resolution of chiral allylic alcohols. Tetrahedron: Asymmetry, 14: 2839-2844.
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  22. Kamal, A., M. Sandbhor and A.A. Shaik, 2003. Application of a one-pot lipase resolution strategy for the synthesis of chiral γ- and δ-lactones. Tetrahedron: Asymmetry, 14: 1575-1580.
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  23. Kamal, A., M. Sandbhor, K. Ahmed, S.F. Adil and A.A. Shaik, 2003. Chemoenzymatic synthesis of enantiomerically pure terminal 1,2-diols. Tetrahedron: Asymmetry, 14: 3861-3866.
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