Dr. Thamaraiselvan  Rengarajan

Dr. Thamaraiselvan Rengarajan

Research Scientist
Scigen Research & Innovation Pvt Ltd,India


Highest Degree
PostDoc. in Chemical Pathology from University of Science, Malaysia

Share this Profile

Area of Interest:

Molecular Sciences
100%
Environmental Pathology
62%
Aging Pathology
90%
Biochemical
75%
Oncology
55%

Selected Publications

  1. Rengarajan, T. and N.S. Yaacob, 2016. Fisetin as a chemopreventive agent: A promising molecule against cancer. Eur. J. Pharmacol., 789: 8-16.
  2. Rajendran, P., T. Rengarajan, Y. Nishigaki, R. Palaniswami and I. Nishigaki, 2016. In vitro studies on mangiferin protection against cadmium-induced human renal endothelial damage and cell death via the MAP kinase and NF-κB pathways. J. Recept. Signal Transduct., 36: 57-66.
    CrossRef  |  Direct Link  |  
  3. Booupathy, L.K., S. Venkatachalam, N. Natarajan, R. Thamaraiselvan, M. Arumugam and B.M. Periyasamy, 2016. Chemopreventive effect of myrtenal on bacterial enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant crypt foci in Wistar rats. J. Food Drug Anal., 24: 206-213.
    CrossRef  |  Direct Link  |  
  4. Rengarajan, T., P. Rajendran, N. Nandakumar, B. Lokeshkumar, P. Rajendran and I. Nishigaki, 2015. Exposure to polycyclic aromatic hydrocarbons with special focus on cancer. Asian Pac. J. Trop. Biomed., 5: 182-189.
    CrossRef  |  Direct Link  |  
  5. Rengarajan, T., P. Rajendran, N. Nandakumar, B. Lokeshkumar and M.P. Balasubramanian, 2015. D-pinitol protects against carbon tetrachloride-induced hepatotoxicity in rats. J. Environ. Pathol. Toxicol. Oncol., 34: 287-298.
    CrossRef  |  Direct Link  |  
  6. Rengarajan, T., N. Nandakumar, P. Rajendran, M.K. Ganesh, M.P. Balasubramanian and I. Nishigaki, 2015. D-pinitol mitigates tumor growth by modulating interleukins and hormones and induces apoptosis in rat breast carcinogenesis through inhibition of NF-κB. J. Physiol. Biochem., 71: 191-204.
    CrossRef  |  Direct Link  |  
  7. Rajendran, P., T. Rengarajan, N. Nandakumar, H. Divya and I. Nishigaki, 2015. Mangiferin in cancer chemoprevention and treatment: Pharmacokinetics and molecular targets. J. Recept. Signal Transduct., 35: 76-84.
    CrossRef  |  Direct Link  |  
  8. Lokeshkumar, B., V. Sathishkumar, N. Nandakumar, T. Rengarajan, A. Madankumar and M.P. Balasubramanian, 2015. Anti-oxidative effect of myrtenal in prevention and treatment of colon cancer induced by 1,2-dimethyl hydrazine (DMH) in experimental animals. Biomol. Therapeut., 23: 471-478.
    CrossRef  |  Direct Link  |  
  9. Rengarajan, T., P. Rajendran, N. Nandakumar, M.P. Balasubramanian and I. Nishigaki, 2014. The epidemiology of human breast cancer. Int. J. Med. Health Sci., 3: 62-71.
    Direct Link  |  
  10. Rengarajan, T., P. Rajendran, N. Nandakumar, M.P. Balasubramanian and I. Nishigaki, 2014. Free radical scavenging and antioxidant activity of D-pinitol against 7, 12 dimethylbenz (a) anthracene induced breast cancer in Sprague Dawley rats. Asian Pac. J. Trop. Dis., 4: 384-390.
    CrossRef  |  Direct Link  |  
  11. Rengarajan, T., N. Nandakumar, P. Rajendran, L. Haribabu, I. Nishigaki and M.P. Balasubramanian, 2014. D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-κB. Asian Pac. J. Canncer Prev., 15: 1757-1762.
    PubMed  |  Direct Link  |  
  12. Rajendran, P., T. Rengarajan, N. Nandakumar, R. Palaniswami, Y. Nishigaki and I. Nishigaki, 2014. Kaempferol, a potential cytostatic and cure for inflammatory disorders. Eur. J. Med. Chem., 86: 103-112.
    CrossRef  |  Direct Link  |  
  13. Rajendran, P., T. Rengarajan, I. Nishigaki, G. Ekambaram and D. Sakthisekaran, 2014. Potent chemopreventive effect of mangiferin on lung carcinogenesis in experimental Swiss albino mice. J. Cancer Res. Therapeut., 10: 1033-1039.
    CrossRef  |  Direct Link  |  
  14. Rajendran, P., N. Nandakumar, T. Rengarajan, R. Palaniswami and E.N. Gnanadhas et al., 2014. Antioxidants and human diseases. Clinica Chimica Acta, 436: 332-347.
    CrossRef  |  Direct Link  |  
  15. Nandakumar, N., T. Rengarajan, A. Balamurugan and M.P. Balasubramanian, 2014. Modulating effects of hesperidin on key carbohydrate-metabolizing enzymes, lipid profile and membrane-bound adenosine triphosphatases against 7,12-dimethylbenz(a)anthracene-induced breast carcinogenesis. Hum. Exp. Toxicol., 33: 504-516.
    CrossRef  |  Direct Link  |  
  16. Sridhar, M.P.N., N. Nandakumar, T. Rengarajan and M.P. Balasubramanian, 2013. Amelioration of mercuric chloride induced oxidative stress by Hygrophila auriculata (K. Schum) Heine via modulating the oxidant-antioxidant imbalance in rat liver. J. Biochem. Technol., 4: 622-627.
    Direct Link  |  
  17. Rengarajan, T., P. Rajendran, N. Nandakumar, M.P. Balasubramanian and I. Nishigaki, 2013. Cancer preventive efficacy of marine carotenoid fucoxanthin: Cell cycle arrest and apoptosis. Nutrients, 5: 4978-4989.
    CrossRef  |  Direct Link  |  
  18. Rengarajan, T., N. Nandakumar and M.P. Balasubramanian, 2013. Protective Effect of D-Pinitol against Breast Cancer: D-Pinitol Inhibits Breast Cancer: An In-vitro and In-vivo Approach. LAP Lambert Academic Publishing, Germany, ISBN: 978-3-659-41693-4, Pages: 284.
  19. Rengarajan, T., N. Nandakumar and M.P. Balasubramanian, 2013. D-Pinitol prevents rat breast carcinogenesis induced by 7, 12-Dimethylbenz [a] anthracene through inhibition of Bcl-2 and induction of p53, caspase-3 proteins and modulation of hepatic biotransformation enzymes and antioxidants. Biomed. Prev. Nutr., 3: 31-41.
    CrossRef  |  Direct Link  |  
  20. Rajendran, P., T. Rengarajan, J. Thangavel, Y. Nishigaki, D. Sakthisekaran, G. Sethi and I. Nishigaki, 2013. The vascular endothelium and human diseases. Int. J. Biol. Sci., 9: 1057-1069.
    CrossRef  |  Direct Link  |  
  21. Lingaiah, H.B., N. Natarajan, R. Thamaraiselvan, P. Srinivasan and B.M. Periyasamy, 2013. Myrtenal ameliorates diethylnitrosamine-induced hepatocarcinogenesis through the activation of tumor suppressor protein p53 and regulation of lysosomal and mitochondrial enzymes. Fundam. Clin. Pharmacol., 27: 443-454.
    CrossRef  |  Direct Link  |  
  22. Rengarajan, T., N. Nandakumar and M.P. Balasubramanian, 2012. Protective efficacy of dietary D-pinitol on hepatic and renal tissues during experimental breast cancer in rats challenged with 7,12-dimethylbenz (a) anthracene: A biochemical approach. Biomed. Aging Pathol., 2: 85-93.
    CrossRef  |  Direct Link  |  
  23. Rengarajan, T., N. Nandakumar and M.P. Balasubramanian, 2012. D-Pinitol attenuates 7, 12 dimethylbenz [a] anthracene induced hazards through modulating protein bound carbohydrates, adenosine triphosphatases and lysosomal enzymes during experimental mammary carcinogenesis. Exp. Therapeut. Oncol., 10: 39-49.
    PubMed  |  
  24. Rengarajan, T., N. Nandakumar and M.P. Balasubramanian, 2012. D-Pinitol a low-molecular cyclitol prevents 7,12-Dimethylbenz [a] anthracene induced experimental breast cancer through regulating anti-apoptotic protein Bcl-2, mitochondrial and carbohydrate key metabolizing enzymes. Biomed. Prev. Nutr., 2: 25-30.
    CrossRef  |  Direct Link  |  
  25. Lingaiah, H.B., R. Thamaraiselvan and B.M. Periyasamy, 2012. Dexamethasone induced alterations in lipid peroxidation, antioxidants, membrane bound ATPase in Wistar albino rats. Int. J. Pharm. Pharmaceut. Sci., 4: 497-499.
    Direct Link  |  
  26. Jagadeesan, J., N. Nandakumar, T. Rengarajan and M.P. Balasubramanian, 2012. Diosgenin, a steroidal saponin, exhibits anticancer activity by attenuating lipid peroxidation via enhancing antioxidant defense system during NMU-induced breast carcinoma. J. Environ. Pathol. Toxicol. Oncol., 31: 121-129.
    CrossRef  |  Direct Link  |  
  27. Rengarajan, T., A.J. Jagadeesan, A. Balamurugan and M.P. Balasubramanian, 2011. Chemotherapeutic potential of D-pinitol against 7, 12 dimethylbenz (a) anthracene (DMBA) induced mammary carcinoma in Sprague Dawley rats. Int. J. Pharma Bio Sci., 2: 232-241.
    Direct Link  |  
  28. Natarajan, N., R. Thamaraiselvan, H. Lingaiah, P. Srinivasan and B.M. Periyasamy, 2011. Effect of flavonone hesperidin on the apoptosis of human mammary carcinoma cell line MCF-7. Biomed. Prev. Nutr., 1: 207-215.
    CrossRef  |  Direct Link  |  
  29. Nandakumar, N., R. Jayaprakash, T. Rengarajan, V. Ramesh and M.P. Balasubramanian, 2011. Hesperidin, a natural citrus flavonoglycoside, normalizes lipid peroxidation and membrane bound marker enzymes in 7, 12-dimethylbenz (a) anthracene induced experimental breast cancer rats. Biomed. Prev. Nutr., 1: 255-262.
    CrossRef  |  Direct Link  |