Dr. Pappu  Srinivasan

Dr. Pappu Srinivasan

Associate Professor
Alagappa University, India


Highest Degree
Ph.D. in Biotechnology from University of Madras, India

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Biography

Dr. Pappu Srinivasan obtained his Ph.D. in Biotechnology from University of Madras, Chennai, India. His main area of interest related to Biosciences, Phage Biotechnology and Bioinformatics, Aquaculture Biotechnology, Molecular Interactions of Aquatic Animals and Microbes, Cancer Biology and Diabetes, and Natural Bioactive Compounds. He has published 31 research papers in journals contributed as author/co-author.

Area of Interest:

Molecular Sciences
100%
Microbiology
62%
Biotechnology
90%
Aquaculture
75%
Infectious Diseases
55%

Selected Publications

  1. Arthia, P., D. Mahendiran, S. Shobana, P. Srinivasan and A.K. Rahiman, 2018. Theoretical, biological and in silico studies of pendant-armed heteroleptic copper(II) phenolate complexes. J. Mol. Struct., 1161: 306-319.
  2. Sudha, A., J. Jeyakanthan and P. Srinivasan, 2017. Green synthesis of silver nanoparticles using Lippia nodiflora aerial extract and evaluation of their antioxidant, antibacterial and cytotoxic effects. Resource-Efficient Technol., 3: 506-515.
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  3. Stalin, N. and P. Srinivasan, 2017. Efficacy of potential phage cocktails against Vibrio harveyi and closely related Vibrio species isolated from shrimp aquaculture environment in the south east coast of India. Vet. Microbiol., 207: 83-96.
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  4. Srinivasan, P. and P. Ramasamy, 2017. Morphological characterization and biocontrol effects of Vibrio vulnificus phages against Vibriosis in the shrimp aquaculture environment. Microb. Pathogenesis, 111: 472-480.
  5. Sindhu, T. and P. Srinivasan, 2017. Pharmacophore modeling, comprehensive 3D-QSAR and binding mode analysis of TGR5 agonists. J. Receptors Signal Transduction, 37: 109-123.
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  6. Sasikala, D., J. Jeyakanthan and P. Srinivasan, 2017. Structure-based virtual screening and biological evaluation of LuxT inhibitors for targeting Quorum sensing through an in vitro biofilm formation. J. Mol. Struct., 1127: 322-336.
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  7. Rajamanikandan, S., J. Jeyakanthan and P. Srinivasan, 2017. Molecular docking, molecular dynamics simulations, computational screening to design quorum sensing inhibitors targeting LuxP of Vibrio harveyi and its biological evaluation. Applied Biochem. Biotechnol., 181: 192-218.
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  8. Rajamanikandan, S., J. Jeyakanthan and P. Srinivasan, 2017. Discovery of potent inhibitors targeting Vibrio harveyi LuxR through shape and e-pharmacophore based virtual screening and its biological evaluation. Microb. Pathogenesis, 103: 40-56.
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  9. Rajamanikandan, S., J. Jeyakanthan and P. Srinivasan, 2017. Binding mode exploration of LuxR-thiazolidinedione analogues, e-pharmacophore-based virtual screening in the designing of LuxR inhibitors and its biological evaluation. J. Biomol. Struct. Dynamics, 35: 897-916.
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  10. Rajamanikandan, S. and P. Srinivasan, 2017. Exploring the selectivity of auto-inducer complex with LuxR using molecular docking, mutational studies and molecular dynamics simulations. J. Mol. Struct., 1131: 281-293.
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  11. Vanajothi, R. and P. Srinivasan, 2016. An anthraquinone derivative from Luffa acutangula induces apoptosis in human lung cancer cell line NCI-H460 through p53-dependent pathway. J. Receptors Signal Transduction, 36: 292-302.
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  12. Thamilarasan, V., N. Sengottuvelan, A. Sudha, P. Srinivasan and G. Chakkaravarthi, 2016. Cobalt(III) complexes as potential anticancer agents: Physicochemical, structural, cytotoxic activity and DNA/protein interactions. J. Photochem. Photobiol. B: Biol., 162: 558-569.
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  13. Sudha, A., J. Jeyakanthan and P. Srinivasan, 2016. Protective effect of 5-hydroxy-3′,4′,7-trimethoxyflavone against inflammation induced by lipopolysaccharide in RAW 264.7 macrophage: In vitro study and in silico validation. Med. Chem. Res., 25: 1754-1767.
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  14. Stalin, N. and P. Srinivasan, 2016. Molecular characterization of antibiotic resistant Vibrio harveyi Isolated from shrimp aquaculture environment in the South East Coast of India. Microb. Pathogenesis, 97: 110-118.
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  15. Stalin, N. and P. Srinivasan, 2016. Characterization of Vibrio parahaemolyticus and its specific phage from shrimp pond in Palk Strait, South East coast of India. Biologicals, 44: 526-533.
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  16. Sasikala, D., J. Jeyakanthan and P. Srinivasan, 2016. Structural insights on identification of potential lead compounds targeting WbpP in Vibrio vulnificus through structure-based approaches. J. Receptors Signal Transduction, 36: 515-530.
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  17. Sasikala, D. and P. Srinivasan, 2016. Characterization of potential lytic bacteriophage against Vibrio alginolyticus and its therapeutic implications on biofilm dispersal. Microb. Pathogenesis, 101: 24-35.
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  18. Ramar, V. and S. Pappu, 2016. Exploring the inhibitory potential of bioactive compound from Luffa acutangula against NF-κB-a molecular docking and dynamics approach. Comput. Biol. Chem., 62: 29-35.
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  19. Rajamanikandan, S. and P. Srinivasan, 2016. Pharmacophore modeling and structure-based virtual screening to identify potent inhibitors targeting LuxP of Vibrio harveyi. J. Receptors Signal Transduction, 36: 617-632.
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  20. Dhananasekaran, S., R. Palanivel and S. Pappu, 2016. Adsorption of methylene blue, bromophenol blue, and coomassie brilliant blue by α-chitin nanoparticles. J. Adv. Res., 7: 113-124.
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  21. Thamilarasan, V., N. Sengottuvelan, A. Sudha, P. Srinivasan and A. Siva, 2015. Synthesis, molecular structure, theoretical calculation, DNA/protein interaction and cytotoxic activity of manganese(III) complex with 8-hydroxyquinoline. J. Photochem. Photobiol. B: Biol., 142: 220-231.
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  22. Sudha, A., P. Srinivasan, V. Thamilarasan and N. Sengottuvelan, 2015. Exploring the binding mechanism of 5-hydroxy- 3',4',7- trimethoxyflavone with bovine serum albumin: Spectroscopic and computational approach. Spectrochim. Acta Part A: Mol. Biomol. Spectrosc., 157: 170-181.
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  23. Sudha, A., P. Srinivasan and P. Rameshthangam, 2015. Exploration of potential EGFR inhibitors: A combination of Pharmacophore-based virtual screening, atom-based 3D-QSAR and molecular docking analysis. J. Receptors Signal Transduction, 35: 137-148.
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  24. Sudha, A. and P. Srinivasan, 2015. In vitro, fluorescence-quenching and computational studies on the interaction between lipoxygenase and 5-hydroxy-3′,4′,7-trimethoxyflavone from Lippia nodiflora L. J. Receptors Signal Transduction, 35: 569-577.
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  25. Sindhu, T. and P. Srinivasan, 2015. Identification of potential dual agonists of FXR and TGR5 using e-pharmacophore based virtual screening. Mol. BioSyst., 11: 1305-1318.
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  26. Sindhu, T. and P. Srinivasan, 2015. Exploring the binding properties of agonists interacting with human TGR5 using structural modeling, molecular docking and dynamics simulations. RSC Adv., 5: 14202-14213.
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  27. Arthi, P., S. Shobana, P. Srinivasan and A.K. Rahiman, 2015. Synthesis, characterization, biological evaluation and docking studies of macrocyclic binuclear manganese(II) complexes containing 3,5-dinitrobenzoyl pendant arms. Spectrochim. Acta Part A: Mol. Biomol. Spectrosc., 143: 49-58.
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  28. Arthi, P., P. Srinivasan and A.K. Rahiman, 2015. Dinuclear manganese(II) complexes of hexaazamacrocycles bearing N-benzoylated pendant separated by aromatic spacers: Antibacterial, DNA interaction, cytotoxic and molecular docking studies. J. Photochem. Photobiol. B: Biol., 153: 247-260.
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  29. Vanajothi, R. and P. Srinivasan, 2014. Bioassay-guided isolation and identification of bioactive compound from aerial parts of Luffa acutangula against lung cancer cell line NCI-H460. J. Receptors Signal Transduction, 35: 295-302.
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  30. Sudha, A. and P. Srinivasan, 2014. Bioassay-guided isolation, identification and molecular ligand-target insight of lipoxygenase inhibitors from leaves of Anisomeles malabarica R. Br. Pharmacogn. Magaz., 10: S596-S605.
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  31. Sudha, A. and P. Srinivasan, 2014. Bioassay-guided isolation and antioxidant evaluation of flavonoid compound from aerial parts of Lippia nodiflora L. BioMed Res. Int., Vol. 2014. 10.1155/2014/549836.
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  32. Srinivasan, P., P. Chellaperumal and A. Sudha, 2014. Discovery of novel inhibitors for Nek6 protein through homology model assisted structure based virtual screening and molecular docking approaches. Scient. World J., Vol. 2014. 10.1155/2014/967873.
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  33. Sindhu, T., S. Rajamanikandan and P. Srinivasan, 2014. In vitro anti-oxidant and anti-bacterial activities of Kyllinga nemoralis. Indian J. Pharm. Sci., 76: 170-174.
  34. Sindhu, T. and P. Srinivasan, 2014. Pharmacophore modeling, 3D-QSAR and molecular docking studies of benzimidazole derivatives as potential FXR agonists. J. Receptors Signal Transduction, 34: 241-253.
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  35. Durai, P., C. Arulvasu, B. Gajendran, M. Ramar, S. Pappu, G. Kasivelu and A. Thirunavukkarasu, 2014. Synthesis and characterization of silver nanoparticles using crystal compound of sodium para-hydroxybenzoate tetrahydrate isolated from Vitex negundo. L leaves and its apoptotic effect on human colon cancer cell lines. Eur. J. Med. Chem., 84: 90-99.
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  36. Arthi, P., S. Shobana, P. Srinivasan and A.K. Rahiman, 2014. Synthesis, antibacterial, docking and anticancer evaluation of N-substituted benzoyl derivatives. J. Chosun Nat. Sci., 7: 241-252.
  37. Arthi, P., A. Haleel, P. Srinivasan, D. Prabhu, C. Arulvasu and A.K. Rahiman, 2014. Antibacterial, DNA interaction and cytotoxic activities of pendant-armed polyamine macrocyclic dinuclear nicke (II) and copper(II) complexes. Spectrochim. Acta Part A: Mol. Biomol. Spectrosc., 129: 400-414.
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  38. Suryanarayanan, V., A. Sudha, S. Rajamanikandan, R. Vanajothi and P. Srinivasan, 2013. Atom-based 3D QSAR studies on novel N-β-D-Xylosylindole derivatives as SGLT2 inhibitors. Med. Chem. Res., 22: 615-624.
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  39. Sudha, A., K. Sumathi, S. Manikandaselvi, N.M. Prabhu and P. Srinivasan, 2013. Anti-hepatotoxic activity of crude flavonoid fraction of lippia nodiflora l. on ethanol induced liver injury in rats. Asian J. Anim. Sci., 7: 1-13.
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  40. Sudha, A. and P. Srinivasan, 2013. Physicochemical and Phytochemical profiles of aerial parts of Lippia nodiflora L. Int. J. Pharm. Sci. Res., 4: 4263-4271.
  41. Sengottuvelan, N., P. Srinivasan, M. Kandaswamy and H.K. Fun, 2013. DNA cleavage electrochemical and magnetic studies of scorpionand copper (II) complex. Int. J. ChemTech. Res., 5: 367-375.
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  42. Prabhu, D., C. Arulvasu, G. Babu, R. Manikandan and P. Srinivasan, 2013. Biologically synthesized green silver nanoparticles from leaf extract of Vitex negundo L. induce growth-inhibitory effect on human colon cancer cell line HCT15. Process Biochem., 48: 317-324.
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  43. Vaseeharan, B., S.P. Sonibarathi, N.M. Prabhu, R. Manikandan, M. Esakkirajan and P. Srinivasan, 2012. Surveillance and antibacterial activity of commercial antibiotics against Vibrio spp. isolated from Cattle (Bos indicus) farms of Tamil Nadu, India. Inter. J. Curr. Sci., 4: 7-11.
  44. Vanajothi, R., S. Rajamanikandan, A. Sudha and P. Srinivasan, 2012. Structural and functional analysis of KIT gene encoding receptor tyrosine kinase and its interaction with sunitinib and HDAC inhibitors: An in silico approach. Pakistan J. Biol. Sci., 15: 121-131.
    PubMed  |  
  45. Vanajothi, R., A. Sudha, R. Manikandan, P. Rameshthangam and P. Srinivasan, 2012. Luffa acutangula and Lippia nodiflora leaf extract induces growth inhibitory effect through induction of apoptosis on human lung cancer cell line. Biomed. Preventive Nutr., 2: 287-293.
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  46. Sudha, A., P. Srinivasan, N.S. Manikandaselvi and R. Thinagarbabu, 2012. Protective effect and antioxidant role of Achyranthus aspera L. against ethanol-induced oxidative stress in rats. Inter. J. Pharm. Pharm. Sci., 4: 280-284.
  47. Srinivasan, P., R. Manikandan and C. Arulvasu, 2012. Inhibition of cyclin dependent kinase-2 and glycogen synthase kinase-3 by herbal derivative 1, 2 disubstituted idopyranose through in silico analysis. J. Adv. Sci. Res., 3: 65-72.
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  48. Srinivasan, P., P. Rameshthangam, N.M. Prabhu and C. Arulvasu, 2012. Variation in lipid classes and fatty acid content during ovarian maturation of Albunea symmysta. J. Adv. Sci. Res., 3: 60-64.
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  49. Srinivasan, P., A. Sudha, N. Umamaheswari, R. Vanajothi and P. Rameshthangam, 2012. Modeling of quorum sensing regulatory protein of Vibrio harveyi from shrimp aquaculture system and in silico prediction of active drugs. Inter. J. Curr. Sci., 2: 5-13.
  50. Singh, K.D., P. Kirubakaran, S. Manikandaprabhu, S. Nagamani, P. Srinivasan, M. Karthikeyan, 2012. Docking studies of adenosine analogues with NS5 methyltransferase of yellow fever virus. Indian J. Microbiol., 52: 28-34.
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  51. Sindhu, T., S. Rajamanikandan and P. Srinivasan, 2012. Computational prediction of phylogenetically conserved sequence motifs for the candidate genes involved in Type II diabetic nephropathy. Iran. J. Pub. Health, 41: 24-33.
  52. Rajamanikandan, S., R. Vanajothi, A. Sudha, P. Rameshthangam and P. Srinivasan, 2012. In silico analysis of deleterious SNPs of the FGFR2 gene. J. Biol. Sci., 12: 83-90.
  53. Kumar, S.P., S.K. Patel, Y.T. Jasrai, H.A. Pandya and P. Srinivasan, 2012. Biocomputational analysis of filaggrin sequence repeats for rheumatoid arthritis. Electron. J. Biol., 8: 29-33.
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  54. Vaseeharan, B., P. Ramasamy, P. Srinivasan, R. Manikandan, C. Arulvasu and N.M. Prabhu, 2011. Isolation and characterization of pharmaceutically important fungal microflora from Penaeus monodon culture system. Inventi Impact: Pharm. Tech., 3: 156-160.
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  55. Srinivasan, P., S.P. Kumar, M. Karthikeyan, J. Jeyakanthan and Y.T. Jasrai et al, 2011. Epitope-based immunoinformatics and molecular docking studies of nucleocapsid protein and ovarian tumor domain of crimean-congo hemorrhagic fever virus. Front. Genet., Vol: 2 .
    PubMed  |  
  56. Srinivasan, P., A. Sudha, R. Manikandan and C. Arulvasu, 2011. Molecular docking studies of 1, 2 disubstituted Idopyranose from Vitex negundo with anti-diabetic activity of type 2 diabetes. Int. J. Pharma. Bio. Sci., 2: 68-83.
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  57. Srinivasan, P., A. Sudha, A.S. Hameed, S.P. Kumar and M. Karthikeyan, 2011. Screening of medicinal plant compounds against NS5B polymerase of hepatitis C virus (HCV) using molecular docking studies. J. Pharm. Res., 4: 136-140.
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  58. Rameshthangam, P., P. Srinivasan, C. Arulvasu, D. Gowdhaman and P. Neeraja, 2011. Protein carbonylation as biomarker(s) in serum patients with type 2 diabetes. J. Pharm. Res., 4: 348-351.
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  59. Rameshthangam, P., P. Srinivasan and P. Ramasamy, 2011. White Spot Syndrome Virus (WSSV): An overview. Int. J. Curr. Res. Rev., 2: 28-41.
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  60. Prasanth Kumar, S., P. Srinivasan, S.K. Patel, R. Kapopara and Y.T. Jasrai, 2011. In silico development of inhibitors against pantothenate synthetase of mycobacterium tuberculosis. J. Adv. Bioinf. Appl. Res., 2: 142-148.
  61. Sudha, A., P. Srinivasan, N. Rameshkannan and R. Vanajothi, 2010. Protective effects of Achras zapota Linn. Seed extract in carbon tetrachloride induced hepatotoxicity in rats. Inventi Impact: Ethnopharmacol., 1: 1-3.
  62. Srinivasan, P., A. Sudha, P. Bharathajothi, K. Rajaguru, P. Rameshthangam, R. Manikandan and C. Arulvasu, 2010. Effects of anti-inflammatory and anti-pyretic activity of Anisomeles malabarica R.Br. J. Pharm. Res., 3: 1598-1601.
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  63. Maheshwari, U.N., A. Josphine, M. Kannahi and P. Srinivasan, 2010. Molecular characterization of probiotic bacteria, Bacillus sp. from shrimp aquaculture environment of Tamilnadu, India. Geobios, 37: 73-75.
  64. Arulvasu, C., G. Babu, R. Manikandan, P. Srinivasan and N. Radhakrishnan et al., 2010. Anti-cancer effect of Datura innoxia P.mill. leaf extract in vitro through induction of apoptosis in human colon adenocarcinoma and larynx cancer cell lines. J. Pharm. Res., 3: 1485-1488.
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  65. Arulvasu, C., D. Prabhu, R. Manikandan, P. Srinivasan, D. Dinesh, G. Babu and S. Sellamuthu, 2010. Induction of apoptosis by the aqueous and ethanolic leaf extract of Vitex negundo L. in MCF-7 human breast cancer cells. Int. J. Drug Discovery, 2: 1-7.
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  66. Arulvasu, C., D. Dinesh, R. Manikandan, P. Srinivasan and N. Radhakrishnan et al., 2010. Evaluation of anti-proliferative effect of sardine oil emulsion on A549 and HCT 15 cancer cell lines. Int. J. Pharm. Technol. Res., 2: 1171-1177.
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  67. Srinivasan, P. and P. Ramasamy, 2009. Occurrence, distribution and antibiotic resistance patterns of Vibrio species associated with viral diseased Shrimp of South Indian aquaculture environment. Int. J. Agric. Sci., 1: 1-10.
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  68. Manikandan, R., R. Sundaram, P. Srinivasan, S. Beulaja and C. Arulvasu, 2009. Isolation of 1, 2 di-substituted idopyranose from Vitex negundo and its effects on diabetic rats. Int. J. Pharm. Anal., 1: 4-10.
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  69. Srinivasan, P., P. Ramasamy, G.P. Brennan and R.E.B. Hanna, 2007. Inhibitory effects of bacteriophages on the growth of Vibrio sp., pathogens of shrimp in the Indian aquaculture environment. Asian J. Anim. Vet. Adv., 2: 166-183.
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