Dr. Mallikarjuna  Rao Pichika
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Dr. Mallikarjuna Rao Pichika

Professor, Associate Dean
International Medical University, Malaysia

Highest Degree
Ph.D. in Pharmaceutical Sciences from Andhra University, India

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Area of Interest:

Pharmacology and Toxicology
Pharmaceutical Sciences
Clinical Research
Drug Delivery

Research Publications in Numbers


Selected Publications

  1. Rathinasabapathy, T., K.M.P. Jackson, Y. Thor, A.S. Buru and D. Esposito et al., 2017. Thiazolopyridines improve adipocyte function by inhibiting 11 Beta-HSD1 oxoreductase activity. J. Chem., Vol. 2017. 10.1155/2017/3182129.
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  2. Meka, V.S., M.K. Sing, M.R. Pichika, S.R. Nali, V.R. Kolapalli and P. Kesharwani, 2017. A comprehensive review on polyelectrolyte complexes. Drug Discovery Today, 22: 1697-1706.
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  3. Kun, N.C., L.A. Wei, C.J. Wei, L.L. Jie, M.R. Pichika and L.S.H. Erin, 2017. An evaluation of antimicrobial activity of different extracts of Dillenia suffruticosa stem bark. Int. Med. J., 24: 104-110.
  4. Kandasamy, M., M. Salihin, M.R. Pichika, S. Komarnytsky and T. Rathinasabapathy, 2017. A metabolic stability determination of tetrahydrothiazolopyridine derivate: A selective 11 - hydroxysteroiddehydrogenase type 1 (11B-HSD1) inhibitor. Int. J. Pharm. Bio Sci., 8: 120-130.
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  5. Balijepalli, M.K., A.S. Buru, R. Sakirolla and M.R. Pichika, 2017. Cinnamomum genus: A review on its biological activities. Int. J. Pharm. Pharm. Sci., 9: 1-11.
  6. Rajasingam, R., S.R. Sagineedu, Y.H. Tan, N. Jeyashanthini and M.R. Pichika, 2016. Stress degradation studies and development of a validated RP-HPLC method for determination of tiagabine in presence of its degradation products. Int. J. Pharm. Pharm. Sci., 8: 230-236.
  7. Mahita, J., K. Harini, M.R. Pichika and R. Sowdhamini, 2016. An in silico approach towards the identification of novel inhibitors of the TLR-4 signaling pathway. J. Biomolecular Structure Dynamics, 34: 1345-1362.
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  8. Mai, C.W., R. Anitha, J.J.L. Tiong, P.K. Lai, M.R. Pichika and A.I. Gray, 2015. Chemistry content in the pharmacy curriculum: Relevance to develop pharmacists fit-to-work in diverse pharmacy profession sectors. Indian J. Pharm. Educ. Res., 49: 240-247.
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  9. Kaki, V.R., R.R. Akkinepalli, P.K. Deb and M.R. Pichika, 2015. Basic ionic liquid [bmIm] OH-mediated Gewald reaction as green protocol for the synthesis of 2-aminothiophenes. Synthetic Commun., 45: 119-126.
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  10. Jeyashanthini, N., S.R. Sagineedu, R. Rajasingam, Z. Kassim and M.R. Pichika, 2015. A Stability-indicating RP-HPLC method for simultaneous determination of simvastatin and niacin in a combined dosage form. Int. J. Pharm. Pharm. Sci., 7: 262-268.
  11. Balijepalli, M.K., V. Suppaiah, A.M. Chin, A.S. Buru, S.R. Sagineedu and M.R. Pichika, 2015. Acute oral toxicity studies of Swietenia macrophylla seeds in sprague dawley rats. Pharm. Res., 7: 38-44.
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  12. Mai, C.W., M. Yaeghoobi, N. Abd-Rahman, Y.B. Kang and M.R. Pichika, 2014. Chalcones with electron-withdrawing and electron-donating substituents: Anticancer activity against TRAIL resistant cancer cells, structure–activity relationship analysis and regulation of apoptotic proteins. Eur. J. Med. Chem., 77: 378-387.
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  13. Deb, P.K., D. El-Rabie, A. Junaid, L.C. Siong, A. Kulasekar, L. Kulasingam and M.R. Pichika, 2014. In silico binding mode analysis (Molecular docking studies) and absorption, distribution, metabolism and excretion prediction of some novel inhibitors of aurora kinase a in clinical trials. Asian J. Chem., 26: 6221-6226.
  14. Deb, P.K., A. Junaid, D. El-Rabie, T.Y. Hon, E.M. Nasr and M.R. Pichika, 2014. Molecular docking studies and comparative binding mode analysis of FDA approved HIV protease inhibitors. Asian J. Chem., 26: 6227-6232.
  15. Buru, A.S., M.R. Pichika, V. Neela and K. Mohandas, 2014. In vitro antibacterial effects of Cinnamomum extracts on common bacteria found in wound infections with emphasis on methicillin-resistant Staphylococcus aureus. J. Ethnopharmacol., 153: 587-595.
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  16. Yap, P.S.X., Y.T.E. Chong, Y.Y. Wong, X.Y. Lim and J.H. Ang et al., 2013. Antibacterial and antifungal testing of the different extracts of Dillenia obovata (Blue) Hoogl. World J. Pharm. Pharm. Sci., 2: 3946-3962.
  17. Tan, B.S., O. Kang, C.W. Mai, K.H. Tiong and A.S.B. Khoo et al., 2013. 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ). Cancer Lett., 336: 127-139.
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  18. Pichika, M.R., Y.B. Kang and S.W. Ng, 2013. 2-Methoxy-4-(prop-2-en-1-yl) phenyl benzoate. Acta Crystallographica Sect. E: Structure Rep. Online, Vol. 69. 10.1107/S1600536813015791.
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  19. Pichika, M.R., Y.B. Kang and S.W. Ng, 2013. 2-Methoxy-4-(prop-2-en-1-yl) phenyl 2, 4-dichlorobenzoate. Acta Crystallographica Sect. E: Structure Rep. Online, Vol. 69. 10.1107/S1600536813015675.
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  20. Pichika, M.R., B.K. Yew and S.W. Ng, 2013. 2-Methoxy-4-(prop-2-en-1-yl) phenyl 4-methoxybenzoate. Acta Crystallographica Sect. E: Structure Rep. Online, Vol. 69. 10.1107/S1600536813011458.
    CrossRef  |  
  21. Mai, C.W., Y.B. Kang and M.R. Pichika, 2013. Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: Its expression and effects in the ten most common cancers. OncoTargets Therapy, 6: 1573-1587.
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  22. Kishore, D.P., R. Maillabaram, A.R. Rao and P.M. Rao, 2013. Antiinflammatory evaluation and docking studies of some new thienopyrimidines. Asian J. Chem., 25: 10583-10587.
  23. Kishore, D.P., A. Rana, U.K. Jain and P.M. Rao, 2013. Pharmacophore-based 3D-QSAR studies of aromatase inhibitors. Asian J. Chem., 25: 10588-10594.
  24. Erin, L.S.H., P.P. Mun, N.S. Ling, O.C. Ping and S.X. Jie et al., 2013. Evaluation of four extracts of Dillenia ovata stem bark and leaves for antibacterial and antifungal activity. Int. J. Pharm. Pharm. Sci., 5: 471-474.
  25. Haw, K.Y., S. Chakravarthi, N. Haleagrahara and M. Rao, 2012. Effects of Etlingera elatior extracts on lead acetate-induced testicular damage: A morphological and biochemical study. Exp. Ther. Med., 3: 99-104.
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  26. Srinivasan, R., W.H. Wong and M.R. Pichika, 2011. Impact of extraction processes on the 6-shogaol content in Zingiber officinale (Halia Penang) and its antiproliferative activities on human colorectal cancer cell lines (HT-29). Planta Med., Vol. 77. 10.1055/s-0031-1273641.
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  27. Katyayani, B.M., T. Satyanarayana and P.M. Rao, 2010. Antiproliferative and induction of apoptosis in estorgen-receptor positive and negative human breast carcinoma cell lines by Gmelina asiatica roots. Pharm. Res., 2: 113-119.
  28. Haleagrahara, N., T. Jackie, S. Chakravarthi, M. Rao and T. Pasupathi, 2010. Protective effects of Etlingera elatior extract on lead acetate-induced changes in oxidative biomarkers in bone marrow of rats. Food Chem. Toxicol., 48: 2688-2694.
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  29. Dugasani, S., M.R. Pichika, V.D. Nadarajah, M.K. Balijepalli, S. Tandra and J.N. Korlakunta, 2010. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol,[8]-gingerol,[10]-gingerol and [6]-shogaol. J. Ethnopharmacol., 127: 515-520.
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  30. Dugasani, S., M.K. Balijepalli, S. Tandra and M.R. Pichika, 2010. Antimicrobial activity of Bauhinia tomentosa and Bauhinia vahlii roots. Pharm. Mag., 6: 204-207.
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  31. Balijepalli, M.K., C.Y. Rou and M.R. Pichika, 2010. Antiproliferative activity of Bauhinia blakeana on estrogen receptor negative human breast cancer (MDA-MB-231) cells. Planta Med., Vol. 76. 10.1055/s-0030-1251857.
    CrossRef  |  
  32. Adinarayana, K., K.N. Jayveera and M.R. Pichika, 2010. Evaluation of antiulcerogenic activity of Tephrosia calophylla roots on aspirin plus pyloric ligation-induced ulcers in experimental rats. Planta Med., Vol. 76. 10.1055/s-0030-1251856.
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  33. Swarnalatha, D., B.M. Katyayani and P.M. Rao, 2009. Growth inhibition and induction of apoptosis in estrogen receptor-positive and negative human breast carcinoma cells lines by Adenocalymma alliaceum. Curr. Trends Biotechnol. Pharm., 3: 278-286.
  34. Sreenivasulu, V., P.M. Rao and K.N. Jayaveera, 2009. Mutation induced enhanced biosynthesis of antitumour L-asparaginase. J. Pharm. Chem., 2: 236-240.
  35. Sreenivasulu, V., K.N. Jayaveera and P.M. Rao, 2009. Solid-state fermentation for the production of l-asparaginase by Aspergillus Sp. Res. J. Pharm. Phytochem., 1: 21-25.
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  36. Sreenivasulu, V., K.N. Jayaveera and P.M. Rao, 2009. Optimization of process parameters for the production of L-asparaginase from an isolated fungus. Res. J. Pharm. Phytochem., 1: 30-34.
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  37. Siddaiah, M., K.N. Jayavcera, R.P. Mallikarjuna, R.K. Ravindra, K.Y. Yasodha and R.G. Narender, 2009. Phytochemical screening and analgesic activity of methanolic extract of Ximenia americana. J. Pharm. Chem., 3: 23-25.
  38. Munna, S., K.N. Jayaveera and PM. Rao, 2009. Phytochemical screening and antimicrobial activity of alcohol extracts from leaf and bark of Ficus mollis. J. Pharm. Chem., 3: 48-50.
  39. Mai, C.W., S.Y. Wong, E.L. Tan, M.K. Balijepalli and M.R. Pichika, 2009. Antiproliferative and apoptotic studies of the standardised extracts of Etlingera elatior on human colorectal carcinoma cells. Malays. J. Chem., 11: 136-142.
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  40. Mai, C.W., P. Pakirisamy, E.F. Tay, S. Subramaniam, Z.H. Shamsuddin and M.R. Pichika, 2009. Nasopharyngeal Carcinoma cell proliferation and apoptosis induced by the standardised ethanolic extracts of Mucuna bracteata. Mal. J. Chem., 11: 143-148.
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  41. Adinarayana, K., K.N. Jayaveera, B.M. Katyayani and P.M. Rao, 2009. Growth inhibition and induction of apoptosis in estrogen receptor-positive and negative human breast carcinoma cells lines by Tephrosia calophylla. J. Pharm. Chem., 3: 137-143.
  42. Rao, P.M., V.D. Nadarajah, H.M. Er, B.C. Yiap and M.K. Fee et al., 2008. Antioxidant, chemopreventive and antiproliferative activities Malayisan Zingiber officinale variants. Planta Med., 74: 337-339.
  43. Jayaveera, K.N., V. Sreenivasulu, P.M. Rao and T. Bharathi, 2008. Screening of antitumour L-asparaginase positive fungal cultures from soil. J. Pharm. Chem., 2: 94-96.
  44. Sudhakar, M., C.V. Rao, P.M. Rao, D.B. Raju and Y. Venkateswarlu, 2006. Antimicrobial activity of Caesalpinia pulcherrima, Euphorbia hirta and Asystasia gangeticum. Fitoterapia, 77: 378-380.
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  45. Sudhakar, M., C.V. Rao, P.M. Rao and D.B. Raju, 2006. Evaluation of antimicrobial activity of Cleome viscosa and Gmelina asiatica. Fitoterapia, 77: 47-49.
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  46. Sudhakar, M., C.V. Rao, A.L. Rao, A. Ramesh, N. Srinivas, D.B. Raju and B.K. Murthy, 2004. Antinociceptive and anti-inflammatory effects of the standardized oil of Indian Callistemon lanceolatus leaves in experimental animals. East Central Afr. J. Pharm. Sci., 7: 10-15.
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  47. Devi, P.A., P.M. Rao, K.M.M. Krishna Prasad and C.S.P. Sastry, 2003. Four simple spectrophotometric methods of determination of lisinopril in pure state and in tablets. Indian J. Pharm. Sci., 65: 296-299.
  48. Rao, P.M., A.P. Devi, P.K. Krishna and C.S.P. Sastry, 2002. A note on the estimation of clomiphene citrate and pimozide in bulk forms and pharmaceutical formulations by precipitation reagents. Indian Drugs, 39: 395-397.
  49. Katyayani, B.M., P.M. Rao, G. Muralichand, D.S. Rao and T. Satyanarayana, 2002. Antimicrobial activity of bark of Alangium salvifoloium Linn. F. Indian J. Microbiol., 42: 87-89.
  50. Madhu, K.B., P. Rao Mallikarjuna, P. Balakrishna, T. Vedavathi and T. Satyanarayana, 2001. Antimicrobial potential of Gmelina asiatica leaves and Bauhinia Vahlii pods. Indian Drugs-Bombay, 38: 299-302.
  51. Mallikarjuna, P., V.U. Maheswara Rao and T. Satyanarayana, 1999. Antimicrobial activity of Zanthoxylum limonella stem. Indian Drugs, 36: 476-478.
  52. Rao, R.K., R. Jena and P.M. Rao, 1997. Studies on hepatoprotective activity of Vitex leucoxylon L. Ancient Sci. Life, 17: 128-134.
  53. Rao, R.K., G.P.M. Rao and B.G. Rao, 1997. Anti-inflammatory activity of the leaves and bark of Delonix elata. Ancient Sci. Life, 17: 141-143.
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