Dr. Gaurisankar Sa
My Social Links

Dr. Gaurisankar Sa

Professor
Bose Institute, India


Highest Degree
Ph.D. in Biochemistry from University of Calcutta, India

Share this Profile

Biography

Dr. Gaurisankar Sa is currently working as Senior Professor of Molecular Medicine, Division of Molecular Medicine, Bose Institute, WB, India. His area of research interest and expertise are Biochemistry, Molecular biology, Cell signaling, Cancer biology, Cancer stem cell, Tumor Immunology, Drug development. He completed his PhD in 1989 in Biochemistry from Calcutta University. He received number of Achievements at Departmental level and in Research Projects. He is serving as Associate Editor/Editorial Board Member/ Ad-hoc Reviewer of more than 10 scientific journals. His prior work experience includes Assistant Professor, Senior Assistant Professor, Associate Professor, Full Professor at Bose Institute, India. He published 84 research articles in national and international peer reviewed journals. He is author and reviewer of 13 book chapters. He is also 2 patent holder and has a patent on “Curcumin: an anti-cancer drug from plant source” in his credit which is on the process of commercialization.

Area of Interest:

Molecular Sciences
100%
Biochemistry
62%
Cancer Biology
90%
Cell Culture
75%
Tumor Biology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
117
Abstracts
0

Selected Publications

  1. Saha, T. and G. Sa, 2017. Constraint-driven docking: a logistic docking approach for deriving protein-protein complex structure. Nat. Protoc. Exch., 10.1038/protex.2017.011.
    CrossRef  |  Direct Link  |  
  2. Panda, A.K., D. Chakraborty, I. Sarkar, T. Khan and G. Sa, 2017. New insights into therapeutic activity and anticancer properties of curcumin. J. Exp. Pharm., 9: 31-45.
    CrossRef  |  Direct Link  |  
  3. Chakraborty, S., A.K. Panda, S. Bose, D. Roy, K. Kajal, D. Guha and G. Sa, 2017. Transcriptional regulation of FOXP3 requires integrated activation of both promoter and CNS regions in tumor-induced CD8+ Treg cells. Sci. Rep., Vol. 7.No. 1. 10.1038/s41598-017-01788-z.
    CrossRef  |  Direct Link  |  
  4. Saha, T., D. Guha, A. Manna, A.K. Panda, J. Bhat, S. Chatterjee and G. Sa, 2016. G-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53. Sci. Rep., Vol. 6. 10.1038/srep32626.
    CrossRef  |  Direct Link  |  
  5. Ray, P., D. Guha, J. Chakraborty, S. Banerjee, A. Adhikary, S. Chakraborty, T. Das and G. Sa, 2016. Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer. Sci. Rep.,Vol. 6. 10.1038/srep32979.
    CrossRef  |  Direct Link  |  
  6. Saha, T., R.K. Kar and G. Sa, 2015. Structural and sequential context of p53: A review of experimental and theoretical evidence. Prog. Biophy. Mol. Biol., 117: 250-263.
    CrossRef  |  Direct Link  |  
  7. Saha, S., S. Mukherjee, M. Majumder, A. Manna and P. Khan, 2015. Mithramycin A sensitizes therapy-resistant breast cancer stem cells toward genotoxic drug doxorubicin. Transl. Res., 165: 558-577.
    CrossRef  |  PubMed  |  Direct Link  |  
  8. Saha, S., P. Bhattacharjee, D. Guha, K. Kajal, P. Khan and S. Chakraborty, 2015. Sulphur alters NFκB-p300 cross-talk in favour of p53-p300 to induce apoptosis in non-small cell lung carcinoma. Int. J. Oncol., 47: 573-582.
    CrossRef  |  PubMed  |  Direct Link  |  
  9. Panda, A.K., S. Bose, S. Banerjee, S. Chakraborty, K. Kajal and G. Sa, 2015. Intratumoral immune landscape: Immunogenicity to tolerogenicity. Austin J. Clin. Immunol., 2: 1-10.
  10. Bose, S., A.K. Panda, S. Mukherjee and G. Sa, 2015. Curcumin and tumor immune-editing: Resurrecting the immune system. Cell Div., 12: 10-16.
    CrossRef  |  Direct Link  |  
  11. Saha, S., P. Bhattacharjee, S. Mukherjee, M. Mazumdar and S. Chakraborty, 2014. Contribution of the ROS-p53 feedback loop in thuja-induced apoptosis of mammary epithelial carcinoma cells. Oncol. Rep., 31: 1589-1598.
    CrossRef  |  PubMed  |  Direct Link  |  
  12. Mohanty, S., S. Saha, D.M. Hossain, A. Adhikary and S. Mukherjee, 2014. ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors. Cell Death Dis.,Vol. 5. 10.1038/cddis.2013.534.
    CrossRef  |  Direct Link  |  
  13. Jana, D., D.K. Sarkar, S. Ganguly, S. Saha, G. Sa, A.K. Manna, A. Banerjee and S. Mandal, 2014. Role of cyclooxygenase 2 (COX-2) in prognosis of breast cancer. Indian J. Surg. Oncol., 5: 59-65.
    CrossRef  |  Direct Link  |  
  14. Hossain, D.M., A.K. Panda, S. Chakrabarty, P. Bhattacharjee and K. Kajal, 2014. MEK inhibition prevents tumour-shed transforming growth factor-β-induced T-regulatory cell augmentation in tumour milieu. Immunology, 144: 561-573.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Das, T. and G. Sa, 2014. Anti-Cancer Effects of Curcumin: Cycle of Life and Death. In: Recent Advances in Plant-Based, Traditional, and Natural Medicines, Vemulpad, S. and J. Jamie (Eds.)., Apple Academic Press, USA, ISBN:9781771880138 pp:151-197..
  16. Chaudhuri, S., M.K. Singh, D. Bhattacharya, S. Acharya and S. Chatterjee et al., 2014. The novel immunotherapeutic molecule T11TS modulates glioma-induced changes of key components of the immunological synapse in favor of T cell activation and glioma abrogation. J. Neurooncol., 120: 19-31.
    CrossRef  |  PubMed  |  Direct Link  |  
  17. Chakraborty, S., K. Das, S. Saha, M. Mazumdar and A. Manna, 2014. Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone deacetylation. J. Biol. Chem., 289: 29074-29085.
    CrossRef  |  PubMed  |  Direct Link  |  
  18. Chakraborty, S., A. Adhikary, M. Mazumdar, S. Mukherjee and P. Bhattacharjee et al., 2014. Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis. PLoS ONE, Vol. 9.No. 6 10.1371/journal.pone.0099743.
    CrossRef  |  Direct Link  |  
  19. Bhattacharjee, P., M. Mazumdar, D. Guha and G. Sa, 2014. Ubiquitination-Proteosome System in the Hallmarks of Cancer. In: Role of Proteases in Cellular Dysfunctions, Dhalla, N.S. and S. Chakraborti (Eds.)., Part II: Chapter 9. Springer Publishing Company New York, USA. ISBN 978-1-4614-9098-2, pp:159-186..
  20. Adhikary, A., S. Chakraborty, M. Mazumdar, S. Ghosh and S. Mukherjee et al., 2014. Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of slug transcription and inhibition of E-cadherin degradation: Dual role of scaffold/matrix attachment region-binding protein 1 (SMAR1) in breast cancer cells. J. Biol. Chem., 289: 25431-25444.
    CrossRef  |  PubMed  |  Direct Link  |  
  21. Saha, S., D.M. Hossain, S. Mukherjee, S. Mohanty and M. Mazumdar, 2013. Calcarea carbonica induces apoptosis in cancer cells in p53-dependent manner via an immuno-modulatory circuit. BMC Complement Altern. Med., Vol. 13:230. 10.1186/1472-6882-13-230.
    CrossRef  |  PubMed  |  Direct Link  |  
  22. Mukherjee, S., S. Ghosh, S. Choudhury, A. Adhikary and K. Manna et al., 2013. Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-κB pathways. J. Nutr. Biochem., 24: 2040-2050.
    CrossRef  |  PubMed  |  Direct Link  |  
  23. Mazumdar, M., A. Adhikary, S. Chakraborty, S. Mukherjee and A. Manna et al., 2013. Targeting RET to induce medullary thyroid cancer cell apoptosis: An antagonistic interplay between PI3K/Akt and p38MAPK/caspase-8 pathways. Apoptosis, 18: 589-604.
    CrossRef  |  PubMed  |  Direct Link  |  
  24. Hossain, D.M., A.K. Panda, A. Manna, S. Mohanty and P. Bhattacharjee, 2013. FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells. Immunity, 30: 1057-1069.
    CrossRef  |  PubMed  |  Direct Link  |  
  25. Saha, S., A. Adhikary, P. Bhattacharyya, T. DAS and G. Sa, 2012. Death by Design: Where Curcumin Sensitizes Drug-Resistant Tumours. Anticancer Res., 32: 2567-2584.
    PubMed  |  Direct Link  |  
  26. Mohanty, S., A. Adhikary, S. Chakrabarty, G. Sa and T. Das, 2012. Operation 'p53 Hunt' to Combat Cancer: Theaflavins in Action. Front. Biosci., 4: 300-320.
    CrossRef  |  PubMed  |  Direct Link  |  
  27. Hossain, D.M., S. Mohanty, P. Ray, T. Das and G. Sa, 2012. Tumor Gangliosides and T Cells: a Deadly Encounter. Front. Biosci., 4: 502-519.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Hossain, D.M., S. Bhattacharyya, T. Das and G. Sa, 2012. Curcumin: The Multi-Targeted Therapy for Cancer Regression. Front. Biosci., 4: 335-355.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Ghosh, S., A. Adhikary, S. Chakraborty, P. Nandi and S. Mohanty et al., 2012. Nifetepimine, a Dihydropyrimidone, Ensures CD4+ T Cell Survival in a Tumor Microenvironment by Maneuvering Sarco(endo)plasmic Reticulum Ca2+ ATPase (SERCA). J. Biol. Chem., 287: 32881-32896.
    CrossRef  |  PubMed  |  Direct Link  |  
  30. Sen, G.S., S. Mohanty, D.M. Hossain, S. Bhattacharyya and S. Banerjee et al., 2011. Curcumin Enhances the Efficacy of Chemotherapy by Tailoring p65NFκB-p300 Cross-Talk in Favor of p53-p300 in Breast Cancer. J. Biol. Chem., 286: 42232-42247.
    CrossRef  |  PubMed  |  Direct Link  |  
  31. Saha, B., A. Adhikary, P. Ray, S. Saha and S. Chakraborty et al., 2011. Restoration of Tumor Suppressor p53 by Differentially Regulating Pro- and Anti-p53 Networks in HPV-18-Infected Cervical Cancer Cells. Oncogene, 31: 173-186.
    CrossRef  |  PubMed  |  Direct Link  |  
  32. Sa, G., T. Das, S. Banerjee and J. Chakraborty, 2010. Curcumin: From exotic spice to modern anticancer drug. Al Ameen J. Med. Sci., 3: 21-37.
    Direct Link  |  
  33. Lahiry, L., B. Saha, J. Chakraborty, A. Adhikary and S. Banerjee et al., 2010. Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells. Carcinogenesis, 31: 259-268.
    CrossRef  |  PubMed  |  Direct Link  |  
  34. Das, T., G. Sa, B. Saha and K. Das, 2010. Multifocal signal modulation therapy of cancer: Ancient weapon, modern targets. Mol. Cell. Biochem., 336: 85-95.
    CrossRef  |  PubMed  |  Direct Link  |  
  35. Chakraborty, J., S. Banerjee, P. Ray, D.M. Hossain and S. Bhattacharyya et al., 2010. Gain of Cellular Adaptation Due to Prolonged p53 Impairment Leads to Functional Switchover from p53 to p73 During DNA Damage in Acute Myeloid Leukemia Cells. J. Biol. Chem., 285: 33104-33112.
    CrossRef  |  PubMed  |  Direct Link  |  
  36. Bhattacharyya, S., D.M.S. Hossain, S. Mohanty, S.G. Sankar and S. Chattopadhyay et al., 2010. Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts. Cell. Mol. Immunol., 7: 306-315.
    CrossRef  |  PubMed  |  Direct Link  |  
  37. Sa, G., T. Das, P. Roy, S. Banerjee and J. Chakraborty, 2009. Oncogenes as Molecular Target for Curcumin-Induced Cancer Cell Apoptosis. Prospective Cytol. Genet., 14: 95-104.
  38. Sa, G., T. Das, C. Moon, C.M. Hilston, P.A. Rayman and B.I. Rini et al., 2009. GD3, an overexpressed tumor-derived ganglioside, mediates the apoptosis of activated but not resting T cells. Cancer Res., 69: 3095-3104.
    CrossRef  |  PubMed  |  Direct Link  |  
  39. Parton, M., T. Das, G. Sa, J. Finke, T. Eisen and C. Tannenbaum, 2009. Tumour Necrosis Factor - Misnomer and Therapeutic Target. In: Targeted Therapy for Renal Cell Carcinoma, Bukowski, R. (Ed.). Springer Publishing Co., New York, pp: 425-448.
    CrossRef  |  Direct Link  |  
  40. Das, T., G. Sa, S. Saha, S. Mukherjee, M. Mazumdar and S. Mukherjee, 2009. 2009. p53, a tumor suppressor at the crossroads of the oncogenic networks in cancer: Targeting the ‘guardian of the genome’. Prospective Cytol. Genet., 14: 85-94.
  41. Chattopadhyay, S., S. Bhattacharyya, B. Saha, J. Chakrabarty and S. Mohanty et al., 2009. Tumor-shed PGE2 impairs IL2Rγc-signaling to inhibit CD4+ T cell survival: Regulation by theaflavins. PLoS One, 4: e7382-e7382.
    CrossRef  |  PubMed  |  Direct Link  |  
  42. Chatterjee, S., A. Mookerjee, J.M. Basu, P. Chakraborty and A. Ganguly et al., 2009. A novel copper chelate modulates tumor associated macrophages to promote anti-tumor response of T cells. PLoS One, 4: e7048-e7048.
    CrossRef  |  PubMed  |  Direct Link  |  
  43. Sa, G., T. Das and C. Tannenbaum, 2008. Immune evasion by tumor: Lets get back to the root of the problem. Anticancer Res., 28: 3466-3467.
  44. Sa, G. and T. Das, 2008. Anti cancer effects of curcumin: Cycle of life and death. Cell Div., 3: 14-14.
    CrossRef  |  PubMed  |  Direct Link  |  
  45. Lahiry, L., B. Saha, J. Chakraborty, S. Bhattacharyya and S. Chattopadhyay et al., 2008. Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis. Apoptosis, 13: 771-781.
    CrossRef  |  PubMed  |  Direct Link  |  
  46. Das, T., G. Sa, S. Chattopadhyay and B. Saha, 2008. Black tea: The future panacea for cancer. Al AmeenJ. Med. Sci., 1: 70-83.
    Direct Link  |  
  47. Das, T., G. Sa, E. Paszkiewicz-Kozik, C. Hilston and L. Molto et al., 2008. Renal cell carcinoma tumors induce T cell apoptosis through receptor-dependent and receptor-independent pathways. J. Immunol., 180: 4687-4696.
    PubMed  |  Direct Link  |  
  48. Das, T., G. Sa, C. Tannenbaum and S. Chattopadhyay, 2008. A multi-targeted therapy for cancer: An age-old remedy for an age-old disease. Anticancer Res., 28: 3252-3252.
  49. Das, T., G. Sa, C. Hilston, D. Kudo and P. Rayman et al., 2008. GM1 and TNFa, overexpressed in renal cell carcinoma, synergize to induce T cell apoptosis. Cancer Res., 68: 2014-2023.
    CrossRef  |  PubMed  |  Direct Link  |  
  50. Raval, G., S. Biswas, P. Rayman, K. Biswas and G. Sa et al., 2007. TNF-α induction of GM2 expression on renal cell carcinomas promotes T cell dysfunction. J. Immunol., 178: 6642-6652.
    PubMed  |  Direct Link  |  
  51. Mandal, D., S. Bhattacharyya, L. Lahiry, S. Chattopadhyay, G. Sa and T. Das, 2007. Black tea-induced decrease in IL-10 and TGF-β of tumor cells promotes Th1/Tc1 response in tumor bearer. Nutr. Cancer, 58: 213-221.
    CrossRef  |  PubMed  |  Direct Link  |  
  52. Chattopadhyay, S., B. Saha, D. Mandal, G. Sa and T. Das, 2007. Black Tea: A Review. In: Economic Crisis in Tea Industry: Strategies for Scientific Management, Rahman, F. and P. Baker (Eds.). Studium Press, USA.
  53. Bhattacharyya, S., D. Mandal, G.S. Sen, S. Pal and S. Banerjee et al., 2007. Tumor-induced oxidative stress perturbs nuclear factor-κB activity-augmenting tumor necrosis factor-α-mediated T-cell death: Protection by curcumin. Cancer Res., 67: 362-370.
    CrossRef  |  PubMed  |  Direct Link  |  
  54. Bhattacharyya, S., D. Mandal, B. Saha, G.S. Sen, T. Das and G. Sa, 2007. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. J. Biol. Chem., 282: 15954-15964.
    CrossRef  |  PubMed  |  Direct Link  |  
  55. Bhattacharyya, A., D. Mandal, L. Lahiry, S. Bhattacharyya and S. Chattopadhyay et al., 2007. Black tea-induced amelioration of hepatic oxidative stress through antioxidative activity in EAC-bearing mice. J. Environ. Pathol. Toxicol. Oncol., 26: 245-254.
    CrossRef  |  PubMed  |  Direct Link  |  
  56. Sa, G., S. Pal and T. Choudhuri, 2006. Curcumin: A Journey from Spice to Cancer Chemoprevention. In: Emerging Pollutants: Impact on Agriculture, Environment and Health, De A. and S. Gupta (Eds.). Allied Publishers, India, pp: 139-153.
  57. Mookerjee, A., J.M. Basu, P. Dutta, S. Majumder and S. Bhattacharyya et al., 2006. Overcoming drug-resistant cancer by a newly developed copper chelate through host-protective cytokine-mediated apoptosis. Clin. Cancer Res., 12: 4339-4349.
    CrossRef  |  PubMed  |  Direct Link  |  
  58. Dasgupta, R., I. Saha, S. Pal, A. Bhattacharyya and G. Sa et al., 2006. Immunosuppression, hepatotoxicity and depression of antioxidant status by arecoline in albino mice. Toxicology, 227: 94-104.
    CrossRef  |  PubMed  |  Direct Link  |  
  59. Das, T., G. Sa and M. Siddiqi, 2006. Potential Targets of Tea Polyphenols in Cancer Prevention: Significance in Angiogenesis, Metastasis and Apoptosis as Well as in Protection of Host Defense System. In: Protective Effects of Tea on Human Health, Weisberger, J., N.K. Jain and M. Siddiqi (Eds.). Cabi, London, pp: 76-90.
  60. Biswas, K., A. Richmond, P. Rayman, S. Biswas and M. Thornton et al., 2006. GM2 Expression in renal cell carcinoma: Potential role in tumor-induced T-cell dysfunction. Cancer Res., 66: 6816-6825.
    CrossRef  |  PubMed  |  Direct Link  |  
  61. Sa, G., Y. Guo and D.W. Stacey, 2005. The Regulation of S Phase Initiation by p27Kip1 in NIH3T3 Cells. Cell Cycle, 4: 611-620.
    CrossRef  |  PubMed  |  Direct Link  |  
  62. Pal, S., S. Bhattacharyya, T. Choudhuri, G.K. Datta, T. Das and G. Sa, 2005. Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin. Cancer Detect. Prevent., 29: 470-478.
    CrossRef  |  PubMed  |  Direct Link  |  
  63. Naha, N., G. Sa, V. Ganesan, R. Bhar and A.R. Chowdhury, 2005. Is occupational lead exposure detrimental to human spermatozoa? A question of recent concern. J. CMS, 2: 105-110.
  64. Mandal, D., L. Lahiry, A. Bhattacharyya, S. Chattopadhyay and M. Siddiqi et al., 2005. Black tea protects thymocytes in tumor-bearing animals by differential regulation of intracellular ROS in tumor cells and thymocytes. J. Environ. Toxicol. Pathol. Oncol., 24: 91-104.
    CrossRef  |  PubMed  |  Direct Link  |  
  65. Mandal, D., A. Bhattacharyya, L. Lahiry, G. Sa and T. Das, 2005. Failure in peripheral immuno-surveillance due to thymic atrophy: Importance of thymocyte maturation and apoptosis in adult tumor-bearer. Life Sci., 77: 2703-2716.
    CrossRef  |  PubMed  |  Direct Link  |  
  66. Mandal, D., L. Lahiry, A. Bhattacharyya, S. Bhattacharyya, G. Sa and T. Das, 2005. Tumor-Induced Thymic Involution Via Inhibition of IL-7Rα and its JAK-STAT Signaling Pathway: Protection by Black Tea. Int. Immunopharmacol, 6: 433-444.
    CrossRef  |  PubMed  |  Direct Link  |  
  67. Lahiry, L., D. Mandal, A. Bhattacharyya, G. Sa and T. Das, 2005. Cancer Prevention by Cancer Regression and Rejuvenation of Host Defense System: Dual Role of Tea. In: Tea Therapeutics, Banerjee, B. and T.C. Chaudhury (Eds.). Science Publishers, UK., pp: 89-112.
  68. Choudhuri, T., S. Pal, T. Das and G. Sa, 2005. Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner. J. Biol. Chem., 280: 20059-20068.
    CrossRef  |  PubMed  |  Direct Link  |  
  69. Bhattacharyya, A., L. Lahiry, D. Mandal, G. Sa and T. Das, 2005. Black tea induces tumor cell apoptosis by Bax translocation, loss in mitochondrial transmembrane potential, cytochrome c release and caspase activation. Int. J. Cancer, 117: 308-315.
    CrossRef  |  PubMed  |  Direct Link  |  
  70. Bandyopadhyay, S., A. Bhattacharyya, A. Mallick, A.K. Sen and G. Tripathiet al., 2005. Over expressed IgG2 antibodies against O-acetylated sialoglycoconjugates incapable of proper effector functioning in childhood acute lymphoblastic leukemia. Int. Immunol., 17: 177-191.
    CrossRef  |  PubMed  |  Direct Link  |  
  71. Sa, G. and D.W. Stacey, 2004. P27 expression is regulated by separate signaling pathways, downstream of Ras, in each cell cycle phase. Exp. Cell. Res., 300: 427-439.
    CrossRef  |  PubMed  |  Direct Link  |  
  72. Mandal, D., L. Lahiry, A. Bhattacharyya, A. Bhattacharyya, G. Sa and T. Das, 2004. Pharmacotherapeutics of tea: Proposed strategies and pharmacological studies. Int. J. Tea Sci., 3: 261-272.
  73. Bhattacharyya, A., D. Mandal, L. Lahiry, G. Sa and T. Das, 2004. Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio. Cancer Lett., 209: 147-154.
    PubMed  |  
  74. Sa, G., M. Hitomi, J. Harwalkar, A.W. Stacey, G. Chen and D.W. Stacey, 2003. Ras is active throughout the cell cycle, but is able to induce cyclin D1 only during G2 phase. Cell Cycle, 1: 46-54.
    CrossRef  |  PubMed  |  Direct Link  |  
  75. Bhattacharyya, A., T. Choudhuri, S. Pal, S. Chattopadhyay, G.K. Datta G. Sa and T. Das, 2003. Apoptogenic effects of black tea on Ehrlich's ascites carcinoma cell. Carcinogenesis, 24: 75-80.
    CrossRef  |  PubMed  |  Direct Link  |  
  76. Bhattacharyya, A., G. Sa, T. Das and M. Siddiqi, 2003. Black tea-induced cellular survival: Evidence for reduced toxicity and enhanced immunity in mice under stress. Int. J. Tea Sci., 2: 34-39.
  77. Ghosh, S., S. Bhattacharyya, M. Sirkar, G.S. Sa, T. Das, D. Majumdar, S. Roy and S. Majumdar, 2002. Leishmania donovani suppresses activated protein 1 and NF-κB activation in host macrophages via ceramide generation: Involvement of extracellular signal-regulated kinase. Infect Immunol., 70: 6828-6838.
    CrossRef  |  PubMed  |  Direct Link  |  
  78. Das, T., G. Sa, S. Chattopadhyay and P.K. Ray, 2002. Protein a-induced apoptosis of cancer cells is effected by soluble immune mediators. Cancer Immunol. Immunotherapy, 51: 376-380.
    CrossRef  |  PubMed  |  Direct Link  |  
  79. Choudhuri, T., S. Pal, M.L. Aggarwal, T. Das and G. Sa, 2002. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett., 512: 334-340.
    CrossRef  |  PubMed  |  Direct Link  |  
  80. Chattopadhyay, S., T. Das, G. Sa and P.K. Ray, 2002. Protein a-activated macrophages induce apoptosis in Ehrlich's ascites carcinoma through a nitric oxide-dependent pathway. Apoptosis, 7: 49-57.
    CrossRef  |  PubMed  |  Direct Link  |  
  81. Ray, P.K., T. Das and G. Sa, 2001. How to Activate Intrinsic Stress Resistance Mechanisms to Obtain Thera-Peutic Benefit. In: Cell and Molecular Responses to Stress, Storey, J.M. and K.B. Storey (Eds.). Volume 2, Elsevier Science, USA., pp: 195-202.
  82. Pal, S., T. Choudhuri, S. Chattopadhyay, A. Bhattacharya, G.K. Datta, T. Das and G. Sa, 2001. Mechanisms of curcumin-induced apoptosis of Ehrlich's ascites carcinoma cells. Biochem. Biophys. Res. Commun., 288: 658-665.
    CrossRef  |  PubMed  |  Direct Link  |  
  83. Ray, P.K., T. Das, G. Sa, A.K. Ghosh and S. Chattopadhyay, 2000. Protection of apoptotic cell death by protein A. Apoptosis, 5: 509-514.
    CrossRef  |  PubMed  |  Direct Link  |  
  84. Das, T., G. Sa, V. Subbulakshmi, S. Subramaniam, P.C. Sen, S. Biswas and P.K. Ray, 2000. Protein a-activated rat splenic lymphocyte proliferation involves tyrosine kinase-phospholipase C-protein kinase C pathway. Immunopharmacol. Immunotoxicol., 22: 75-90.
    CrossRef  |  PubMed  |  Direct Link  |  
  85. Sinha, P., A.K. Ghosh, T. Das, G. Sa and P.K. Ray, 1999. Protein A of Staphylococcus aureus evokes Th1 type response in mice. Immunol. Lett., 67: 157-165.
    CrossRef  |  PubMed  |  Direct Link  |  
  86. Sa, G. and T. Das, 1999. Basic fibroblast growth factor stimulates phospholipase A2, phospholipase C-γ1 and phospholipase D through distinguishable signaling mechanisms. Mol. Cell. Biochem., 198: 19-30.
    PubMed  |  
  87. Ghosh, A.K., S. Jana, T. Das, G. Sa, N. Mondal and P.K. Ray, 1999. Protection by protein A of apoptotic cell death caused by anti-AIDS drug zidovudine. Biochem. Biophys. Res. Commun., 264: 601-604.
    CrossRef  |  PubMed  |  Direct Link  |  
  88. Ghosh, A.K., P. Sinha, T. Das, G. Sa and P.K. Ray, 1999. S. aureus superantigen protein A expands CD4+/CD8+/CD19+/CD34+ cells in mice: a potential immunorestorer. Biochem. Biophys. Res. Commun., 256: 142-146.
    CrossRef  |  PubMed  |  Direct Link  |  
  89. Das, T., G. Sa, P. Sinha and P.K. Ray, 1999. Induction of Cell Proliferation and Apoptosis: Dependence on the Dose of the Inducer. Biochem. Biophys. Res. Commun., 260: 105-110.
    CrossRef  |  PubMed  |  Direct Link  |  
  90. Das, T., G. Sa and P.K. Ray, 1999. Mechanisms of protein a superantigen-induced signal transduction for proliferation of mouse B cell. Immunol. Lett., 70: 43-51.
    CrossRef  |  PubMed  |  Direct Link  |  
  91. Ray, P.K., T. Das, V. Subbulakshmi, A.K. Ghosh, G. Sa, P. Sinha and P. Dasgupta, 1999. Immunophar Macological Modulation of Host Response to Increase Therapeutic Index of Drugs. In: Immunopharmacology: Strategies for immunotherapy, Upadhyay, S.N. (Ed.). Narosa Press, India, PP: 72-83.
  92. Ray, P.K., S. Goenka, T. Das, G. Sa, P. Sinha and M. Srivastava, 1998. Role of Nitric Oxide in Immune Function and Amelioration of Toxicity and Carcinogenicity of Drugs and Chemicals. In: In: Biological Oxidants and Anti-Oxidants: Molecular Mechanisms and Health Effects, Packer, L., (Ed.). Ch. 7, AOCS Press, USA, pp: 42-53.
  93. Goenka, S., T. Das, G. Sa and P.K. Ray, 1998. Protein A induces NO production: Involvement of tyrosine kinase, phospholipase C, and protein kinase C. Biochem. Biophys. Res. Commun., 250: 425-429.
    CrossRef  |  PubMed  |  Direct Link  |  
  94. Sa, G., G. Murugesan, M. Jaye, Y. Ivashenko and P.L. Fox, 1995. Activation of cytosolic phospholipase A2 by basic fibroblast growth factor via a p42 mitogen-activated protein kinase-dependent phosphorylation pathway in endothelial cells. J. Biol. Chem., 270: 2360-2366.
    CrossRef  |  PubMed  |  Direct Link  |  
  95. Bandhopadhyay, A.K., T. Das, G. Sa and M. Mukherjea, 1995. Relationship between glycerol-3-phosphate dehydrogenase, fatty acid synthase and fatty acid binding proteins of developing human placenta. J. Biosci., 20: 141-149.
    CrossRef  |  Direct Link  |  
  96. Sa, G. and P.L. Fox, 1994. Basic fibroblast growth factor-stimulated endothelial cell movement is mediated by a pertussis toxin-sensitive pathway regulating phospholipase A2 activity. J. Biol. Chem., 269: 3219-3225.
    PubMed  |  Direct Link  |  
  97. Murugesan, G., G. Sa and P.L. Fox, 1994. High-density lipoprotein stimulates endothelial cell movement by a mechanism distinct from basic fibroblast growth factor. Circulation Res., 74: 1149-1156.
    CrossRef  |  PubMed  |  Direct Link  |  
  98. Fox, P.L., G. Sa, S.F. Dobrowolski and D.W. Stacey, 1994. The regulation of endothelial cell motility by p21 ras. Oncogene, 9: 3519-3526.
    PubMed  |  
  99. Bandhopadhyay, A.K., T. Das, G.S. Sa and M. Mukherjea, 1994. Effect of fatty acid binding proteins on developing human placental malate dehydrogenase activity. Indian J. Exp. Biol., 32: 800-803.
    PubMed  |  
  100. Bandhopadhyay, A.K., T. Das, G. Sa and M. Mukherjea, 1994. Effect of fatty acid bind¬ing protein on cytosolic malate dehydrogenase of developing human placenta. Indian J. Experi. Biol., 32: 800-803.
    PubMed  |  Direct Link  |  
  101. Sa, G.S., T. Das and M. Mukherjea, 1993. The evaluation of lung maturity by lecithin, L/S and PG/PI ratios in human fetus. Med. Sci. Res., 21: 365-366.
  102. Sa, G.S., T. Das and M. Mukherjea, 1993. Characterization and binding properties of human fetal lung fatty acid-binding proteins. Mol. Cell Biochem., 129: 67-75.
    CrossRef  |  PubMed  |  Direct Link  |  
  103. Sa, G.S. and P.L. Fox, 1993. Basic fibroblast growth factor-mediated migration and proliferation of endothelial cells are distinguished by pertussis toxin. FASEB J., 7: A1-A2.
  104. Fox, P.L., G.M. Chisolm, G. Murugesan and G.S. Sa, 1993. Regulation of endothelial cell migra-tion by plasma lipoproteins. Annu. Biomed. Eng., 21: 1-31.
  105. Das T., G.S. Sa and M. Mukherjea, 1993. Characterization of cardiac fatty-acid-binding protein from human placenta. Comparison with placenta hepatic types. Eur. J. Biochem., 211: 725-730.
    CrossRef  |  PubMed  |  Direct Link  |  
  106. Mukhopadhyay, D., T. Das, G. Sa, P.K. Ghosh and M. Mukherjea, 1992. Isolation of fatty acid binding protein from developing human fetal brain. Med. Sci. Res., 20: 641-642.
  107. Ghosh, P.K., T. Das, G.S. Sa and M. Mukherjea, 1992. Gestational variation in the fluidity of human placental brush border membrane assessed by a liposomal transfer study. Med. Sci. Res., 20: 705-706.
    Direct Link  |  
  108. Sa, G.S., M. Chatterjee, P.K. Das and A. Nandy, 1991. Perception of biotechnology amongst Indian biologists. Indian Biologist, 28: 53-57.
  109. Das, T., G.S. Sa, A.K. Bandhopadhyay and M. Mukherjea, 1991. Relationship between fatty acid binding proteins, acetyl-CoA formation and fatty acid synthesis in developing human placenta. J. Biosci., 16: 235-242.
    CrossRef  |  Direct Link  |  
  110. Chatterjee, M., G.S. Sa, A.G. Datta, A.N. Bhaduri, P.K. Das and A. Nandy, 1991. Perception of biotechnology amongst non-biologists in India. Everymans Sci., 26: 48-50.
  111. Sa, G.S., T. Das and M. Mukherjea, 1990. Relationship between fatty acid synthesis, transport and total lipid content during human fetal lung development. Indian J. Biochem. Biophys., 27: 43-47.
    PubMed  |  
  112. Sa, G.S., T. Das and M. Mukherjea, 1989. Purification and characterization of fatty acid-binding proteins from human fetal lung. Exp. Lung Res., 15: 619-632.
    CrossRef  |  PubMed  |  Direct Link  |  
  113. Das, T., G.S. Sa, P.K. Ghosh, D. Mukhopadhyay and M. Mukherjea, 1989. Isolation of fatty acid-binding protein from human fetal intestine and heart: Comparison with corresponding hepatic proteins. Med. Sci. Res., 17: 985-986.
  114. Das, T., G.S. Sa and M. Mukherjea, 1989. Human fetal liver fatty acid binding proteins. Role on glucose-6-phosphate dehydrogenase activity. Biochim. Biophys. Acta, 1002: 164-172.
    CrossRef  |  PubMed  |  Direct Link  |  
  115. Das, T., G. Sa, P.K. Ghosh, D. Mukhopadhyay and M. Mukherjea, 1989. Isolation of fatty acid binding protein from human fetal intestine and heart: Comparison with corresponding hepatic proteins. Med. Sci. Res., 17: 985-986.
  116. Das, T., G.S. Sa and M. Mukherjea, 1988. Purification and characterization of fatty acid-binding protein from human placenta. Lipids, 23: 528-533.
    CrossRef  |  PubMed  |  Direct Link  |  
  117. Sa, G.S., T. Das and M. Mukherjea, 1987. Ontogenic profile and properties of glucose-6-phosphate dehydrogenase in human fetal tissues. Indian J. Biochem. Biophys., 23: 133-135.
    PubMed  |