Dr. Jamal M.  Arif

Dr. Jamal M. Arif

Professor
University of Hail, Saudi Arabia


Highest Degree
Ph.D. in Biochemical Toxicology from University of Hail, Saudi Arabia

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Area of Interest:

Pharmacology and Toxicology
100%
Biochemical Toxicology
62%
Carcinogenesis
90%
Oncology
75%
Cancer Prevention
55%

Selected Publications

  1. Suhail S., D. Biswas, A. Farooqui, J.M. Arif and M. Zeeshan, 2011. Antibacterial and free radical scavenging potential of some cyanobacterial strains and their growth characteristics. J. Chem. Pharm. Res., 3: 472-478.
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  2. Siddiqui, M.H., K. Kapoor, K.K. Kesari, R. Prasad and J.M. Arif, 2011. Evaluation of antimicrobial potential of synthesized dibromotyrosine analogs using in vitro and in silico approaches. J. Chem. Pharm. Res., 3: 414-427.
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  3. Siddiqui, M.H., A. Kumar, A. Farooqui, K.K. Kesari and J.M. Arif, 2011. Biodiesel production from crude oil of Jatropha curcas and Pongamia pinnata by transesterification process. Int. J. Oil Gas Coal Technol., 4: 192-206.
    CrossRef  |  
  4. Siddiqui, H., M. Ashquin, R. Prasad, J.M. Arif, T.N. Patil and I. Ahmad, 2011. Industrial hygiene and toxicity studies in unorganized bone-based industrial units. Environ. Monit. Assess., 176: 213-223.
    PubMed  |  
  5. Rizvi, S.M.D., M. Zeeshan, S. Khan, D. Biswas, O.A. Al-Sagair and J.M. Arif, 2011. Evaluation and distribution of antibacterial potential in the aerial parts of wild Tridax procumbens. J. Chem. Pharm. Res., 3: 80-87.
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  6. Rizvi, S.M.D., D. Biswas, J.M. Arif and M. Zeeshan, 2011. In vitro antibacterial and antioxidant potential of leaf and flower extracts of Vernonia cinerea and their phytochemical constituents. Int. J. Pharm. Sci. Rev. Res., 9: 164-169.
  7. Kuddus, M., Roohi, J.M. Arif and P.W. Ramteke, 2011. An overview of cold-active microbial α-amylase: Adaptation strategies and biotechnological potentials. Biotechnology, 10: 246-258.
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  8. Khan, M.S., S. Akhtar, O.A. Al-Sagair and J.M. Arif, 2011. Protective effect of dietary tocotrienols against infection and inflammation-induced hyperlipidemia: An in vivo and in silico study. Phytother. Res. 10.1002/ptr.3448.
    CrossRef  |  
  9. Khan, M.S., M.K.A. Khan, M.H. Siddiqui and J.M. Arif, 2011. An in vivo and in silico approach to elucidate the Tocotrienol-mediated fortification against infection and inflammation induced alterations in antioxidant defense system. Eur. Rev. Med. Pharmacol. Sci., 15: 916-930.
    PubMed  |  
  10. Khan, M.K.A., S. Akhtar, M.H. Siddiqui, O.A. Al-Sagair and J.M. Arif, 2011. Insilico elucidation and validation of metabolic activation/detoxification process of dibenzo [a,l] pyrene and its metabolites using AutoDock Tools 4.0. J. Chem. Pharm. Res., 3: 753-756.
  11. Khan, M.K.A., S. Akhtar and J.M. Arif, 2011. Homology modeling of CYP1A1, CYP1B1 and its subsequent molecular docking studies with resveratrol and its analogues using AutoDock Tools 4.0. Biochem. Cell. Arch., 11: 49-55.
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  12. Farooqui, A., S. Suhail, J.M. Arif and M. Zeeshan, 2011. Antioxidants enzyme activity, total phenols and proline content in Nostoc muscorum exposed to metal stress. Biochem. Cell. Arch., 11. .
  13. Arif, J.M., M.K.A. Khan, M.S. Khan, M.H. Siddiqui, S.A. Siddiqui and K.V. Srinivasan, 2011. An Insilico elucidation of inhibition of cathepsin D by 2, 4, 5-triaryl imidazole derivatives. Biomirror. 2: 1-8/bm-0305061011. .
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  14. Arif, J.M., A.M. Al-Saif, M.A. Al-Karrawi and O.A. Al-Sagair, 2011. Causative relationship between diabetes mellitus and breast cancer in various regions of Saudi Arabia: An overview. Asian Pacific J. Cancer Prev., 12: 589-592.
    PubMed  |  
  15. Aqil, F., M. Zahin, K.A. El Sayed, I. Ahmad, K.Y. Orabi and J.M. Arif, 2011. Antimicrobial, antioxidant, and antimutagenic activities of selected marine natural products and tobacco cembranoids. Drug Chem. Toxicol., 34: 167-179.
    PubMed  |  
  16. Akhtar, S., O.A. Al-Sagair and J.M. Arif, 2011. Novel aglycones of steroidal glycoalkaloids as potent tyrosine kinase inhibitors: Role in VEGF and EGF receptors targeted angiogenesis. Lett. Drug Des. Discovery, 8: 205-215.
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  17. Ahmad, I., H. Siddiqui, M.J. Akhtar, M.I. Khan and G. Patil et al., 2011. Toxic responses in primary rat hepatocytes exposed with occupational dust collected from work environment of bone-based industrial units. Chemosphere, 83: 455-460.
    PubMed  |  
  18. Zeeshan, M., S. Suhail, D. Biswas, A. Farooqui and J.M. Arif, 2010. Screening of selected cyanobacterial strains for phycochemical compounds and biological activities in vitro. Biochem. Cell. Arch., 10: 163-168.
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  19. Saquib, Q., A.A. Al-Khedhairy, B.R. Singh, J.M. Arif and J. Musarrat, 2010. Genotoxic fungicide methyl thiophanate as an oxidative stressor inducing 8-oxo-7,8-dihydro-2'-deoxyguanosine adducts in DNA and mutagenesis. J. Environ. Sci. Health, 45: 40-45.
  20. Kamal, A., J.M. Arif and I.Z. Ahmad, 2010. Potential of Nigella sativa L. seed during different phases of germination on inhibition of bacterial growth. J. Biotech. Pharm. Res., 1: 9-13.
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  21. Al-Saleh, I., I. El-Doush, J.M. Arif, S. Coskun, K. Jaroudi, A. Al-Shahrani and G. El-Din Mohamed, 2010. Levels of DNA adducts in the blood and follicular fluid of women undergoing in vitro fertilization treatment and its correlation with the pregnancy outcome. Bull. Environ. Contam. Toxicol., 84: 23-28.
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  22. Ahmad, I.Z., A. Kamal and J.M. Arif, 2010. Alteration of sugar and protein contents in Nigella sativa L. seeds during different phases of germination. Aspects Applied Biol., 96: 415-420.
  23. Siddiqui, M.H., A. Kumar, K.K. Kesari and J.M. Arif, 2009. Biomining-A useful approach toward metal extraction. Am. Eurasian J. Agron., 2: 84-88.
  24. Salem, M.L., F.Q. Alenzi, N. Nath, S.A. El-Naggar and A.A. Al-Khami et al., 2009. Plasticity of T cell differentiation and cytokine signature: A double-edged sword for immune responses. Immun. Endoc. Metab. Agents Med. Chem., 9: 90-105.
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  25. Al-Enzi, F., M.W. Al-Rabia, B.Q. Al-Enazi, A.M. Mubaraki and M. Lotfy et al., 2009. Role of CTLA-4 in xenotransplantation. Pak. J. Physiol., 5: 40-45.
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  26. Arif, J.M., M. Kunhi, M.P. Subramanian, A.A. Bekhit and O.A. El-Sayed et al., 2008. Cytotoxic and genotoxic potentials of newly synthesized antiviral aminopyrazoloquinoline derivatives. Med. Chem. Res., 17: 297-304.
    CrossRef  |  
  27. Al-Saleh, I., J.M. Arif, I. El-Doush, N. Al-Sanea and A.A. Jabbar et al., 2008. Carcinogen-DNA adducts and the risk of colon cancer: Case-control study. Biomarkers, 13: 201-216.
    PubMed  |  
  28. Al-Johar, D., N. Shinwari, J. Arif, N. Al-Sanea and A.A. Jabbar et al., 2008. Role of Nigella sativa and a number of its antioxidant constituents towards azoxymethane-induced genotoxic effects and colon cancer in rats. Phytother. Res., 22: 1311-1323.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Arif, J.M., S.S. Sawant, K.A. El Sayed, M. Kunhi and M.P. Subramanian et al., 2007. Antiproliferative potential of sarcophine and its semisynthetic sulfur-containing derivatives against human mammary carcinoma cell lines. J. Nat. Med., 61: 154-158.
    CrossRef  |  
  30. Arif, J.M., M. Kunhi, A.A. Bekhit, M.P. Subramanian, K.A. Al-Hussein, H.Y. Aboul-Enein and F.M. Al-Khodairy, 2006. Evaluation of apoptosis-induction by newly synthesized phthalazine derivatives in breast cancer cell lines. Asian Pacific J. Cancer Prev., 7: 249-252.
    PubMed  |  
  31. Arif, J.M., C. Dresler, M.L. Clapper, G.C. Gairola, C. Srinivasan, R.A. Lubet and R.C. Gupta, 2006. Lung DNA adducts detected in human smokers are unrelated to typical polyaromatic carcinogens. Chem. Res. Toxicol., 19: 295-299.
    PubMed  |  
  32. Bekhit, A.A., O.A. El-Sayed, T.A.K. Al-Allaf, H.Y. Aboul-Enein and M. Kunhi et al., 2004. Synthesis, characterization and cytotoxicity evaluation of some new platinum(II) complexes of tetrazolo[1,5-A]quinolines. Eur. J. Med. Chem., 39: 499-505.
    PubMed  |  
  33. Arif, J.M., M. Kunhi, Y.M. Siddiqui, K.A. El-Sayed and K.Y. Orabi et al., 2004. Role of intermediary biomarkers in determining the anticancer efficacy of marine compounds. Med. Chem. Res., 6-7: 553-562.
    CrossRef  |  
  34. Arif, J.M., M. Kunhi, Y.M. Siddiqui, K.A. El-Sayed and K.Y. Orabi et al., 2004. Differential modulation of benzo[a]pyrene-derived DNA adducts in MCF-7 cells by marine compounds. Int. J. Cancer Prev., 1: 259-268.
  35. Arif, J.M., A.A. Al-Hazzani, M. Kunhi and F.M. Al-Khodairy, 2004. Novel marine compounds: Anticancer or genotoxic? J. Biomed. Biotech., 2: 93-98.
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  36. Al-Khodairy, F.M., M. Kunhi, Y.M. Siddiqui, J.M. Arif, M.N. Al-Ahdal and M.A. Hannan, 2004. Deficiency n the repair of UV induced DNA damage in the cultured normal skin fibroblasts from thyroid cancer patients. Asian. Pac. J. Cancer Prev., 5: 137-141.
  37. Arif, J.M., H.J. Lehmler, L.W. Robertson and R.C. Gupta, 2003. Identification of DNA adducts of benzo- and hydroquinones of polychlorinated biphenyls. Chem. Biol. Interact., 142: 307-316.
  38. Arif, J.M. and R.C. Gupta, 2003. Artifactual formation of 8-oxo-2'-deoxyguanosine: Role of fluorescent light and inhibitors. Oncol. Rep., 10: 2071-2074.
    PubMed  |  
  39. Srinivasan, P., M.V. Vadhanam, J.M. Arif and R.C. Gupta, 2002. A rapid screening assay for antioxidant potential of natural and synthetic agents in vitro. Int. J. Oncol., 20: 983-986.
    PubMed  |  
  40. Smith, W.A., J.M. Arif and R.C. Gupta, 2001. 1,2-Dithioe-3-thione and its structural analogue oltipraz are potent inhibitors of dibenzo[a,l]pyrene-DNA adduction in female Sprague-Dawley rats. Int. J. Cancer, 91: 132-136.
  41. Gupta, R.C. and J.M. Arif, 2001. An improved 32P-postlabeling assay for the sensitive detection of 8-oxo-2'-deoxyguanosine in tissue DNA. Chem. Res. Toxicol., 14: 951-957.
    CrossRef  |  
  42. Arif, J.M., M.V. Vadhanam, A.J.L. de Groot, A.A. van Zeeland, G.C. Gairola and R.C. Gupta, 2001. Effect of cigarette smoke exposure on the modulation of 8-oxo-2'-deoxyguanosine (8-oxodG) in rat lungs as measured by 32P-postlabeling-TLC and HPLC-ECD. Int. J. Oncol., 19: 763-766.
  43. Robertson, L.W., P. Espandiari, H.J. Lehmler, D. Pereg AND A. Srinivasan et al., 2000. Metabolism and activation of polychlorinated biphenyls (PCBs). Cent. Eur. J. Publ. Health, 8: 14-15.
    PubMed  |  
  44. Arif, J.M., C.G. Gairola, G.J. Kelloff, R.A. Lubet and R.C. Gupta, 2000. Inhibition of cigarette smoke-related DNA adducts in rat tissues by indole-3-carbinol. Mut. Res., 452: 11-18.
    PubMed  |  
  45. Gupta, R.C., J.M. Arif and C.G. Gairola, 1999. Enhancement of pre-existing DNA adducts in rodents exposed to cigarette smoke. Mut. Res., 425: 195-205.
    PubMed  |  
  46. Arif, J.M., W.A. Smith and R.C. Gupta, 1999. DNA adduct formation and persistence in rat tissues following exposure to the mammary carcinogen dibenzo[a.l]pyrene. Carcinogenesis, 20: 1147-1150.
    CrossRef  |  
  47. Arif, J.M., N. Shappel, H. Sikka, S. Kumar and R.C. Gupta, 1999. Identification of (±)-3-hydroxy-trans-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-DNA adducts by 32P-postlabeling. Chem. Biol. Interac., 118: 87-97.
  48. Abidi, P., F. Afaq, J.M. Arif, M. Lohani and Q. Rahman, 1999. Chrysotile-mediated imbalance in the glutathione redox system in the development of pulmonary injury. Toxicol. Lett., 106: 31-39.
    PubMed  |  
  49. Smith, W.A., J.M. Arif and R.C. Gupta, 1998. Effect of cancer chemopreventive agents on microsome-mediated DNA adduction of the breast carcinogen dibenzo[a,l]pyrene. Mut. Res., 412: 307-314.
    PubMed  |  
  50. Arif, J.M., C.G. Gairola, H.P. Glauert, R.A. Lubet, G.J. Kelloff and R.C. Gupta, 1998. Inhibition of cigarette smoke-related lipophilic DNA adducts in rat tissues by dietary oltipraz. Carcinogenesis, 19: 1515-1517.
    PubMed  |  
  51. Rahman, Q., N. Mahmood, S.G. Khan, J.M. Arif and M. Athar, 1997. Mechnaism of asbestos-mediated DNA damage: role of heme and heme proteins. Environ. Health Perspect., 105: 1109-1112.
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  52. Arif, J.M., W.A. Smith and R.C. Gupta, 1997. Tissue distribution of stable DNA adducts in rat tissues treated with benzo[a]pyrene, 7,12-dimethylbenz[a]anthracene and dibenzo[a,l]pyrene. Mut. Res., 378: 31-39.
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  53. Arif, J.M., S.G. Khan, I. Ahmad, L.D. Joshi and Q. Rahman, 1997. Effect of kerosene and its soot on the chrysotile-mediated cytotoxicity to the rat alveolar macrophages. Environ. Res., 72: 151-161.
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  54. Arif, J.M., C.G. Gairola, H.P. Glauert, G.J. Kelloff, R.A. Lubet and R.C. Gupta, 1997. Effects of dietary supplementation of N-acetylcysteine on cigarette smoke-related DNA adducts in rat tissues. Int. J. Oncol., 11: 1227-1233.
    PubMed  |  
  55. Arif, J.M. and R.C. Gupta, 1997. Microsome-mediated bioactivation of dibenzo[a,l]pyrene and identification of DNA adducts by 32P-postlabeling. Carcinogenesis, 18: 1999-2007.
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  56. Arif, J.M., I. Ahmad and Q. Rahman, 1996. Chrysotile inhibits glutathione-dependent protection against the onset of lipid peroxidation in rat lung microsomes. Pharmacol. Toxicol., 79: 205-210.
    PubMed  |  
  57. Arif, J.M. and R.C. Gupta, 1996. Role of DNA adducts in defining bioactivation mechanism(s) of genotoxic compounds. Int. J. Oncol., 8: 681-685.
  58. Arif, J.M. and R.C. Gupta, 1996. Detection of DNA-reactive metabolites in serum and their tissue distribution in mice exposed subchronically to carcinogens mixtures: Role in Human Biomonitoring. Carcinogenesis, 17: 2213-2219.
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  59. Aslam, M., J.M. Arif and Q. Rahman, 1995. Red blood cells damage by Wollastonite: In vitro study. J. Appl. Toxicol., 15: 27-31.
    PubMed  |  
  60. Ahmad, I., K. Krishnamurthi, J.M. Arif, M. Ashquin, N. Mahmood, M. Athar and Q. Rahman, 1995. Augmentation of chrysotile-induced oxidative stress by BHA in mice lungs. Food Chem. Toxicol., 33: 209-215.
    PubMed  |  
  61. Arif, J.M., S.G. Khan, N. Mahmood, M. Aslam and Q. Rahman, 1994. Effect of co-exposure to asbestos and kerosene soot on pulmonary drug metabolizing enzyme system. Environ. Health Perspect., 102: 181-183.
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  62. Rahman, Q., J.M. Arif, N. Mahmood and S.G. Khan, 1993. Asbestos and Lung Diseases: A Mechanistic Approach.II. In: In: Source Book on Asbestos Diseases, Peters, G.A. and B.J. Peters (Eds.)., Butterworth Legal, USA, pp: 113.
  63. Arif, J.M., S.G. Khan, M. Ashquin and Q. Rahman, 1993. Modulation of macrophage-mediated cytotoxicity by kerosene soot: Possible role of reactive oxygen species. Environ. Res., 61: 232-238.
    PubMed  |  
  64. Khan, S.G., N. Mahmood, J.M. Arif and Q. Rahman, 1992. Asbestos and lung disease: A mechanistic approach. J. Sci. Indust. Res., 51: 507-514.
  65. Arif, J.M., S.G. Khan, M. Aslam, N. Mahmood and Q. Rahman, 1992. Diminution in kerosene mediated induction of drug metabolizing enzymes by asbestos in rat lung. Pharmacol Toxicol., 71: 37-40.
    PubMed  |  
  66. Arif, J.M., S.G. Khan, M. Aslam, N. Mahmood, L.D. Joshi and Q. Rahman, 1991. Early biochemical changes in kerosene exposed rat lung. Chemosphere, 22: 705-712.
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