Dr. Senthil  Selvaraj
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Dr. Senthil Selvaraj

Post-doctoral Fellow
Qatar Cardiovascular Research Center, Qatar

Highest Degree
Ph.D. in Biochemistry from Annamalai University, Tamil Nadu, India

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Dr. Senthil Selvaraj is currently working as Post-doctoral Fellow at Qatar Cardiovascular Research Center, Qatar. He obtained his Ph.D. in Biochemistry from Annamalai University, Tamil Nadu, India. His area of interest related to Calcium Signaling in Excitable & Non-excitable Cells, Signal Transduction (plasma membrane to nucleus), Membrane Microdomains (caveolae, focal adhesions), Gene Regulation (RNAi, miRNA, transcription). His professional experience includes over four years of Post Doctoral experience in School of Medicine & Health Sciences, UND, Pre Doctoral experience Cardio Vascular Diseases (CVD) and Free Radical Biology. Dr. Senthil Selvaraj received honors includes Madison’s Who’s Who of Executives and Professionals honors, New York, USA, Honorable Mention for poster presentation at 17th Biennial meeting of the ISDN, Asilomar, USA, Senior Research Fellowship, awarded by Indian Council of Medical Research, University Research Studentship, and Best Paper Award at the Indian Society for Atherosclerosis Research and International symposia/CME on atherosclerosis and XVIIIth annual conference of Indian Society of Atherosclerosis, New Delhi, India. He is member of Society for Free Radical Research (SFRR), India, and Indian Society of Atherosclerosis Research (ISAR), India. He is also serving as reviewer of some journals. He has published 1 article in journals, presented 2 invited oral presentations, and 18 abstracts and poster presentations as author/co-author.

Area of Interest:

Biomedical Sciences
Molecualar Biology

Research Publications in Numbers


Selected Publications

  1. Selvaraj, S., Y. Sun, P. Sukumaran and B.B. Singh, 2015. Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway. Mol. Carcinog. (In Press). .
  2. Yu, F., L. Sun, S. Hubrack, S. Selvaraj and K. Machaca, 2013. Intramolecular shielding maintains the ER Ca2+ sensor STIM1 in an inactive conformation. J. Cell Sci., 126: 2401-2410.
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  3. Sun, Y., S. Selvaraj, A. Varma, S. Derry, A.E. Sahmoun and B.B. Singh, 2013. Increase in serum Ca2+/Mg2+ ratio promotes proliferation of prostate cancer cells by activating TRPM7 channels. J. Biol. Chem., 288: 255-263.
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  4. Muruhan, S., S. Selvaraj and P.K. Viswanathan, 2013. In vitro antioxidant activities of Solanum surattense leaf extract. Asian Pac. J. Trop. Biomed., 3: 28-34.
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  5. Selvaraj, S., Y. Sun, J.A. Watt, S. Wang, S. Lei, L. Birnbaumer and B.B. Singh, 2012. Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling. J. Clin. Invest., 122: 1354-1367.
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  6. Radhiga, T., C. Rajamanickam, S. Senthil and K.V. Pugalendi, 2012. Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats. Food Chem. Toxicol., 50: 3971-3977.
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  7. Kost, G.C., S. Selvaraj, Y.B. Lee, D.J. Kim, C.H. Ahn and B.B. Singh, 2012. Clavulanic acid inhibits MPP+-induced ROS generation and subsequent loss of dopaminergic cells. Brain Res., 1469: 129-135.
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  8. Kost, G.C., S. Selvaraj, Y.B. Lee, D.J. Kim, C.H. Ahn and B.B. Singh, 2011. Clavulanic acid increases dopamine release in neuronal cells through a mechanism involving enhanced vesicle trafficking. Neurosci. Lett., 504: 170-175.
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  9. Bollimuntha, S., S. Selvaraj and B.B. Singh, 2011. Emerging Roles of Canonical TRP Channels in Neuronal Function. In: Transient Receptor Potential Channels, Islam, S. (Ed.). Chapter 31, Springer, New York, USA., ISBN: 978-94-007-0264-6, pp: 573-593.
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  10. Selvaraj, S., Y. Sun and B.B. Singh, 2010. TRPC channels and their implications for neurological diseases. CNS Neurolog. Disorders-Drug Targets, 9: 94-104.
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  11. Selvaraj, S., J.A. Watt and B.B. Singh, 2009. TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP/MPP+. Cell Calcium, 46: 209-218.
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  12. Senthil, S., M. Sridevi and K.V. Pugalendi, 2007. Cardioprotective effect of oleanolic acid on isoproterenol-induced myocardial ischemia in rats. Toxicol. Pathol., 35: 418-423.
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  13. Senthil, S., G. Chandramohan and K.V. Pugalendi, 2007. Protective effect of ursolic acid against myocardial ischemia induced by isoproterenol in rats. Toxicol. Mechanisms Methods, 17: 57-65.
    CrossRef  |  
  14. Senthil, S., G. Chandramohan and K.V. Pugalendi, 2007. Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats. Int. J. Cardiol., 119: 131-133.
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  15. Veerappan, R.M., S. Senthil, M.R. Rao, R. Ravikumar and K.V. Pugalendi, 2004. Redox status and lipid peroxidation in alcoholic hypertensive patients and alcoholic hypertensive patients with diabetes. Clin. Chim. Acta, 340: 207-212.
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  16. Senthil, S., R.M. Veerappan, M. Ramakrishna Rao and K.V. Pugalendi, 2004. Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction. Clin. Chim. Acta, 384: 131-137.
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