Dr. Senthilkumar  Rajagopal

Dr. Senthilkumar Rajagopal

Assistant Professor/Ramalingaswami Re-entry fellow
Rayalaseema University, India


Highest Degree
PostDoc Fellow in Pharmacology and Toxicology from Virginia Commonwealth University, Virginia

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Biography

Dr. Senthil kumar Rajagopal is currently working as a Scientist at Nizam College, Osmania University, Hyderabad, INDIA. He secured his PhD in Biochemistry from Annamalai University, INDIA. He did his three Post-doctoral researches in Anesthesiology in University of Virginia, Charlottesville, Virginia, followed by Department of Cancer Immunology & AIDS, Dana Farber Cancer Institute, Harvard University, Boston, Massachusetts and, Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia, USA. Dr.Senthil kumar has more than 10 years of research experiences in various fields such as Alcoholic hepatotoxicity, Voltage gated calcium channels, protein kinase C phosphorylation, ADAM family, Smooth muscle physiology, G-protein coupled receptor signaling pathways, Neurotransmitters transporters to Central Nervous system. He has published nearly 60 research articles in various peer-reviewed international journals, 8 book chapters, 7 abstracts, 55 Conferences proceedings/abstracts and attended 40 various workshops/seminars in India, Canada and USA. He is on the editorial/reviewer board in 20 peer-reviewed international journals such as Frontiers in Cellular Neuroscience, American Journal of Biochemistry and Molecular Biology, Neuroscience, etc. He has a life member of well-known scientific associations like Indian Society for Atherosclerosis Research (ISAR), The International Science Congress Association (ISCA), Society of Biological Chemistry (SBC), Society for Free Radical Research India (SFRR), The Indian Society of Cell Biology (ISCB) and member of American Association of Pharmaceutical Scientists (AAPS) and Science Advisory Board (SAB). He conducts research in the area of G-protein coupled receptor mediated intracellular mechanisms by Alcohol-induced digestive disorders in the gastrointestinal tract. Currently, he is mentoring graduate students and having research projects from various funding agencies.

Area of Interest:

Pharmacology and Toxicology
100%
Protein Kinases
62%
Biochemistry
90%
Toxicity
75%
Hepatotoxicity
55%

Selected Publications

  1. Singh, S., S.R. Sangam and R. Senthilkumar, 2020. Regulation of Dietary Amino Acids and Voltage-Gated Calcium Channels in Autism Spectrum Disorder In: Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management. Essa M. and M. Qoronfleh, Springer International Publishing Cham, ISBN-13: 978-3-030-30401-0, pp: 647-660.
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  2. Ramachandran, S. and S. Rajagopal, 2019. Zebrafish: A Model for Marine Peptide Based Drug Screening. 1st Edn., Springer Singapore Singapore, ISBN-13: 978-981-13-7843-0, Pages: 73.
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  3. Kumar, D.P., S. Koka, C. Li and S. Rajagopal, 2019. Inflammatory mediators in obesity. Mediators Inflammation, 10.1155/2019/9481819.
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  4. Rajagopal, S. and M. Ponnusamy, 2018. Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases. 1st Edn., Springer Singapore Singapore, ISBN-13: 978-981-13-1570-1, Pages: 76.
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  5. Singh, S., M. Abdul Razak, S.R. Sangam, B. Viswanath, P.S. Begum and S. Rajagopal, 2017. The Impact of Functional Food and Nutraceuticals in Health. In: Therapeutic Food (Handbook of Food Bioengineering, Volume 8), Grumezescu, A.M. and A.M. Holban (Eds.). Chapter 2, Academic Press, Cambridge, USA., ISBN-13: 9780128115176.
  6. Rajagopal, S., B.K. Burton, B.L. Fields, I.O. El and G.L. Kamatchi, 2017. Stimulatory and inhibitory effects of PKC isozymes are mediated by serine/threonine PKC sites of the Cav2.3α1 subunits. Arch. Biochem. Biophys., 621: 24-30.
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  7. Rajagopal, S. and M. Ponnusamy, 2017. Calcium Signaling: From Physiology to Diseases. Springer Publications, Singapore, ISBN-13: 978-9811051593.
  8. Begum, P.S., G. Madhavi, S. Rajagopal, B. Viswanath, M.A. Razak and V. Venkataratnamma, 2017. Probiotics as functional foods: Potential effects on human health and its impact on neurological diseases. Int. J. Nutr. Pharmacol. Neurol. Dis., 7: 23-33.
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  9. Abdul Razak, M., P.S. Begum, B. Viswanath and S. Rajagopal, 2017. Multifarious beneficial effect of nonessential amino acid, glycine: A review. Oxid. Med. Cell. Longevity, Vol. 2017. 10.1155/2017/1716701.
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  10. Viswanath, B., S. Rajagopal, P.A. Basha, D.M. Rao, P.S. Begum, D. Rajakumari and M.A. Razak, 2016. Enhancing the activity of aspartate kinase for an overproduction of L-lysine by Corynebacterium glutamicum. Am. J. Biochem. Mol. Biol., 6: 33-44.
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  11. Singh, S., S.R. Sangam and S. Rajagopal, 2016. Role of Dietary Amino Acids on Parkinson's Diseases. In: The Benefits of Natural Products for Neurodegenerative Diseases, Essa, M.M., A. Mohammed and G. Guillemin (Eds.). Springer Publications, New York, USA., ISBN: 978-3-319-28383-8.
  12. Ramanathan, V. and S. Rajagopal, 2016. Chrysin ameliorates the lipid profiles in Nω-nitro-l-arginine-methylester-induced hypertensive rats. Am. J. Biochem. Mol. Biol., 6: 60-66.
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  13. Rajagopal, S., S.R. Sangam, S. Singh and V.R. Joginapally, 2016. Modulatory Effects of Dietary Amino Acids on Neurodegenerative Diseases. In: The Benefits of Natural Products for Neurodegenerative Diseases, Essa, M.M., A. Mohammed and G. Guillemin (Eds.). Springer Publications, New York, USA., ISBN: 978-3-319-28383-8.
  14. Rajagopal, S., S.R. Sangam, S. Singh and V.R Joginapally, 2016. Modulatory effects of dietary amino acids on neurodegenerative diseases. Adv. Neurobiol., 12: 401-414.
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  15. Rajagopal, S., S.R. Sangam and S. Singh, 2016. Understanding the Impacts of Alcohol; Gastric Functions and Therapy. In: Disorders of Gastrointestinal Systems and Clinical Manifestations, Rajagopal, S., S. Murugan and S. Ramachandran (Eds.). Chapter 1, Nova Publications, New York, USA., ISBN: 978-1-63485-366-8, pp: 1-12.
  16. Ponnusamy, M., S. Rajagopal and A. Maruthamuthu, 2016. Gastrointestinal Complications in Solid Organ Transplant Recipients. In: Disorders of Gastrointestinal Systems and Clinical Manifestations, Rajagopal, S., S. Murugan and S. Ramachandran (Eds.). Chapter 12, Nova Publications, New York, USA., ISBN: 978-1-63485-366-8, pp: 183-209.
  17. Fatima, S. and S. Rajagopal, 2016. Impact of Gut Microflora on Human Health and Diseases. In: Disorders of Gastrointestinal Systems and Clinical Manifestations, Rajagopal, S., S. Murugan and S. Ramachandran (Eds.). Chapter 14, Nova Publications, New York, USA., ISBN: 978-1-63485-366-8, pp: 227-243.
  18. Abdul Razak, M., U.S. Allam, A.B. Pinjari, B. Viswanath, S. Rajagopal, P.S. Begum and D.M. Rao, 2016. Nanotechnology based Diagnosis and Therapeutics for Gastrointestinal Disorders. In: Disorders of Gastrointestinal Systems and Clinical Manifestations, Rajagopal, S., S. Murugan and S. Ramachandran (Eds.). Chapter 6, Nova Publications, New York, USA., ISBN: 978-1-63485-366-8, pp: 89-102.
  19. Veerappan, R. and S. Rajagopal, 2015. Chrysin enhances antioxidants and oxidative stress in L-NAME-induced hypertensive rats. Int. J. Nutr. Pharmacol. Neurol. Dis., 5: 20-27.
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  20. Srinivasan, T.S.P. and S. Rajagopal, 2015. Hepatocarcinogenicity of Aflatoxin-B1. In: Hepatocarcinogenicity of Aflatoxin-B1. Rajagopal, S. and M. Sengottuvelan (Ed.). Nova Publications, New York, USA., ISBN: 978-1-63482-650-1, pp: 229-246.
  21. Singh, S., S.R. Sangam, V.R. Joginapally and S. Rajagopal, 2015. Alcohol-induced gastric inflammation. J. Pharmaceut. Biomed. Sci., 5: 174-177.
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  22. Singh, S., S.R. Sangam, V.R. Joginapally and S. Rajagopal, 2015. Alcohol, glycine and gastritis. Int. J. Nutr. Pharmacol. Neurol. Dis., 5: 1-5.
  23. Rajagopal, S., S.R. Sangam, S. Singh and V.R. Joginapally, 2015. Alcohol-induced Hepatotoxicity; Symptoms and Management. In: Hepatotoxicity, Symptoms, Management and Health Implications. Rajagopal, S. and S. Murugan (Ed.). Nova Publications, New York, USA., ISBN: 978-1-63482-650-1, pp: 1-22.
  24. Rajagopal, S., S.R. Sangam and S. Singh, 2015. Differential regulation of volatile anesthetics on ion channels. Int. J. Nutr. Pharmacol. Neurol. Dis., 5: 128-134.
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  25. Rajagopal, S., S. Singh and S.R. Sangam, 2015. Contribution of protein kinase C (PKC) in the modulation of voltage gated calcium channels. J. Pharm. Biomed. Sci., 5: 351-354.
  26. Rajagopal, S., A.D. Nalli, D.P. Kumar, S. Bhattacharya and W. Hu et al., 2015. Cytokine-induced S-nitrosylation of soluble guanylyl cyclase and expression of phosphodiesterase 1A contribute to dysfunction of longitudinal smooth muscle relaxation. J. Pharmacol. Exp. Therapeut., 352: 509-518.
  27. Nalli, A.D., S. Rajagopal, S. Mahavadi, J.R. Grider and K.S. Murthy, 2015. Inhibition of RhoA-dependent pathway and contraction by endogenous hydrogen sulfide in rabbit gastric smooth muscle cells. Am. J. Physiol. Cell Physiol., 10.1152/ajpcell.00280.2014.
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  28. Fatima, S. and S. Rajagopal, 2015. Burdon of bacterial bio-films on Hepatocytes. In: Hepatotoxicity, Symptoms, Management and Health Implications. Rajagopal, S. and M. Sengottuvelan (Ed.). Nova Publications, New York, USA., ISBN: 978-1-63482-650-1, pp: 247-264.
  29. Sangam. S. and S. Rajagopal, 2014. Mitochondrial abnormalities and pathways of cancer. Res. J. Recent Sci., 3: 1-6.
  30. Rajagopal, S., V.R. Joginapally, T.S.P. Srinivasan and V. Ramanathan, 2014. Beneficial Effects of Dietary Amino acids on Brain Health. In: Food and Brain Function. Essa, M.M. and M.A. Memon (Ed.). Nova Publications, New York, USA., ISBN: 978-1-63117-734-7, pp: 221-224.
  31. Rajagopal, S., B.L. Fields, B.K. Burton, C. On, A.A. Reeder, A.L. Wilson and G.L. Kamatchi, 2014. Inhibition of protein kinase C response of voltage-gated calcium (Cav) 2.2 channels expressed in Xenopus oocytes by Cavβ subunits. Neuroscience, 280: 1-9.
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  32. Rajagopal, S., B.L. Fields and G.L. Kamatchi, 2014. Contribution of protein kinase Cα in the stimulation of insulin by the down-regulation of Cavβ subunits. Endocrine, 47: 463-471.
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  33. Rajagopal, S., 2014. Glycine stabilize the tissue fatty acid composition in an experimental model of Alcohol-induced hepatotoxicity. J. Clin. Exp. Hepatol., 4: S30-S31.
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  34. Bala, V., S. Rajagopal, D.P. Kumar, A.D. Nalli and S. Mahavadi et al., 2014. Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S. Frontiers Physiol., 5: 1-11.
  35. Senthilkumar, R., 2013. Amino Acids from Food as Medicine: Valuable Function. In: Food as Medicine. Essa, M.M. and M.A. Memon (Ed.). Nova Publications, New York, USA., ISBN: 978-1-62417-747-7, pp: 411-442.
  36. Rajagopal, S., D.P. Kumar, S. Mahavadi, S. Bhattacharya and R. Zhou et al., 2013. Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway. Am. J. Physiol.-Gastrointestinal Liver Physiol., 304: G527-G535.
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  37. Nalli, A.D., S. Rajagopal, S. Mahavadi, J.R. Grider and K.S. Murthy, 2013. Inhibition of RhoA/Rho kinase pathway and contraction by endogenous and exogenous hydrogen sulfide in gastrointestinal smooth muscle. FASEB J., Vol. 27. .
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  38. Bhattacharya, S., S. Mahavadi, O. Al-Shboul, S. Rajagopal, J.R. Grider and K.S. Murthy, 2013. Differential regulation of muscarinic M2 and M3 receptor signaling in gastrointestinal smooth muscle by caveolin-1. Am. J. Physiol.-Cell Physiol., 305: C334-C347.
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  39. Rajagopal, S., D.P. Kumar, S. Bhattacharya, J.R. Grider and K.S. Murthy, 2012. Characterization of Gz-coupled dopamine D3 receptors in gastric smooth muscle. Faseb J., Vol. 26. .
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  40. Kumar, D.P., S. Rajagopal, S. Mahavadi, F. Mirshahi, J.R. Grider, K.S. Murthy and A.J. Sanyal, 2012. Activation of transmembrane bile acid receptor TGR5 stimulates both insulin gene transcription and insulin release in pancreatic β cells. Biochem. Biophys. Res. Commun., 427: 600-625.
  41. Bala, V., S. Rajagopal, D.P. Kumar, S. Mahavadi and R. Zhou et al., 2012. Hydrogen sulfide (H2S) inhibits bile acid receptor TGR5-mediated GLP-1 release from enteroendrocrine cells: Possible involvement of H2S in altered glucose metabolism in diabetes. Gastroenterol., Vol. 142. .
  42. Rajagopal, S., O. Al-Shboul, S. Mahavadi, J.F. Kuemmerle and K.S. Murthy, 2011. Expression and function of bile acid receptor TGR5 in gastrointestinal smooth muscle. FASEB J., Vol. 25. .
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  43. Rajagopal, S., H. Fang, C.Lynch, J.J. Sando and K.L. Ganesan, 2011. Effects of isoflurane on the expressed Cav2.2 currents in Xenopus oocytes depend on the activation of protein kinase C δ and its Phosphorylation Sites in the α12.2 subunits. Neuroscience, 182: 232-240.
  44. Bala, V., S. Mahavadi, S. Rajagopal, R. Zhou, J.F. Kuemmerle, A.J. Sanyal and K.S. Murthy, 2011. Bile acid-induced stimulation of ERK1/2 activity, GLP-1 and PYY release in enteroendocrine cells is mediated by the activation of Epac/PLC-ε signaling pathway via G S-coupled TGR5. Gastroenterol., Vol. 140. .
  45. Al-Shboul, O., S. Mahavadi, S. Rajagopal, R. Zhou and K.S. Murthy, 2011. Differences in the Expression of VPAC2 receptors and adenylyl cyclase V/VI and VIP-induced cAMP generation in phasic and tonic smooth muscles. Faseb J., Vol. 25. .
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  46. Rajagopal, S., H. Fang, C. Lynch III and G.L. Kamatchi, 2010. Formalin-induced-short and long-term modulation of Cav currents expressed in Xenopus oocytes: An in vitro cellular model for formalin-induced pain. Basic Clin. Pharamacol. Toxicol., 106: 338-347.
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  47. Rajagopal, S., H. Fang, C.I.A. Oronce, S. Jhaveri and S. Taneja et al., 2009. Site-specific regulation of CAV2.2 channels by protein kinase C isozymes βII and ε. Neuroscience, 159: 618-628.
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  48. Rajagopal, S., H. Fang, S. Patanavanich, G. Varghese, J.J. Sando and G.L. Kamatchi, 2008. Protein kinase C isozyme specific potentiation of expressed CaV2.3 currents by Acetyl-β-methylcholine and phorbol-12-myristate, 13-acetate. Brain Res., 1210: 1-10.
    PubMed  |  
  49. Rajagopal, S., H. Fang, C. Lynch III, J.J. Sando and G.L. Kamatchi, 2007. Identification of the PKC isozymes involved in acetyl-β-methylcholine or phorbol-12-myristate, 13-acetate-induced potentiation of expressed Cav 2.3 currents. Biophys. J., 1: 602A-603A.
  50. Sengottuvelan, M., R. Senthilkumar and N. Nalini, 2006. Modulatory influence of dietary resveratrol during different phases of 1,2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesis. Biochim. Biophys. Acta, 1760: 1175-1183.
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  51. Fang, H., S. Patanavanich, S. Rajagopal, X. Yi, M.S. Gill, J.J. Sando and G.L. Kamatchi, 2006. Inhibitory role of Ser-425 of the alpha1 2.2 subunit in the enhancement of Cav 2.2 currents by phorbol-12-myristate, 13-acetate. J. Biol. Chem., 281: 20011-20017.
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  52. Senthilkumar, R., M. Sengottuvelan and N. Nalini, 2004. Protective effect of glycine supplementation on the levels of lipid peroxidation and antioxidant enzymes in the erythrocyte of rats with alcohol induced liver injury. Cell Biochem. Function, 22: 123-128.
    PubMed  |  
  53. Senthilkumar, R. and N. Nalini, 2004. Glycine modulates lipids and lipoproteins levels in rats with alcoholic liver injury. Int. J. Pharmacol., Vol. 2, 10.5580/2955.
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  54. Rajagopal, S., P. Viswanathan and N. Nalini, 2004. Effect of glycine on oxidative stress in rats with alcohol induced liver injury. Pharmazie, 59: 55-60.
    PubMed  |  
  55. Rajagopal, S. and N. Nalini, 2004. The potential beneficial effect of glycine on the carbohydrate moieties of glycoproteins in an experimental model of alcohol induced hepatotoxicity. J. Med. Food, 7: 108-113.
    PubMed  |  
  56. Rajagopal, S. and N. Nalini, 2004. Glycine prevent-s the hepatic fibrosis by preventing the accumulation of collagen in alcohol induced liver injury. Polish J. Pharmacol., 56: 121-128.
    PubMed  |  
  57. Rajagopal, S. and N. Nalini, 2004. Glycine ameliorates ethanol induced liver injury in albino rats. Alcohol Res., 9: 63-70.
  58. Rajagopal, S. and N. Nalini, 2004. Effect of glycine on tissue fatty acid composition in an experimental model of alcohol-induced hepatotoxicity. Clin. Exp. Pharmacol. Physiol., 31: 456-461.
    PubMed  |  
  59. Rajagopal, S.K., P. Manickam, V. Periyasamy and N. Namasivayam, 2003. Activity of Cassia auriculata leaf extract in rats with alcoholic liver injury. J. Nutr. Biochem., 14: 452-458.
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  60. Rajagopal, S.,P. Viswanathan and N. Nalini, 2003. Glycine modulates hepatic lipid accumulation in alcohol induced liver injury. Polish J. Pharmacol., 55: 603-611.
    PubMed  |  
  61. Vijayakumar, R.S., D. Surya, S. Rajagopal and N. Nalini, 2002. Hypolipidemic effect of black pepper (Piper nigrum Linn.) in rats fed high fat diet. J. Clin. Biochem. Nutr., 32: 31-42.
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  62. Surya, D., R.S. Vijayakumar, S. Rajagopal and N. Nalini, 2002. Hypolipidemic effect of Cuminun cyminum L. on alloxan induced diabetic rats. Pharmacol. Res., 46: 11-15.
  63. Rajagopal, S., M. Ponmozhi, P. Viswanathan and N. Nalini, 2002. Effect of Cassia auriculata leaf extract on lipids in rats with alcoholic liver injury. Asia Pacific J. Clin. Nutr., 11: 157-163.
    PubMed  |  
  64. Nalini, N., M. Ponmozhi and S. Rajagopal, 2002. Effect of Phaseolus vulgaris Extraction Lipid Metabolism in Experimental Diabetes Mellitus. In: Current Advances in Atherosclerosis Research, Gupta, R. (Ed.). Indian Society of Atherosclerosis Research, USA., pp: 113-124.