Dr. Mohammad Imtaiyaz Hassan
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Dr. Mohammad Imtaiyaz Hassan

Assistant Professor
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi , India

Highest Degree
Ph.D. in Structural Biology from All India Institute of Medical Sciences, New Delhi, India

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Area of Interest:

Biological Sciences
100%
Gel Electrophoresis
62%
Cancer Biology
90%
Chromatography
75%
Molecular Biology
55%

Research Publications in Numbers

Books
3
Chapters
3
Articles
447
Abstracts
0

Selected Publications

  1. Waseem, R., A. Shamsi, T. Khan, A. Anwer and M. Shahid et al., 2023. Characterization of advanced glycation end products and aggregates of irisin: Multispectroscopic and microscopic approaches. J. Cell. Biochem., 124: 156-168.
    CrossRef  |  Direct Link  |  
  2. Voura, M., S. Anwar, I. Sigala, E. Parasidou, S. Fragoulidou, M.I. Hassan and V. Sarli, 2023. Synthesis, structural modification, and bioactivity evaluation of substituted acridones as potent microtubule affinity-regulating kinase 4 inhibitors. ACS Pharmacol. Transl. Sci., 6: 1052-1074.
    CrossRef  |  Direct Link  |  
  3. Singh, P., A. Rathi, R. Minocha, A. Sinha, M. Mahfuzul Haque, M.I. Hassan and R. Dohare, 2023. Breast cancer prognostic hub genes identified by integrated transcriptomic and weighted network analysis: A road toward personalized medicine. OMICS: J. Integr. Biol., 27: 227-236.
    CrossRef  |  Direct Link  |  
  4. Mushtaq, A., P. Singh, G. Tabassum, T. Mohammad, M.I. Hassan, M.A. Syed and R. Dohare, 2023. Unravelling hub genes as potential therapeutic targets in lung cancer using integrated transcriptomic meta-analysis and in silico approach. J. Biomol. Struct. Dyn., 41: 9089-9102.
    CrossRef  |  Direct Link  |  
  5. Mann, G.S., N. Azum, A. Khan, M. Abdul Rub, M.I. Hassan, K. Fatima and A.M. Asiri, 2023. Green composites based on animal fiber and their applications for a sustainable future. Polymers, Vol. 15. 10.3390/polym15030601.
    CrossRef  |  Direct Link  |  
  6. Kumar, D., G.M. Hasan, Asimul Islam and M.I. Hassan, 2023. Therapeutic targeting of Huntington's disease: Molecular and clinical approaches. Biochem. Biophys. Res. Commun., 655: 18-24.
    CrossRef  |  Direct Link  |  
  7. Khatoon, F., S. Ali, V. Kumar, A.M. Elasbali and H.H. Alhassan et al., 2023. Pharmacological features, health benefits and clinical implications of honokiol. J. Biomol. Struct. Dyn., 41: 7511-7533.
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  8. Hasan, G.M., M.I. Hassan, S.S. Sohal, A. Shamsi and M. Alam, 2023. Therapeutic targeting of regulated signaling pathways of non-small cell lung carcinoma. ACS Omega, 8: 26685-26698.
    CrossRef  |  Direct Link  |  
  9. Basheer, N., T. Smolek, I. Hassan, F. Liu, K. Iqbal, N. Zilka and P. Novak, 2023. Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer’s disease? From preclinical studies to the clinical trials. Mol. Psychiatry, 28: 2197-2214.
    CrossRef  |  Direct Link  |  
  10. Azhar, M.K., S. Anwar, G.M. Hasan, A. Shamsi, Asimul Islam, S. Parvez and M.I. Hassan, 2023. Comprehensive insights into biological roles of rosmarinic acid: Implications in diabetes, cancer and neurodegenerative diseases. Nutrients, Vol. 15. 10.3390/nu15194297.
    CrossRef  |  Direct Link  |  
  11. Azeem, K., M. Ahmed, T. Mohammad, Amad Uddin and A. Shamsi et al., 2023. A multi-spectroscopic and computational simulations study to delineate the interaction between antimalarial drug hydroxychloroquine and human serum albumin. J. Biomol. Struct. Dyn., 41: 6377-6393.
    CrossRef  |  Direct Link  |  
  12. Alotaibi, B.S., J. Joshi, M. Raghibul Hasan, M.S. Khan and S.H. Alharethi et al., 2023. Identifying isoononin and candidissiol as rho-associated protein kinase 1 (ROCK1) inhibitors: A combined virtual screening and MD simulation approach. J. Biomol. Struct. Dyn., 41: 6749-6758.
    CrossRef  |  Direct Link  |  
  13. Alam, M., S. Ahmed, M. Abid, G.M. Hasan, Asimul Islam and M.I. Hassan, 2023. Therapeutic targeting of microtubule affinity-regulating kinase 4 in cancer and neurodegenerative diseases. J. Cell. Biochem., 124: 1223-1240.
    CrossRef  |  Direct Link  |  
  14. Yousuf, M., M. Alam, A. Shamsi, P. Khan, G.M. Hasan, Q.M. Rizwanul Haque and M.I. Hassan, 2022. Structure-guided design and development of cyclin-dependent kinase 4/6 inhibitors: A review on therapeutic implications. Int. J. Biol. Macromol., 218: 394-408.
    CrossRef  |  Direct Link  |  
  15. Yousuf, M., A. Shamsi, T. Mohammad, N. Azum and S.Y.M. Alfaifi et al., 2022. Iinhibiting cyclin-dependent kinase 6 by taurine: Implications in anticancer therapeutics. ACS Omega, 7: 25844-25852.
    CrossRef  |  Direct Link  |  
  16. Yousuf, M., A. Shamsi, S. Khan, P. Khan and M. Shahwan et al., 2022. Naringenin as a potential inhibitor of human cyclin-dependent kinase 6: Molecular and structural insights into anti-cancer therapeutics. Int. J. Biol. Macromol., 213: 944-954.
    CrossRef  |  Direct Link  |  
  17. Yadav, M., J. Pandey, A. Chakraborty, M.I. Hassan and J.K. Kundu et al., 2022. A comprehensive analysis of calmodulin-like proteins of glycine max indicates their role in calcium signaling and plant defense against insect attack. Front. Plant Sci., Vol. 13. 10.3389/fpls.2022.817950.
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  18. Xue, B., M. Chaddha, A.M. Elasbali, Z. Zhu and D.S. Jairajpuri et al., 2022. Death-associated protein kinase 3 inhibitors identified by virtual screening for drug discovery in cancer and hypertension. OMICS: J. Integr. Biol., 26: 404-413.
    CrossRef  |  Direct Link  |  
  19. Xue, B., D. DasGupta, M. Alam, M.S. Khan and S. Wang et al., 2022. Investigating binding mechanism of thymoquinone to human transferrin, targeting Alzheimer's disease therapy. J. Cell. Biochem., 123: 1381-1393.
    CrossRef  |  Direct Link  |  
  20. Waseem, R., A. Shamsi, M. Shahbaz, T. Khan and S.N. Kazim et al., 2022. Effect of pH on the structure and stability of irisin, a multifunctional protein: Multispectroscopic and molecular dynamics simulation approach. J. Mol. Struct., Vol. 1252. 10.1016/j.molstruc.2021.132141.
    CrossRef  |  Direct Link  |  
  21. Singh, M., K. Jayant, D. Singh, S. Bhutani and N.K. Poddar et al., 2022. Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy. Front. Cell. Infect. Microbiol., Vol. 12. 10.3389/fcimb.2022.933824.
    CrossRef  |  Direct Link  |  
  22. Shamsi, A., T. Mohammad, S. Anwar, K. Nasreen, M.I. Hassan, F. Ahmad and Asimul Islam, 2022. Insight into the binding of PEG-400 with eye protein alpha-crystallin: Multi spectroscopic and computational approach: possible therapeutics targeting eye diseases. J. Biomol. Struct. Dyn., 40: 4496-4506.
    CrossRef  |  Direct Link  |  
  23. Roy, S., S. Khan, D.S. Jairajpuri, A. Hussain and M.F. Alajmi et al., 2022. Investigation of sphingosine kinase 1 inhibitory potential of cinchonine and colcemid targeting anticancer therapy. J. Biomol. Struct. Dyn., 40: 6350-6362.
    CrossRef  |  Direct Link  |  
  24. Raina, N., M.I. Hassan, F. Ahmad, Asimul Islam and A.K. Singh, 2022. PEG mediated destabilization of holo α-lactalbumin probed by in silico and in vitro studies: Deviation from excluded volume effect. J. Biomol. Struct. Dyn., 40: 13265-13277.
    CrossRef  |  Direct Link  |  
  25. Queen, A., H.N. Bhutto, M. Yousuf, M.A. Syed and M.I. Hassan, 2022. Carbonic anhydrase IX: A tumor acidification switch in heterogeneity and chemokine regulation. Sem. Cancer Biol., 86: 899-913.
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  26. Parray, Z.A., F. Ahmad, A.A. Chaudhary, H.A. Rudayni, M. Al-Zharani, M.I. Hassan and Asimul Islam, 2022. Size-dependent interplay of volume exclusion versus soft interactions: Cytochrome C in macromolecular crowded environment. Front. Mol. Biosci., Vol. 9. 10.3389/fmolb.2022.849683.
    CrossRef  |  Direct Link  |  
  27. Parray, Z.A., A.A.T. Naqvi, I.A. Ahanger, M. Shahid, F. Ahmad, M.I. Hassan and Asimul Islam, 2022. Measuring structural changes in cytochrome c under crowded conditions using in vitro and in silico approaches. Polymers, Vol. 14. 10.3390/polym14224808.
    CrossRef  |  Direct Link  |  
  28. Naiyer, A., B. Khan, Asimul Islam, M.I. Hassan, M. Sundd and F. Ahmad, 2022. Heme-iron ligand (M80-Fe) in cytochrome c is destabilizing: Combined in vitro and in silico approaches to monitor changes in structure, stability and dynamics of the protein on mutation. J. Biomol. Struct. Dyn., 40: 4122-4139.
    CrossRef  |  Direct Link  |  
  29. Mohammad, T., P. Singh, D.S. Jairajpuri, L.A. Al-Keridis and N. Alshammari et al., 2022. Differential gene expression and weighted correlation network dynamics in high-throughput datasets of prostate cancer. Front. Oncol., Vol. 12. 10.3389/fonc.2022.881246.
    CrossRef  |  Direct Link  |  
  30. Mathur, Y., T. Mohammad, F. Anjum, A. Shafie, A.M. Elasbali, V.N. Uversky and M.I. Hassan, 2022. PyPAn: An automated graphical user interface for protein sequence and structure analyses. Protein Pept. Lett., 29: 306-312.
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  31. Kumar, D., G.M. Ashraf, A.L. Bilgrami and M.I. Hassan, 2022. Emerging therapeutic developments in neurodegenerative diseases: A clinical investigation. Drug Discovery Today, Vol. 27. 10.1016/j.drudis.2022.06.005.
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  32. Kumar, D. and M.I. Hassan, 2022. Targeted protein degraders march towards the clinic for neurodegenerative diseases. Ageing Res. Rev., Vol. 78. 10.1016/j.arr.2022.101616.
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  33. Khatoon, F., V. Kumar, F. Anjum, A. Shafie, M. Adnan and M.I. Hassan, 2022. Frustration analysis of TBK1 missense mutations reported in ALS/FTD and cancer patients. 3 Biotech, Vol. 12. 10.1007/s13205-022-03240-0.
    CrossRef  |  Direct Link  |  
  34. Khan, T., R. Waseem, Z. Zehra, A. Aiman and P. Bhardwaj et al., 2022. Mitochondrial dysfunction: Pathophysiology and mitochondria-targeted drug delivery approaches. Pharmaceutics, Vol. 14. 10.3390/pharmaceutics14122657.
    CrossRef  |  Direct Link  |  
  35. Khan, S., Z. Fakhar, A. Hussain, A. Ahmad, D.S. Jairajpuri, M.F. Alajmi and M.I. Hassan, 2022. Structure-based identification of potential SARS-CoV-2 main protease inhibitors. J. Biomol. Struct. Dyn., 40: 3595-3608.
    CrossRef  |  Direct Link  |  
  36. Khan, S., F.A. Alhumaydhi, M.S. Khan, S.E. Sharaf and W. Al Abdulmonem et al., 2022. Exploring binding mechanism of naringenin to human transferrin using combined spectroscopic and computational methods: Towards therapeutic targeting of neurodegenerative diseases. J. Mol. Liq., Vol. 356. 10.1016/j.molliq.2022.119001.
    CrossRef  |  Direct Link  |  
  37. Khan, A., T. Mohammad, A. Shamsi, A. Hussain and M.F. Alajmi et al., 2022. Identification of plant-based hexokinase 2 inhibitors: Combined molecular docking and dynamics simulation studies. J. Biomol. Struct. Dyn., 40: 10319-10331.
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  38. Idrees, D., A.A.T. Naqvi, M.I. Hassan, F. Ahmad and S. Gourinath, 2022. Insight into the conformational transitions of serine acetyl transferase isoforms in E. histolytica: Implications for structural and functional balance. ACS Omega, 7: 24626-24637.
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  39. Habib, I., S. Khan, T. Mohammad, A. Hussain and M.F. Alajmi et al., 2022. Impact of non-synonymous mutations on the structure and function of telomeric repeat binding factor 1. J. Biomol. Struct. Dyn., 40: 9053-9066.
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  40. Guhe, V., F. Anjum, A. Shafie, M.I. Hassan, V.R. Pasupuleti and S. Singh, 2022. Infection dynamics of ATG8 in Leishmania: Balancing autophagy for therapeutics. Molecules, Vol. 27. 10.3390/molecules27103142.
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  41. Fatima, U., S. Roy, S. Ahmad, S. Ali and W.M. Elkady et al., 2022. Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation. Front. Nutr., Vol. 9. 10.3389/fnut.2022.972379.
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  42. Fatima, U., S. Roy, S. Ahmad, L.A. Al-Keridis and N. Alshammari et al., 2022. Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications. Biomed. Pharmacother., Vol. 153. 10.1016/j.biopha.2022.113469.
    CrossRef  |  Direct Link  |  
  43. Baig, M.H., P. Gupta, M.I. Khan, M.F. Alajmi, A. Hussain, M.I. Hassan and J.J. Dong, 2022. Probing the interaction of selonsertib with human serum albumin: In
    silico     and In vitro approaches. Curr. Top. Med. Chem., 22: 879-890.
    CrossRef  |  Direct Link  |  
  44. Baig, M.H., M. Yousuf, M.I. Khan, I. Khan and I. Ahmad et al., 2022. Investigating the mechanism of inhibition of cyclin-dependent kinase 6 inhibitory potential by selonsertib: Newer insights into drug repurposing. Front. Oncol., Vol. 12. 10.3389/fonc.2022.865454.
    CrossRef  |  Direct Link  |  
  45. Asrani, P., K. Tiwari, M.S. Eapen, M.D.I. Hassan and S.S. Sohal, 2022. Containment strategies for COVID-19 in India: Lessons from the second wave. Expert Rev. Anti-infective Ther., 20: 829-835.
    CrossRef  |  Direct Link  |  
  46. Asrani, P., K. Tiwari, M.S. Eapen, K.D. McAlinden and G. Haug et al., 2022. Clinical features and mechanistic insights into drug repurposing for combating COVID-19. Int. J. Biochem. Cell Biol., Vol. 142. 10.1016/j.biocel.2021.106114.
    CrossRef  |  Direct Link  |  
  47. Anwar, S., M. Shahwan, G.M. Hasan, Asimul Islam and M.I. Hassan, 2022. Microtubule-affinity regulating kinase 4: A potential drug target for cancer therapy. Cell. Signalling, Vol. 99. 10.1016/j.cellsig.2022.110434.
    CrossRef  |  Direct Link  |  
  48. Anwar, S., D. DasGupta, N. Azum, S.Y.M. Alfaifi and A.M. Asiri et al., 2022. Inhibition of PDK3 by artemisinin, a repurposed antimalarial drug in cancer therapy. J. Mol. Liq., Vol. 355. 10.1016/j.molliq.2022.118928.
    CrossRef  |  Direct Link  |  
  49. Anwar, S., D. DasGupta, A. Shafie, F.A. Alhumaydhi and S.A. Alsagaby et al., 2022. Implications of tempol in pyruvate dehydrogenase kinase 3 targeted anticancer therapeutics: Computational, spectroscopic, and calorimetric studies. J. Mol. Liq., Vol. 350. 10.1016/j.molliq.2022.118581.
    CrossRef  |  Direct Link  |  
  50. Amad Uddin, S. Gupta, T. Mohammad, D. Shahi and A. Hussain et al., 2022. Target-based virtual screening of natural compounds identifies a potent antimalarial with selective falcipain-2 inhibitory activity. Front. Pharmacol., Vol. 13. 10.3389/fphar.2022.850176.
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  51. Allai, F.M., B.N. Dar, K. Gul, M. Adnan and S.A. Ashraf et al., 2022. Development of protein rich pregelatinized whole grain cereal bar enriched with nontraditional ingredient: Nutritional, phytochemical, textural, and sensory characterization. Front. Nutr., Vol. 9. 10.3389/fnut.2022.870819.
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  52. Ali, S., M. Alam, G.M. Hasan and M.I. Hassan, 2022. Potential therapeutic targets of Klebsiella pneumoniae: A multi-omics review perspective. Briefings Funct. Genomics, 21: 63-77.
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  53. Ali, S., M. Alam, F. Khatoon, U. Fatima and A.M. Elasbali et al., 2022. Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights. Biomed. Pharmacother., Vol. 147. 10.1016/j.biopha.2022.112658.
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  54. Ali, N., Z. Zehra, A. Shamsi, M.A. Beg, Z.A. Parray and Israil et al., 2022. Elucidating the role of santalol as a potent inhibitor of tyrosinase: In vitro and in silico approaches. Molecules, Vol. 27. 10.3390/molecules27248915.
    CrossRef  |  Direct Link  |  
  55. Ali, N., A. Aiman, A. Shamsi, I. Hassan, M. Shahid, N.A. Gaur and Asimul Islam, 2022. Identification of thermostable xylose reductase from Thermothelomyces thermophilus: A biochemical characterization approach to meet biofuel challenges. ACS Omega, 7: 44241-44250.
    CrossRef  |  Direct Link  |  
  56. Alam, M., S. Alam, A. Shamsi, M. Adnan and A.M. Elasbali et al., 2022. Bax/Bcl-2 cascade is regulated by the EGFR pathway: Therapeutic targeting of non-small cell lung cancer. Front. Oncol., Vol. 12. 10.3389/fonc.2022.869672.
    CrossRef  |  Direct Link  |  
  57. Alam, M., S. Ahmed, A.M. Elasbali, M. Adnan, S. Alam, M.I. Hassan and V.R. Pasupuleti, 2022. Therapeutic implications of caffeic acid in cancer and neurological diseases. Front. Oncol., Vol. 12. 10.3389/fonc.2022.860508.
    CrossRef  |  Direct Link  |  
  58. Alam, M., M.M. Ansari, S. Noor, T. Mohammad, G.M. Hasan, S.N. Kazim and M.I. Hassan, 2022. Therapeutic targeting of TANK-binding kinase signaling towards anticancer drug development: Challenges and opportunities. Int. J. Biol. Macromol., 207: 1022-1037.
    CrossRef  |  Direct Link  |  
  59. Alam, M., G.M. Ashraf, K. Sheikh, A. Khan and S. Ali et al., 2022. Potential therapeutic implications of caffeic acid in cancer signaling: Past, present, and future. Front. Pharmacol., Vol. 13. 10.3389/fphar.2022.845871.
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  60. Ahmed, S., M. Mobashir, L.A. Al-Keridis, N. Alshammari, M. Adnan, M. Abid and M.I. Hassan, 2022. A network-guided approach to discover phytochemical-based anticancer therapy: Targeting MARK4 for hepatocellular carcinoma. Front. Oncol., Vol. 12. 10.3389/fonc.2022.914032.
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  61. Ahmad, S., M.I. Hassan, D. Gupta, N. Dwivedi and Asimul Islam, 2022. Design and evaluation of pyrimidine derivatives as potent inhibitors of ABCG2, a breast cancer resistance protein. 3 Biotech, Vol. 12. 10.1007/s13205-022-03231-1.
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  62. Aggarwal, S., K. Bhadana, B. Singh, M. Rawat and T. Mohammad et al., 2022. Cinnamomum zeylanicum extract and its bioactive component cinnamaldehyde show anti-tumor effects via inhibition of multiple cellular pathways. Front. Pharmacol., Vol. 13. 10.3389/fphar.2022.918479.
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  63. Adnan, M., S. Koli, T. Mohammad, A.J. Siddiqui and M. Patel et al., 2022. Searching for novel anaplastic lymphoma kinase inhibitors: Structure-guided screening of natural compounds for a tyrosine kinase therapeutic target in cancers. OMICS: J. Integr. Biol., 26: 461-470.
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  64. Adnan, M., A. Shamsi, A. Elasbali, A. Siddiqui and M. Patel et al., 2022. Structure-guided approach to discover tuberosin as a potent activator of pyruvate kinase M2, targeting cancer therapy. Int. J. Mol. Sci., Vol. 23. 10.3390/ijms232113172.
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  65. Rustagi, V., M. Bajaj, Tanvi, P. Singh and R. Aggarwal et al., 2021. Analyzing the effect of vaccination over COVID cases and deaths in Asian countries using machine learning models. Front. Cell. Infect. Microbiol., Vol. 11. 10.3389/fcimb.2021.806265.
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