Dr. Rajesh  Kumar Singh

Dr. Rajesh Kumar Singh

Assistant Professor
Punjab Technical University, India


Highest Degree
Ph.D. in Pharmacy from Punjab Technical University, India

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Biography

Dr. Rajesh Kumar Singh is presently an Assistant Professor of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal affiliated to Punjab Technical University, India. He completed his PhD in 2013 from Punjab Technical University, Jalandhar, India. Dr. Singhs major area of research interests are drug-design, polymer-drug conjugates for targeted delivery, CNS active therapeutic agents and green chemistry approach for chemical synthesis. Dr. Singh has above 9 years of teaching experience and guided 16 postgraduate students. He has published more than 34 peer-reviewed scientific research papers in various Chemistry and Pharmacy Journals. He has also to his credit 46 National And International Conference Abstracts, 1 Book, 5 Best Paper Presentation Awards, 1 Travel grant to attend International Conference and 5 Research Projects funded by Punjab State Council for Science and Technology (PSCST), Chandigarh. Dr. Singh is approved paper setter and evaluator of various Universities, reviewer of various reputed International Journals and editorial board member of one Journal. He has reviewed more than twenty research papers of six different International Journals of Springer, Elseveir and Bentham. He is an elected member of Association of Institution of Chemist (AIC), registered Pharmacist of Punjab State Pharmacy Council and life member of APTI. Recently his biographical profile has been nominated for Marquis Whos Who in Medicine and Healthcare 2015-1016 as worlds foremost achievers.

Area of Interest:

Biomedical Sciences
100%
Pharmacy
62%
Chemotherapy
90%
Pharmaceutical Sciences
75%
Pharmaceutical Chemistry
55%

Education

2008

Ph.D.

Punjab Technical University, India

Pharmacy

Selected Publications

  1. Singh, R.K., S. Kumar, D.N. Prasad and T.R. Bhardwaj, 2018. Therapeutic journey of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives. Eur. J. Med. Chem., 151: 401-433.
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  2. Singh, R.K. and R. Duvedi, 2018. Environment-friendly green chemistry approaches for an efficient synthesis of 1-amidoalkyl-2-naphthols catalyzed by tannic acid. Arab. J. Chem., 11: 91-98.
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  3. Sharda, S., D.N. Prasad, S. Kumar and R.K. Singh, 2018. Hexachlorocyclotriphosphazene Catalyzed One-Pot Multicomponent Synthesis of 2,3-Dihydro-1H-1,5-benzodiazepines. Asian J. Org. Med. Chem., 31: 176-180.
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  4. Sehajpal, S., D.N. Prasad and R.K. Singh, 2018. Synthesis and evaluation of produrgs of ketoprofen with antioxidants as gastroprotective NSAIDs. Asian J. Chem., 30: 2145-2150.

  5. Sehajpal, S., D.N. Prasad and R.K. Singh, 2018. Prodrugs of Non-steroidal Anti-inflammatory Drugs (NSAIDs): A long march towards synthesis of safer NSAIDs. Mini Rev. Med. Chem., 18: 1199-1219.
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  6. Kumari, A., O. Silakari and R.K. Singh, 2018. Recent advances in colony stimulating factor-1 receptor/c-FMS as an emerging target for various therapeutic implications. Biomed. Pharmacother., 103: 662-679.
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  7. Kumar, S., T.R. Bhardwaj, D.N. Prasad and R.K. Singh, 2018. Emerging treatment approaches and targets for drug-resistant Malaria: A wrestle towards innovation in the advanced chemotherapy of malaria. Biomed. Pharmacother., 104: 8-27.

  8. Chaudhary, S., S. Sharda, D.N. Prasad, S. Kumar and R.K. Singh, 2018. Synthetic methodologies and pharmacological significance of 2-Aminobenzophenones as versatile building block. Asian J. Org. Med. Chem., 3: 107-115.
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  9. Chaudhary, S., D.N. Prasad, S. Kumar and R.K. Singh, 2018. An atom-economic efficient synthesis of 1-Amidoalkyl-2-naphthols mediated by Hexachlorocyclotriphosphazene (HCCP) as novel catalyst. Lett. Org. Chem., 10.2174/1570178616666181210103350 .
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  10. Singh, R.K., D.N. Prasad and T.R. Bhardwaj, 2017. Design, synthesis, chemical and biological evaluation of brain targeted alkylating agent using reversible redox prodrug approach. Arabian J. Chem., 10: 420-429.
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  11. Singh, R.K., D.N. Prasad and T.R. Bhardwaj, 2017. Design, synthesis and in vitro cytotoxicity study of benzodiazepine-mustard conjugates as potential brain anticancer agents. J. Saudi Chem. Soc., 21: S86-S93.
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  12. Kumar, S., R.K. Singh, D.N. Prasad and T.R. Bhardwaj, 2017. Synthesis and in vitro degradation studies of substituted poly (organophosphazenes) for drug delivery applications. J. Drug Delivery Sci. Technol., 38: 135-142.
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  13. Kumar, S., R.K. Singh and T.R. Bhardwaj, 2017. Therapeutic role of nitric oxide as emerging molecule. Biomed. Pharm., 85: 182-201.
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  14. Singh, R.K., S. Sharma, A. Sandhar, M. Saini and S. Kumar, 2016. Recent advances in the development of various catalysts for an efficient green synthesis of 1,5-benzodiazepines. Iran. J. Catal., 6: 389-408.

  15. Singh, R.K., R. Bala and S. Kumar, 2016. Investigating various green chemistry techniques for an efficient synthesis of 1-amidoalkyl-2-naphthols catalyzed by zinc oxide nanoparticles under solvent-free conditions. Ind. J. Chem., 55: 381-386.

  16. Singh, R.K., K. Sahore, R. Rana, D.N. Prasad and S. Kumar, 2016. Recent advances in the synthetic approaches and current pharmacological applications of 1, 4-dihydropyridines. Iran. J. Catal., .

  17. Kumar, S., R.K. Singh, B. Patial, S. Goyal and T.R. Bhardwaj, 2016. Recent advances in novel heterocyclic scaffolds for the treatment of drug-resistant malaria. J. Enzyme Inhib. Med. Chem., 31: 173-186.
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  18. Zhao, Y., D. Kumar, DN. Prasad, R.K. Singh and Y. Ma, 2015. Morphoanatomic, physicochemical and phytochemical standardization with HPTLC fingerprinting of aerial parts of Aerva lanata (Linn) Juss ex Schult. J. Tradit. Chin. Med. Sci. 10.1016/j.jtcms.2014.12.002.
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  19. Zhao, Y., D. Kumar, D.N. Prasad, R.K. Singh and Y. Ma, 2015. Morphoanatomic, physicochemical, and phytochemical standardization with HPTLC fingerprinting of aerial parts of Aerva lanata (Linn) Juss ex Schult. J. Traditional Chin. Med. Sci., 2: 39-44.
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  20. Singh, R.K., S. Kumar and M. Saini, 2015. Green chemistry approach for an efficient synthesis of 1, 5-benzodiazepines promoted by stannic oxide nanoparticles under solvent-free condition. Ind. J. Heterocycl. Chem., 25: 151-156.

  21. Singh, R.K., S. Devi and D.N. Prasad, 2015. Synthesis, physicochemical and biological evaluation of 2-amino-5-chlorobenzophenone derivatives as potent skeletal muscle relaxants. Arab. J. Chem., 8: 307-312.
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  22. Singh, R.K., R. Bala, R. Duvedi and S. Kumar, 2015. Recent advances in the development of various catalysts for an efficient green synthesis of amidoalkyl-naphthols. Iran. J. Catal., 5: 187-206.

  23. Singh, R.K., R. Bala and S. Kumar, 2015. Microwave assisted facile synthesis of 1-amidoalkyl-2-naphthols catalyzed by stannous oxide nanoparticles. J. Ind. Chem. Soc., 92: 1161-1165.

  24. Singh, R.K., D.N. Prasad and T.R. Bhardwaj, 2015. Synthesis, physicochemical and kinetic studies of redox derivative of bis(2-chloroethylamine) as alkylating cytotoxic agent for brain delivery. Arab. J. Chem., 8: 380-387.
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  25. Singh, R.K., D.N. Prasad and T.R. Bhardwaj, 2015. Hybrid pharmacophore-based drug design, synthesis and antiproliferative activity of 1, 4-dihydropyridines-linked alkylating anticancer agents. Med. Chem. Res., 24: 1534-1545.
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  26. Singh, R.K., B. Singh, R. Duvedi and S. Kumar, 2015. Sulfanilic acid: a versatile and efficient catalyst among various organocatalysts screened for the synthesis of 1-amidoalkyl-2-naphthols under solvent-free condition. Res. Chem. Intermed., 41: 4083-4099.
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  27. Li, T., S. Singh, X. Zhai, X. Meng and R.K. Singh, 2015. Microwave-assisted synthesis, insilico ADME prediction and antibacterial study of 2-(substituted acetamido)-5-nitrobenzophenone derivatives. Asian. J. Chem., 27: 2452-2456.
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  28. Kumar, S., R.K. Singh, R.S.R. Murthy and T.R. Bhardwaj, 2015. Synthesis and evaluation of substituted poly(organophosphazenes) as a novel nanocarrier system for combined antimalarial therapy of primaquine and dihydroartemisinin. Pharm. Res., 32: 2736-2752.
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  29. Kumar, S., R.K. Singh, R. Sharma, R.S.R. Murthy and T.R. Bhardwaj, 2015. Design, synthesis and evaluation of antimalarial potential of polyphosphazene linked combination therapy of primaquine and dihydroartemisinin. Eur. J. Pharmaceut. Sci., 66: 123-137.
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  30. Kumar, S., R.K. Singh, B. Patial, S. Goyal and T.R. Bhardwaj, 2015. Recent advances in novel heterocyclic scaffolds for the treatment of drug-resistant malaria. J. Enzyme Inhib. Med. Chem. 10.3109/14756366.2015.1016513.
    CrossRef  |  Direct Link  |  

  31. Zhao, Y., X. Yu, M. Kaur, Y. Ma and R.K. Singh, 2014. Highly efficient zinc oxide nanoparticles catalyzed green synthesis of 1,5-benzodiazepines under solvent-free path. Asian J. Chem., 26: 8539-8542.
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  32. Zhao, Y., S. Sharma, M. Huang, A. Sandhar, R.K. Singh and Y.X. Ma, 2014. Investigation of various organocatalysts for improved and efficient one pot synthesis of 2,3-dihydro-1h-1,5-benzodiazepines under solvent-free condition. Asian. J. Chem., 26: 5116-5120.
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  33. Singh, R.K., S. Kumar, D.N. Prasad and T.R. Bhardwaj, 2014. Reversible redox system-based drug design, synthesis and evaluation for targeting nitrogen mustard across brain. Med. Chem. Res., 23: 2405-2416.
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  34. Singh, R.K., D.N. Prasad and T.R. Bhardwaj, 2014. Design, synthesis, chemical and biological evaluation of brain targeted alkylating agent using reversible redox prodrug approach. Arabian J. Chem., (In Press). 10.1016/j.arabjc.2013.12.008.
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  35. Singh, R.K., B. Singh, R. Duvedi and S. Kumar, 2014. Sulfanilic acid: A versatile and efficient catalyst among various organoacids screened for the synthesis of 1-amidoalkyl-2-naphthols under solvent-free condition. Res. Chem. Intermediates, (In Press). 10.1007/s11164-013-1513-5.
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  36. Singh, R.K., 2014. Synthesis, alkylating activity and physicochemical study of nitrogen mustard agent for brain delivery. Int. J. Pharm. Teach. Pract., 5: 925-929.
    Direct Link  |  

  37. Singh, R.K. and R. Duvedi, 2014. Environmental-friendly green chemistry approaches foran efficient synthesis of 1-amidoalkyl-2-naphthols catalyzed by tannic acid. Arab. J. Chem., .

  38. Singh, R.K. and R. Duvedi, 2014. Environment-friendly green chemistry approaches for an efficient synthesis of 1-amidoalkyl-2-naphthols catalyzed by tannic acid. Arabian J. Chem., (In Press). 10.1016/j.arabjc.2014.08.022.
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  39. Li, T., X. Zhai, D. Singh, R.K. Singh and X. Xu, 2014. Multicomponent one-pot green synthesis of 1-amidoalkyl-2-naphthols promoted by p-nitrobenzoic acid under solvent-free condition. Asian J. Chem., 26: 5207-5211.
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  40. Li, P., K. Sahore, J. Liu and R.K. Singh, 2014. Synthesis and antimicrobial evaluation of 2-aminobenzophenone linked 1,4-dihydropyridine derivatives. Asian J. Chem., 26: 5291-5294.
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  41. Singh, R.K., D.N. Prasad and T.R. Bhardwaj, 2013. Synthesis in vitro/in vivo evaluation and in silico physicochemical study of prodrug approach for brain targeting of alkylating agent. Med. Chem. Res., 22: 5324-5336.
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  42. Singh, R.K., D.N. Prasad and T.R. Bhardwaj, 2013. Design, synthesis and in vitro cytotoxicity study of benzodiazepine-mustard conjugates as potential brain anticancer agents. J. Saudi Chem. Soc., .
    Direct Link  |  

  43. Singh, R.K., D.N. Prasad and T.R. Bhardwaj, 2013. Design, synthesis and evaluation of aminobenzophenone derivatives containing nitrogen mustard moiety as potential central nervous system antitumor agent. Med. Chem. Res., 22: 5901-5911.
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  44. Singh, R.K., D.N. Prasad and T.R. Bhardwaj, 2013. Design, synthesis and in vitro cytotoxicity study of benzodiazepine-mustard conjugates as potential brain anticancer agents. J. Saudi Chem. Soc., (In Press). 10.1016/j.jscs.2013.10.004.
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  45. Sharma, S. and R.K. Singh, 2013. Restructuring pharmaceutical education for next generation pharmacist: A survey report. Int. J. Pharm. Teach. Pract., 4: 568-570.
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  46. Sandhar, A. and R.K. Singh, 2013. Rapid and efficient synthesis of 2,3-dihydro-1H-1,5-benzodiazepines catalyzed by chloroacetic acid screened among various aliphatic acids under solvent free conditions. Chem. Sci. Trans., 2: 176-180.
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  47. Kaur, P. and R.K. Singh, 2013. Investigation of various green chemistry approaches for the efficient synthesis of dialkyl-1, 4-dihydro-4-(substituted phenyl)-2, 6-dimethylpyridine-3, 5-dicarboxylate. Chem. Sci. Trans., 2: S295-S301.
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  48. Singh, R.K., Sumit, S. Malik, D. Sharma, D.N. Prasad and T.R. Bhardwaj, 2012. Synthesis and study of chemical delivery system for targeting nitrogen mustard to the brain. Asian J. Chem., 24: 5635-5638.
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  49. Singh, R.K., D.N. Prasad and T.R. Bhardwaj, 2012. Synthesis, alkylation activity and physico-chemical evaluation of benzodiazepine linked nitrogen mustard agent to penetrate the blood-brain barrier. Asian J. Chem., 24: 5605-5608.
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  50. Singh, A. and R.K. Singh, 2012. A study on student's perception of ideal teacher: A survey on students of pharmacy colleges in Punjab. Int. J. Pharm. Teach. Pract., 3: 298-300.
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  51. Sandhar, A., D.N. Prasad, A. Kapoor and R.K. Singh, 2012. Efficient p-amino benzoic acid catalyzed eco-friendly synthesis of 1,5-benzodiazepines among various amino acids under solvent free conditions. Curr. Res. Chem., 4: 68-75.
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  52. Sandhar, A., D.N. Prasad and R.K. Singh, 2012. Salicylic acid catalyzed synthesis of 2,3-dihydro-1H-1,5-benzodiazepines under solvent-free condition. Indian J. Heterocyclic Chem., 21: 369-374.

  53. Sandhar, A. and R.K. Singh, 2012. A simple, efficient and eco-friendly synthesis of 2,3-dihydro-1H-1,5-benzodiazepines mediated by tannic acid under solvent-free condition. Asian J. Chem., 24: 5643-5645.
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  54. Malik, S., S. Sharma and R.K. Singh, 2012. Microwave assisted synthesis of 1-amidoalkyl-2-naphthols catalyzed by anhydrous zinc chloride. Asian J. Chem., 24: 5669-5672.
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  55. Kaur, P., H. Sharma, R. Rana, D.N. Prasad and R.K. Singh, 2012. Comparative study of various green chemistry approaches for the efficient synthesis of 1,4-dihydropyridines. Asian J. Chem., 24: 5649-5651.
    Direct Link  |  

  56. Duvedi, R. and R.K. Singh, 2012. Environment friendly, efficient chloroacetic acid promoted synthesis of 1-amidoalkyl-2-naphthols under neat condition. Asian J. Chem., 24: 5665-5668.
    Direct Link  |  

  57. Singh, R.K., S. Devi and D.N. Prasad, 2011. Synthesis, physicochemical and biological evaluation of 2-amino-5-chlorobenzophenone derivatives as potent skeletal muscle relaxants. Arabian J. Chem., (In Press). 10.1016/j.arabjc.2011.11.013.
    CrossRef  |  Direct Link  |  

  58. Singh, R.K., S. Devi and D.N. Prasad, 2011. Synthesis and Physicochemicl evaluation of 2-amino-5-chlorobenzophenone derivatives. Int. J. Pharm. Med. Innovat., Vol. 1, .
    Direct Link  |  

  59. Sharma, S., D.N. Prasad and R.K. Singh, 2011. One pot synthesis of 2,3-dihydro-1H-1,5-benzodiazepines under solvent-free conditions using anhydrous stannous chloride as catalyst. J. Chem. Pharmaceut. Res., 3: 382-389.
    Direct Link  |  

  60. Kumar, S., R.K. Singh, R.S.R. Murthy and T.R. Bhardwaj, 2011. Emerging treatment approaches and targets for drug-resistant Malaria: A wrestle towards innovation in the advanced chemotherapy of malaria. Curr. Drug Targets, .

  61. Singh, R.K., A. Singh, S. Devi, D.N. Prasad, M. Kumar and T.R. Bhardwaj, 2010. Targeting aniline mustard across brain by reversible redox drug delivery system. Proceedings of the 14th ISCB International Conference on Chemical Biology for Discovery: Perspective and Challenges, January 15-18, 2010, Lucknow, India -.

  62. Singh, R.K., D. Sonia, D.N. Prasad and T.R. Bhardwaj, 2009. Synthesis and physicochemical characterization of dibenzazepine linked nitrogen mustard as potential brain antitumour agent. Proceedings of the 61th Indian Pharmaceutical Congress, December 11-13, 2009, Ahamedabad -.

  63. Dipti, S., J. Richa and R.K. Singh, 2009. Nanomedicine: Nanotechnology in health care. Proceedings of the Silver Jubilee Conference of IPGA, November 7-8, 2009, ISF college of Pharmacy, Moga -.

  64. Sharma, S., S. Duggal, R. Kumar, R.K. Singh and D.N. Prasad, 2007. Antiinflammatory activity of aqueous extract of stem bark of A. indica. Proceedings of the 10th Punjab Science Congress, February 7-9, 2007, India -.

  65. Sharma, S., R.K. Singh, D.N. Prasad and S. Duggal, 2007. Effect of fresh leaf juice of C. roseus on fructose induced hyperlipedemia and hyperglycemia. Proceedings of the 59th Indian Pharmaceutical Congress, December 20-23, 2007, Varanasi -.