Dr. Amit  Alexander

Dr. Amit Alexander

Associate Professor
Rungta College of Pharmaceutical Sciences and Research, Bhilai, India


Highest Degree
Ph.D. in Pharmaceutics from Pt. Ravishankar Shukla University, India

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Biography

Mr. Amit Alexander is currently working as Associate Professor at Rungta College of Pharmaceutical Sciences and Research, India. He obtained his PhD in Pharmaceutics from Pt. Ravishankar Shukla University, India. His main area of interest related to In Situ Gelling Systems. His main area of expertise includes In Situ Gelation, Solubility Enhancement, Mucoadhesion, SMEDDS, SEDDS, Pegylation, Transdermal Drug Delivery Systems, and Phyto-Phospholipids. He has published 12 research papers in national and international journals, 27 review articles in national and international journals, 9 presentations in conference/seminars, and 1 book contributed as author/co-author.

Area of Interest:

Pharmacology and Toxicology
100%
Alzheimer`s Disease
62%
Nanoparticle Research
90%
Breast Cancer
75%
Pharmaceutics
55%

Selected Publications

  1. Tripathi, D.K. and A. Alexander, 2019. Novel Drug Delivery System. Pharma Med Press, India, ISBN: 978-93-89354-07-2..
  2. Saraf, S., A. Alexander and Ajazuddin, 2019. Textbook of Drug Delivery Based on Chronopharmaceutical Approach. LAP Lambert Academic Publication, Germany, ISBN: 978-3-659-30260-2..
  3. Krishna, K.V., G. Wadhwa, A. Alexander, N. Kanojia and N. Saha et al., 2019. Design and biological evaluation of lipoprotein-based donepezil nanocarrier for enhanced brain uptake through oral delivery. ACS Chem. Neurosci., 10: 4124-4135.
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  4. Khan, J., A. Alexander, M. Agrawal, S.K. Dubey and S. Siddique et al., 2019. Stem cell-based therapies: A new ray of hope for diabetic patients. Curr. Stem Cell Res. Ther., 14: 146-151.
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  5. Giri, T.K., A. Alexander, M. Agrawal, S. Saraf and S. Saraf, 2019. Current status of stem cell therapies in tissue repair and regeneration. Curr. Stem Cell Res. Ther., 14: 117-126.
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  6. Dubey, S.K., S. Salunkhe, M. Agrawal, M. Kali and G. Singhvi et al., 2019. Understanding the pharmaceutical aspects of dendrimers for the delivery of anticancer drugs. Curr. Drug Targ., 10.2174/1389450120666191031092259.
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  7. Dubey, S.K., M.S. Ram, K.V. Krishna, R.N. Saha and G. Singhvi et al., 2019. Recent expansions on cellular models to uncover the scientific barriers towards drug development for alzheimer’s disease. Cell. Mol. Neurobiol., 39: 181-209.
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  8. Dubey, S.K., K.S. Pradyuth, R.N. Saha, G. Singhvi and A. Alexander et al., 2019. Application of photodynamic therapy drugs for management of glioma. J. Porphyrins Phthalocyan., 10.1142/S1088424619300192.
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  9. Dubey, S.K., A. Alexander, K.S. Pradhyut, M. Agrawal and R. Jain et al., 2019. Recent avenues in novel patient-friendly techniques for the treatment of diabetes. Curr. Drug Del., 10.2174/1567201816666191106102020.
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  10. Badwaik, H.R., A. Alexander and K. Sakure, 2019. Understanding the significance of microwave radiation for the graft copolymerization of acrylamide on carboxymethyl xanthan gum. Curr. Microw. Chem., 6: 13-22.
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  11. Alexander, A., S. Siddique, M. Agrawal, A. uddin, A.M. Shehata et al., 2019. Nanotechnology: A non- invasive diagnosis and therapeutic tool for brain disorders. Afr. J. Pharm. Pharmacol., 13: 118-123.
  12. Alexander, A., S. Saraf, S. Saraf, M. Agrawal, R.J. Patel, P. Agrawal and J. Khan, 2019. Amalgamation of stem cells with nanotechnology: A unique therapeutic approach. Curr. Stem cell Res and Ther., 14: 83-92.
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  13. Alexander, A., M. Agrawal, A. Uddin, S. Siddique, A.M. Shehata and M.A. Shaker et al., 2019. Recent expansions of novel strategies towards the drug targeting into the brain. Int. J. Nanomed., 14: 5895-5909.
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  14. Ajazuddin, S. Siddique, A. Alexander, P. Yadav and M. Agrawal et al., 2019. A. shaker. nanomedicines: Challenges and perspectives for future nanotechnology in the healthcare system. Sci. Res. Essays, 14: 32-38.
  15. Agrawal, M., A. Alexander, J. Khan, T.K. Giri and S. Siddique et al., 2019. Recent biomedical applications on stem cell therapy: A brief overview. Curr. Stem Cell Res. Ther., 14: 127-136.
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  16. Shukla, T., N. Upmanyu, M. Agrawal, S. Saraf, S. Saraf and A. Alexander, 2018. Biomedical applications of microemulsion through dermal and transdermal route. Biomed. Pharm., 108: 1477-1494.
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  17. Pradhan, M., A. Alexander, M.R. Singh, D. Singh, S. Saraf and S. Saraf, 2018. Understanding the prospective of nano-formulations towards the treatment of psoriasis. Biomed. Pharm., 107: 447-463.
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  18. Khan, J., A. Alexander, S. Saraf and S. Saraf, 2018. Exploring the role of polymeric conjugates toward anti-cancer drug delivery: Current trends and future projections. Int. J. Pharm., 548: 500-514.
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  19. Gothwal, A., K.T. Nakhate, A. Alexander,Ajazuddin and U. Gupta, 2018. Boosted memory and improved brain bioavailability of rivastigmine: Targeting effort to the brain using covalently tethered lower generation PAMAM Dendrimers with Lactoferrin. Mol. Pharm., 15: 4538-4549.
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  20. Alexander, A. and S. Saraf, 2018. Nose-to-brain drug delivery approach: a key to easily access the brain for the treatment of the Alzheimer’s disease (AD). Neur. Regen. Res., 13: 2102-2104.
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  21. Agrawal, M., S. Saraf, S. Saraf, S.G. Antimisiaris, M.B. Chougule, S.A. Shoyele and A. Alexander, 2018. Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs. J. Cont. Releas, 281: 139-177.
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  22. Agrawal, M., S. Saraf, S. Saraf, S.G. Antimisiaris and N. Hamano et al, 2018. Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region. Exp. Opin. Drug Deliv., 15: 589-617.
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  23. Kumar, H., A. Gothwal, I. Khan, K.T. Nakhate, A. Alexander, V. Singh and U. Gupta, 2017. Galactose-anchored gelatin nanoparticles for primaquine delivery and improved pharmacokinetics: A biodegradable and safe approach for effective antiplasmodial activity against p. falciparum 3D7 and in vivo hepatocyte targeting. Mol. Pharm., 14: 3356-3369.
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  24. Badwaik, H.R., K. Sakure, K.T. Nakhate, P. Kashayap, H. Dhongade, A. Alexander and D.K. Tripathi, 2017. Effect of Ca+ 2 ion on the release of diltiazem hydrochloride from matrix tablets of carboxymethyl xanthan gum graft polyacrylamide. Int. J. Biol. Macromol., 94: 691-697.
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  25. Agrawal, M., D.K. Tripathi, S. Saraf, S. Saraf, S.G. Antimisiaris, S. Mourtas and A. Alexander, 2017. Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease. J. Cont. Rele., 260: 61-77.
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  26. Giri, T.K., A. Alexander, T.K. Barman and S. Maity, 2016. Infringement of the barriers of cancer via dietary phytoconstituents capsaicin through novel drug delivery system. Curr. Drug Deliv., 13: 27-39.
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  27. Badwaik, H.R., K. Sakure, A. Alexander, H. Dhongade and D.K. Tripathi, 2016. Synthesis and characterisation of poly (acryalamide) grafted carboxymethyl xanthan gum copolymer. Int. J. Boil. Macromol., 85: 361-369.
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  28. Alexander, A., S. Saraf and S. Saraf, 2016. Understanding the role of poloxamer 407 based thermoreversible in situ gelling hydrogel for delivery of PEGylated melphalan conjugate. Cur. Drug Delivery, 13: 621-630.
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  29. Alexander, A., R.J. Patel, S. Saraf and S. Saraf, 2016. Recent expansion of pharmaceutical nanotechnologies and targeting strategies in the field of phytopharmaceuticals for the delivery of herbal extracts and bioactives. J. Controll. Release, 241: 110-124.
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  30. Saraf, S., A. Gupta, A. Alexander, J. Khan, M.Jangde and S. Saraf, 2015. Advancements and avenues in nanophytomedicines for better pharmacological responses. J. Nanosci. Nanotechnol., 15: 4070-4079.
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  31. Jeswani, G., A. Alexander, S. Saraf, S. Saraf and A. Qureshi, 2015. Recent approaches for reducing hemolytic activity of chemotherapeutic agents. J. Controll. Release, 211: 10-21.
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  32. Alexander, A., S. Saraf and S. Saraf, 2015. A comparative study of chitosan and poloxamer based thermosensitive hydrogel for the delivery of PEGylated melphalan conjugates. Drug Dev. Ind. Pharm., 41: 1954-1961.
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  33. Khan, J., A. Alexander, S. Saraf and S. Saraf, 2014. Luteolin–phospholipid complex: preparation, characterization and biological evaluation. J. Pharm. Pharmacol., 66: 1451-1462.
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  34. Alexander, A., J. Khan, S. Saraf and S. Saraf, 2014. Polyethylene glycol (PEG)–Poly (N-isopropylacrylamide)(PNIPAAm) based thermosensitive injectable hydrogels for biomedical applications. Eur. J. Pharm. Biopharm., 88: 575-585.
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  35. Alexander, A., J. Khan, S. Saraf and S. Saraf, 2014. Formulation and evaluation of chitosanbased longacting injectable hydrogel for PEG ylated melphalan conjugate. J. Pharm. Pharmacol., 66: 1240-1250.
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  36. Alexander, A., A. Qureshi, L. Kumari, P. Vaishnav, M. Sharma, S. Saraf and S. Saraf, 2014. Role of herbal bioactives as a potential bioavailability enhancer for Active Pharmaceutical Ingredients. Fitoterapia, 97: 1-14.
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  37. Khan, J., A. Alexander, S. Saraf and S. Saraf, 2013. Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives. J. Controlled Release, 168: 50-60.
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  38. Giri, T.K., S. Verma, A. Alexander, B.H. Ajazuddin, M. Tripathy and D.K. Tripathi, 2013. Crosslinked biodegradable alginate hydrogel floating beads for stomach site specific controlled delivery of metronidazole. Farmacia, 61: 533-550.
  39. Giri, T.K., D. Thakur, A. Alexander, H. Badwaik, M. Tripathy and D.K. Tripathi, 2013. Biodegradable IPN hydrogel beads of pectin and grafted alginate for controlled delivery of diclofenac sodium. J. Mater. Sci. Mater. Med., 24: 1179-1190.
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  40. Giri, T.K., C. Choudhary, A. Alexander, H. Badwaik and D.K. Tripathi, 2013. Prospects of pharmaceuticals and biopharmaceuticals loaded microparticles prepared by double emulsion technique for controlled delivery. Saudi Pharm. J., 21: 125-141.
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  41. Giri, T.K., C. Choudhary and A. Alexander, 2013. Sustained release of diltiazem hydrochloride from cross-linked biodegradable IPN hydrogel beads of pectin and modified xanthan gum. Indian J. Pharm. Sci., 75: 619-627.
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  42. Giri, K.T., K. Kumar, A. Alexander, H. Badwaik, M. Tripathy and K.D. Tripathi, 2013. Novel controlled release solid dispersion for the delivery of diclofenac sodium. Curr. Drug Deliv., 10: 435-443.
    Direct Link  |  
  43. Alexander, A., J. Khan, S. Saraf and S. Saraf, 2013. Poly (ethylene glycol)–poly (lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications. J. Controll. Release, 172: 715-729.
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  44. Ajazuddin, A. Alexander, B. Amarji and P. Kanaujia, 2013. Synthesis, characterization and in vitro studies of pegylated melphalan conjugates. Drug Dev. Ind. Pharm., 39: 1053-1062.
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  45. Ajazuddin, A. Alexander, A. Khichariya, S. Gupta, R.J. Patel, T.K. Giri and D.K. Tripathi, 2013. Recent expansions in an emergent novel drug delivery technology: Emulgel. J. Controlled Release, 171: 122-132.
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  46. Tiwle, R., Ajazuddin, T.K. Giri, D.K. Tripathi, V. Jain and A. Alexander, 2012. An Exhaustive Review on Solubility Enhancement for Hydrophobic Compounds by Possible Applications of Novel Techniques. Trends Appl. Sci. Res., 7: 596-619.
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  47. Rajput, D.S., A. Alexander, V. Jain, T.K. Giri, D.K. Tripathi and Ajazuddin, 2012. Novel integrated approach for the strategic delivery of hydrophobic drugs by the use of self emulsifying drug delivery system. J. Applied Sci., 12: 502-517.
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  48. Mohanty, S., M. Sharma, K. Dubey, Ajazuddin and A. Alexander et al., 2012. Significance of Herbal Plants in the Treatment of Sickle Cell Anaemia. Res. J. Pharm. Tech., 5: 297-301.
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  49. Giri, T.K., S. Verma, Ajazuddin, A. Alexander and H. Badwaik et al., 2012. Prospective and New Findings of Hydroxypropyl Methylcellulose (HPMC) as a Potential Carrier for Gastrorententive Drug Delivery Systems. Drug Delivery Lett., 2: 98-107.
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  50. Giri, T.K., R. Sahu, K. Kumar, A. Alexander and Ajazuddin et al., 2012. In-vitro Quality Control Measurement of Some Commercially Available Sustained Release Tablet Containing Diclofenac Sodium. Res. J. Pharm. Technol., 5: 687-690.
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  51. Giri, T.K., N. Parveen, D. Thakur, A. Alexander and Ajazuddin et al., 2012. In vitro Evaluation of Commercially Available Enteric Coated Tablet Containing Diclofenac Sodium. Int. J. Res. Pharm. Biomed. Sci., 3: 875-881.
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  52. Giri, T.K., N. Barwey, S. Verma, A. Alexander and Ajazuddin et al., 2012. Comparative Assessment of the Quality Measurement of Some Commercially Available Paracetamol Tablets. Int. J. Pharm. Sci. Rev. Res., 14: 42-46.
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  53. Giri, T.K., K. Kumar, A. Alexander, Ajazuddin and H. Badwaik et al., 2012. A Novel and Alternative Approach to Controlled Release Drug Delivery System Based on Solid Dispersion Technique. Bull. Faculty Pharm. Cairo Univ., 50: 147-159.
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  54. Giri, T.K., H.K. Tandan, C. Choudhary, A. Alexander and Ajazuddin et al., 2012. In-Vitro Evalution of Commercially Available Sustained Release Capsule Containing Diltiazem Hydrochloride. Int. J. Pharm. Pharm. Sci., 4: 523-526.
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  55. Giri, T.K., D. Thakur, A. Alexander, Ajazuddin and H. Badwaik et al., 2012. Alginate based Hydrogel as a Potential Biopolymeric Carrier for Drug Delivery and Cell Delivery Systems: Present Status and Applications. Curr. Drug Delivery, 9: 539-555.
    CrossRef  |  PubMed  |  
  56. Giri, T.K., A. Thakur, A. Alexander, Ajazuddin and H. Badwaik et al., 2012. Modified Chitosan Hydrogels As Drug Delivery and Tissue Engineering Systems: Present Status and Applications. Acta Pharm. Sin. B, 2: 439-449.
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  57. Bhoyar, N., T.K. Giri, D.K. Tripathi, A. Alexander and Ajazuddin, 2012. Recent Advances in Novel Drug Delivery System Through Gels: Review. J. Pharm. Allied Health Sci., 2: 21-39.
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  58. Bhoyar, N., T.K. Giri, A. Alexander, D.K. Tripathi and Ajazuddin, 2012. Development of UV Spectrophotometric Method for Qualitative and Quantitative Estimation of Tolnaftate in Different Formulations. Res. J. Pharm. Tech., 5: 207-209.
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  59. Behra, A., T.K. Giri, D.K. Tripathi, Ajazuddin and A. Alexander, 2012. An exhaustive review on recent advancement in pharmaceutical bioadhesive used for systemic drug delivery through oral mucosa for achieving maximum pharmacological response and effect. Int. J. Pharmacol., 8: 283-305.
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  60. Angare, D., T. Giri, D.K. Tripathi, A. Alexander and Ajazuddin, 2012. Unexplored areas and new findings in lipid emulsion serving as a potential drug carrier for lipophilic drugs: A review. Trends Med. Res., 7: 1-24.
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  61. Alexander, A., S. Dwivedi, Ajazuddin, T.K. Giri, S. Saraf, S. Saraf and D.K. Tripathi, 2012. Approaches for breaking the barriers of drug permeation through transdermal drug delivery. J. Controlled Release, 164: 26-40.
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  62. Alexander, A., N. Bhoyar, M. Sharma, J. Khan and A. Behra et al., 2012. Important Aspects and Fundamentals of Chronotherapeutic Drug Delivery System for Optimizing Therapeutic Effect. A Review. Am. J. PharmTech Res., 2: 75-91.
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  63. Ajazuddin, A. Alexander, J. Khan, T.K. Giri. D.K. Tripathi, S. Saraf and S. Saraf, 2012. Advancement in stimuli triggered in situ gelling delivery for local and systemic route. Expert Opin. Drug Delivery, 9: 1573-1592.
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  64. Agrawal, S., T.K. Giri, D.K. Tripathi, Ajazuddin and A. Alexander, 2012. A review on novel therapeutic strategies for the enhancement of solubility for hydrophobic drugs through lipid and surfactant based self micro emulsifying drug delivery system: A novel approach. Am. J. Drug Dis. Dev., 2: 143-183.
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  65. Shukla, P., A. Singh, S. Gawri, A. Alexande and S. Sonwane, 2011. In vitro propagation of Barleria prionitis Linn and its antibacterial activity. Int. J. Pharma Prof. Res., 2: 198-200.
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  66. Sharma, M.K. and A. Alexander, 2011. Pharmacognostical and Phytochemical Investigations of Root of Heliotropium Indicum Linn. Int. J. Pharm. Sci. Res., 2: 1569-1571.
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  67. Nagori, K., M.K. Singh, A. Alexander, T. Kumar and D. Dewangan et al., 2011. Piper betle L.: A Review on its Ethnobotany, Phytochemistry, Pharmacological Profile and Profiling by New Hyphenated Technique DART-MS (Direct Analysis in Real Time Mass Spectrometry). J. Pharm. Res., 4: 2991-2997.
  68. Kumar, T., D. Dewangan, A. Alexander, K. Nagori and D.K. Tripathi, 2011. Synthesis and Characterization of 8-[(2-Amino-6aryl-Pyrimidin-4-Yl) Oxy]-4-Methyl-2H-Chromen-2-Ol Derivatives. Asian J. Biochem. Pharm. Res., 1: 393-401.
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  69. Kumar, T., A. Alexander, Ajazuddin, D. Dewangan and J. Khan et al., 2011. Investigation of In-Vitro Anthelmintic Activity of Bauhinia racemosa linn. J. Appl. Pharm. Sci., 1: 73-75.
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  70. Dewangan, D., T. Kumar, A. Alexander, K. Nagori and D.K. Tripathi, 2011. Pyrazole: Their Chemistry and Pharmacological Potentials: A Review. Curr. Pharma Res., 1: 369-377.
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  71. Amit, A., R. Chaurasia, J. Khan, Swarna, S. Sahu and S. Patel, 2011. Spectrophotometric method of standard curve preparation and calculation for metronidazole. Int. J. Pharm. Professional's Res., 2: 206-209.
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  72. Alexander, Amit Sharad Sharma, Ajazuddin, Khan Mohammed Junaid and Swarna, 2011. Theories and factors affecting mucoadhesive drug delivery systems: A review. Int. J. Ayurveda Pharm., 2: 1155-1161.
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  73. Alexander, A., M. Ajazuddin, M. Swarna, M. Sharma and D.K. Tripathi, 2011. Polymers and permeation enhancers: Specialized components of mucoadhesives. Stamford J. Pharm. Sci., 4: 91-95.
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  74. Alexander, A., D.K. Tripathi, Ajazuddin, M. Singh and M. Sahu et al., 2011. Multidose Therapy (MDT) Treatment for Helicobacter Pylori Infection Leading to Gastric Ulcer and Carcinoma: A Review. Res. J. Pharmacol. Pharmacodyn., 3: 140-147.
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  75. Alexander, A., Ajazuddin, T. Giri, Swarna and P. Shukla, 2011. Various Evaluation Parameters Used for the Evaluation of Different Mucoadhesive Dosage Forms. A Review. Int. J. Drug Formulation Res., 2: 1-26.
  76. Alexander, A., Ajazuddin, D.K. Tripathi, T. Verma, Swarna, J. Maurya and S. Patel, 2011. Mechanism responsible for mucoadhesion of mucoadhesive drug delivery system: A review. Int. J. Applied Biol. Pharm. Technol., 2: 434-445.
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  77. Alexander, A., Ajazuddin, A. Singh and Swarna, 2011. Herbal Drugs Used for the Treatment of Asthma: An Overview. Int. J. Curr. Biomed. Pharm. Res., 1: 67-79.
  78. Alexander, A., Ajazuddin, D.K. Tripathi, V. Tekeshwar, P. Sandip, D. Harsh and Swarna, 2011. Role of excipients to enhance the disintegration property of different formulations: An Overview. Res. J. Pharmacy Technol., 4: 1519-1525.
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  79. Suryawanshi, V., C.D. Kaur, A. Alexander, M.A. Rasool and S. Singh, 2010. Development and in-vitro evaluation of buccoadhesive formulation of dimenhydrinate tablet. Int. J. Pharm. Prof. Res., 1: 109-113.
  80. Giri, T.K., H. Badwaik, A. Alexander and D.K. Tripathi, 2010. Solubility enhancement of ibuprofen in the presence of hydrophilic polymer and surfactant. Int. J. Applied Biol. Pharm. Technol., 1: 793-800.
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  81. Giri, T.K., A. Alexander and D.K. Tripathi, 2010. Physicochemical classification and formulation development of solid dispersion of poorly water soluble drugs: An updated review. Int. J. Pharm. Biol. Arch., 1: 309-324.