Dr. Shashank  Kumar

Dr. Shashank Kumar

Research Scientist
University of Allahabad, India


Highest Degree
Ph.D. in Biochemistry from University of Allahabad, India

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Biography

Dr. Shashank Kumar is currently working as Research Associate at Molecular Cell Biology Lab, Department of Biochemistry, King Georges Medical University, Lucknow. He obtained his Ph.D. in Biochemistry from University of Allahabad, Allahabad, India. His main area of interest related to Pharmacology, Toxicology and Clinical Biology, Plant Products, Oxidative Stress DNA Repair Pathway, Biochemical Activities, and Cancer Biology. He has published 15 articles in journals contributed as author/co-author.

Area of Interest:

Pharmacology and Toxicology
100%
Oxidative Stress
62%
DNA Repair
90%
Cancer Biology
75%
Biochemistry
55%

Selected Publications

  1. Verma, S., K.S. Prajapati, P.P. Kushwaha, M. Shuaib, A.K. Singh, S. Kumar and S. Gupta, 2020. Resistance to second generation antiandrogens in prostate cancer: pathways and mechanisms. Cancer Drug Resist., Vol. 3. 10.20517/cdr.2020.45.
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  2. Senapati, S., S. Kumar, A.K. Singh, P. Banerjee and S. Bhagavatula, 2020. Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human. J. Genet., Vol. 99. 10.1007/s12041-020-01217-7.
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  3. Kushwaha, P.P., S.K. Prajapati, S.V. Pothabathula, A.K. Singh, M. Shuaib, K. Joshi and S. Kumar, 2020. Prenylated flavonoids as a promising drug discovery candidate. In: Phytochemicals as Lead Compounds for New Drug Discovery, Egbuna, C., S. Kumar and S. Kaliyaperumal, Elsevier, Amsterdam, Netherlands, pp: 347-355.
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  4. Kushwaha, P.P., P.S. Vardhan, P. Kumari, A.G. Mtewa and S. Kumar, 2020. Bioactive lead compounds and targets for the development of antimalarial drugs. Phytochemicals Lead Comp. New Drug Discovery, : 305-316.
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  5. Kushwaha, P.P., A.K. Singh, M. Shuaib, K.S. Prajapati, P.S. Vardhan, S. Gupta and S. Kumar, 2020. 3-O-(E)-p-Coumaroyl betulinic acid possess anticancer activity and inhibit Notch signaling pathway in breast cancer cells and mammosphere. Chemico-Biol. Interact.,, Vol. 328. 10.1016/j.cbi.2020.109200.
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  6. Gupta, S., A.K. Singh, P.P. Kushwaha, K.S. Prajapati, M. Shuaib, S. Senapati and S. Kumar, 2020. Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies. J. Biomol. Struct. Dyn., 10.1080/07391102.2020.1776157.
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  7. Gupta, S., A.K. Singh, K.S. Prajapati, P.P. Kushwaha, M. Shuaib and S. Kumar, 2020. Emerging role of ZBTB7A as an oncogenic driver and transcriptional repressor. Cancer Lett., 483: 22-34.
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  8. Singh, P., R.S. Singh, P.P. Kushwaha and S. Kumar, 2019. Anticancer and neuroprotective activity of chrysin: recent advancement. In: Phytochemistry: An in-silico and in-vitro Update, Kumar, S. and C. Egbuna Springer, Singapore, pp 183-202.
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  9. Singh, P., P.P. Kushwaha, A.K. Singh and S. Kumar, 2019. Association between nuclear receptor coactivator 1 and stem cell signaling pathway and identification of natural NCOA1 inhibitors: an in-silico study. In: Phytochemistry: An in-silico and in-vitro Update, Kumar, S. and C. Egbuna, Springer, Singapore, pp: 545-564.
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  10. Singh, P., P.P. Kushwaha and S. Kumar, 2019. Parthenin and its similar structure as potential lead inhibitors of Plasmodium vivax and Plasmodium falciparum lactate dehydrogenase. In: Phytochemistry: An in-silico and in-vitro Update, Kumar, S. and C. Egbuna, Springer, Singapore, pp: 565-577.
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  11. Kushwaha, P.P., S. Gupta, A.K. Singh, K.S. Prajapati, M. Shuaib and S. Kumar, 2019. MicroRNA targeting nicotinamide adenine dinucleotide phosphate oxidases in cancer. Antioxid. Redox Signaling, 32: 267-284.
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  12. Kushwaha, P.P., S. Gupta, A.K. Singh and S. Kumar, 2019. Emerging role of migration and invasion enhancer 1 (MIEN1) in cancer progression and metastasis. Front. Oncol., Vol. 9. 10.3389/fonc.2019.00868.
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  13. Kushwaha, P.P., P.S. Vardhan, P. Kapewangolo, M. Shuaib, S.K. Prajapati, A.K. Singh and S. Kumar, 2019. Bulbine frutescens phytochemical inhibits notch signaling pathway and induces apoptosis in triple negative and luminal breast cancer cells. Life Sci., Vol. 234. 10.1016/j.lfs.2019.116783.
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  14. Kashyap, N., P.P. Kushwaha, A.K. Singh, S. Maurya, A.K. Sahoo and S. Kumar, 2019. Phytochemicals, cancer and miRNAs: An in-silico approach. In: Phytochemistry: An in-silico and in-vitro Update, Kumar, S. and C. Egbuna, Springer, Singapore, pp: 421-459.
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  15. Ezebuo, F.C., P.P. Kushwaha A.K. Singh, S. Kumar and P. Singh, 2019. In-silico methods of drug design: molecular simulations and free energy calculations. In: Phytochemistry: An in-silico and in-vitro Update, Kumar, S. and C. Egbuna, Springer, Singapore, pp: 521-533.
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  16. Pushpendra, S., P.P. Kushwaha and K. Shashank, 2018. Novel potent inhibitors of plasmodium vivax dihydrofolate reductase: an in silico antimalarial drug discovery. Indian J. Pharm. Edu. Res., 52: 122-134.
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  17. Patel, K., N. Singh, J. Yadav, J.M. Nayak, S.K. Sahoo et al., 2018. Polydopamine films change their physicochemical and antimicrobial properties with a change in reaction conditions. Phys. Chem. Chem. Phys., 20: 5744-5755.
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  18. Waseem, M., M. Ahmad, V. Srivastava, N. Rastogi and M. Serajuddin et al., 2017. Evaluation of miR-711 as novel biomarker in prostate cancer progression. Asian Pacific J. Cancer Prev., 18: 2185-2191.
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  19. Singh, P., S. Kumar and F. Bast, 2017. Natural compounds are smart players in context to anticancer potential of receptor tyrosine kinases: an in silico and in vitro advancement. In: Translational Bioinformatics and Its Application, Wei, D.Q., Y. Ma, W.C.S. Cho, Q. Xu and F. Zhou, Springer, Netherlands, pp: 177-202.
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  20. Kumar, S., S.R. Hussain, M. Waseem, F. Mahdi, C. Bansal and M.K. Ahmad, 2017. D allele frequency in insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene is associated with development of breast cancer risk in Indian women. Curr. Proteomics, 13: 297-304.
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  21. Waseem, M., S.R. Hussain, S. Kumar, M. Serajuddin and F. Mahdi, 2016. Association of MTHFR (C677T) gene polymorphism with breast cancer in North India. Biomarkers Cancer, 8: 111-117.
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  22. Kushwaha, P.P., K.C. Rapalli and S. Kumar, 2016. Geminin a multi task protein involved in cancer pathophysiology and developmental process: A review. Biochimie, 131: 115-127.
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  23. Kumar, S., 2015. MicroRNAs an evolving prognostic, diagnostic and therapeutic target in prostate cancer. World J. Pharm. Sci., 3: 387-389.
  24. Kumar, S. and A.K. Pandey, 2015. Free radicals, from oxidative stress to disease and their mitigation by herbals. Br. J. Med. Med. Res., 7: 438-457.
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  25. Bais, S.S., K. Lawrence, S. Kumar and R. Lawrence, 2015. Eichhornia crassipes (Mart.) Solm: A biotic resource for waste water treatment. World J. Pharmaceut. Sci., Vol. 3. .
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  26. Sharma, A.K., S. Kumar, G. Chashoo, A.K. Saxena and A.K. Pandey, 2014. Cell cycle inhibitory activity of Piper longum against A549 cell line and its protective effect against metal-induced toxicity in rats. Indian J. Biochem. Biophys., 51: 358-364.
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  27. Sharma, A.K., S. Kumar and A.K. Pandey, 2014. Ferric reducing, antiradical and cytotoxic activites of Tinospora cordifolia stem extract. Biochem. Anal. Biochem. Vol. 3. 10.4172/2161-1009.1000153.
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  28. Sanjay, S.S., A.C. Pandey, S. Kumar and A.K. Pandey, 2014. Membrane protective efficacy of ZnO nanoparticles. SOP Trans. Nano-Technol., 1: 21-29.
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  29. Kumar, S., S. Pandey and A.K. Pandey, 2014. In vitro antibacterial, antioxidant, cytotoxic activities of Parthenium hysterophorus and characterization of extracts by LC MS analysis. BioMed. Res. Int., Vol. 2014. 10.1155/2014/495154.
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  30. Kumar, S., R. Kumar, A. Diwedi and A.K. Pandey, 2014. In vitro antioxidant, antibacterial, cytotoxic activity and in vivo efficacy of Syngonium podophyllum and Eichhornia crassipes leaf extracts on isoniazid induced oxidative stress and hepatic markers. BioMed. Res. Int., Vol. 2014. 10.1155/2014/459452.
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  31. Kumar, S., R. Gupta, A.M. Kaleem and A.K. Pandey, 2014. Mitigation of pain and anesthetic drugs. OA Anaesthetics, Vol. 2. .
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  32. Kumar, S., 2014. Emerging trends in pharmaceutical sciences: An introduction. World J. Pharm. Sci., 2: 1592-1593.
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  33. Kumar, S. and A.K. Pandey, 2014. Pharmacological activities of some common Indian weeds: A review. Mintage J. Pharmaceut. Med. Sci., 3: 12-17.
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  34. Kumar, S. and A.K. Pandey, 2014. Medicinal attributes of S. xanthocarpum fruit consumed by several tribal communities as food: An antioxidant, anticancer and anti HIV perspective. BMC Complement. Alternat. Med., Vol. 14. 10.1186/1472-6882-14-112.
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  35. Pandey, A.K. and S. Kumar, 2013. Perspective on plant products as antimicrobials agents: A review. Pharmacologia, 4: 469-480.
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  36. Mishra, A., S. Kumar and A.K. Pandey, 2013. Scientific validation of the medicinal efficacy of Tinospora cordifolia. Scient. World J. .
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  37. Mishra, A., A.K. Sharma, S. Kumar, A.K. Saxena and A.K. Pandey, 2013. Bauhinia variegata leaf extracts exhibit consideradble antibacterial, antioxidant and anticancer activities. BioMed Res. Int. 10.1155/2013/915436.
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  38. Kumar, S., G. Chashoo, A.K. Saxena and A.K. Pandey, 2013. Parthenium hysterophorus: A probable source of anticancer, antioxidant and anti-HIV agents. BioMed Res. Int. 10.1155/2013/810734.
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  39. Kumar, S., A.K. Gupta and A.K. Pandey, 2013. Calotropis procera root extract has the capability to combat free radical mediated damage. ISRN Pharmacol. 10.1155/2013/691372.
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  40. Kumar, S., A. Mishra and A.K. Pandey, 2013. Antioxidant mediated protective effect of Parthenium hysterophorus against oxidative damage using in vitro models. BMC Complementary Altern. Med., Vol. 13. 10.1186/1472-6882-13-120.
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  41. Kumar, S. and A.K. Pandey, 2013. Phenolic content, reducing power and membrane protective activities of Solanum xanthocarpum root extracts. Vegetos-Int. J. Plant Res., 26: 301-307.
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  42. Kumar, S. and A.K. Pandey, 2013. Chemistry and biological activities of flavonoids: An overview. Scient. World J. 10.1155/2013/162750.
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  43. Kumar, S., U.K. Sharma, A.K. Sharma and A.K. Pandey, 2012. Protective efficacy of Solanum xanthocarpum root extracts against free radical damage: Phytochemical analysis and antioxidant effect. Cell. Mol. Biol., 58: 174-181.
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  44. Kumar, S. and A.K. Pandey, 2012. Antioxidant, lipo-protective and antibacterial activities of phytoconstituents present in Solanum Xanthocarpum root. Int. Rev. Biophys. Chem., 3: 42-47.
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  45. Mishra, A., S. Kumar, A. Bhargava, B. Sharma and A.K. Pandey, 2011. Studies on in vitro antioxidant and antistaphylococcal activities of some important medicinal plants. Cell. Mol. Biol., 57: 16-25.
    PubMed  |  
  46. Pandey, A.K., A.K. Mishra, A. Mishra, S. Kumar and A. Chandra, 2010. Therapeutic potential of C. zeylanicum extracts: An antifungal and antioxidant perspective. Int. J. Biol. Med. Res., 1: 228-233.
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