Dr. Asad Ullah Khan
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Dr. Asad Ullah Khan

Professor, Coordinator (Head)
Aligarh Muslim University, India

Highest Degree
Ph.D. in Biochemistry from Aligarh Muslim University, India

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Area of Interest:

Biomedical Sciences
100%
Drug Resistance Mechanism
62%
Alternative Medicine
90%
Drug Designing
75%
Biofilm
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Salahuddin, P., A. Kumar and A.U. Khan, 2018. Structure, function of serine and metallo-β-lactamases and their inhibitors. Curr. Protein Peptide Sci., 19: 130-144.
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  2. Parvez, S. and A.U. Khan, 2018. Hospital sewage water: A reservoir for variants of New Delhi metallo-β-lactamase (NDM)-and extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. Int. J. Antimicrobial Agents, 51: 82-88.
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  3. Parveen, H., R.A.S. Alatawi, M.A. Alsharif, M.I. Alahmdi and S. Mukhtar et al., 2018. Novel pyrazoline-based organometallic compounds containing ferrocenyl and quinoline units: Synthesis, characterization and microbial susceptibilities. Applied Organometallic Chem., Vol. 32. 10.1002/aoc.4257.
    CrossRef  |  
  4. Mukhtar, S., M.A. Alsharif, M.I. Alahmdi, H. Parveen and A.U. Khan, 2018. Novel spiro‐thiazolidin‐4‐one and thioether derivatives of benzylidene flavanones: New leads in cancer and microbial chemotherapy. Archiv der Pharmazie. 10.1002/ardp.201700397.
    CrossRef  |  
  5. Misba, L. and A.U. Khan, 2018. Enhanced photodynamic therapy using light fractionation against Streptococcus mutans biofilm: Type I and type II mechanism. Future Microbiol., 13: 437-454.
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  6. Maryam, L., A. Sharma, M.W. Azam, S.N. Khan and A.U. Khan, 2018. Understanding the mode of binding mechanism of doripenem to human serum albumin: Spectroscopic and molecular docking approaches. J. Mol. Recognition. 10.1002/jmr.2710.
    CrossRef  |  
  7. Khan, S., A. Ali and A.U. Khan, 2018. Structural and functional insight of New Delhi Metallo β-lactamase-1 variants. Future Med. Chem., 10: 221-229.
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  8. Ali, A., M.W. Azam and A.U. Khan, 2018. Non-active site mutation (Q123A) in New Delhi metallo-β-lactamase (NDM-1) enhanced its enzyme activity. Int. J. Biol. Macromolecules, 112: 1272-1277.
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  9. Ahmad, N., S.M. Ali and A.U. Khan, 2018. Detection of new Delhi metallo-β-lactamase variants NDM-4, NDM-5 and NDM-7 in Enterobacter aerogenes isolated from a neonatal intensive care unit of a North India hospital: A first report. Microbial Drug Resistance, 24: 161-165.
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  10. Ahmad, N., S. Khalid, S.M. Ali and A.U. Khan, 2018. Occurrence of blaNDM variants among enterobacteriaceae from a neonatal intensive care unit in a Northern India hospital. Frontiers Microbiol. 10.3389/fmicb.2018.00407.
    CrossRef  |  
  11. Abidi, S.S.A., Y. Azim, S.N. Khan and A.U. Khan, 2018. Sulfaguanidine cocrystals: Synthesis, structural characterization and their antibacterial and hemolytic analysis. J. Pharm. Biomed. Analysis, 149: 351-357.
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  12. Zuberi, A., N. Ahmad and A.U. Khan, 2017. CRISPRI induced suppression of Fimbriae gene (fimH) of a Uropathogenic Escherichia coli: An approach to inhibit microbial biofilms. Frontiers Immunol., Vol. 8. 10.3389/fimmu.2017.01552.
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  13. Zuberi, A., L. Misba and A.U. Khan, 2017. CRISPR Interference (CRISPRi) inhibition of luxS gene expression in E. coli: An approach to inhibit biofilm. Frontiers Cell. Infect. Microbiol., Vol. 7. 10.3389/fcimb.2017.00214.
    CrossRef  |  
  14. Zaidi, S., L. Misba and A.U. Khan, 2017. Nano-therapeutics: A revolution in infection control in post antibiotic era. Nanomedicine: Nanotechnol. Biol. Med., 13: 2281-2301.
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  15. Ullah, R., A. Rehman, M.F. Zafeer, L. Rehman and Y.A. Khan et al., 2017. Anthelmintic potential of thymoquinone and curcumin on fasciola gigantica. PloS One, Vol. 12. 10.1371/journal.pone.0171267.
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  16. Raghav, A., J. Ahmad, K. Alam and A.U. Khan, 2017. New insights into non-enzymatic glycation of human serum albumin biopolymer: A study to unveil its impaired structure and function. Int. J. Biol. Macromolecules, 101: 84-99.
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  17. Qayyum, S., M. Oves and A.U. Khan, 2017. Obliteration of bacterial growth and biofilm through ROS generation by facilely synthesized green silver nanoparticles. PloS One, Vol. 12. 10.1371/journal.pone.0181363.
    CrossRef  |  
  18. Neelakantan, P., M. Romero, J. Vera, U. Daood, A.U. Khan, A. Yan and G.S.P. Cheung, 2017. Biofilms in endodontics-current status and future directions. Int. J. Mol. Sci., Vol. 18. 10.3390/ijms18081748.
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  19. Misba, L., S. Zaidi and A.U. Khan, 2017. A comparison of antibacterial and antibiofilm efficacy of phenothiazinium dyes between Gram positive and Gram negative bacterial biofilm. Photodiagnosis Photodynamic Therapy, 18: 24-33.
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  20. Maryam, L. and A.U. Khan, 2017. Synergistic effect of doripenem and cefotaxime to inhibit CTX-M-15 type β-lactamases: Biophysical and microbiological views. Frontiers Pharmacol., Vol. 8. 10.3389/fphar.2017.00449.
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  21. Maryam, L. and A.U. Khan, 2017. Structural insight into mode of binding of Meropenem to CTX-M-15 type β-lactamase. Int. J. Biol. Macromolecules, 96: 78-86.
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  22. Kulshrestha, S., S. Qayyum and A.U. Khan, 2017. Antibiofilm efficacy of green synthesized graphene oxide-silver nanocomposite using Lagerstroemia speciosa floral extract: A comparative study on inhibition of gram-positive and gram-negative biofilms. Microbial Pathogenesis, 103: 167-177.
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  23. Khan, S.N., S. Khan, J. Iqbal, R. Khan and A.U. Khan, 2017. Enhanced killing and antibiofilm activity of encapsulated cinnamaldehyde against Candida albicans. Frontiers Microbiol., Vol. 8. 10.3389/fmicb.2017.01641.
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  24. Khan, S., S.N. Khan, R. Meena, A.M. Dar, R. Pal and A.U. Khan, 2017. Photoinactivation of multidrug resistant bacteria by monomeric methylene blue conjugated gold nanoparticles. J. Photochem. Photobiol. B: Biol., 174: 150-161.
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  25. Khan, A.U., L. Maryam and R. Zarrilli, 2017. Structure, genetics and worldwide spread of new Delhi Metallo-β-lactamase (NDM): A threat to public health. BMC Microbiol., Vol. 17. 10.1186/s12866-017-1012-8.
    CrossRef  |  
  26. Khan, A.U., A.Z. Beg and P.K. Verma, 2017. Draft genome sequence of the first new Delhi Metallo-lactamase-4- producing escherichia coli strain (AK1), Isolated from Sewage water of a north Indian hospital. Genome Announcements, Vol. 5. 10.1128/genomeA.01366-17.
    CrossRef  |  
  27. Khan, A.U., A. Ali, G. Srivastava and A. Sharma, 2017. Potential inhibitors designed against NDM-1 type metallo-β-lactamases: An attempt to enhance efficacies of antibiotics against multi-drug-resistant bacteria. Sci. Rep., Vol. 7. 10.1038/s41598-017-09588-1.
    CrossRef  |  
  28. Khan, A., D. Sharma, M. Faheem, D. Bisht and A.U. Khan, 2017. Proteomic analysis of a carbapenem-resistant Klebsiella pneumoniae strain in response to meropenem stress. J. Global Antimicrobial Resistance, 8: 172-178.
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  29. Gupta, D., A. Singh and A.U. Khan, 2017. Nanoparticles as efflux pump and biofilm inhibitor to rejuvenate bactericidal effect of conventional antibiotics. Nanoscale Res. Lett., Vol. 12. 10.1186/s11671-017-2222-6.
    CrossRef  |  
  30. Danishudin, A. Kumar, F. Mobeen and A.U. Khan, 2017. Development of Ligand and Structure based classification models to design novel inhibitors against antibiotic hydrolysing enzymes: Integration of web server. J. Biomol. Struc. Dynamics, 29: 1-48.
  31. Ali, A., Danishuddin, L. Maryam, G. Srivastava, A. Sharma and A.U. Khan, 2017. Designing of inhibitors against CTX-M-15 type β-lactamase: Potential drug candidate against β-lactamases-producing multi-drug-resistant bacteria. J. Biomolecular Struct. Dynamics, 8: 1-16.
  32. Ahmad, N., S.M. Ali and A.U. Khan, 2017. First reported New Delhi metallo-β-lactamase-1-producing Cedecea lapagei. Int. J. Antimicrobial Agents, 49: 118-119.
  33. Sharma, D., M. Lata, M. Faheem, A.U. Khan and B. Joshi et al., 2016. M. tuberculosis ferritin (Rv3841): Potential involvement in Amikacin (AK) & Kanamycin (KM) resistance. Biochem. Biophys. Res. Commun., 478: 908-912.
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  34. Qayyum, S., D. Sharma, D. Bisht and A.U. Khan, 2016. Protein translation machinery holds a key for transition of planktonic cells to biofilm state in Enterococcus faecalis: A proteomic approach. Biochem. Biophys. Res. Commun., 474: 652-659.
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  35. Qayyum, S. and A.U. Khan, 2016. Nanoparticles vs. biofilms: A battle against another paradigm of antibiotic resistance. Med. Chem. Comm., 7: 1479-1498.
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  36. Qayyum, S. and A.U. Khan, 2016. Biofabrication of broad range antibacterial and antibiofilm silver nanoparticles. IET Nanobiotechnol., 10: 349-357.
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  37. Misba, L., S. Kulshrestha and A.U. Khan, 2016. Antibiofilm action of a toluidine blue O-silver nanoparticle conjugate on Streptococcus mutans: A mechanism of type I photodynamic therapy. Biofouling, 32: 313-328.
    CrossRef  |  Direct Link  |  
  38. Maryam, L. and A.U. Khan, 2016. A mechanism of synergistic effect of streptomycin and cefotaxime on CTX-M-15 type β-lactamase producing strain of E. cloacae: A first report. Frontiers Microbiol., Vol. 7. 10.3389/fmicb.2016.02007.
    CrossRef  |  
  39. Kulshrestha, S., S. Khan, S. Hasan, M.E. Khan, L. Misba and A.U. Khan, 2016. Calcium fluoride nanoparticles induced suppression of Streptococcus mutans biofilm: An in vitro and in vivo approach. Applied Microbiol. Biotechnol., 100: 1901-1914.
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  40. Khan, S.N. and A.U. Khan, 2016. Breaking the spell: Combating multidrug resistant Superbugs. Frontiers Microbiol., Vol. 7. 10.3389/fmicb.2016.00174.
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  41. Khan, S., A.U. Khan and S. Hasan, 2016. Genotoxic assessment of chlorhexidine mouthwash on exfoliated buccal epithelial cells in chronic gingivitis patients. J. Indian Soc. Periodontol., 20: 584-591.
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  42. Khan, A.U. and M.T. Rehman, 2016. Role of non-active-site residue trp-93 in the function and stability of new Delhi Metallo-β-Lactamase 1. Antimicrobial Agents Chemotherapy, 60: 356-360.
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  43. Danishuddin and A.U. Khan, 2016. Descriptors and their selection methods in QSAR analysis: Paradigm for drug design. Drug Discovery Today, 21: 1291-1302.
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  44. Ahmad, A., A. Ahmad, R. Sudhakar, H. Varshney and N. Subbarao et al., 2016. Designing, synthesis and antimicrobial action of oxazoline and thiazoline derivatives of fatty acid esters. J. Biomol. Struc Dynamics, 28: 1-20.
  45. Zafar, H., A. Ahmad, A.U. Khan and T.A. Khan, 2015. Synthesis, characterization and antimicrobial studies of Schiff base complexes. J. Mol. Structure, 1097: 129-135.
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  46. Uzzaman, S., K.A.A. Baqi, M. Asif, A. Ali and H. Khanam et al., 2015. Design, synthesis and docking studies of novel spiroazetidinone substituted steroidal derivatives possessing potent diversified pharmacological properties. Eur. Chem. Bull., 4: 154-164.
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  47. Sharma, D., M. Lata, M. Faheem, A.U. Khan and B. Joshi et al., 2015. Cloning, expression and correlation of Rv0148 to amikacin & kanamycin resistance. Curr. Proteomics, 12: 96-100.
    Direct Link  |  
  48. Rehman, M.T., S. Ahmed and A.U. Khan, 2015. Interaction of meropenem with ‘N’and ‘B’isoforms of human serum albumin: A spectroscopic and molecular docking study. J. Biomolecular Struct. Dynamics, 34: 1849-1864.
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  49. Rehman, M.T., M. Faheem and A.U. Khan, 2015. An insight into the biophysical characterization of different states of cefotaxime hydrolyzing β-lactamase 15 (CTX-M-15). J. Biomolecular Struct. Dynamics, 33: 625-638.
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  50. Rehman, M.T. and A.U. Khan, 2015. Understanding the interaction between human serum albumin and anti-bacterial/anti-cancer compounds. Curr. Pharm. Design, 21: 1785-1799.
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  51. Parveen, H., R.A.S. Alatawi, N.H. El Sayed, S. Hasan, S. Mukhtar and A.U. Khan, 2015. Synthesis, characterization and biological evaluation of some novel nitrogen and sulphur containing organometallic heterocycles. Arabian J. Chem., 10: 1098-1106.
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  52. Khan, T.A., H. Zafar, S.N. Khan and A.U. Khan, 2015. Metal-ion directed synthesis of 18-membered tetrathia macrocyclic complexes of Co (II), Ni (II), Cu (II) and Zn (II), their physicochemical studies and DNA binding study of copper complex. Synthesis Reactivity Inorganic Metal-Organic Nano-Metal Chem., 45: 1175-1183.
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  53. Khan, A.U., 2015. Worldwide spread of NDM-1: Are migratory birds culprits? J. Infect. Dev. Countries, 9: 120-121.
  54. Hasan, S., M. Danishuddin and A.U. Khan, 2015. Inhibitory effect of Zingiber officinale towards Streptococcus mutans virulence and caries development: In vitro and in vivo studies. BMC Microbiol., Vol. 15. 10.1186/s12866-014-0320-5.
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  55. Danishuddin, M. and A.U. Khan, 2015. Virtual screening strategies: A state of art to combat with multiple drug resistance strains. MOJ Proteomics Bioinform, Vol. 2. 10.15406/mojpb.2015.02.00042.
    CrossRef  |  
  56. Danishuddin, M. and A.U. Khan, 2015. Structure based virtual screening to discover putative drug candidates: Necessary considerations and successful case studies. Methods, 71: 135-145.
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  57. Baig, M.H., V.M. Balaramnavar, G. Wadhwa and A.U. Khan, 2015. Homology modeling and virtual screening of inhibitors against TEM‐and SHV‐type‐resistant mutants: A multilayer filtering approach. Biotechnol. Applied Biochem., 62: 669-680.
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  58. Salahuddin, P. and A.U. Khan, 2014. Studies on structure-based sequence alignment and phylogenies of beta-lactamases. Bioinformation, 10: 308-313.
    CrossRef  |  Direct Link  |  
  59. Rehman, M.T., H. Shamsi and A.U. Khan, 2014. Insight into the binding mechanism of imipenem to human serum albumin by spectroscopic and computational approaches. Mol. Pharm., 11: 1785-1797.
    CrossRef  |  Direct Link  |  
  60. Kulshrestha, S., S. Khan, R. Meena, B.R. Singh and A.U. Khan, 2014. A graphene/zinc oxide nanocomposite film protects dental implant surfaces against cariogenic Streptococcus mutans. Biofouling, 30: 1281-1294.
    CrossRef  |  Direct Link  |  
  61. Khan, A.U., 2014. Beta-lactomics: A new term coined in OMICS. J. Proteomics Bioinform., Vol. 7. 10.4172/jpb.1000 0e27.
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  62. Khan, A.U., 2014. An In silco approach to battle with NDM-1 superbug: From wet to dry. J. Proteomics Bioinform., Vol. 7. 10.4172/jpb.1000 0e23.
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  63. Khan, A.U. and S. Parvez, 2014. Detection of blaNDM-4 in Escherichia coli from hospital sewage. J. Med. Microbiol., 63: 1404-1406.
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  64. Khan, A., M. Faheem, M. Danishuddin and A.U. Khan, 2014. Evaluation of inhibitory action of novel non β-lactam inhibitor against Klebsiella pneumoniae carbapenemase (KPC-2). PloS One, Vol. 9. 10.1371/journal.pone.0108246.
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  65. Hasan, S., K. Singh, M. Danisuddin, P.K. Verma and A.U. Khan, 2014. Inhibition of major virulence pathways of Streptococcus mutans by quercitrin and deoxynojirimycin: A synergistic approach of infection control. PLoS One, Vol. 9. 10.1371/journal.pone.0091736.
    CrossRef  |  
  66. Danishuddin, M., A. Khan, M. Faheem, P. Kalaiarasan, M.H. Baig, N. Subbarao and A.U. Khan, 2014. Structure-based screening of inhibitors against KPC-2: Designing potential drug candidates against multidrug-resistant bacteria. J. Biomol. Struct. Dyn., 32: 741-750.
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  67. Baig, M.H., D.R. Sudhakar, P. Kalaiarasan, N. Subbarao and G. Wadhawa et al., 2014. Insight into the effect of inhibitor resistant S130G mutant on physico-chemical properties of SHV type beta-lactamase: A molecular dynamics study. PloS One, Vol. 9. 10.1371/journal.pone.0112456.
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  68. Ali, S.Z., S.M. Ali and A.U. Khan, 2014. Prevalence of IncI1-Iγ and IncFIA-FIB type plasmids in ESBLs producing K. pneumoniae strains isolated from NICU of north Indian hospital. Microbiology, 160: 1153-1161.
  69. Adil, M., K. Singh, P.K. Verma and A.U. Khan, 2014. Eugenol-induced suppression of biofilm-forming genes in Streptococcus mutans: An approach to inhibit biofilms. J. Global Antimicrobial Resistance, 2: 286-292.
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  70. Varshney, H., A. Ahmad, N.N. Farshori, A. Ahmad, A.U. Khan and A. Rauf, 2013. Synthesis and evaluation of in vitro antimicrobial activity of novel 2, 3-disubstituted-4-thiazolidinones from fatty acid hydrazides. Med. Chem. Res., 22: 3204-3212.
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  71. Rehman, M.T., M. Faheem and A.U. Khan, 2013. Insignificant β-lactamase activity of human serum albumin: No panic to Nonmicrobial-based drug resistance. Lett. Applied Microbiol., 57: 325-329.
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  72. Parveen, M., A. Ali, M. Alam, A.U. Khan and A. Ahmad, 2013. Synthesis, characterization, biological evaluation and in silico screening of oxadiazinanones. Med. Chem. Res., 22: 3085-3095.
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  73. Mashrai, A., A. Ahmad, A.M. Dar, H. Khanam, M. Danishuddin and A.U. Khan, 2013. Synthesis, evaluation and docking studies on steroidal pyrazolones as anticancer and antimicrobial agents. Med. Chem. Res., 10.1007/s00044-013-0636-y.
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  74. Khan, A.U., 2013. Structural basis for the inhibition of bacterial multidrug exporters. Nature, 500: 102-106.
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  75. Hasan, S., S.Z. Ali and A.U. Khan, 2013. Novel combinations of antibiotics to inhibit ESBL and MBL producers in vitro: A synergistic approach. Future Microbiol., 8: 939-944.
  76. Fahim, M., M.T. Rehman, M. Danishuddin and A.U. Khan, 2013. Biochemical characterization of CTX-M-15 from Enterobacter cloacae and designing a novel non-β-lactam-β-lactamase inhibitor. PloS ONE, Vol. 8. 10.1371/journal.pone.0056926.
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  77. Danishuddin, M., M.H. Baig, L. Kaushal and A.U. Khan, 2013. BLAD: A comprehensive database of widely circulated beta-lactamases. Bioinformatics, 29: 2515-2516.
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  78. Ahmad, A., A. Ahmad, H. Varshney, A. Rauf, M. Rehan, N. Subbarao and A.U. Khan, 2013. Designing and synthesis of novel antimicrobial heterocyclic analogs of fatty acids. Eur. J. Med. Chem., 70: 887-900.
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  79. Tabassum, S., M. Parveen, A. Ali, M. Alam, A. Ahmad, A.U. Khan and R.A. Khan, 2012. Synthesis of Aryl-1, 2, 4, 5-tetrazinane-3-thiones, in vitro DNA binding studies, nuclease activity and its antimicrobial activity. J. Mol. Struct., 1020: 33-40.
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  80. Siddiqui, Z.N., S. Praveen, T.N. Musthafa, A. Ahmad and A.U. Khan, 2012. Thermal solvent-free synthesis of chromonyl chalcones, pyrazolines andtheir in vitro antibacterial, antifungal activities. J. Enzyme Inhibition Med. Chem., 27: 84-91.
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  81. Rizvi, A., R. Khan, A.U. Khan, Z. Ghani and S. Ghani et al., 2012. Observations on in vitro and in vivo antimicrofilarial effects of Bishop's weed (Trachispermum ammi). J. Parasitic Dis., 36: 125-128.
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  82. Latif, A., S. Ahmad, A.U. Khan and S. Rehman, 2012. In-vitro antibacterial screening of swertia chirayita linn. against some gram negative pathogenic strains. Int. J. Pharm. Res. Dev., 4: 188-194.
  83. Khan, S.N., M. Danishuddin, B. Varshney and S.K. Lal and A.U. Khan, 2012. Inhibition of N-terminal lysines acetylation and transcription factor assembly by epirubicin induced deranged cell homeostasis. PLOS One, Vol. 7. 10.1371/journal.pone.0051850.
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  84. Khan, S., F. Alam, A. Azam and A.U. Khan, 2012. Gold nanoparticles enhance methylene blue-induced photodynamic therapy: A novel therapeutic approach to inhibit Candida albicans biofilm. Int. J. Nanomed., 7: 3245-3257.
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  85. Khan, R., Z. Khanam and A.U. Khan, 2012. Isolation and characterization of n-octacosanoic acid from Viburnum foetens: A novel antibiofilm agent against Streptococcus mutans. Med. Chem. Res., 21: 1411-1417.
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  86. Khan, R., M. Adil, M. Danishuddin, P.K. Verma and A.U. Khan, 2012. In vitro and in vivo inhibition of Streptococcus mutans biofilm by Trachyspermum ammi seeds: An approach of alternative medicine. Phytomedicine, 19: 747-755.
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  87. Khan, A.U., 2012. Nanodrugs: Optimism for emerging trend of Multidrug resistance. Int. J. Nanomed., 7: 4323-4324.
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  88. Khan, A.U., 2012. Medicine at nanoscale: A new horizon. Int. J. Nanomed., 7: 2997-2998.
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  89. Khan, A.U. and S.Z. Ali, 2012. Quick screening and easy detection method of NDM-gene in clinical isolates: A need of the time. Asian Pacific J. Trop. Med., 5: 839-840.
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  90. Khan, A.U. and P. Nordmann, 2012. Spread of carbapenemase NDM-1 producers: The situation in India and what may be proposed. Scandinavian J. Infect. Dis., 44: 531-535.
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  91. Khan, A.U. and P. Nordmann, 2012. NDM-1-producing Enterobacter cloacae and Klebsiella pneumoniae from diabetic foot ulcers in India. J. Med. Microbiol., 61: 454-456.
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  92. Khan, A. and A.U. Khan, 2012. Biomarker discovery and drug development: A proteomics approach. J. Proteomics Bioinform., 5: 3-4.
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  93. Hasan, S., M. Danishuddin, M. Adil, K. Singh, P.K. Verma and A.U. Khan, 2012. Efficacy of E. officinalis on the cariogenic properties of Streptococcus mutans: A novel and alternative approach to suppress Quorum-sensing mechanism. PloS ONE, Vol. 7. 10.1371/journal.pone.0040319.
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  94. Haque, S.F., S.Z. Ali and A.U. Khan, 2012. Prevalence of plasmid mediated blaTEM-1 and blaCTX-M-15 type extended spectrum beta-lactamases in patients with sepsis. Asian Pacific J. Trop. Med., 5: 98-102.
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  95. Danishuddin, M., L. kaushal, M.H. Beig and A.U. Khan, 2012. AMDD: Antimicrobial Drug Database. Genomics Proteomics Bioinform., 10: 360-363.
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  96. Danishuddin, M. and A.U. Khan, 2012. Molecular modeling and docking analysis of Beta-lactamases with inhibitors: A comparative study. In Silico Biol., 11: 273-280.
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  97. Siddiqui, Z.N., T.N. Musthafa, A. Ahmad and A.U. Khan, 2011. Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. Biorganic Med. Chem. Lett., 21: 2860-2865.
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  98. Siddiqui, Z.N., N.M.M. Musthafa, A. Ahmad and A.U. Khan, 2011. Synthesis of coumarin derivatives from 3-bromo-4-hydroxycoumarin as potent antimicrobial agents. Archiv. Pharmazie-Chem. Life Sci., 344: 394-401.
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  99. Shakir, M., N. Shahid, N. Sami, M. Azam and A.U. Khan, 2011. Synthesis, spectroscopic characterization and comparative DNA binding studies of Schiff base complexes derived from l-leucine and glyoxal. Spectrochim Acta A Mol. Biomol. Spectrosc, 82: 31-36.
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  100. Shakir, M., M. Azam, S. Naseem and A.U. Khan, 2011. Template synthesis and physicochemical studies of 14-membered functionalized pendant arm Schiff-base macrocyclic complexes of Co (II), Ni (II), Cu (II) and Zn (II): DNA binding studies on a Cu (II) complex. Synth. Reactivity Inorganic, Metal-Organic Nano-Metal Chem., 41: 1056-1062.
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  101. Shakir, M., A. Abbasi, M. Azam and A.U. Khan, 2011. Synthesis, spectroscopic studies and crystal structure of the Schiff base ligand L derived from condensation of 2-thiophenecarboxaldehyde and 3,3'-diaminobenzidine and its complexes with Co(II), Ni(II), Cu(II), Cd(II) and Hg(II): Comparative DNA binding studies of L and its Co(II), Ni(II) and Cu(II) complexes. Spectrochim Acta A Mol. Biomol. Spectrosc., 79: 1866-1875.
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  102. Shakir, M., A. Abbasi, A.U. Khan and S.N. Khan, 2011. Synthesis and spectroscopic studies on the Schiff base ligand derived from condensation of 2-furaldehyde and 3,3'-diaminobenzidene, H L and its complexes with Co(II), Ni(II), Cu(II) and Zn(II);comparative DNA binding studies of H L and its Cu(II) and Zn(II) complexes. Spectro Chemica Acta, 78: 29-35.
  103. Khan, S.N., R. Yennamalli, N. Subbarao and A.U. Khan, 2011. Mitoxantrone induced impediment of histone acetylation and structural flexibility of the protein. Cell Biochem. Biophys., 60: 209-218.
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  104. Khan, A.U., M.H. Baig and G. Wadhawa, 2011. Molecular docking analysis of new generation cephalosporins interactions with recently known SHV-variants. Bioinformation, 5: 331-335.
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  105. Khan, A.U., B. Islam, S.N. Khan and M. Akram, 2011. A proteomic approach for exploring biofilm in Streptococcus mutans. Bioinformation, 5: 440-445.
    PubMed  |  
  106. Farshori, N.N., M.R. Banday, A. Ahmad, A.U. Khan and A. Rauf, 2011. Facile one-pot synthesis of novel 3-substituted-1, 6-dihydro-1,2,4-triazin-5-(2H)-ones from fatty acid hydrazides and their in-vitro antimicrobial activity. Indian J. Chem., 50: 605-610.
    Direct Link  |  
  107. Farshori, N.N., M.R. Banday, A. Ahmad, A.U. Khan and A. Rauf, 2011. 7-Hydroxy-coumarin derivatives: Synthesis, characterization and preliminary antimicrobial activities. Med. Chem. Res., 20: 535-541.
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  108. Farshori, N.N., A. Ahmad, A.U. Khan and A. Rauf, 2011. A facile, one-pot synthesis, characterization and antimicrobial activity of o-hydroxy anilide derivatives and 1-substituted-1,3-dicyclohexylurea analogs of long chain carboxylic acids. Eur. J. Med. Chem., 46: 1433-1438.
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  109. Akram, M., S. Shakil and A.U. Khan, 2011. Prevalence of Integrons, blaCTX-M and blaTEM resistance markers among ESBL-producing uropathogenic escherichia coli isolates: First report of genomic blaCTX-M from India. J. Chemother., 23: 131-134.
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  110. Shakil, S., S.Z. Ali, M. Akram, S.M. Ali and A.U. Khan, 2010. Risk factors for extended-spectrum β-lactamase producing Escherichia coli and Klebsiella pneumonia acquisition in a neonatal intensive care unit. J. Trop. Pediatr., 56: 90-96.
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  111. Shakil, S., S. Alvi, M. Beg and A.U. Khan, 2010. Analysis of diabetic foot ulcers in a tertiary care hospital-a clinico-microbiological perspective. Hainan Med. J., 6: 165-170.
  112. Shakil, S., M. Akram, S.M. Ali and A.U. Khan, 2010. Acquisition of extended-spectrum β-lactamase producing Escherichia coli strains in male and female infants admitted to a neonatal intensive care unit: Molecular epidemiology and analysis of risk factors. J. Med. Microbiol., 59: 948-954.
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  113. Shakil, S. and A.U. Khan, 2010. Interaction of CTX-M-15 enzyme with cefotaxime: A molecular modelling and docking study. Bioinformation, 4: 468-472.
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  114. Shakil, S. and A.U. Khan, 2010. Interaction of 2009 CTX-M variants with drugs and inhibitors: A molecular modeling and docking study. J. Proteom. Bioinform., 3: 130-134.
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  115. Shakil, S. and A.U. Khan, 2010. Infected foot ulcers in male and female diabetic patients: A clinico-bioinformative study. Ann. Clin. Microbiol. Antimicrob., 9: 2-2.
  116. Shakil, S. and A.U. Khan, 2010. Detection of CTX-M-15 producing and carbapenem-resistant Acinetobacter baumannii strains in urine: A clinico-bioinformative report. J. Chem., 22: 324-387.
  117. Salahuddin, P. and A.U. Khan, 2010. Structure-function studies on different structural domains of Nucleoprotein of H1N1 subtype. Bioinformation, 5: 28-30.
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  118. Salahuddin, P. and A.U. Khan, 2010. Structural and functional analysis of NS1 and NS2 proteins of H1N1 subtype. Genomics Proteomics Bioinformatics, 8: 190-199.
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  119. Khan, S.N., S.K. Lal, P. Kumar and A.U. Khan, 2010. Effect of mitoxantrone on proliferation dynamics and cell cycle progression. Biosci. Report, 30: 375-381.
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  120. Khan, S.N., M. Danishuddin and A.U. Khan, 2010. Inhibition of transcription factor assembly and structural stability on mitoxantrone binding with DNA. Biosci. Rep., 30: 331-340.
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  121. Khan, S.N. and A.U. Khan, 2010. Role of histone acetylation in cell physiology and diseases: An update. Clin. Chim. Acta, 411: 1401-1411.
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  122. Khan, R., M. Zakir, Z. Khanam, S. Shakil and A.U. Khan, 2010. Novel compound from Trachyspermum ammi (Ajowan caraway) seeds with antibiofilm and antiadherence activities against Streptococcus mutans: A potential chemotherapeutic agent against dental caries. J. Applied Microbiol., 109: 2151-2159.
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  123. Khan, R., M. Zakir, S.H. Afaq, A. Latif and A.U. Khan, 2010. Activity of solvent extracts of Prosopis spicigera, Zingiber officinale and Trachyspermum ammi against multidrug resistant bacterial and fungal strains. J. Infect. Dev. Countries, 4: 292-300.
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  124. Khan, M.S., M. Alam, Z. Tabassum, A. Ahmad and A.U. Khan, 2010. Synthesis, antibacterial and antifungal activities of 6,5 fused steroidal oxazoles in cholestane series. Eur. J. Med. Chem., 45: 1094-1097.
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  125. Khan, A.U., 2010. Swine flu pandemic: A global concern. Asian Pacific J. Trop. Med., 3: 81-82.
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  126. Khan, A.U., 2010. Publication Versus Research: promotion of science or self. Curr. Sci., 99: 995-995.
  127. Farshori, N.N., M.R. Banday, A. Ahmad, A.U. Khan and A. Rauf, 2010. Synthesis, Characterization and In vitro Antimicrobial Activities of 5-alkenyl/hydroxyalkenyl-2-phenylamine-1,3,4-oxadiazoles and thiadiazoles. Bioorganic Med. Chem. Lett., 20: 1933-1938.
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  128. Danishuddin, M., S.N. Khan and A.U. Khan, 2010. Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: An in silico approach. J. Mol. Modeling, 16: 535-541.
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  129. Banday, M.R., N.N. Farshori, A. Ahmad, A.U. Khan and A. Rauf, 2010. Synthesis and characterization of novel fatty acid analogs of cholesterol: In vitro antimicrobial activity. Eur. J. Med. Chem., 45: 1459-1464.
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  130. Shakir, M., M. Azam, S. Parveen, A.U. Khan and F. Firdaus, 2009. Synthesis and spectroscopic studies on complexes of N, N'-bis-(2-pyridinecarboxaldimine)-1, 8-diaminonaphthalene (L); DNA binding studies on Cu (II) complex. Spectrochimica Acta A, 71: 1851-1856.
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  131. Shakil, S., M. Danishuddin and A.U. Khan, 2009. Doripenem versus bacteria: An emerging battleground. J. Chemother., 21: 482-492.
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  132. Salahuddin, P. and A.U. Khan, 2009. Identification of mutations at the antigenic sites: A new glycosylation site in hemagglutinin protein of H5N1 strain. Bioinformation, 4: 30-35.
  133. Khan, T.A., S. Naseem, S.N. Khan, A.U. Khan and M. Shakir, 2009. Synthesis and Spectral Characterization of 14-and 16-membered tetraazamacrocyclic Schiff base ligands and their transition metal complexes and a comparative study of interaction of calf thymus DNA with copper (II) complexes. Spectrochimica Acta A, 73: 622-629.
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  134. Khan, R., B. Islam, M. Akram, S. Shakil and A.A. Ahmad et al., 2009. Antimicrobial activity of five herbal extracts against Multi Drug Resistant (MDR) strains of bacteria and fungus of clinical origin. Molecules, 14: 586-597.
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  135. Khan, A.U., S. Shakil and S.K. Lal, 2009. Efficacy of neuraminidase (NA) inhibitors against H1N1 strains of different geographical regions: An in silico approach. Ind. J. Microbiol., 49: 370-376.
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  136. Islam, B., S.N. Khan, A. Naeem, V. Sharma and A.U. Khan, 2009. Novel effect of plant lectins on the inhibition of Streptococcus mutans biofilm formation on saliva-coated surface. J. Applied Microbiol., 106: 1682-1689.
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  137. Firdaus, F., K. Fatma, M. Azam, S.N. Khan, A.U. Khan and M. Shakir, 2009. Template synthesis and physico-chemical characterization of 14-membered tetraimine macrocyclic complexes, [MLX2] [M = Co(II), Ni(II), Cu(II) and Zn(II)]. DNA binding study on [CoLCl2] complex. Spectrochimica Acta A, 72: 591-596.
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  138. Firdaus, F., K. Fatma, A.U. Khan and M. Shakir, 2009. Metal ion controlled synthesis of 16- and 18-membered binuclear octaazamacrocyclic complexes with Co(II), Ni(II), Cu(II) and Zn(II): A comparative spectroscopic approach to DNA binding to Cu(II) complexes. J. Serbian Chem. Soc., 74: 939-951.
    Direct Link  |  
  139. Danishuddin, M., S.N. Khan and A.U. Khan, 2009. Phylogenetic analysis of surface proteins of novel H1N1 virus isolated from 2009 pandemic. Bioinformation, 4: 94-97.
    PubMed  |  
  140. Danishuddin, M. and A.U. Khan, 2009. Phylogenetic analysis of the neuraminidase gene reveals that the H5N1 strains prevalent in chickens during 2006 bird flu outbreaks in two regions of Maharashtra, India are genetically different. Genomics Proteomics Bioinformatics, 7: 57-61.
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  141. Ahmad, A. and A.U. Khan, 2009. Prevalence of Candida species and potential risk factors for vulvovaginal candidiasis in Aligarh, India. Eur. J. Obstetrics Gynecol. Reprod. Biol., 144: 68-71.
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  142. Zarrilli, R., D. Vitale, A. Di Popolo, M. Bagattini and Z. Daoud et al., 2008. A plasmid-borne blaOXA-58 gene confers imipenem resistance to Acinetobacter baumannii isolates from a Lebanese hospital. Antimicrob. Agents Chemother., 52: 4115-4120.
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  143. Shakil, S., R. Khan, R. Zarrilli and A.U. Khan, 2008. Aminoglycosides versus bacteria-a description of the action, resistance mechanism and nosocomial battleground. J. Biomed. Sci., 15: 5-14.
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  144. Shakil, S., M. Akram and A.U. Khan, 2008. Tigecycline: A critical update. J. Chemother., 20: 411-419.
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  145. Shahid, M., A. Malik, M. Akram, L.M. Agrawal, A.U. Khan and M. Agrawal, 2008. Prevalent phenotypes and antibiotic resistance in Escherichia coli and Klebsiella pneumonia at an Indian tertiary care hospital: Plasmid-mediated cefoxitin resistance. Int. J. Infect. Dis., 12: 256-264.
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  146. Salahuddin, P. and A.U. Khan, 2008. Proteolytic enzymes database. J. Proteomics Bioinform., 1: 109-111.
  147. Khan, S.N., B. Islam, R. Yennamalli, Q. Zia, N. Subbarao and A.U. Khan, 2008. Effect of adriamycin on structural state of hemoglobin: Spectroscopic and molecular docking studies. J. Pharm. Biomed. Anal., 48: 1096-1104.
  148. Khan, S.N., B. Islam, R. Yennamalli, A. Sultan, N. Subbarao and A.U. Khan, 2008. Interaction of mitoxantrone with human serum albumin: Spectroscopic and molecular modeling studies. Eur. J. Pharm. Sci., 35: 371-382.
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  149. Khan, S.N., B. Islam, M. Rajeshwari, H. Usmani and A.U. Khan, 2008. Characterizing the interaction of anesthetic supplement thiopental with human serum albumin. Acta Biochim. Polonica, 55: 399-409.
  150. Khan, N.S. and A.U. Khan, 2008. An in silico approach to map the binding site of doxorubicin on hemoglobin. Bioinformation, 2: 401-404.
    PubMed  |  Direct Link  |  
  151. Khan, A.U., S.Z. Ali and M.S. Zaman, 2008. Plasmid mediated multiple antibiotic resistance in Escherichia coli isolated from community acquired infection of urinary tract in Aligarh Hospital. Asian Pac. J. Trop. Med., 1: 12-15.
    Direct Link  |  
  152. Khan, A.U., A. Sultan, A. Tyagi, S. Zahoor and M. Akram et al., 2008. Amplification of mecA gene in multi-drug resistant Staphylococcus aureus strains from hospital personnel. J. Infect. Dev. Countries, 1: 289-295.
    PubMed  |  Direct Link  |  
  153. Khan, A.U., 2008. Multidrug resistance and bacterial infection. Asian Pac. J. Trop. Med., 1: 76-82.
  154. Khan, A.U. and S.N. Khan, 2008. Ribozymes: An anti-viral agent. Asian Pac. J. Trop. Med., 1: 76-82.
    Direct Link  |  
  155. Islam, B., S.N. Khan, I. Haque, M. Alam, M. Mushfiq and A.U. Khan, 2008. Novel anti-adherence activity of mulberry leaves: Inhibition of Streptococcus mutans biofilm by 1-deoxynojirimycin isolated from Morus alba. J. Antimicrob. Chemother., 62: 751-757.
    CrossRef  |  PubMed  |  Direct Link  |  
  156. Firdaus, F., K. Fatima, H. Azam, S.N. Khan and A.U. Khan, 2008. Template synthesis and physico-chemical studies on 14 membered hexaazino crocyclic complexes of Co (II, Ni(II), Co (II and Zn (II): A comparative approach in binding studies of DNA with Cu (II) and Ni (II) complex. Trans. Met. Chem., 33: 467-473.
  157. Danishuddin, M. and A.U. Khan, 2008. Analysis of PB2 protein from H9N2 and H5N1 avian flu virus. Bioinformation, 3: 41-46.
    PubMed  |  
  158. Anwar, T. and A.U. Khan, 2008. Identification of a point mutation causing splitting of antigenic domain in M1 protein of H5n1 strain from 2006 outbreak in India. J. Proteomics Bioinformatics, 1: 302-306.
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  159. Shakir, M., M. Azam, Y. Azim, S. Parveen and A.U. Khan, 2007. Synthesis and Physico-chemical studies on compound of 1,2-diamino phenyl-N,N'-bis (2-pyridine carboxaldimine) (L): A spectroscopic approach on binding studies of DNA with copper complex. Polyhedron, 26: 5513-5518.
  160. Khan, S.N., B. Islam and A.U. Khan, 2007. Probing midazolam interaction with human serum albumin and its effect on structural state of protein. Int. J. Integrat. Biol., 1: 102-112.
    Direct Link  |  
  161. Islam, B., S.N. Khan and A.U. Khan, 2007. Dental caries: From infection to prevention. Med. Sci. Monit., 13: 196-203.
    PubMed  |  Direct Link  |  
  162. Anwar, T. and A.U. Khan, 2007. Identification of a casein kinase II phosphorylation domain in NS1 protein of H5N1 influenza virus. Bioinformation, 2: 57-61.
    PubMed  |  
  163. Akram, M., M. Shahid and A.U. Khan, 2007. Etiology and antibiotic resistance patterns of community-acquired urinary tract infections in J N M C Hospital Aligarh, India. Ann. Clin. Microbial. Antimicrob., Vol. 6. 10.1186/1476-0711-6-4.
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  164. Shakir, M., S. Parveen, P. Chingsubam, K. Aoki, S.N. Khan and A.U. Khan, 2006. Cation supported self-assembly of coordination polymers, [(H2en)(ntpMCl2)]n (M = ZnII, CdII, HgII) involving the tripodal acid, ntp: X-ray crystal structure and DNA binding studies on zinc helicate. Polyhedron, 25: 2929-2934.
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  165. Khan, A.U., 2006. Ribozyme: A clinical tool. Clin. Chim. Acta., 367: 20-27.
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  166. Khan, A.U., 2006. Bird Flu: A recent threat to human health. Bioinformation, 1: 132-132.
    PubMed  |  
  167. Khan, A.U. and M.S. Zaman, 2006. Multiple drug resistance pattern in Urinary Tract Infection patients in Aligarh. Biomed. Res., 17: 179-181.
  168. Anwar, T., S.K. Lal and A.U. Khan, 2006. Matrix protein 1: A comparative In Silico study on different strains of influenza A H5N1 virus. Bioinformation, 1: 253-256.
    PubMed  |  
  169. Anwar, T., K. Lal Sunil and U. Khan, 2006. In silico analysis of genes Nucleoprotein, Neuraminidase and Hemagglutinin: A comparative study on different strains of influenza A (Bird Flu) virus Sub-type H5N1. J. Silico Biol., 6: 161-168.
    PubMed  |  Direct Link  |  
  170. Anwar, T. and A.U. Khan, 2006. SSRscanner: A program for reporting distribution and exact location of simple sequence repeats. Bioinformation, 1: 89-91.
    PubMed  |  
  171. Anwar, T. and A.U. Khan, 2006. MAP MUTATION: A program for analyzing mutations in protein sequences. Bioinformation, 1: 92-93.
    PubMed  |  Direct Link  |  
  172. Khan, A.U. and S. Krishnamurthy, 2005. Histone modifications as key regulators of transcription. Front. Biosci., 10: 866-872.
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  173. Anwar, T. and A.U. Khan, 2005. Mapping and analysis of simple sequence repeats in the Arabidopsis thaliana genome. Bioinformation, 1: 64-68.
    Direct Link  |  
  174. Khan, A.U. and A. Musharraf, 2004. Plasmid-mediated multiple antibiotic resistance in Proteus mirabilis isolated from patients with urinary tract infection. Med. Sci. Monit., 10: 598-602.
    PubMed  |  
  175. Khan, A.U. and S.K. Lal, 2003. Ribozymes: A modern tool in medicine. J. Biomed. Sci., 10: 457-467.
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  176. He, X., A.U. Khan, H. Cheng, D.L. Jr. Papas, M. Hampsey and C.L. Moore, 2003. Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1. Genes Dev., 17: 1030-1042.
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  177. Malik, A., A.U. Khan and S.K. Lal, 2002. Chemoprotection profiles of sodium thiosulfate on methyl methanesulfonate-induced mutagenesis of bacteriophage T4. Med. Sci. Monit., 8: BR212-BR220.
    PubMed  |  
  178. Khan, A.U. and M. Hampsey, 2002. Connecting the DOTs: Covalent histone modifications and the formation of silent chromatin. Trends Genet., 18: 387-389.
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  179. Khan, A.U., M. Ajamaluddin and M. Ahmad, 2001. A unique group of self-splicing introns in bacteriophage T4. Indian J. Biochem. Biophys., 38: 289-293.
    PubMed  |  Direct Link  |  
  180. Khan, A.U. and S.K. Lal, 2001. The white halo plaque phenotype of bacteriophage T4: Its uses and applications in screening and mapping of splicing-defective mutants. J. Biochem. Mol. Biol. Biophys., 5: 237-242.
  181. Khan, A.U., M. Ahmad and S.K. Lal, 2000. Restoration of mRNA splicing by a second-site intragenic suppressor in the t4 ribonucleotide reductase (Small Subunit) self-splicing intron. Biochem. Biophys. Res. Commun., 268:: 359-364.
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  182. Ajamaluddin, M., M.A. Khan and A.U. Khan, 2000. Prevalence of multiple antibiotic resistance and r-plasmid in Escherichia coli isolates of hospital sewage of Aligarh city in India. Indian J. Clin. Biochem., 15: 104-109.
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  183. Khan, A.U. and S.K. Lal, 1999. Ribozyme: Structure and potential applications in the field of modern medicine. Med. Sci. Res., 28: 507-512.
  184. Khan, A.U., S.K. Lal and M. Ahmad, 1998. Isolation and characterization of EMS induced splicing defective point mutations within the intron of thenrdB gene of bacteriophage T4. Biochem. Biophys. Res Commun., 242: 10-15.
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