Dr. Gul  Shahnaz

Dr. Gul Shahnaz

Assistant Professor
Quaid-i-Azam University, Pakistan


Highest Degree
Ph.D. in Pharmacology from University of Innsbruck, Innsbruck, Austria

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Area of Interest:

Biomedical Sciences
100%
Pharmaceutical Research
62%
Clinical Pharmacology
90%
Drug Design
75%
Drug Delivery
55%

Selected Publications

  1. Sajjad, M., M.I. Khan, S. Naveed, S. Ijaz and O.S. Qureshi et al., 2019. Folate-functionalized thiomeric nanoparticles for enhanced docetaxel cytotoxicity and improved oral bioavailability. AAPS PharmSciTech, Vol. 20, No. 2. 10.1208/s12249-019-1297-z.
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  2. Kiyani, M.M., M.F. Sohail, G. Shahnaz, H. Rehman and M.F. Akhtar et al., 2019. Evaluation of turmeric nanoparticles as anti-gout agent: Modernization of a traditional drug. Medicina, Vol. 55, No. 1. 10.3390/medicina55010010.
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  3. Baloch, J., M.F. Sohail, H.S. Sarwar, M.H. Kiani and G.M. Khan et al., 2019. Self-Nanoemulsifying Drug Delivery System (SNEDDS) for improved oral bioavailability of chlorpromazine: In vitro and in vivo evaluation. Medicina, Vol. 55, No. 5. 10.3390/medicina55050210.
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  4. Arshad, R., M.F. Sohail, H.S. Sarwar, H. Saeed and I. Ali et al., 2019. ZnO-NPs embedded biodegradable thiolated bandage for postoperative surgical site infection: In vitro and in vivo evaluation. PLoS ONE, Vol. 14. 10.1371/journal.pone.0217079.
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  5. Afzal, I., H.S. Sarwar, M.F. Sohail, S. Varikuti and S. Jahan et al., 2019. Mannosylated thiolated paromomycin-loaded PLGA nanoparticles for the oral therapy of visceral leishmaniasis. Nanomedicine, 14: 387-406.
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  6. Sohail, M.F., S.Z. Hussain, H. Saeed, I. Javed and H.S. Sarwar et al., 2018. Polymeric nanocapsules embedded with ultra-small silver nanoclusters for synergistic pharmacology and improved oral delivery of Docetaxel. Scient. Rep., Vol. 8. 10.1038/s41598-018-30749-3.
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  7. Sohail, M.F., M. Rehman, H.S. Sarwar, S. Naveed and O. Salman et al., 2018. Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends. Int. J. Nanomed., 13: 3145-3161.
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  8. Sarwar, H.S., S. Ashraf, S. Akhtar, M.F. Sohail and S.Z. Hussain et al., 2018. Mannosylated thiolated polyethylenimine nanoparticles for the enhanced efficacy of antimonial drug against Leishmaniasis. Nanomedicine, 13: 25-41.
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  9. Sarwar, H.S., M.F. Sohail, N. Saljoughian, A.U. Rehman and S. Akhtar et al., 2018. Design of mannosylated oral amphotericin B nanoformulation: efficacy and safety in visceral leishmaniasis. Artif. Cells Nanomed. Biotechnol., (In Press). 10.1080/21691401.2018.1430699.
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  10. Sohail, M.F., H.S. Sarwar, I. Javed, A. Nadhman and S.Z. Hussain et al., 2017. Cell to rodent: Toxicological profiling of folate grafted thiomer enveloped nanoliposomes. Toxicol. Res., 6: 814-821.
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  11. Shahnaz, G., B.J. Edagwa, J. McMillan, S. Akhtar and A. Raza et al., 2017. Development of mannose-anchored thiolated amphotericin B nanocarriers for treatment of visceral leishmaniasis. Nanomedicine, 12: 99-115.
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  12. Sarwar, H.S., S. Akhtar, M.F. Sohail, Z. Naveed and M. Rafay et al., 2017. Redox biology of Leishmania and macrophage targeted nanoparticles for therapy. Nanomedicine, 12: 1713-1725.
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  13. Ovais, M., A. Nadhman, A.T. Khalil, A. Raza and F. Khuda et al., 2017. Biosynthesized colloidal silver and gold nanoparticles as emerging leishmanicidal agents: An insight. Nanomedicine, 12: 2807-2819.
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  14. Naz, K., G. Shahnaz, N. Ahmed, N.A. Qureshi, H.S. Sarwar, M. Imran and G.M. Khan, 2017. Formulation and in vitro characterization of thiolated buccoadhesive film of fluconazole. AAPS PharmSciTech, 18: 1043-1055.
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  15. Khan, H., A. Nadhman, S.S. Azam, M. Anees and I. Khan et al., 2017. In-vitro antileishmanial potential of peptide drug hirudin. Chem. Biol. Drug Des., 89: 67-73.
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  16. Tahir, A.H., M. Tanveer, A. Ahmed, A. Arshad and G. Shahnaz, 2016. Rise of single organopathy theory from ayurveda system-a short report from Pakistan's perspective. World J. Pharm. Pharmaceut. Sci., 5: 323-328.
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  17. Sohail, M.F., I. Javed, S.Z. Hussain, S. Sarwar and S. Akhtar et al., 2016. Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxel. J. Mater. Chem. B, 4: 6240-6248.
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  18. Rauf, M.K., U. Shaheen, F. Asghar, A. Badshah and A. Nadhman et al., 2016. Antileishmanial, DNA interaction and docking studies of some ferrocene-based heteroleptic pentavalent antimonials. Arch. Pharm., 349: 50-62.
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  19. Nadhman, A., M.I. Khan, S. Nazir, M. Khan and G. Shahnaz et al., 2016. Annihilation of Leishmania by daylight responsive ZnO nanoparticles: A temporal relationship of reactive oxygen species-induced lipid and protein oxidation. Int. J. Nanomed., 11: 2451-2461.
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  20. Javed, I., S.Z. Hussain, I. Ullah, I. Khan and M. Ateeq et al., 2015. Synthesis, characterization and evaluation of lecithin-based nanocarriers for the enhanced pharmacological and oral pharmacokinetic profile of amphotericin B. J. Mater. Chem. B, 3: 8359-8365.
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  21. Dunnhaupt, S., J. Barthelmes, S. Kollner, D. Sakloetsakun, G. Shahnaz, A. Duregger and A. Bernkop-Schnurch, 2015. Thiolated nanocarriers for oral delivery of hydrophilic macromolecular drugs. Carbohydr. Polym., 117: 577-584.
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  22. Qureshi, Q.A.H., A. Nadhman, M. Sirajuddin, G. Shahnaz, S. Ali, A. Shah and M.M. Yasinzai, 2014. Organotin(IV) complexes of carboxylate derivative as potential chemotherapeutic agents against Leishmania. Inorg. Chim. Acta, 423: 220-228.
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  23. Nadhman, A., S. Nazir, M.I. Khan, S. Arooj, M. Bakhtiar, G. Shahnaz and M. Yasinzai, 2014. PEGylated silver doped zinc oxide nanoparticles as novel photosensitizers for photodynamic therapy against Leishmania. Free Radic. Biol. Med., 77: 230-238.
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  24. Millotti, G., A. Vetter, K. Leithner, F. Sarti, G. Shahnaz Bano, P. Augustijns and A. Bernkop-Schnurch, 2014. Development of thiolated poly(acrylic acid) microparticles for the nasal administration of exenatide. Drug Dev. Ind. Pharm., 40: 1677-1682.
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  25. Laffleur, F., F. Hintzen, G. Shahnaz, D. Rahmat, K. Leithner and A. Bernkop-Schnurch, 2014. Development and in vitro evaluation of slippery nanoparticles for enhanced diffusion through native mucus. Nanomedicine, 9: 387-396.
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  26. Yasinzai, M., M. Khan, A. Nadhman and G. Shahnaz, 2013. Drug resistance in leishmaniasis: Current drug-delivery systems and future perspectives. Future Med. Chem., 5: 1877-1888.
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  27. Shahnaz, G., C. Kremser, A. Reinisch, A. Vetter and F. Laffleur et al., 2013. Efficient MRI labeling of endothelial progenitor cells: Design of thiolated surface stabilized superparamagnetic iron oxide nanoparticles. Eur. J. Pharmaceut. Biopharmaceut., 85: 346-355.
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  28. Rahmat, D., C. Muller, J. Barthelmes, G. Shahnaz, R. Martien and A. Bernkop-Schnurch, 2013. Thiolated hydroxyethyl cellulose: Design and in vitro evaluation of mucoadhesive and permeation enhancing nanoparticles. Eur. J. Pharmaceut. Biopharmaceut., 83: 149-155.
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  29. Rahmat, D., C. Muller, G. Shahnaz, K. Leithner and F. Laffleur et al., 2013. HEC-cysteamine particles: Influence of particle size, zeta potential, morphology and sulfhydryl groups on permeation enhancing properties. Drug Dev. Ind. Pharm., 39: 1338-1345.
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  30. Laffleur, F., G. Shahnaz, Z. Islambulchilar and A. Bernkop-Schnurch, 2013. Design and in vitro evaluation of a novel polymeric excipient for buccal applications. Future Med. Chem., 5: 511-522.
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  31. Laffleur, F., F. Hintzen, D. Rahmat, G. Shahnaz, G. Millotti and A. Bernkop-Schnurch, 2013. Enzymatic degradation of thiolated chitosan. Drug Dev. Ind. Pharm., 39: 1531-1539.
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  32. Shahnaz, G., J. Iqbal, D. Rahmat, G. Perera, F. Laffleur, D. Rossi and A. Bernkop-Schnurch, 2012. Development and in vivo characterization of a novel peptide drug delivery system providing extended plasma half life. J. Controlled Release, 157: 375-382.
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  33. Shahnaz, G., A. Vetter, J. Barthelmes, D. Rahmat and F. Laffleur et al., 2012. Thiolated chitosan nanoparticles for the nasal administration of leuprolide: Bioavailability and pharmacokinetic characterization. Int. J. Pharmaceut., 428: 164-170.
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  34. Sarti, F., J. Iqbal, C. Muller, G. Shahnaz, D. Rahmatand A. Bernkop-Schnurch, 2012. Poly(acrylic acid)-cysteine for oral vitamin B12 delivery. Anal. Biochem., 420: 13-19.
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  35. Rahmat, D., M.I. Khan, G. Shahnaz, D. Sakloetsakun, G. Pereraand A. Bernkop-Schnurch, 2012. Synergistic effects of conjugating cell penetrating peptides and thiomers on non-viral transfection efficiency. Biomaterials, 33: 2321-2326.
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  36. Rahmat, D., D. Sakloetsakun, Gul Shahnaz, F. Sarti, F. Laffleur and A.B. Schnurch, 2012. HEC-cysteamine conjugates: Influence of degree of thiolation on efflux pump inhibitory and permeation enhancing properties. Int. J. Pharma., 422: 40-46.
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  37. Iqbal, J., G. Shahnaz, S. Dunnhaupt, C. Muller, F. Hintzen and A. Bernkop-Schnurch, 2012. Preactivated thiomers as mucoadhesive polymers for drug delivery. Biomaterials, 33: 1528-1535.
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  38. Iqbal, J., G. Shahnaz, G. Perera, F. Hintzen, F. Sarti and A. Bernkop-Schnurch, 2012. Thiolated chitosan: Development and in vivo evaluation of an oral delivery system for leuprolide. Eur. J. Pharmaceut. Biopharmaceut., 80: 95-102.
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  39. Hintzen, F., F. Laffleur, F. Sarti, G. Shahnaz and A. Bernkop-Schnurch, 2012. Thiomers: Influence of molar mass on in situ gelling properties. Int. J. Pharmaceut., 436: 120-126.
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  40. Shahnaz, G., M. Hartl, J. Barthelmes, K. Leithner and F. Sarti et al., 2011. Uptake of phenothiazines by the harvested chylomicrons ex vivo model: Influence of self-nanoemulsifying formulation design. Eur. J. Pharmaceut. Biopharmaceut., 79: 171-180.
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  41. Rahmat, D., D. Sakloetsakun, G. Shahnaz, G. Perera, R. Kaindl and A. Bernkop-Schnurch, 2011. Design and synthesis of a novel cationic thiolated polymer. Int. J. Pharmaceut., 411: 10-17.
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  42. Shahnaz, G., G. Perera, D. Sakloetsakun, D. Rahmat and A. Bernkop-Schnurch, 2010. Synthesis, characterization, mucoadhesion and biocompatibility of thiolated carboxymethyl dextran-cysteine conjugate. J. Controlled Release, 144: 32-38.
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  43. Murtaza, G., M. Ahmad and G. Shahnaz, 2010. Microencapsulation of diclofenac sodium by non-solvent addition technique. Trop. J. Pharma. Res., 9: 187-195.
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