Dr. Khalid Hussain
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Dr. Khalid Hussain

Professor
University of the Punjab, Lahore, Pakistan

Highest Degree
PostDoc. in Pharmaceutical Chemistry from Universiti Sains Malaysia, Malaysia

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Area of Interest:

Pharmacology and Toxicology
100%
Pharmacokinetics
62%
Herbal Medical Toxicology
90%
Pharmaceutical Chemistry
75%
Toxicological Evaluation of Drugs
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Shamim, R., S. Shafique, U. Kanwal, K. Hussain and N. Asif et al., 2019. Surfactant-assisted wet granulation: A simpler approach to improve solubility and sustain ketoprofen release. Latin Am. J. Pharm., 38: 281-290.
  2. Qamar, S., K. Hussain, N.I. Bukhari, S.Z. Siddique and M.A. Aziz-ur-Rehman et al., 2019. Evaluating the antidiabetic and antioxidant properties of 5-benzyl-1,3,4-oxadiazole-2-thiol. Trop. J. Pharm. Res., 18: 1095-1100.
    CrossRef  |  Direct Link  |  
  3. Parveen, S., N.I. Bukhari, N. Shehzadi, S. Qamar and E. Ali et al., 2019. Chemical and pharmacological comparison of modern and traditional dosage forms of Joshanda. Nat. Prod. Res., 33: 858-861.
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  4. Kanwal, U., N.I. Bukhari, N.F. Rana, M. Rehman and K. Hussain et al., 2019. Doxorubicin-loaded quaternary ammonium palmitoyl glycol chitosan polymeric nanoformulation: Uptake by cells and organs. Int. J. Nanomed., 14: 1-15.
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  5. Islam, M., N. Shehzadi, M. Salman, F. Zahid and Z. Danish et al., 2019. Metabolomics and marker-based stability studies of methanol extract of seeds of Syzygium cumini L. Pak. J. Pharm. Sci., 32: 499-504.
  6. Hussain, K., A. Qamar, N.I. Bukhari, A. Hussain, N. Shehzadi, S. Qamar and S. Parveen, 2019. Impact of particle-size reduction on the solubility and antidiabetic activity of extracts of leaves of Vinca rosea. Turk. J. Pharm. Sci., 16: 335-339.
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  7. Husnain, S.Z., N.I. Bukhari, K. Hussain, Z.U.D. Babar and F.K. Hashmi et al., 2019. Cross verification of prescribing trends through loop evaluation of physicians, patients and medical store personnel. BMC Health Serv. Res., Vol. 19. 10.1186/s12913-019-4145-7.
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  8. Shehzadi, N., K. Hussain, N.I. Bukhari, M. Islam and M.T. Khan et al., 2018. Hypoglycemic, hepatoprotective and molecular docking studies of 5-[(4-chlorophenoxy) methyl]-1, 3, 4-oxadiazole-2-thiol. Bangladesh J. Pharmacol., 13: 149-156.
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  9. Shehzadi, N., K. Hussain, M.T. Khan, N.I. Bukhari and M. Islam et al., 2018. Radical scavenging and endogenous defence system inducing activities of 5-[(4-chlorophenoxy)methyl]-1,3,4-oxadiazole-2-thiol: A novel antioxidant. Indian J. Pharm. Sci., 80: 1125-1135.
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  10. Shehzadi, N., K. Hussain, M. Islam, N.I. Bukhari and N. Asif et al., 2018. Development and validation of a stability-indicating RP-HPLC-FLD method for determination of 5-[(4-chlorophenoxy) methyl]-1, 3, 4-oxadiazole-2-thiol; A novel drug candidate. Pak. J. Pharm. Sci., 31: 603-609.
    Direct Link  |  
  11. Shehzadi, N., K. Hussain, M. Islam, N.I. Bukhari and M.T. Khan et al., 2018. Reverse-phase chromatographic determination and intrinsic stability behavior of 5-[(4-chlorophenoxy)methyl]-1,3,4-oxadiazole-2-thiol. Acta Pharm., 68: 409-424.
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  12. Salman, M., M.H. Raza, Zia Ul Mustafa, S. Shrestha and M. Ali et al., 2018. Knowledge, attitudes and practices of hand hygiene among Pakistani health professionals: A cross-sectional study. J. Infect. Dev. Countries, 12: 63-66.
    CrossRef  |  
  13. Salman, M., A.H. Khan, S.A.S. Sulaiman, J. Hughes, J.H. Khan and K. Hussain, 2018. The modified urdu version of international prostate symptom score: A psychometric validation study. Turk. J. Urol., 44: 335-340.
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  14. Qamar, S., K. Hussain, N.I. Bukhari, N. Shehzadi, M. Islam, S.Z. Siddique and Aziz-ur-Rehman, 2018. Method development and stress degradation profile of 5-benzyl-1,3,4-oxadiazole-2-thiol studied by UV spectroscopy. Pharm. Chem. J., 52: 278-283.
    CrossRef  |  Direct Link  |  
  15. Mustafa, Z.U., M. Salman, M.S.K. Afridi, N. Asif, N. Shehzadi and K. Hussain, 2018. A cross-sectional assessment of knowledge, attitudes and beliefs concerning HIV/AIDS among Pakistani university population. Indian J. Pharm. Sci., 80: 210-214.
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  16. Latif, A., K. Hussain, N.I. Bukhari, H. Shafi and M. Mazhar, 2018. Metabolomics and marker based accelerated stability of kanji and ethanol extract of its main ingredient, Daucus carota L. roots. Pharm. Anal. Acta, Vol. 9. 10.4172/2153-2435.1000589.
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  17. Kanwal, U., N.I. Bukhari, M. Ovais, N. Abass, K. Hussain and A. Raza, 2018. Advances in nano-delivery systems for doxorubicin: An updated insight. J. Drug Target., 26: 296-310.
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  18. Husnain, S.Z., N.I. Bukhari, K. Hussain, Z.D. Baber and Z. Saleem, 2018. Inappropriateness of medication use and associated health risks: A cross-sectional study from Pakistan. Trop. J. Pharm. Res., 17: 715-721.
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  19. Husnain, S.Z., N.I. Bukhari, K. Hussain and Z. Saleem, 2018. Impact of prescribed multiple tablet dosage forms on the disintegration time of tablets and physicochemical parameters of disintegration medium. Transylvanian Rev., 26: 6769-6774.
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  20. Beh, H.K., Z. Ismail, L.J. Seow, M.Z. Asmawi and P. Ibrahim et al., 2018. Investigation of anti-obesity and anti-hyperlipidemic activities of Morinda citrifolia fruits in rat model. Chiang Mai J. Sci., 45: 1335-1344.
  21. Ahmad, S., A. Khalique, T.N. Pasha, S. Mehmood, S.S. Ahmad, A.M. Khan and K. Hussain, 2018. Influence of Moringa oleifera leaf meal used as phytogenic feed additive on the serum metabolites and egg bioactive compounds in commercial layers. Braz. J. Poult. Sci., 20: 325-332.
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  22. Ahmad, S., A. Khalique, T.N. Pasha, S. Mehmood and K. Hussain et al., 2018. Influence of feeding Moringa oleifera pods as phytogenic feed additive on performance, blood metabolites, chemical composition and bioactive compounds of breast meat in broiler. Kafkas Univ. Vet. Fakultesi Dergis, 24: 195-202.
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  23. Sultana, M., M.A. Butt, T. Saeed, R. Mahmood and Saeed ul Hassan et al., 2017. Effect of rheology and poloxamers properties on release of drugs from silicon dioxide gel-filled hard gelatin capsules-A further enhancement of viability of liquid semisolid matrix technology. AAPS PharmSciTech, 18: 1998-2010.
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  24. Shehzadi, N., K. Hussain, M.T. Khan, M. Salman and M. Islam, 2017. Evaluation of dynamics of derivatization and development of RP-HPLC method for the determination of amikacin sulphate. Pak. J. Pharm. Sci., 30: 1767-1777.
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  25. Shehzadi, N., K. Hussain, M. Salman, N. Arshad and M.T. Khan, 2017. Amikacin sulphate and corticosteroid admixtures: A medication misadventure. Latin Am. J. Pharm., 36: 882-890.
  26. Salman, M., N. Shehzadi, K. Hussain, F. Saleem and M.T. Khan et al., 2017. Knowledge of Ebola virus disease among a university population: A cross-sectional study. Am. J. Infect. Control, 45: e23-e25.
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  27. Salman, M., A.H. Khan, S.A.S. Suleiman, J.H. Khan, K. Hussain and N. Shehzadi, 2017. Effect of calcium channel blockers on lower urinary tract symptoms: A systematic review. BioMed Res. Int., Vol. 2017. 10.1155/2017/4269875.
    CrossRef  |  
  28. Salman, M., A.H. Khan, A.S. Adnan, S.A.S. Sulaiman and F. Saleem et al., 2017. Evaluation of medication use in Malaysian predialysis patients. Saudi J. Kidney Dis. Transplantation, 28: 517-523.
    Direct Link  |  
  29. Khalid, S., E.T. Razia, M.H. Raza, H. Sheikh and M. Salman et al., 2017. It’s not just a “female issue”: Eating attitudes and behaviors of Pakistani male and female pharmacy students. Russian Open Med. J., Vol. 6. .
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  30. Shehzadi, N., K. Hussain, M.T. Khan, M. Salman and M. Islam, 2016. Development of a validated colorimetric assay method for estimation of amikacin sulphate in bulk and injectable dosage form. J. Chem. Soc. Pak., 38: 63-69.
    Direct Link  |  
  31. Shehzadi, N., K. Hussain, M. Islam, N.I. Bukhari and M.T. Khan et al., 2016. In silico drug-qualifying parameters of 5-[(4-chlorophenoxy) methyl]-1,3,4-oxadiazole-2-thiol. Latin Am. J. Pharm., 35: 1991-1997.
  32. Salman, M., N. Shehzadi, M.T. Khan, M. Islam and S. Amjad et al., 2016. Erectile dysfunction: Prevalence, risk factors and involvement of antihypertensive drugs intervention. Trop. J. Pharm. Res., 15: 869-876.
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  33. Salman, M., K. Hussain, A.H. Khan, A.S. Adnan, N. Shehzadi and S.A.S. Sulaiman, 2016. Anemia: The troublemaker child of chronic kidney disease. Value Health, 19: A130-A130.
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  34. Salman, M., A.H. Khan, A.S. Adnan, S.A.S. Sulaiman and K. Hussain et al., 2016. Prevalence and management of anemia in pre-dialysis Malaysian patients: A hospital-based study. Rev. Assoc. Med. Bras., 62: 742-747.
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  35. Saleem, U., B. Ahmad, M. Ahmad, A. Erum, K. Hussain and N.I. Bukhari, 2016. Is folklore use of Euphorbia helioscopia devoid of toxic effects? Drug Chem. Toxicol., 39: 233-237.
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  36. Latif, A., K. Hussain, N. Shehzadi, M. Islam and M.T. Khan et al., 2016. Glutathione sulfotransferase inhibition activity of a self-fermented beverage, Kanji. Pharm. Biol., 55: 547-553.
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  37. Islam, M., N. Shehzadi, M. Salman, F. Zahid and H.M. Khan et al., 2016. Pharmacokinetics of caffeic acid from methanol seed extract of Syzygium cumini L. in rats. Trop. J. Pharm. Res., 15: 363-369.
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  38. Hussain, T., M.K. Shahzad, K. Hayat, K. Hussain and N.I. Bukhari, 2016. Simple and sensitive colorimetric method for the determination of milnacipran in bulk and swellable matrix tablets. Pharm. Chem. J., 50: 346-352.
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  39. Hussain, A., M.A. Syed, N. Abbas, S. Hanif and M.S. Arshad et al., 2016. Development of ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental pain. Acta Pharm., 66: 245-256.
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  40. Hussain, A., A.M. Mumtaz, M.S. Arshad, N. Abbas and A. Latif et al., 2016. Effect of cellulose acetate phthalate and polyethylene glycol on physical properties and release of theophylline from microcapsules. Braz. J. Pharm. Sci., 52: 27-34.
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  41. Fayyaz, S., S. Saddique, K. Hussain, N. Shehzadi and M. Salman et al., 2016. Is quercetin accumulating in eggs using flavonoids-enriched poultary feed? J. Anim. Plant Sci., 26: 1479-1485.
  42. Tipu, M., U. Saleem, T. Rehman, M. Aslam and K. Muhammad et al., 2015. Protective role of Lactobacillus acidophilus (probiotics) in aflatoxin B1-induced immunosuppression. J. Anim. Plant Sci., 25: 1566-1571.
    Direct Link  |  
  43. Salman, M., A.H. Khan, A.S. Adnan, S.A.S. Sulaiman, K. Hussain, S. Mansoor and N. Shehzadi, 2015. Patterns of medication use in chronic kidney disease stage 5d: Emphasis on medications for the management of Ckd-Mbd. Value Health, 18: A508-A509.
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  44. Salman, M., A.H. Khan, A.S. Adnan, S.A.S. Sulaiman, K. Hussain, N. Shehzadi and F. Jummaat, 2015. Attributable causes of chronic kidney disease in adults: A five-year retrospective study in a tertiary-care hospital in the northeast of the Malaysian Peninsula. Sao Paulo Med. J., 133: 502-509.
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  45. Saleem, U., M. Saleem, B. Ahmad, K. Hussain, M. Ahmad, N.I. Bukhari and A.A. Anjum, 2015. In-vitro antimicrobial susceptibility testing of leaves methanol extract and latex of euphorbia helioscopia using agar well diffusion and broth dilution methods. J. Anim. Plant Sci., 25: 261-267.
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  46. Saleem, U., B. Ahmad, M. Ahmad, K. Hussain, N.I. Bukhari and M. Ashraf, 2015. Evaluation of anti-angiogenic activity of latex and extracts of Euphorbia helioscopia using chorioallontoic membrane (CAM) Assay. Int. J. Agric. Biol., 17: 339-344.
  47. Saleem, U., B. Ahmad, M. Ahmad, K. Hussain, N.I. Bukhari and M. Ashraf, 2015. Anti-nociceptive, anti-inflammatory and anti-pyretic activities of latex and leaves methanol extract of Euphorbia helioscopia. Asian Pac. J. Trop. Dis., 5: 322-328.
  48. Saleem, M., F. Naseer and K. Hussain, 2015. Cytotoxic effect of methanol extract of Conyza bonariensis on DMBA-induced skin carcinogenesis: An in vivo study. Bangladesh J. Pharmacol., 10: 467-474.
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  49. Islam, M., K. Hussain, A. Latif, F.K. Hashmi and H. Saeed et al., 2015. Evaluation of extracts of seeds of Syzygium cumini L. for hepatoprotective activity using CCl4-induced stressed rats. Pak. Vet. J., 35: 197-200.
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  50. Hussain, T., A. Hussain, R. Shamim, M.K. Shehzad, Z. Danish, K. Hussain and N.I. Bukhari, 2015. Development and in-vitro evaluation of floating gastro-retentive matrix tablet for a model water soluble drug prepared with the novel blends of chitosan and polycaprolactone. Latin Am. J. Pharm., 34: 1849-1857.
  51. Hussain, K., M. Islam, N. Shehzadi, S. Amjad, N.I. Bukhari and H. Saeed, 2015. Antioxidant activity and isolation studies of extracts of seeds of Syzygium cumini L. Planta Med., 81: 930-930.
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  52. Sohail, I., K. Hussain, N.I. Bukhari, M. Islam and T.A. Khan et al., 2014. Antioxidant and hepatoprotective activities and characterization of extracts of Oxalis corniculata. J. Chem. Soc. Pak., 36: 630-637.
  53. Saleem, U., K. Hussain, M. Ahmad, N.I. Bukhari, A. Malik and B. Ahmad, 2014. Physicochemical and phytochemical analysis of Euphorbia helioscopia (L.). Pak. J. Pharm. Sci., 27: 577-585.
    Direct Link  |  
  54. Saleem, U., B. Ahmad, M. Ahmad, K. Hussain, N.I. Bukhari and A.A. Anjum, 2014. Teratogenic and embryo-toxic effects of latex and leaves methanol extract of Euphorbia helioscopia L. in mice and chicken embryos. J. Anim. Plant Sci., 24: 450-454.
    Direct Link  |  
  55. Saleem, U., B. Ahmad, M. Ahmad, K. Hussain and N.I. Bukhari, 2014. Investigation of in vivo antioxidant activity of Euphorbia helioscopia latex and leaves methanol extract: A target against oxidative stress induced toxicity. Asian Pac. J. Trop. Med., 7: S369-S375.
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  56. Saleem, U., B. Ahmad, K. Hussain, M. Ahmad, N.I. Bukhari and S. Ishtiaq, 2014. Estimation of antioxidant power in various extracts of Euphorbia helioscopia L. with five different in vitro antioxidant models. Asian J. Chem., 26: 1241-1245.
  57. Saleem, U., B. Ahmad, K. Hussain, M. Ahmad and N.I. Bukhari, 2014. Simultaneous quantification of quercetin, myricetin and kaempferol in extracts and latex of Euphorbia helioscopia using RP-HPLC. Asian J. Chem., 26: 7673-7676.
  58. Saleem, U., A. Bashir, A. Mobasher, K. Hussain, N.I. Bukhari and A.A. Anjum, 2014. Determination of cytotoxicity of latex and methanol extract of Euphorbia helioscopia leaves on vero cell line with MTT assay. Pak. J. Zool., 46: 741-745.
    Direct Link  |  
  59. Saleem, M., M.I. Qadir, B. Ahmad, U. Saleem and F. Naseer et al., 2014. Cytotoxic effect of ethanol extract of Convolvulus arvensis L (Convolvulaceae) on lymphoblastic leukemia Jurkat cells. Trop. J. Pharmaceut. Res., 13: 705-709.
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  60. Saleem, M., K. Abbas, F. Naseer, M. Ahmad and N.H. Syed et al., 2014. Anticancer activity of n-hexane extract of Cichorium intybus on lymphoblastic leukemia cells (Jurkat cells). Afr. J. Plant Sci., 8: 315-319.
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  61. Riaz, M.K., F.K. Hashmi, N.I. Bukhari, M. Riaz and K. Husssain, 2014. Occurrence of medication errors and comparison of manual and computerized prescription systems in public sector hospitals in Lahore, Pakistan. Plos One, Vol. 9. 10.1371/journal.pone.0106080.
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  62. Hussain, K., A. Latif, M. Islam, B. Ahmad and S.S. Ul-Hassan, 2014. Isolation of markers from roots of Daucus carota (Black carrots) to standardize Kanji. Planta Med., Vol. 80. 10.1055/s-0034-1389693.
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  63. Hashmi, F.K., R. Cail, M. Islam, Z. Saleem, U. Amin, K. Hussain and H. Saeed, 2014. Adaptation of WM-68 hybridoma cell-line in minimal serum and serum free culture conditions. Pak. J. Zool., 46: 355-362.
  64. Asif, M., K. Hussain, N.I. Bukhari, A. Latif and Dur-E-Shahwar et al., 2014. Effect of pH on adsorption profile of Phoenix sylvestris pits activated carbon using paracetamol as a model drug. Latin Am. J. Pharm., 33: 1561-1566.
  65. Amjad, S., K. Hussain, N.I. Bukhari, M.T. Khan and M. Islam et al., 2014. Analytical, nutritional and biological evaluation of various brands of fortified and non-fortified wheat flour. Pak. J. Pharm. Sci., 27: 445-452.
  66. Saeed-ul-Hassan, S., M. Khalil-ur-Rehman, U. Niaz, M.A. Saeed, K. Hussain, S.A. Rao and I. Ahmed, 2013. Isolation and characterization of irritant components of Euphorbia pilulifera L. Pak. J. Pharm. Sci., 26: 31-37.
  67. Latif, A., K. Hussain, N.I. Bukhari, S. Karim and A. Hussain et al., 2013. Analytical and biological studies of Kanji and extracts of its ingredient, Daucus carota L. J. Chem. Soc. Pak., 35: 1481-1489.
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  68. Karim, S., S.H. Baie, Y.K. Hay, A. Latif, R. Shamim, K. Hussain and N.I. Bukhari, 2013. Stability study of paracetamol and omeprazole pellets formulated through sieving-spheronisation. Latin Am. J. Pharm., 32: 431-436.
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  69. Bilal, A., K. Rehman, M.S.H. Akash, K. Hussain, M. Ibrahim and S.S. Hussan, 2013. Development and validation of analytical method for qualitative and quantitative determination of glibenclamide in different brands of tablet dosage form using UV-visible spectroscopy. J. Mol. Genet. Med., Vol. 7. 10.4172/1747-0862.1000080.
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  70. Tipu, M.K., U. Saleem, K. Hussain, K. Muhammad, F.K. Hashmi, M. Islam and B. Ahmad, 2012. The role of zinc on anti-Newcastle disease virus specific antibody response and agranulocytes count in rabbits treated with methotrexate and prednisolone. Pak. J. Pharm. Sci., 25: 845-849.
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  71. Tahira, A., U. Saleem, S. Mahmood, F.K. Hashmi, K. Hussain, N.I. Bukhari and B. Ahmad, 2012. Evaluation of protective and curative role of α-lipoic acid and selenium in gentamicin-induced nephrotoxicity in rabbits. Pak. J. Pharm. Sci., 25: 103-110.
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  72. Sohail, I., M.T. Khan, F. Zahid, S. Amjad, R. Javed, S. Naheed and K. Hussain, 2012. Pharmacognostical and phytochemical studies of Oxalis corniculata. Pak. J. Pharm., 25: 27-36.
  73. Khan, M.T., K. Hussain, N.I. Bukhari, A. Latif, F.K. Hashmi, M. Islam and M. Masood, 2012. Evaluation of seeds of Phoenix sylvestris as novel candidate adsorbent in paracetamol poisoning. Latin Am. J. Pharm., 31: 678-685.
  74. Hussain, K., Z. Ismail, A. Sadikun, A.M.A.M. Shah, A. Latif and F.K. Hashmi, 2012. Antiangiogenic activity and bioassay‐guided isolation of aqueous extract of Orthosiphon stamineus. J. Chinese Chem. Soc., 59: 1137-1143.
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  75. Hussain, K., M.T. Khan, Z. Ismail and A. Sadikun, 2012. Rapid separation and determination of betulinic acid from a complex matrix using combination of TLC and RP-HPLC. Pak. J. Pharm. Sci., 25: 413-422.
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  76. Hussain, K., F.K. Hashmi, A. Latif, Z. Ismail and A. Sadikun, 2012. A review of the literature and latest advances in research of Piper sarmentosum. Pharm. Biol., 50: 1045-1052.
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  77. Hashmi, F.K., K. Hussain, N.I. Bukhari, M. Islam and M. Ali et al., 2012. Cisplatin-induced nephrotoxicity in different regimens of cancer chemotherapy. HealthMed, 6: 1922-1929.
  78. Majeed, M.T., K. Hussain, M. Noreen and M. Izhar, 2011. Optimum range of plasmid supercoiled DNA for preparation of competent top 10 E. coli. Arch. Pharm. Pract., 2: 76-80.
  79. Hussain, K., Z. Ismail, A. Sadikun and P. Ibrahim, 2011. Bioactive markers based pharmacokinetic evaluation of extracts of a traditional medicinal plant, Piper sarmentosum. Evid. Based Complement. Altern. Med., Vol. 2011. 10.1093/ecam/nep143.
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  80. Hussain, K., Z. Ismail, A. Sadikun and P. Ibrahim, 2011. Accelerated stability and chemical kinetics of fruit ethanol extract of Piper sarmentosum using high performance liquid chromatography. Iran. J. Pharm. Res., 10: 403-413.
  81. Hussain, K., Z. Ismail and A. Sadikun, 2011. High performance thin-layer chromatography method for quantification of betulinic acid in extracts of leaves of Orthosiphon stamineus Benth. Asian J. Chem., 23: 977-979.
  82. Hussain, K., F.K. Hashmi, S.S. Hassan, A. Latif, Z. Ismail, A. Sadikun and P. Ibrahim, 2011. Evaluation of Orthosiphon stamineusaqueous extract for in vitro antimycobacterial activity and its interaction with isoniazid. Latin Am. J. Pharm., 30: 1298-1302.
  83. Hussain, K. and F.K. Hashmi, 2011. Unlawful and unjustified collection of enrolment fee from pharmacy students. Arch. Pharm. Pract., 2: 141-142.
  84. Hussain, K. and F.K. Hashmi, 2011. Standardization in evaluation system in pharmacy institutes of Pakistan. Am. J. Pharm. Educ., 75: 403-413.
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  85. Hussain, A., N.I. Bukhari, K. Hussain, M. Jamshaid, S. Ali, M. Tayyab and N. Ilyas, 2011. Preliminary assessment of the prescribing errors in outpatient department of public sector teaching hospitals in Lahore. HealthMed, 5: 101-105.