Dr. Mahmoud  Zaki El-Readi
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Dr. Mahmoud Zaki El-Readi

Assistant Professor
Umm Al-Qura University, Saudi Arabia


Highest Degree
Ph.D. in Biochemistry from University of Heidelberg, Germany

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Biography

Dr. Mahmoud Zaki El-Readi is currently working as Assistant Professor of Biochemistry, Department of Biochemistry, College of Medicine-Umm Al-Qura University, Makkah Al-Mukarramah, Kingdom of Saudi Arabia. He has completed his Ph.D. in Biochemistry and Post Doctorate from University of Heidelberg, Germany. Previously he was appointed as Teaching Assistant and Assistant Professor at Biochemistry and Molecular Biology Department; Faculty of Pharmacy, Al-Azhar University, Assiut-Egypt. He is member of Society for Biochemistry and Molecular Biology E.V, Society for Medicinal Plant and Natural Product Research, Egyptian Society of Biochemistry, and editor for Journal of Phytopharmacology. His main area of interest focuses on Drug Discovery from Plants, his research spans a wide range of objects, start from the Biochemical activities (Anticancer, antioxidant, anti-inflammatory and anti-infective) to Molecular Mechanisms of isolated Phytochemicals and Medicinal Plants and their role in Cancer Prevention. He has published 25 research articles in journals contributed as author/co-author.

Area of Interest:

Pharmacology and Toxicology
100%
Drug Discovery
62%
Anticancer Activity
90%
Molecular Mechanisms
75%
Medicinal Plants
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
65
Abstracts
0

Selected Publications

  1. Nour Eldin, E.E.M., H.A.F. Elshebiny, T.M. Mohamed, M.A.A. Abdel-Aziz and M.Z. El-Readi, 2015. The role of antiepileptic drugs in free radicals generation and antioxidant levels in epileptic patients. Int. J. Neurosci., 10.3109/00207454.2014.994207.
    CrossRef  |  PubMed  |  Direct Link  |  
  2. El-Naa, M.M., M.F. El-Refaei, W.A. Nasif, S.H. Abduljawad, A.I. El-Brairy and M.Z. El-Readi, 2015. In-vivo antioxidant and anti-inflammatory activity of rosiglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonists in animal model of bronchial asthma. J. Pharm. Pharmacol., 10.1111/jphp.12445.
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  3. Eid, S.Y., M.Z. El-Readi, S.H. Fatani, E.E.M.N. Eldin and M. Wink, 2015. Natural products modulate the multifactorial multidrug resistance of cancer. Pharmacol. Pharm., 6: 146-176.
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  4. Eid, S.Y., M.Z. El-Readi, M.L. Ashour and M. Wink, 2015. Fallopia japonica, a natural modulator, can overcome multidrug resistance in cancer cells. Evidence-Based Complement. Altern. Med. 10.1155/2015/868424.
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  5. Hanafi, R.S., M. Sobeh, M.L. Ashour, M.Z. El-Readi and S.Y. Desoukey et al., 2014. Chemical composition and biological activity of essential oils of cumin and coriander fruits from Egypt. Nat. Prod. J., 4: 63-69.
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  6. Ashour, M.L., M.Z. El-Readi, R. Hamoud, S.Y. Eid and S.H. El Ahmady et al., 2014. Anti-infective and cytotoxic properties of Bupleurum marginatum. Chin. Med., Vol. 9. 10.1186/1749-8546-9-4.
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  7. Mamadalieva, N.Z., M.Z. El-Readi, E. Ovidi, M.L. Ashour and R. Hamoud et al., 2013. Antiproliferative, antimicrobial and antioxidant activities of the chemical constituents of Ajuga turkestanica. Phytopharmacology, 4: 1-18.
  8. El-Readi, M.Z., S. Eid, M.L. Ashour, A. Tahrani and M. Wink, 2013. Modulation of multidrug resistance in cancer cells by chelidonine and Chelidonium majus alkaloids. Phytomed., 20: 282-294.
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  9. El-Readi, M.Z., H.H. Eid, M.L. Ashour, S.Y. Eid, R.M. Labib, F. Sporer and M. Wink, 2013. Variations of the chemical composition and bioactivity of essential oils from leaves and stems of Liquidambar styraciflua (Altingiaceae). J. Pharm. Pharmacol., 65: 1653-1663.
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  10. Eid, S.Y., M.Z. El-Readi, E.E.M.N. Eldin, S.H. Fatani and M. Wink, 2013. Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells. Phytomed., 21: 47-61.
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  11. Abd El-kader, A.M., M.Z. El-Readi, A.S. Ahmed, A.M. Nafady, M. Wink and Z.Z. Ibraheim, 2013. Polyphenols from aerial parts of Polygonum bellardii and their biological activities. Pharm. Biol., 51: 1026-1034.
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  12. Wink, M., M.L. Ashour and M.Z. El-Readi, 2012. Secondary metabolites inhibiting ABC transporters and reversing resistance of cancer cells and fungi to cytotoxic and antimicrobial agents. Front Microbiol., 362: 130-130.
    CrossRef  |  PubMed  |  
  13. Eid, S.Y., M.Z. El-Readi and M. Wink, 2012. Synergism of three-drug combinations of sanguinarine and other plant secondary metabolites with digitonin and doxorubicin in multi-drug resistant cancer cells. Phytomed., 19: 1288-1297.
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  14. Eid, S.Y., M.Z. El-Readi and M. Wink, 2012. Digitonin synergistically enhances the cytotoxicity of plant secondary metabolites in cancer cells. Phytomed., 19: 1307-1314.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Eid, S.Y., M.Z. El-Readi and M. Wink, 2012. Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomed., 19: 977-987.
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  16. Ashour, M.L., M.Z. El-Readi, A. Tahrani, S.Y. Eid and M. Wink, 2012. A novel cytotoxic aryltetraline lactone from Bupleurum marginatum (Apiaceae). Phytochem. Lett., 5: 387-392.
    CrossRef  |  
  17. Mamadalieva, N.Z., M.Z. El-Readi, A.A. Janibekov, A. Tahrani and M. Wink, 2011. Phytoecdysteroids of silene guntensis and their in vitro cytotoxic and antioxidant activity. Z. Naturforsch., C, 66: 215-224.
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  18. Mamadalieva, N.Z., F. Herrmann, M.Z. El‐Readi, A. Tahrani and R. Hamoud et al., 2011. Flavonoids in Scutellaria immaculata and S. ramosissima (Lamiaceae) and their biological activity. J. Pharm. Pharmacol., 63: 1346-1357.
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  19. Hamdan, D., M.Z. El-Readi, A. Tahrani, F. Herrmann and D. Kaufmann et al., 2011. Chemical composition and biological activity of Citrus jambhiri Lush. Food Chem., 127: 394-403.
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  20. Hamdan, D., M.Z. El-Readi, A. Tahrani, F. Herrmann and D. Kaufmann et al., 2011. Secondary metabolites of ponderosa lemon (citrus pyriformis) and their antioxidant, anti-inflammatory and cytotoxic activities. Z. Naturforsch., C, 66: 385-393.
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  21. Mulyaningsih, S., M. Youns, M.Z. El-Readi, M.L. Ashour and E. Nibret et al., 2010. Biological activity of the essential oil of Kadsura longipedunculata (Schisandraceae) and its major components. J. Pharm. Pharmacol., 62: 1037-1044.
    CrossRef  |  PubMed  |  
  22. Hamdan, D., M.Z. El-Readi, E. Nibret, F. Sporer, N. Farrag, A. El-Shazly and M. Wink, 2010. Chemical composition of the essential oils of two Citrus species and their biological activities. Die Pharmazie, 65: 141-147.
    PubMed  |  Direct Link  |  
  23. El-Readi, M.Z., D. Hamdan, N. Farrag, A. El-Shazly and M. Wink, 2010. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from citrus species in human colon and leukaemia cell lines. Eur. J. Pharmacol., 66: 139-145.
    CrossRef  |  PubMed  |  Direct Link  |  
  24. Ashour, M.L., M. El-Readi, M. Youns, S. Mulyaningsih, F. Sporer, T. Efferth and M. Wink, 2009. Chemical composition and biological activity of the essential oil obtained from Bupleurum marginatum (Apiaceae). J. Pharm. Pharmacol., 61: 1079-1087.
    CrossRef  |  PubMed  |  
  25. El-Melegy, N.T., S.M. Abdel Ghany, F.A. Abdel Moezz and M.Z. El-Readi, 2005. Levels of sFas/apo-1, caspase 3 and tumor necrosis factor alpha in patients with acute ischemic cerebral stroke. Arab J. Lab. Med., 31: 267-284.