Dr. Adel Sharaf Al-Zubairi

Dr. Adel Sharaf Al-Zubairi

Associate Professor
Al Baha University, Saudi Arabia


Highest Degree
PostDoc Fellow in Cancer Research from University of Putra Malaysia, Malaysia

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Biography

Dr. Adel Sharaf Al-Zubairi is presently working as Associate Professor of Biochemistry at Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia. He worked as Principal Post Doctorate Research Fellow at the Laboratory of Cancer Research MAKNA-UPM, IBS, University Putra Malaysia (2007-2009) and Post Doctorate Research Fellow in the Laboratory of Cancer Research MAKNA-UPM, IBS, UPM, Malaysia. He received his PhD degree in Molecular Biology in 2007 at Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Putra Malaysia, Malaysia. His PhD thesis title: “Biochemical and Mutagenic Effects of “khat” (Catha edulis) in rats”. His prior work experience includes Medical Laboratory Specialist, Research Assistant, Demonstrator, Lecturer and Assistant Professor of Biochemistry at different institutions. He is also 6 patents holder. He attended many trainings/workshops. He published 56 Academic writings in national and international journals and conferences. He is serving as regional editor/associate editor/editorial board/reviewer in more than 15 journals. He also received many research awards. His research interests are in cytogenetics, genotoxicity assessment, cancer research, mechanism of action of anticancer drugs, anticancer drug discovery from natural products, lipid peroxidation and free radical generation.

Area of Interest:

Biomedical Sciences
100%
Cancer Research
62%
Cytogenetics
90%
Anticancer Drug Discovery
75%
Antioxidants
55%

Selected Publications

  1. Al-Zubairi, A.S., 2019. Assessment of mutagenicity of herbal preparations from Al- Baha region, Saudi Arabia. Egypt. Acad. J. Biol. Sci., 11: 51-62.
  2. Al-Zubairi, A.S., 2018. Anti-proliferative activity of Zerumbone against tumour cell lines. OnLine J. Biol. Sci., 18: 123-139.
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  3. Al-Zubairi, A.S., M.A. Al-Mamary and E. Al-Ghasani, 2017. The antibacterial, antifungal and antioxidant activities of essential oil from different aromatic plants. Global Adv. Res. J. Med. Med. Sci., 6: 224-233.
  4. Al-Zubairi, A.S., M. Al-Mamary, E. Al-Ghasani, A.B. Abdul and S. Mohan, 2017. Antiproliferative activity of EO extracted from different aromatic plants on different cell lines. MOJ Toxicol. 10.15406/mojt.2017.03.00069.
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  5. Al-Zubairi, A.S., 2017. Genotoxicity assessment of fresh khat leaves extract in Chinese hamster ovary cell lines. J. Med. Sci., 17: 126-132.
  6. Mohan, S., S.I. Abdelwahab, Y.H. Hobani, S. Syam, A.S. Al-Zubairi, R. Al-Sanousi and M.E. Oraiby, 2016. Catha edulis extract induces H9c2 cell apoptosis by increasing reactive oxygen species generation and activation of mitochondrial proteins. Pharmacogn. Mag., 12: S312-S326.
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  7. Bayoumi, R., S. de Fanti, M. Sazzini, C. Giuliani and A. Quagliariello et al., 2016. Positive selection of lactase persistence among people of Southern Arabia. Am. J. Phys. Anthropol., 161: 676-684.
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  8. Al-Zubairi, A.S., 2016. Evaluation of cytogenetic and DNA damage effects induced by Zerumbone. Asian J. Cell Biol., 11: 13-20.
  9. Al-Mamary, H., A. El-Shaibany, M. Al-Habori, A. Al-Meeri, A.S. Al-Zubairi and M. Al-Mamary, 2014. Effect of catha edulis on the activities of enzyme markers of carcinogenicity in chemically-induced hepatocellular carcinoma in rabbits. Int. J. Cancer Res., 10: 1-13.
  10. Al-Zubairi, A.S., 2012. Genotoxicity assessment of a natural anti-cancer compound zerumbone in CHO Cell Lines. Int. J. Cancer Res., 8: 119-129.
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  11. Al-Shoaibi, Z., M.A. Al-Mamary, M.A. Al-Habori, A.S. Al-Zubairi and S.I. Abdelwahab, 2012. In vivo antioxidative and hepatoprotective effects of palm date fruits (Phoenix dactylifera). Int. J. Pharmacol., 8: 185-191.
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  12. Al-Abri, A.R., O. Al-Rawas, S. Al-Yahyaee, M. Al-Habori, A.S. Al-Zubairi and R. Bayoumi, 2012. Distribution of the lactase persistence-associated variant alleles-13910* T and-13915* G among the people of Oman and Yemen. Human Biol., 84: 271-286.
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  13. Mohan, S., A. Bustamam, S. Ibrahim, A.S. Al-Zubairi, M. Aspollah, R. Abdullah and M.M. Elhassan, 2011. In vitro ultramorphological assessment of apoptosis on CEMss induced by linoleic acid-rich fraction from typhonium flagelliforme tuber. Evidence-Based Complement. Altern. Med. .
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  14. Al-Zubairi, A.S., B.A. Ahmad and M. Yousif, 2011. Effects of zerumbone on cisplatin-induced clastogenesis in sprague-dawley rats bone marrow cells. Afr. J. Biotechnol., 10: 5414-5417.
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  15. Al-Naqeep, G., A.S. Al-Zubairi, M. Ismail, Z.H. Amom and N.M. Esa, 2011. Antiatherogenic potential of Nigella sativa seeds and oil in diet-induced hypercholesterolemia in rabbits. Evidence-Based Complemen. Altern. Med., .
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  16. Mohan, S., A.B. Abdul, S.I. Abdel-Wahab, A.S. Al-Zubairi, M.A. Sukari and R, Abdullah et al., 2010. Typhonium flagelliforme inhibits the proliferation of murine leukemia WEHI-3 cells in vitro and induces apoptosis in vivo. Leukemia Res., 34: 1483-1492.
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  17. Mohan, S., A. Bustamam, S.I. Abdel-Wahab, A.S. Al- Zubairi and M. Aspollah et al., 2010. Typhonium flagelliforme induces apoptosis in CEMss cells via activation of caspase-9, PARP cleavage and cytochrome C release: Its activation coupled with G0/G1 phase cell cycle arrest. J. Ethnopharmacol., 131: 592-600.
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  18. Hussein, E.A., A.M. Taj-Eldeen, A.S. Al-Zubairi, A.S. Elhakimi and A.R. Al-Dubaie, 2010. Phytochemical screening, total phenolics and antioxidant and antibacterial activities of callus from Brassica nigra L. hypocotyl explants. Int. J. Pharmacol., 6: 464-471.
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  19. Eid, E.E.M., A.B. Abdul, A.S. Al-Zubairi, M.A. Sukari and R. Abdullah, 2010. Validated High Performance Liquid Chromatographic (HPLC) method for analysis of zerumbone in plasma. Afr. J. Biotechnol., 9: 1260-1265.
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  20. Al-Zubairi, A.S., A.B. Abdul, M. Yousif, S.I. Abdelwahab, M.M. Elhassan and S. Mohan, 2010. In vivo and in vitro genotoxic effects of zerumbone. Caryologia, 63: 11-17.
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  21. Al-Zubairi, A.S., A.B. Abdul and M.M. Syam, 2010. Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood Lymphocytes. Toxicol In vitro, 24: 707-712.
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  22. Al-Zubairi, A.S. and E.E.M. Eid, 2010. Molecular targets in the development of antidiabetic drugs. Int. J. Pharmacol., 6: 784-795.
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  23. Al-Mamary, M., M. Al-Habori and A.S. Al-Zubairi, 2010. The in vitro antioxidant activity of different types of palm dates (Phoenix dactylifera) syrups. Arabian J. Chem., 7: 964-971.
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  24. Abdel-Wahab, S.I., A.B. Abdul, N. Devi, M.M.E. Taha and A.S. Al-Zubairi et al., 2010. Regression of cervical intraepithelial neoplasia by zerumbone in female Balb/c mice prenatally exposed to diethylstilboestrol: Involvement of mitochondria-regulated apoptosis. Exp. Toxicol. Pathol., 62: 461-469.
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  25. Taha, M.M.E., S.I.A. Wahab, F. Othman, P. Hanachi, A.B. Abdul and A.S. Al-Zubairi, 2009. In vivo Anti-tumor effects of Azadirachta indica in rat liver cancer. Res. J. Biol. Sci., 4: 48-53.
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  26. Ibrahim, M.Y., A.B. Abdul, S.I. Abdel Wahab, M.M. Elhassan, A.S. Alzubairi and M.M. Syam, 2009. Attenuation of cisplatin-induced hepatotoxicity in rats using zerumbone. Res. J. Biol. Sci., 4: 777-784.
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  27. Al-Zubairi, A.S., A.B. Abdul, S.I.A. Wahab, C.Y. Peng and S. Mohan et al., 2009. Eleucine indica possesses antioxidant, antibacterial and cytotoxic properties. Evidence-Based Complement. Altern. Med. 10.1093/ecam/nep091.
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  28. Al-Naqeep, G.N., M.M. Ismail, A.S. Al-Zubairi and N.M. Esa, 2009. Nutrients composition and minerals content of three different samples of Nigella sativa L. cultivated in yemen. Asain J. Biol. Sci., 2: 43-48.
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  29. Al-Naqeeb, G., M. Ismail and A.S. Al-Zubairi, 2009. Fatty acid profile, α-tocopherol content and total antioxidant activity of oil extracted from Nigella sativa seeds. Int. J. Pharmacol., 5: 244-250.
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  30. Abdul, A.B., S.I. Abdel-Wahab, J.B. Jalinas, A.S. Al-Zubairi and M.M. Elhassan, 2009. Combination of zerumbone and cisplatin to treat cervical intraepithelial neoplasia in female balb/c mice. Int. J. Gyanacol., 19: 1004-1010.
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  31. Abdul, A.B., S.I. Abdel-Wahab, H.K. Fong, S.M. Mohan, A.S. Al-Zubairi and M.M. Elhassan, 2009. In vitro response of cancer cells to the growth inhibitory effects of Dichloromethane extract of Goniothalamus umbrosus. Res. J. Pharmacol., 3: 1-6.
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  32. Abdelwahab, S.I., A.B. Abdul, M.M. Elhassan, S. Mohan and A.S. Al-Zubairi et al., 2009. Biological and phytochemical investigations of Goniothalamus umbrosus leaves hexane extract. J. Med. Plants Res., 3: 883-888.
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  33. Abdel-Wahab, S.I., A.B. Abdul, S.M. Mohan, A.S. Al-Zubairi, M.M. Elhassan and M.Y. Ibrahim, 2009. Biological activities of Pereskia bleo extracts. Int. J. Pharmacol., 5: 71-75.
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  34. Abdel-Wahab, S.I., A.B. Abdul, S.M. Mohan, A.S. Al-Zubairi and M.M. Elhassan, 2009. Oncolysis of breast, liver and leukemia cancer cells using ethyl acetate and methanol extracts of Goniothalamus umbrosus. Res. J. Biol. Sci., 4: 209-215.
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  35. Abdel-Wahab, S.I., A.B. Abdul, H.K. Fong, S. Mohan, M.M. Elhassan, A.S. Al-Zubairi and A.A. Mariod, 2009. Antimicrobial and free radical scavenging activities of the dichloromethane extract of Goniothalamus umbrosus. Int. J. Trop. Med., 4: 32-36.
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  36. Abdel-Wahab, S.I., A.B. Abdul, A.S. Alzubairi, M.M. El-Hassan and M.S. Mohan, 2009. In vitro Ultramorphological assessment of apoptosis induced by Zerumbone on (HeLa). J. Biomed. Biotechnol. 10.1155/2009/769568.
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  37. Wahab, S.I.A., A.W.H. Mohamed, O.Y. Mohamed, M.M.E. Taha, A.B. Abdul and A.S. Al-Zubairi, 2008. Serotonergic properties of the roots of Clerodendron capitatum. Am. J. Biochem. Biotechnol., 4: 425-430.
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  38. Taha, M.M.E., S.I.A. Wahab, F. Othman, P. Hanachi, A.B. Abdul and A.S. Al-Zubairi, 2008. Chemopreventive properties of Azadirachta indica aqueous extract on DEN-AAF hepatocarcinogenized rats. Int. J. Mol. Med. Adv. Sci., 4: 50-54.
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  39. Mohan, S., A.B. Abdul, S.I.A. Wahab, A.S. Al-Zubairi, M.M. Elhassan and M. Yousif, 2008. Investigations of antioxidant and antibacterial activities of Typhonium flagelliforme (Lodd.) blume leaves. Res. J. Pharmacol., 2: 47-51.
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  40. Mohan, S., A.B. Abdul, S.I. Abdel-Wahab, A.S. Al-Zubairi, M.M. Elhassan and M. Yousif, 2008. Antibacterial and antioxidant activities of Typhonium flagelliforme (Lodd.) blume tuber. Am. J. Biochem. Biotechnol., 4: 402-407.
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  41. Mohan, S., A. Bustamam, S.I. Abdel-Wahab, A.S. Al-Zubairi and M. Aspollah, 2008. Anticancerous effect of Typhonium flagelliforme on human t4-lymphoblastoid cell line CEM-ss. J. Pharmacol. Toxicol., 3: 449-456.
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  42. Bustamam, A., S. Ibrahim, N. Devi, M.N. Halkim, A.S. Al-Zubairi and M.M. Syam, 2008. The establishment and use of an in vivo animal model for cervical intra-epithelial neoplasia. Int. J. Cancer Res., 4: 61-70.
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  43. Bustamam, A., S. Ibrahim, A.S. Al-Zubairi, M.E.T. Manal and S. Mohan, 2008. Zerumbone: A natural compound with anti-cholinesterase activity. Am. J. Pharma. Toxicol., 3: 209-211.
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  44. Al-Zubairi, A.S., P. Ismail, C. Pei Pei, A.B. Abdul , R.S. Ali, S.I.A. Wahab and A. Rahmat, 2008. Short-term repeated dose biochemical effects of Catha edulis (Khat) crude extract administration in rats. Int. J. Trop. Med., 3: 19-25.
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  45. Al-Zubairi, A., P. Ismail, C.P. Pei and A. Rahmat, 2008. Genotoxic effect of Catha edulis (khat) crude extract after sub-chronic administration in rats. Environ. Toxicol. Pharmacol., 25: 298-303.
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  46. Abdul, A.B.H., A.S. Al-Zubairi, N.D. Tailan, S.I. Abdel-Wahab, Z.N.M. Zain, S. Ruslay and M.M. Syam, 2008. Anticancer activity of natural compound (Zerumbone) extracted from Zingiber zerumbet in human hela cervical cancer cells. Int. J. Pharmacol., 4: 160-168.
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  47. Abdul, A.B., S.I. Abdel-Wahab, A.S. Al-Zubairi, M.M. El-Hassan and S.M. Murali, 2008. Anticancer and antimicrobial activities of zerumbone from the rhizomes of Zingiber zerumbut. Int. J. Pharmacol., 4: 301-304.
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  48. Abdel-Wahab, S.I., A.B. Abdul, H.C. Yee, A.S. Alzubairi, M.M. ElHassan and M.M. Syam, 2008. Anti-tumor activities of analogues derived from the bioactive compound of Zingiber zerumbet. Int. J. Cancer Res., 4: 154-159.
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  49. Al-Zubairi, A.S., P. Ismail, C. Pei Pei, S.I.A. Wahab and A. Rahmat, 2007. Biochemical effects of sub-chronic administration of Catha edulis (Khat) crude extract in rats. Res. J. Pharmacol., 1: 84-90.
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  50. Al-Zubairi, A., M. Al-Habori and A. Al-Geiry, 2003. Effect of Catha edulis (Khat) chewing on plasma lipid peroxidation. J. Ethnopharmacol., 87: 3-9.
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