Dr. Keivan  Zandi

Dr. Keivan Zandi

Associate Professor
University of Malaya, Malaysia


Highest Degree
Ph.D. in Virology from Tarbiat Modares University, Iran

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Biography

Dr. Keivan Zandi is currently working as Associate Professor at University Malaya, Kuala Lumpur, Malaysia. He obtained his Ph.D. in Virology from Tarbiat Modares University, Iran. His area of research interest related to Antiviral Research (Intracellular and Molecular Mechanism Study), Molecular Virology, and Natural Products for Drug Discovery, Infectious Disease Molecular Epidemiology, and Cancer Research (Intracellular and Molecular Mechanism Study). He successfully completed 17 research projects as Principal Investigator. He is also serving as member of editorial board and reviewer for many journals. He is member of scientific societies and committees such as Iranian Society for virology, International Society for Medicinal Plants, International Society for Infectious Diseases, Asian Pacific Virology Society, International Society for Antiviral Research, European Society for Clinical Virology, and Scientific committee member for the first, second, third and fourth Iranian Virology Congress, Scientific Advisory Board Member for the First International Symposium on Human Vector-Borne Diseases December 2013, Hawaii, USA, and Organizing Committee Member for the Pharmacognosy 2014 Conference, Beijing, China. He has published 54 research articles in journals, 8 patents and 36 papers in conferences contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Virology
62%
Anticancer Research
90%
Natural Compounds
75%
Molecular Virology
55%

Selected Publications

  1. Lani, R., R.N. Mohd, H. Hassan, R. Yaghoobi, L.Y. Chang, S. AbuBakar and K. Zandi, 2015. First report on the seroprevalence of the Crimean-Congo haemorrhagic fever virus, a tick-borne virus, in Malaysia's Orang Asli population. Eur. Rev. Med. Pharmacol. Sci., 19: 461-466.
    Direct Link  |  

  2. Lani, R., P. Hassandarvish, C.C. Wei, E. Moghaddam and J.J. Chu et al., 2015. Antiviral activity of silymarin against chikungunya virus. Scient. Rep. .

  3. Barathan, M., K. Gopal, R. Mohamed, R. Ellegard and A. Saeidi et al., 2015. Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes. Apoptosis, 20: 466-480.
    CrossRef  |  Direct Link  |  

  4. Shirazi, F.S., E. Moghaddam, M. Mehrali, A.A. Oshkour and H.S.C. Metselaar et al., 2014. In vitro characterization and mechanical properties of β-calcium silicate/POC composite as a bone fixation device. J. Biomed. Mater. Res. Part A, 102: 3973-3985.
    CrossRef  |  Direct Link  |  

  5. Moghaddam, E., B.T. Teoh, S.S. Sam, R. Lani and P. Hassandarvish et al., 2014. Baicalin, a metabolite of baicalein with antiviral activity against dengue virus. Scient. Rep., Vol. 4. 10.1038/srep05452.
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  6. Moghadamtousi, S.Z., H. Karimian, R. Khanabdali, M. Razavi, M. Firoozinia, K. Zandi and H. Abdul Kadir, 2014. Anticancer and antitumor potential of Fucoidan and Fucoxanthin, two main metabolites isolated from Brown algae. Scient. World J., Vol. 2014. 10.1155/2014/768323.
    CrossRef  |  Direct Link  |  

  7. Moghadamtousi, S.Z., H. Abdul Kadir, P. Hassandarvish, H. Tajik, S. Abu Bakar and K. Zandi, 2014. A review on antibacterial, antiviral and antifungal activity of curcumin. BioMed Res. Int., Vol. 2014. 10.1155/2014/186864.
    CrossRef  |  Direct Link  |  

  8. Mehrali, M., E. Moghaddam, S.F.S. Shirazi, S. Baradaran and M. Mehrali et al., 2014. Mechanical and in vitro biological performance of graphene nanoplatelets reinforced calcium silicate composite. PLoS ONE, Vol. 9. 10.1371/journal.pone.0106802.
    CrossRef  |  Direct Link  |  

  9. Mehrali, M., E. Moghaddam, S.F. Shirazi, S. Baradaran and M. Mehrali et al., 2014. Synthesis, mechanical properties and in vitro biocompatibility with osteoblasts of calcium silicate-reduced graphene oxide composites. ACS Applied Mater. Interfaces, 6: 3947-3962.
    CrossRef  |  Direct Link  |  

  10. Marlina, S., S.F. Radzi, R. Lani, K.C. Sieng and N.F. Rahim et al., 2014. Seroprevalence screening for the West Nile virus in Malaysia's Orang Asli population. Parasites Vectors, Vol. 7. .
    Direct Link  |  

  11. Lani, R., E. Moghaddam, A. Haghani, L.Y. Chang, S. AbuBakar and K. Zandi, 2014. Tick-borne viruses: A review from the perspective of therapeutic approaches. Ticks Tick-Borne Dis., 5: 457-465.
    Direct Link  |  

  12. Farshadpour, F., S. Gharibi, M. Taherzadeh, R. Amirinejad, R. Taherkhani, A. Habibian and K. Zandi, 2014. Antiviral activity of Holothuria sp. a sea cucumber against herpes simplex virus type 1 (HSV-1). Eur. Rev. Med. Pharmacol. Sci., 18: 333-337.
    Direct Link  |  

  13. Zandi, K., T.H. Lim, N.A. Rahim, M.H. Shu and B.T. Teoh et al., 2013. Extract of Scutellaria baicalensis inhibits dengue virus replication. BMC Complement. Altern. Med., Vol. 13. 10.1186/1472-6882-13-91.
    CrossRef  |  Direct Link  |  

  14. Tajbakhsh, S., S. Gharibi, K. Zandi and R. Yaghobi, 2013. Use of a modified fluorescent in situ hybridization procedure to improve the identification of Streptococcus pneumonia in blood cultures. Acta Microbiologica et Immunologica Hungarica, 60: 303-311.
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  15. Shu, M.H., D. Appleton, K. Zandi and S. AbuBakar, 2013. Anti-Inflammatory, gastroprotective and anti-ulcerogenic effects of red algae Gracilaria changii (Gracilariales, Rhodophyta) extract. BMC Complement. Altern. Med., Vol. 13. 10.1186/1472-6882-13-61.
    CrossRef  |  Direct Link  |  

  16. Moghadamtousi, S.Z., M. Hajrezaei, H. Abdul Kadir and K. Zandi, 2013. Loranthus micranthus Linn.: Biological activities and phytochemistry. Evid.-Based Complement. Altern. Med., Vol. 2013. 10.1155/2013/273712.
    CrossRef  |  Direct Link  |  

  17. Zandi, K., R. Lani, P.F. Wong, B.T. Teoh and S.S. Sam et al., 2012. Flavone enhances dengue virus type-2 (NGC Strain) infectivity and replication in Vero cells. Molecules, 17: 2437-2445.
    CrossRef  |  Direct Link  |  

  18. Zandi, K., B.T. Teoh, S.S. Sam, P.F. Wong, M.R. Mustafa and S. AbuBakar, 2012. Novel antiviral activity of baicalein against dengue virus. BMC Complement. Altern. Med., Vol. 12. 10.1186/1472-6882-12-214.
    CrossRef  |  Direct Link  |  

  19. Vahdat, K., F. Azizi, K. Zandi and I. Nabipour, 2012. Chronic inflammation is correlated with percentage of body fat independent of the burden of infection. Inflammation, 35: 1322-1329.
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  20. Meshkat, Z., M.H. Roostaee, M. Soleimanjahi and K. Zandi, 2012. Evaluation of antibodies against glycoprotein D (gD) and glycoprotein (gG) in HSV-1 infected individuals' serum samples. Eur. Rev. Med. Pharmacol. Sci., 16: 499-502.

  21. Johari, J., A. Kianmehr, M.R. Mustafa, S. Abubakar and K. Zandi, 2012. Antiviral activity of baicalein and quercetin against the Japanese encephalitis virus. Int. J. Mol. Sci., 13: 16785-16795.
    CrossRef  |  Direct Link  |  

  22. Eghbali, S.S., R. Amirinejad, N. Obeidi, S. Mosadeghzadeh and K. Vahdat et al., 2012. Oncogenic human papillomavirus genital infection in southern Iranian women: Population-based study versus clinic-based data. Virol. J., Vol. 9. .
    Direct Link  |  

  23. Zandi, K., B.T. Teoh, S.S. Sam, P.F. Wong, M.R. Mustafa and S. Abubakar, 2011. Antiviral activity of four types of bioflavonoid against dengue virus type-2. Virol. J., Vol. 8. 10.1186/1743-422X-8-560.
    CrossRef  |  

  24. Zandi, K., B.T. Teoh, S.S. Sam, P.F. Wong, M.R. Mustafa and S. AbuBakar, 2011. In vitro antiviral activity of fisetin, rutin and naringenin against dengue virus type-2. J. Med. Plants Res., 5: 5534-5539.

  25. Tajbakhsh, S., S. Gharibi, K. Zandi, R. Yaghobi and G. Asayesh, 2011. Rapid detection of Streptococcus pyogenes in throat swab specimens by fluorescent in situ hybridization. Eur. Rev. Med. Pharmacol. Sci., 15: 313-317.
    PubMed  |  

  26. Tajbakhsh, S., M. Pouyan, K. Zandi, P. Bahramian and K. Sartavi et al., 2011. In vitro study of antibacterial activity of the alga Sargassum oligocystum from the Persian Gulf. Eur. Rev. Med. Pharmacol. Sci., 15: 293-298.
    Direct Link  |  

  27. Kargar, M., A. Najafi, K. Zandi and Z. Hashemizadeh, 2011. Genotypic distribution of rotavirus strains causing severe gastroenteritis in children under 5 years old in Borazjan, Iran. Afr. J. Microbiol. Res., 5: 2936-2941.
    Direct Link  |  

  28. Zandi, K., S.S. Eghbali, R. Hamkar, S. Ahmadi and E. Ramedani et al., 2010. Prevalence of various Human Papillomavirus (HPV) genotypes among women who subjected to routine Pap smear test in Bushehr city (South west of Iran) 2008-2009. Virol. J., Vol. 7. .
    Direct Link  |  

  29. Zandi, K., S. Tajbakhsh, I. Nabipour, Z. Rastian, F. Yousefi, S. Sharafian and K. Sartavi, 2010. In vitro antitumor activity of Gracilaria corticata (a red alga) against jurkat and molt-4 human cancer cell lines. Afr. J. Biotechnol., 9: 6787-6790.

  30. Zandi, K., S. Ahmadzadeh, S. Tajbakhsh, Z. Rastian, F. Yousefi, F. Farshadpour and K. Sartavi, 2010. Anticancer activity of Sargassum oligocystum water extract against human cancer cell lines. Eur. Rev. Med. Pharmacol. Sci., 14: 669-673.
    PubMed  |  Direct Link  |  

  31. Zandi, K., E. Ramedani, K. Mohammadi, S. Tajbakhsh and I. Deilami et al., 2010. Evaluation of antiviral activities of curcumin derivatives against HSV-1 in vero cell line. Nat. Prod. Commun., 5: 1935-1938.
    PubMed  |  Direct Link  |  

  32. Vahdat, K., H. Keyvani, S.M. Tabib, S. Rostamabadi and S.M. Valizadeh et al., 2010. Molecular epidemiology of hepatitis C virus genotypes in Bushehr province, Iran. Eur. Rev. Med. Pharmacol. Sci., 14: 861-864.
    Direct Link  |  

  33. Gharibi, S., S. Tajbakhsh, K. Zandi and R. Yaghobi, 2010. Evaluation of fluorescent in situ hybridization for rapid diagnosis of enterococcal wound infection. Afr. J. Microbiol. Res., 4: 2498-2502.
    Direct Link  |  

  34. Fouladvand, M., A. Barazesh, K. Zandi, B. Naeimi and S. Tajbakhsh, 2010. Seroepidemiological study of toxoplasmosis in high school girls in Bushehr city, South West of Iran in 2009. Afr. J. Biotechnol., 4: 1117-1121.
    Direct Link  |  

  35. Fouladvand, M., A. Barazesh, K. Zandi, B. Naeimi and S. Tajbakhsh, 2010. Seroepidemiological study of toxoplasmosis in childbearing age women in Bushehr city, South West of Iran in 2009. Afr. J. Biotechnol., 9: 5809-5812.
    Direct Link  |  

  36. Zandi, K., M. Taherzadeh, R. Yaghoubi, S. Tajbakhsh, Z. Rastian, M. Fouladvand and K. Sartavi, 2009. Antiviral activity of Avicennia marina against herpes simplex virus type 1 and vaccine strain of poliovirus (An in vitro study). J. Med. Plant Res., 3: 771-775.
    Direct Link  |  

  37. Tajbakhsh, S., K. Mohammadi, I. Deilami, K. Zandi, M. Fouladvand, E. Ramedani and G. Asayesh, 2008. Antibacterial activity of indium curcumin and indium diacetylcurcumin. Afr. J. Biotechnol., 7: 3832-3835.
    Direct Link  |  

  38. Pourkarim, M.R., K. Zandi, N.A. Davani, H.R. Pourkarim and S. Amini-Bavil-Olyaee, 2008. An aberrant high prevalence of hepatitis B infection among Afghans residing in one of the Bushehr refugee camps (Dalaki camp) in the southwest of Iran. Int. J. Infect. Dis., 12: 101-102.

  39. Zandi, K., M.H. Roostaee , M. Sadeghizadeh, M.J. Rasaee, R.H. Sajedi and H. Soleimanjahi, 2007. Production of recombinant gG-1 protein of herpes simplex virus type 1 in a prokaryotic system in order to developing a type specific ELISA kit. FEMS Immunol. Med. Mirobiol., 50: 319-323.
    CrossRef  |  

  40. Zandi, K., M.H. Farsangi, I. Nabipour, M. Soleimani, K. Khajeh, R.H. Sajedi and S.M. Jafari, 2007. Isolation of a 60 kDa protein with in vitro anticancer activity against human cancer cell lines from the purple fluid of the Persian gulf sea hare, Aplysia dactylomela. Afr. J. Biotechnol., 6: 1280-1283.
    Direct Link  |  

  41. Zandi, K., M.A. Zadeh, K. Sartavi and Z. Rastian, 2007. Antiviral activity of Aloe vera against herpes simplex virus type 2: An in vitro study. Afr. J. Biotechnol., 6: 1770-1773.
    Direct Link  |  

  42. Zandi, K., M.A. Fouladvand, P. Pakdel and K. Sartavi, 2007. Evaluation of in vitro antiviral activity of a brown alga from the Persian gulf against herpes simplex virus type 1. Afr. J. Biotechnol., 6: 2511-2514.
    Direct Link  |  

  43. Zandi, K., M. Salimi and K. Sartavi, 2007. In vitro antiviral activity of the red marine alga from Persian gulf, Gracilaria salicornia against herpes simplex virus type 2. J. Biol. Sci., 7: 1274-1277.
    CrossRef  |  

  44. Jamehdar, S.A., F. Sabahi, K. Zandi, A. Shafiee, S.F. Zadeh and F.A. Jalilian, 2007. Antigen specific lymphocyte proliferation assay and virus neutralization test measurement of measles specific immunity in 15-19 years old high school students, Tehran Iran. Pak. J. Biol Sci., 10: 4144-4147.
    Direct Link  |  

  45. Soleimanjahi, H., M.H. Roostaee, M.J. Rasaee, F. Mahboudi, A. Kazemnejad, T. Bamdad and K. Zandi, 2006. The effect of DNA priming-protein boosting on enhancing humoral immunity and protecting mice aginst lethal HSV infection. FEMS Immunol. Med. Microbiol., 46: 100-106.
    CrossRef  |  

  46. Vahdat, K., I. Nabipour, M. Motamedi, S.M. Jafari and V. Ghajari et al., 2005. A seroepidemiological survey on leptospirosis in the livestock breeders during the outbreak of haemorrhagic fever in domestic animals of Helleh River area in 2004. Iranian South Med. J., 8: 53-59.

  47. Coa, J., R. Arulananadam, A. Vultur, T. Preston and K. Jaronczyk et al., 2005. Adenovirus-5 E1A suppresses differentiation of 3T3-L1 preadipocytes at lower levels than required lower levels than required for induction of apoptosis. Mol. Carcinogen, 43: 38-50.
    CrossRef  |  

  48. Soleimanjahi, H., M.H. Roostaee, M.J. Rasaee, A. Kazemnejard, Z. Meshkat and K. Zandi, 2004. Inducing humoral immunoresponse against HSV-1 using the recombinant gD protein of virus in BALB/C mice. Iranian South Med. J., 7: 1-10.

  49. Pourkarim, M.R., G.R. Khamisipour, K. Zandi and M.H. Roostaee, 2004. Prevalence of anti-HTLV-1 and anti HTLV-2 antibodies in blood donors in Bushehr province. Iranian South Med. J., 6: 161-166.

  50. Sabet, L.P., M.H. Roostaee, K. Zandi and T. Bamdad, 2003. Restriction enzyme analysis of TK gene in four Iranian isolates of HSV-1. Arch. Razi Ins., 56: 1-10.
    Direct Link  |  

  51. Aghaebrahimian, M., M.H. Roostaee, H. Soleimanjahi and K. Zandi, 2003. Nucleic acid-based immunization with HSV-1 genes specifying gB-1 and gD-1. Iran. S. Med. J., 6: 1-7.

  52. Zandi, K., M.H. Roostaee, M. Sadeghizadeh and M.J. Rasaee, 2002. Construction of a clone expressing gG-1 of HSV-1 in order to produce recombinant protein in prokaryotic system. Iran. S. Med. J., 5: 1-7.

  53. Edalat, R., F. Sabahi, M.H. Roostaee and K. Zandi, 2002. Enzyme linked immunosorbent assay compared with neutralization test for detection of mumps virus IgG antibodies. Modarres Med. J., 1: 8-14.

  54. Zandi, K., S. Tajbakhsh, S.M. Jafari and H.R. Ghaffarian, 1999. Determination of immunity to rubella virus among pre-marriage girls of Bushehr port by HI and ELISA methods. Iran. S. Med. J., 2: 35-40.